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ChangJong Kim(김창종),JongSung Kim(김종성),HyunSu Jang(장현수),YungChan Kim(김영찬) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
In this study, Irradiation-assisted stress corrosion cracking (IASCC) growth analysis was performed through welding residual stress and neutron irradiation analysis of Core Shroud, one of the reactor internal structure. There has not been sufficient research to predict IASCC growth behavior for neutron irradiation, temperature and thermodynamic treatment of reactor internal structure. Therefore, it is important to predict the IASCC growth behavior of the core shroud because there are many welds in the core shroud, one of the reactor internal structures, and it is operated under high temperature and neutron irradiation environment. In the previous study, after residual stress analysis, neutron irradiation and IASCC sensitivity analysis were performed. Through the analysis results, two maximum sensitivity points at 20, 30, and 40 EFPY with IASCC sensitivity of 0.5 or higher were selected as cracks initiation points. All cracks were found in the weld. The growth direction of cracks in the weld was determined according to the direction of the principal stress by deriving the principal stress at the point where the maximum IASCC sensitivity occurred. The IASCC finite element growth analysis results will present the energy release rate according to the crack location.
Time-course response of epichlorohydrin on epididymal histopathology in rats
Kim, Kang-Hyeon,Shin, In-Sik,Lim, Jeong-Hyeon,Kim, Sung-Hwan,Park, Na-Hyeong,Moon, Changjong,Kim, Sung-Ho,Shin, Dong-Ho,Kim, Jong-Choon The Korean Society of Veterinary Science 2009 大韓獸醫學會誌 Vol.49 No.4
This research aimed to investigate the time-course effect of epichlorohydrin (ECH) on epididymal histopathology in Sprague-Dawley rats. Twenty-four male rats were randomly assigned to four groups with 6 rats in each group and were administered a single oral dose of ECH (70 mg/kg) or its vehicle. Six animals each were sacrificed on days 0 (control), 1, 2, and 7 after treatment. During the study period, clinical signs, body weights, reproductive organ weights, testicular spermatid count, epididymal sperm count, motility and morphology, and histopathology were examined. No treatmentrelated effects on body weights and reproductive organ weights were noted at any time point. On the contrary, sperm motility decreased slightly on days 1 and 2 after treatment and then decreased significantly on day 7 after treatment. The first signs of histological changes were the appearance of cell debris in the ducts and vacuolization of the epithelial cells observed in the proximal caput epididymis on day 1 after treatment. The incidences and grades of the histological changes including cell debris in the ducts, epithelial vacuolization, oligospermia, and epithelial disruption increased on day 2 and then decreased slightly on day 7 after treatment. These results show that a single oral dose of 70 mg/kg ECH to male rats results in cell debris in the ducts and vacuolization of the epithelial cells in the proximal caput epididymis, followed by reversible oligospermia, epithelial disruption, and decreased sperm motility.
Opposite Localization of Luteinizing Hormone Receptors and Galectin-3 in Mature Mouse Ovaries
Juhwan Kim(김주환),Miyoung Yang(양미영),Sung-Ho Kim(김성호),Jong-Choon Kim(김종춘),Seungjoon Kim(김승준),Hong-Gu Joo(주홍구),Taekyun Shin(신태균),Changjong Moon(문창종) 한국생명과학회 2012 생명과학회지 Vol.22 No.5
본 연구는 성숙마우스의 난소에서 황체형성호르몬수용체(luteinizing hormone receptor, LHR)와 beta-galctoside-binding animal lectin인 galetin-3 (Gal-3)의 발현분포를 면역조직화학방법으로 평가하였다. LHR은 활동(성숙) 황체에서 강하게 발현되는 반면에, Gal-3의 발현은 퇴행중인 황체와 폐쇄난포에서 높게 나타났다. 또한, 임신중인 마우스의 황체에서는 LHR의 면역반응이 강하게 나타났으나, Gal-3의 면역반응은 현저히 낮았다. 위의 결과를 종합해 볼 때, 성숙마우스의 난소에서 LHR과 Gal-3는 난소의 특정한 시기에 따라 다른 분포양상을 나타냄을 알 수 있었으며, 이들 각각의 단백질의 발현으로 보아 황체의 형성과 퇴행에서 상반된 역할을 할 것으로 여겨진다. Received January 5, 2012 /Revised April 12, 2012 /Accepted May 8, 2012 The present study evaluated the localization of luteinizing hormone receptors (LHR) and galectin-3 (Gal-3), a beta-galactoside-binding animal lectin, in the mature mouse ovaries by immunohistochemical analysis. Intense LHR immunoreactivity was detected in the active corpus luteum (CL), whereas expression of Gal-3 was high in the regressing CL and atretic follicle. In the CL of pregnant mice, LHR immunoreactivity was intense, but Gal-3 expression was low. Thus, LHR and Gal-3 had opposite patterns of expression in mature mouse ovaries, suggesting that both proteins have stage-specific expression patterns and are possibly involved in CL formation and regression.
