스웨징(swagging) 작업자에서 수지진동증후군 및 신경전도장애

김성아,김상우,정상재,이채용,김규상,정보우,박상규 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.2

목 적 : 스웨징작업자들에서 발생한 수지진동증후군 사례를 실제 진동수준 평가와 함께 보고하고, 진단시 신경전도검사의 소견에 대한 해석을 검토하고자 하였다. 방 법 : 2001년 4월과 5월에 구미소재 스웨징작업 종사자 8인을 대상으로 병력문진, 자각증상평가, 이학적 검사를 실시하고 수지진동증후군의심자 4인에대해 냉각부하검사와 신경전도검사를 실시하였다. 작업장조사는 진동측정장비들을 이용하여 실제 작업환경에서 측정후 국제표준화기구에 따라 평가하였으며, 수근관증후군의 동시 가능성을 알아보고자 인간 공학적 요인에 대해 조사평가 하였다. 6개월후인 12월에는 이들 4인에 대해 진동각검사와 싱경전도검사를 추적검사하였다. 결 과 : 진동수준은 주파수가중가속도값이 단일작업은 0.99∼10.79 m/sec^2, 2개의 복합작업은 3.03 ∼12.98 m/sec^2로서 ISO의 권고치를 초과하고 있었다. 1차 대상근로자 8인의 근무기간은 평균 8.7년(범위 0.8∼15)이었고, 1인은 당뇨병자이었다. 스톡홀름 분류에 의한 증상평가, 손톱압박검사, 진동각검사에서 비교적 진동노출수준과 비려하여 임상소견을 나타내었고, 2차 평가대상자 4인의 경우 신경전도검사에서 1인은 정상, 2인은 수근관증후군, 1인은 말초신경병증으로 해석되었다. 그러나, 문헌 고찰을 통해 수근관증후군으로 나온 신경전도검사결과는 오히려 진동으로 인한 다병소 신경장해로 판단하였다. 6개월후 추적 신경전도검사에서 4인 모두 진동으로 인한 다병소 신경자해를 확인하였다. 그러나, 1인에서는 수근관증후군의 동시존재 가능성을 고려하였다. 결 론 : 고정된 진동공구인 스웨징사용자들에서 수지진동증후군발생을 확인하고, 진동노출수준을 실제로 측정하여 그 양-반응관계를 동시에 평가하였다. 신경전도검사의 해석과 관련하여 수지진동증후군에서 종종 동시 존재하는 수근관증후군과의 연관성 및 감별점을 실례로써 제시함으로써 향후 진동장해를 평가하는데 도움을 주고자 하였다. Objectives : To investigate the hand-arm vibration syndrome (HAVS) among symptomatic swagging workers exposed to hand-arm vibration, using medical evaluation and measurement of workplace vibration. Furthermore, to evaluate the neurophysiological findings. Methods : Four workers showing symptoms relevant to HAVS were evaluated. Medical evaluation consisted of medical interview, questionnaire, nail-bed compression test, and sensory perception tests for vibration and pain. Some other diseases were excluded by a medical interview, hematological assessment, and urinalysis. Cold provocation test was used to assess the peripheral vascular changes, and a nerve conduction velocity (NCV) test was implemented to ascertain the peripheral neural changes. Pegboard, hole plate, and tapping board tests were performed to assess motor nerve function. The hand-arm vibration acceleration levels of the swagging machines were measured. Six months later, follow-up NCV tests were performed. Results : The actual exposure time to vibration was not longer than 15 minutes per day. The hand-arm vibration acceleration levels of the swagging machines, according to actual exposure time, were from 3.63 to 12.98 m/sec^2, by ISO 5349. The vibratory perception thresholds and the recovery time of a nail color following finger cooling were significantly increased in all four workers. The perception of pain was mildly increased. The nerve conduction studies at first diagnosis and follow-up showed multifocal neural impairment caused by vibration. However, we could not rule out the concomitant presence of the carpal tunnel syndrome in one worker. Conclusions : These results show that HAVS can be caused by hand-arm vibration in swagging workers. Interestingly, the NCV results suggested that vibration-induced neural conduction impairments could vary, and need to be interpreted cautiously.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

