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Kim Jeonghun,Chun Sang Hun,Amornkitbamrung Lunjakorn,Song Chanyoung,육지수,Ahn So Yeon,Kim Byung Woo,임용택,OH,BYUNG-KEUN,엄숭호 나노기술연구협의회 2020 Nano Convergence Vol.7 No.6
Gold particles have been widely used in the treatment of prostate cancer due to their unique optical properties, such as their light-heat conversion in response to near-infrared radiation. Due to well-defined synthesis mechanisms and simple manufacturing methods, gold particles have been fabricated in various sizes and shapes. However, the low photothermal transduction efficiency in their present form is a major obstacle to practical and therapeutic uses of these particles. In the current work, we present a silica-coated gold nanoparticle cluster to address the therapeutic limit of single gold nanoparticles (AuNPs) and use its photothermal effect for treatment against PC-3, a typical prostate cancer. Due to its specific nanostructure, this gold nanocluster showed three times higher photothermal transduction efficiency than free single AuNPs. Moreover, while free single particles easily clump and lose optical properties, this silica-coated cluster form remained stable for a longer time in a given medium. In photothermal tests under near-infrared radiation, the excellent therapeutic efficacy of gold nanoclusters, referred to as AuNC@SiO 2 , was observed in a preclinical sample. Only the samples with both injected nanoclusters followed by photothermal treatment showed completely degraded tumors after 15 days. Due to the unique intrinsic biocompatibility and higher therapeutic effect of these silica-coated gold nanoclusters, they may contribute to enhancement of therapeutic efficacy against prostate cancer.
ChanYoung Kim,EungChang Mason Lee,JunHo Choi,JinWoo Jeon,SeokTae Kim,Hyun Myung 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
Unmanned Aerial Vehicles (UAVs) have been intensively used in various fields thanks to their excellent maneuverability. However, the short operation time of the UAV is limiting the further utilization of the UAV. The limitation of the UAV can be overcome by landing on ground vehicles and charging the battery on them. Therefore, diverse researches have been done on robust landing on ground platforms. Unfortunately, the existing autonomous landing methods have such limitations that a) special tag or marker should be attached on the landing site; b) visibility of the landing site must be secured; c) platform should be static; In this paper, to robustly estimate the relative pose of the moving platform and successfully land on it, we propose a novel robust landing system of the UAV. A neural network based object detection is used to recognize the landing site without a special tag or marker, and an Ultra-wideband (UWB) sensor is adopted to compensate for the limited field of view of the camera. The Extended Kalman Filter (EKF) for estimating the relative position of the moving platform by fusing the information obtained from various sensors is developed. Additionally, a robust autonomous landing controller is also designed. The performance of the proposed method is verified by the simulation of the UAV and the moving platform.
Optimized single-layer MoS<sub>2</sub> field-effect transistors by non-covalent functionalisation
Kim, HyunJeong,Kim, WungYeon,O'Brien, Maria,McEvoy, Niall,Yim, Chanyoung,Marcia, Mario,Hauke, Frank,Hirsch, Andreas,Kim, Gyu-Tae,Duesberg, Georg S. The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.37
<P>Field-effect transistors (FETs) with non-covalently functionalised molybdenum disulfide (MoS2) channels grown by chemical vapour deposition (CVD) on SiO2 are reported. The dangling-bond-free surface of MoS2 was functionalised with a perylene bisimide derivative to allow for the deposition of Al2O3 dielectric. This allowed the fabrication of top-gated, fully encapsulated MoS2 FETs. Furthermore, by the definition of vertical contacts on MoS2, devices, in which the channel area was never exposed to polymers, were fabricated. The MoS2 FETs showed some of the highest mobilities for transistors fabricated on SiO2 with Al2O3 as the top-gate dielectric reported so far. Thus, gate-stack engineering using innovative chemistry is a promising approach for the fabrication of reliable electronic devices based on 2D materials.</P>
MGOS: A library for molecular geometry and its operating system
Kim, Deok-Soo,Ryu, Joonghyun,Cho, Youngsong,Lee, Mokwon,Cha, Jehyun,Song, Chanyoung,Kim, Sang Wha,Laskowski, Roman A.,Sugihara, Kokichi,Bhak, Jong,Ryu, Seong Eon Elsevier 2020 Computer physics communications Vol.251 No.-
<P><B>Abstract</B></P> <P>The geometry of atomic arrangement underpins the structural understanding of molecules in many fields. However, no general framework of mathematical/computational theory for the geometry of atomic arrangement exists. Here we present “Molecular Geometry (MG)” as a theoretical framework accompanied by “MG Operating System (MGOS)” which consists of callable functions implementing the MG theory. MG allows researchers to model complicated molecular structure problems in terms of elementary yet standard notions of volume, area, etc. and MGOS frees them from the hard and tedious task of developing/implementing geometric algorithms so that they can focus more on their primary research issues. MG facilitates simpler modeling of molecular structure problems; MGOS functions can be conveniently embedded in application programs for the efficient and accurate solution of geometric queries involving atomic arrangements. The use of MGOS in problems involving spherical entities is akin to the use of math libraries in general purpose programming languages in science and engineering.</P> <P><B>Program summary</B></P> <P> <I>Program Title:</I> Molecular Geometry Operating System (MGOS)</P> <P> <I>Program Files doi:</I> http://dx.doi.org/10.17632/hp2wmvxsfz.1 </P> <P> <I>Licensing provisions:</I> CC By 4.0</P> <P> <I>Programming language:</I> C++</P> <P> <I>Supplementary material:</I> (1) Supplementary Video 1, (2) Supplementary Video 2, (3) Supplementary Video 3, (4) Supplementary Video 4, (5) MGOS manual, and (6) 300 test PDB structure files</P> <P> <I>Nature of problem:</I> For both organic and inorganic molecules, structure determines molecular function and molecular structure is highly correlated with molecular shape or geometry. Hence, many studies were conducted for the analysis and evaluation of the geometry of atomic arrangement. However, most studies were based on Monte Carlo, grid-counting, or approximation methods and a high-quality solution requires heavy computational resources, not to mention its dependency on computation environment. In this paper, we introduce a unified framework of computational library, Molecular Geometry Operating System (MGOS), based on an analytic method for the molecular geometry of atomic arrangements. We believe that the powerful MGOS application programming interface (API) functions will free scientists from developing and implementing complicated geometric algorithms and let them focus on more important scientific problems.</P> <P> <I>Solution method:</I> Molecular Geometry (MG) is a general framework of mathematical/computational methods for solving molecular structure problems using a geometry-priority philosophy and is implemented by MGOS which is a library of callable C++ API functions. MGOS is developed based on the Voronoi diagram of three-dimensional spheres and its two derivative constructs called the quasi-triangulation and beta-complex. Note that this Voronoi diagram is different from the ordinary Voronoi diagram of points where the points are atom centers. Being an analytic method, the solutions of many geometric queries on atomic arrangement, if not all, are obtained correctly and quickly. The MGOS architecture is carefully designed in a three-tier architecture so that future modifications and/or improvements can be reflected in the application programs with no additional programming by users.</P>