Heechul Kim,Seungjoon Kim,Jeeyoung Lee,Jeongtae Kim,Jin Won Hyun,Jae Woo Park,Sung-Ho Kim,Changjong Moon,Taekyun Shin 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.2
Radiation therapy is used for cancer treatment, but there are some side effects such as oxidative damage. Sodium salicylate, an anti-inflammatory drug, plays a role in the reduction of oxidative damage. We investigated the antioxidant role of sodium salicylate against gamma-radiation-induced oxidative damage in liver tissue after whole-body irradiation with a single dose of 5 Gy. Twenty adult rats were divided into four equal groups. On the day of the experiment, groups Ⅰ and Ⅱ were treated orally with 200 ㎎/㎏ sodium salicylate, while groups Ⅲ and Ⅳ received distilled water. One hour later, groups Ⅱ and Ⅳ were exposed to 5 Gy whole-body ionizing radiation in a single fraction. Thiobarbituric acid-reactive substances (TSARS) in the liver ware measured in all groups, 4 hours after their exposure to radiation. Whole-body radiation significantly increased TSARS level in the liver, while sodium salicylate significantly reduced hepatic TSARS level in irradiated rats. Furthermore, radiation injury induced Kupffer cell activation, while sodium salicylate significantly inhibited Kupffer cell activation in irradiated rats. The data obtained in this study suggest that sodium salicylate administration prior to irradiation may prevent liver damage by radiation.
대나무 숯과 대나무 잎의 급여가 육계의 생산성과 육질에 미치는 영향
Sung-Hwan Kim(김성환),In-Chul Lee(이인철),Sung-Su Kang(강성수),Changjong Moon(문창종),Sung-Ho Kim(김성호),Dong-Ho Shin(신동호),Hyoung-Chin Kim(김형진),Jin-Cheol Yoo(유진철),Jong-Choon Kim(김종춘) 한국생명과학회 2011 생명과학회지 Vol.21 No.6
본 연구는 대나무 숯과 대나무 잎의 급여가 육계의 성장과 사료효율 및 육질에 미치는 영향을 조사하기 위해 30일간 각각 0.5%의 농도로 급여하였다. 시험결과, 대숯과 대잎 시험군에서 시험기간 중 사망률은 대조군에 비해 낮아진 반면, 출하 시 체중과 증체량은 대조군에 비해 유의성 있게 증가하였다. 또한 대조군에 비해 대숯과 대잎 시험군의 사료효율도 개선되었으며, 계육의 전단력은 대조군에 비해 유의성 있게 감소하였다. 대숯을 급여한 닭에서의 지방함량은 통계학적 차이는 없었으나 감소경향을 나타낸 반면, 대숯과 대잎을 급여한 닭에서의 불포화 지방산 비율은 증가경향을 나타내었다. 계육의 관능검사 결과, 대숯과 대잎 시험군의 선호도는 대조군에 비해 높게 나타났다. 혈액 및 혈청생화학 검사항목에서는 대조군과 시험군간에 유의성 있는 차이가 인정되지 않았다. 본 시험결과는 대나무 숯과 대나무 잎의 사료첨가 급여가 육계의 성장과 사료효율 및 육질을 개선시키는 것으로 나타났다. 본 연구결과는 사료첨가제로서 대나무 숯과 대나무 잎의 유용성과 개발가능성을 시사해 주고 있다. The present study was conducted to investigate the effects of dietary supplementation with bamboo charcoal (BC) and bamboo leaf (BL) on growth performance, feed intake, feed conversion efficiency, and meat quality in broiler chickens. Broiler chickens were fed for 30 days with a diet containing 0.5% bamboo charcoal or bamboo leaf. The results showed that the mortality rate during the study period was slightly lower in the BC and BL groups than the control group, while terminal weight and weight gain were significantly higher in the BC and BL groups than the control group. Dietary supplementation with BC or BL also improved feed conversion rate compared to chickens in the control group. Shear force was significantly lower in the BC and BL groups than that of the control group. The fat content of chickens fed with BC tended to decrease, while the ratio of unsaturated fat acid of chickens fed with BC or BL tended to increase, although without a statistically significant difference. Sensory evaluation revealed that overall acceptability was slightly higher in the BC and BL groups than the control group. There was no statistically significant change in the hematology and serum biochemistry parameters, compared with the control group in any group tested. The results of this experiment indicated that dietary supplementation with BC and BL may improve growth performance, feed conversion efficiency, and meat quality in broiler chickens.