관동맥 우회로술 중 경식도 심초음파도로 관찰한 도부타민 투여후와 우회로술후의 좌심실 국소벽운동

김희열,김종진,윤호중,유기동,박지원,이길환,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

트레드밀 걷기 운동 시 무게부하의 차이가 호흡순환기능 및 대사기능에 미치는 영향

김용규,이채산,김자영,박미숙,김광중,이광호 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

The purpose of this study was to compare on cadiopulmonary and metabolism function of 10㎏ weight loading group(10 females) and W university students with non weight loading group(10 females. Each group did treadmill walking exercise for twenty minutes by the modified balke protocol. Heart rate(HR), systolic(SBP), MVO₂, and VO₂max were analyzed using 2×2(groups×during) repeated measures analysis of variance (MANOVA). And peak blood velocity(PBV) and MBV were analyzed by using 2×2(groups×during) repeated measures analysis of variance (MANOVA). Lactate and glucose were amalyed by separate 2×2 (groupxduring) analysis of variance(ANOVA). Results of this study suggest that: The change of HR, SBP and MVO₂ in experience and control group showed the significant(p<.05) increase during walking exercise. Variables between experience and control group showed not significant level. But VO₂ in each group showed the significant(p<.001) increase during walking exercise. Differenc among each group showed significant(p<.001) level. Lactate and glucose level in each group showed significant(p<.001, p<.05) increase during walking exercise. Differences among each group showed not significant level. PBV and MBV in each group significant(p<.001) increase during walking exercise. Difference among each group showed significant(p<.05) level. According to these results, weight loading walking exercise considering safety promotes to cardiovascular function and it is expected to be an effective exercise methods able to improve the physical inefficiency of long time walking type.

개에서 심실 조율부위 및 조율주기에 따른 혈역학적 변화

김희열,김재형,노태호,김종진,진승원,유기동,이만영,채장성,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

農家所得을 위한 감의 효율적 이용을 위한 젖산발효

김순동,서정식,상채규,구경희 효성여자대학교 새마을연구소 1984 새마을硏究論文集 Vol.4 No.-

This study was carried out to improve the utility of persimmon fruit by lactic acid fermentation and drying. A strain of Streptococcus lactis was used in the fermentation. The changes in acidity, pH, number of microorganism, and the content of sugar, lycopene and tannin were determined during fermentation. Color of the fermented persimmon was checked by using a colorimeter, while quality of persimmon was evaluated by sensory test. The optimum temperature for lactate fermentation was at 25℃ showing on acidity of 50mg lactate per 100g fresh weight, when 10^7 cells per ml(1% inoclum)of Streptococcus lactis was added as the starter. By sterilization at 1kg/cm^2 for 15 minutes, the fruit was coagulated and colored reddish. The loss of brix degree was 2.3%. The content of fructose was increased while sucrose and glucose 23%, respectively. The rate of tannin and lycopene loss were 32% and 23%, respectively. Tannin slightly inhibited growth of the microorganism. Optimum temperature for drying of fermented fruit was at 60℃ with little variation in color. The fermented and dried persimmon was better in texture and taste than the raisin. From above results, it was clear that quality of persimmon fruit such as texture, and storage characteristics can be improved by lactate fermentation and drying.

다시마 추출액의 점성과 향미 개선을 위한 볶음처리 조건

김나미,박명한,전병선,박채규,양재원 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.5

다시마 추출액의 향미와 물성을 개선하기 위하여 볶음처리에 의한 품질변화를 조사하고 최적 볶음조건을 선정하였다. 추출액의 상징액율과 고형분수율 및 조단백질 수율은 볶음온도와 시간이 증가할수록 높아졌다. Algin의 함량은 볶음온도 175℃에서 가장 높았고,회분의 함량은 볶음온도가 증가할수록 많아졌다. 추출액의 점도는 볶음온도와 시간이 증가함에 따라 낮아졌으며 175℃, 10분 볶음처리할 때 점도 감소가 뚜렷하였다. 추출액 의 pH는 볶음온도 150℃까지는 다소 낮아지는 경향이었으며 175℃ 이상의 볶음처리 시 볶음온도와 시간이 증가함에 따라 다소 높아졌다. 볶음온도와 시간이 증가함에 따라 명도(L값)은 감소하였고, 적색도(a값)과 황색도(b값)은 증가하다가 a값은 200℃ 15분처리, b값은 175℃, 30분 처리 이후에서 각각 감소되기 시작하였다. 다시마 추출액의 냄새는 175℃에서 볶음처리하였을 때 고소한 냄새가 크게 증가하고 메스꺼운 냄새가 뚜렷하게 감소되어 전체적인 기호도가 가장 높았다. 구수한 맛과 해조맛은 175℃에서 고소한 맛이 증가되면서 메스꺼운 맛이 뚜렷하게 감소되었고 200℃ 이상에서는 탄맛이 많아져 전체적인 맛의 기호도는 175℃에서 가장 좋은 것으로 평가되었다. 이상의 결과를 종 합하여 볼 때 다시마를 175℃에서 10분간 볶음처리하는 것이 다시마 추출액에서 좋지 않은 향미를 개선하고 점성을 감소시키기에 적합하였다. Roasting conditions for improvement of viscosity and sensory properties of sea tangle extracts were investigated. The supernatant %, solid yield and crude protein yield were increased by increasing of roasting temperature and times. The highest contents of algin was obtained in roasting temperature of 175℃, ash contents were increased by roasting temperature increasing. Viscosities of sea tangle extract were significantly decreased by increasing of roasting temperature and time upto 175℃ and 10 mins more than further roasting conditions. The pH of sea tangle extracts slightly decreased from 5.94 to 5.83 in the roasting of 150℃, however, at temperature more than 175℃, its pH was increased by increasing of temperature and time. According to increase of roasting temperature and time, Lightness (L value) were significantly decreased and redness (a value) and yellowness (b value) reached the highest value in the roasting of 200℃, 15 min. or 175℃, 30 min. and after that, its value were decreased. The odor characteristics showed that sea tangle extract prepared by roasting of 175℃, 10 min. was significantly low in intensity of nauseous odor and high in intensity of roasted odor and acceptability. The taste characteristics showed that sea tangle extract prepared by roasting of 175℃, 10mins was slightly reduced in intensity of savory and seaweed taste but significantly low in intensity of nauseous taste and high in intensity of roasted taste and acceptability. Overall data suggested 175℃, 10 min. was the most effective roasting conditions for improvement of viscosity and sensory properties of sea tangle extract.

水稻에 있어서 葉綠素 突然變異系統의 生理·生化學的 特性에 관한 硏究

金弘燮,林采圭 조선대학교 기초과학연구소 1993 自然科學硏究 Vol.16 No.1

인위 돌연변이 유기에 의한 새로운 유전형질의 개발과 유용한 유전자 정보를 밝히기 위하여 낙동벼에서 유기된 엽록소 돌연변이 계통에 대하여 생리 생화학적 특성을 조사하였다. 얻어진 결과를 요약하면 다음과 같다. 1. 낙동벼에서 고정된 엽록소 결핍계통을 선발하였다. 이 계통은 생육초기부터 엽록소결핍으로 정상엽에 비하여 노란색을 나타내기 때문에 엽록소의 광합 성 관여 유전자 탐색에 이 용가능하다. 2. 엽록소결핍계통은 전 생육기간동안 낙동벼의 51~87% 정도의 엽록소 함량을 보였으나 엽록소 a/b함량비는 차이가 없었다. 엽 록소 결핍계통의 총 엽록소 함량은 낙동벼의 70.2%였으며 anthocy-anin함량과 flavonol함량은 각각 285% 은 142% 로 높 은 함량비를 나타냈다. 3.엽록소 결핍계통의 carotenoids함량은 낙동벼의 71.1%였고, xanthophylls함량은 56.5%였다. 특히 carotenoids성분중 lutein과 neoaxanthin함량의 감소 가 커서 각각 낙동벼의 32%와 34.4%로 매우 낮았으며, β-carotene은 차이가 없었고 antheraxanthin함량은 오히 려 증가하여 106.9%를 나타냈다. 4. 개엽상태에서나 군락상태에서 엽록소 결핍계통의 반사율과 투과율은 모두 낙동벼에 비하 여 많아 광흡수량은 떨어졌다. 5. 엽록소 결핍계통은 낙동벼에 비하여 출수기가 5일 늦고 간장, 수장, 주당수수, 수당입수, 임실율, 천립중 및 수량에서 감소하였다. 6. 엽록소 결핍계통과 낙동벼는 esterase, phosphog1ucose isomerase, malic enzyme, hexokinase 동위원소 특성에서 차이를 나타내지 않았다. 그러나 잎 에서 엽록체만을 순수분리 하여 추출한 엽록체 단백질 pattern에서는 차이를 보였다. Morphological, physiological and biochemical characteristics were examined in the mutant strains of chlorophyll induced in rice(Oryza sativa L).It was to develop a new inherited character and manifest a useful information of genes by induction of its artificial mutations. The results were summarized as follows : 1. The chlorophyll-deficiency strains fixed in the rice (Oryza sativa L.) were selected. This strains will be very of useful as a material to detect genes connected with phot-os3'llthesis of chlorophyll because of displaying yellow colors by chlorophyll-deficiency of leaver compared with normal leaves from early growth. 2. The chlorophyll-deficiency strains didn't differ between a/b content ratio of chlorophyll. Where as, 1 was shown that between but between about 51 and 87 percent contents of chlorophyll compared with the rice during all growing period. Total chlorophyll contents of these strains were measured as only 70.2% of the rice(Oryza sativa L.), but the contents of antocyanin and flavonol were highly increased to 285 and 142 percent respectively. 3. In the chlorophyll-deficiency strains compared with the rice(Oryza sativa L.), the contents of carotenoids and xanthophylls were 71 1 and 56.5 percent repectively. Especially in the carotenoid ingredients, the contents of lutein and neoxanthin highly decreased to 32 and 34.4 persent respectively, but the contents of β-carotene were equal and the contents of antheraxanthins increased to 106.7 percent. 4. In the individual or community condition, the reflexiblity and transmission of the chlorophylldefieiency strains increased and its absorptivity decreased in comparision with the rice(Oryza sativa L. ) 5. In the chlorophyll-deficiency strains compared with the rice(0ryza sativa L.), the earing season was fivedays late, culm length, panicle length, number of panicle perhill, number of spikelets per panicle, ripened grain ratio and 1000-grain weight and vield decreased. 6. The chloroph11-deficiency strains and rice(0ryza sativa L.) differed little in the characteristics of isoenzymes, esterase, phosphogluicose, isomerase, malic enzyme and hexokinase. But the protein pattern of chloroplast extracted by pure seperation differed.