Fast neutron irradiation deteriorates hippocampus-related memory ability in adult mice
Yang, Miyoung,Kim, Hwanseong,Kim, Juhwan,Kim, Sung-Ho,Kim, Jong-Choon,Bae, Chun-Sik,Kim, Joong-Sun,Shin, Taekyun,Moon, Changjong The Korean Society of Veterinary Science 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.1
<P>Object recognition memory and contextual fear conditioning task performance in adult C57BL/6 mice exposed to cranial fast neutron irradiation (0.8 Gy) were examined to evaluate hippocampus-related behavioral dysfunction following acute exposure to relatively low doses of fast neutrons. In addition, hippocampal neurogenesis changes in adult murine brain after cranial irradiation were analyzed using the neurogenesis immunohistochemical markers Ki-67 and doublecortin (DCX). In the object recognition memory test and contextual fear conditioning, mice trained 1 and 7 days after irradiation displayed significant memory deficits compared to the sham-irradiated controls. The number of Ki-67- and DCX-positive cells decreased significantly 24 h post-irradiation. These results indicate that acute exposure of the adult mouse brain to a relatively low dose of fast neutrons interrupts hippocampal functions, including learning and memory, possibly by inhibiting neurogenesis.</P>
Joong-Sun Kim,Miyoung Yang,Yeonghoon Son,Sung-Ho Kim,Jong-Choon Kim,Seungjoon Kim,Yongduk Lee,Taekyun Shin,Changjong Moon 한국독성학회 2008 Toxicological Research Vol.24 No.3
The behavioral phenotypes of out-bred ICR mice were compared with those of in-bred C57BL/6 and BALB/c mice. In particular, this study examined the locomotor activity and two forms of hippocampus-dependent learning paradigms, passive avoidance and object recognition memory. The basal open-field activity of the ICR strain was greater than that of the C57BL/6 and BALB/c strains. In the passive avoidance task, all the mice showed a significant increase in the cross-over latency when tested 24 hours after training. The strength of memory retention in the ICR mice was relatively weak and measurable, as indicated by the shorter cross-over latency than the C57BL/6 and BALB/c mice. In the object recognition memory test, all strains had a significant preference for the novel object during testing. The index for the preference of a novel object was lower for the ICR and BALB/c mice. Nevertheless, the variance and the standard deviation in these strains were comparable. Overall, these results confirm the strain differences on locomotor activity and hippocampus-dependent learning and memory in mice.
Spermatotoxic effects of α-chlorohydrin in rats
Sung-Hwan Kim,In-Chul Lee,Jeong-Hyeon Lim,Changjong Moon,Chun-Sik Bae,Sung-Ho Kim,Dong-Ho Shin,Hyoung-Chin Kim,Jong-Choon Kim 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.1
This study was conducted to investigate the potential effects of α-chlorohydrin (ACH) on epididymal function and antioxidant system in male rats. The test chemical was administered to male rats by gavage at doses of 0, 3, 10, and 30 mg/kg/day for 7 days. Twenty-four male rats were randomly assigned to four experimental groups, with six rats in each group. Spermatotoxicity was assessed by measurement of reproductive organ weight, testicular sperm head count, epididymal sperm motility and morphology, histopathologic examination, and oxidative damage analysis in rats. At 30 mg/kg/day, an increase in the incidence of clinical signs, epididymis weight, and gross necropsy findings of the epididymis, a decrease in the sperm motility, and an increased incidence of histopathological changes of the epididymis were observed in a dose-dependent manner. At 10 mg/kg/day, an increased incidence of clinical signs and histopathological changes and decreased sperm motility were observed. In the oxidative damage analysis, an increase in the malondialdehyde concentration and a decrease in the glutathione content and glutathione peroxidase and catalase activities in the epididymal tissue were detected at ≥3 mg/kg/day. The results show that graded doses of ACH elicit depletion of the antioxidant defense system and that the spermatotoxicity of ACH may be due to the induction of oxidative stress.