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유방암 환자에서 항암 치료 중 생긴 체중 변화와 재발과의 상관 관계
서광욱(Kwangwook Seo),조현진(Hyunjin Cho),안훈(Hoon An),박인석(Insuk Park),곽금희(Geumhee Gwak),양근호(Keunho Yang),배병노(Byungnoe Bae),김기환(Kihwan Kim) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.2
Purpose: Weight change during chemotherapy is reported to be associated with a worse prognosis in breast cancer. Our study was aimed to evaluate the relation of weight change during AC (anthracycline+cyclophosphamide) +taxanes chemotherapy and recurrence. Methods: Patients included 89 women diagnosed with breast cancer who have been treated by AC+taxenes chemotherapy regimen. The weight variation between prechemotherapy and postchemotherapy was calculated ([weight at postchemotherapy-weight at prechemotherapy]/weight at prechemotherapy×100) and categorized into either weight change (≥5%) or stable (<5%). And then, we evaluated the relation of weight change and recurrence through the radiologic image tests (positron emission tomography-computed tomography, breast sonography, mammography, bone scan, magnetic resonance imaging, abdomino-pelvic computed tomography) each group. Results: During chemotherapy, 37of total 89 patients (41.6%) presented notable weight change and 52 patients (58.4%) were not weight change. Median follow-up period was 45.1 months, 17 of total 89 patients (19.1%) presented recurrence on the radiologic image tests. Eight of 17 recurrence patients were presented notable weight change, 9 patients were not weight change. In univariate analyses, weight change was not associated with recurrence. Conclusion: In our study, weight change during AC+taxanes chemotherapy in breast cancer was not associated with recurrence. Many studies that relation of weight change and recurrence were presented various result. So, we need more clinical studies many patients included and well designed.
유두갑상선암의 고식적 갑상선전절제술과 내시경하 갑상선전절제술 후 부갑상선 보존율 비교분석
김정빈,박인석,조현진,곽금희,양근호,배병노,김기환,한세환,Jungbin Kim,Inseok Park,Hyunjin Cho,Geumhee Gwak,Keunho Yang,Byungnoe Bae,Kiwhan Kim and Sehwan Han 대한갑상선-내분비외과학회 2012 The Koreran journal of Endocrine Surgery Vol.12 No.2
Purpose: Incidental parathyroidectomy is the most common and unexpected consequence of a total thyroidectomy. It can cause hypocalcemia symptoms such as muscle cramping and even seizures. We conducted this study to compare several factors including the preservation rate of parathyroid glands during both a bilateral axillo-breast approach endoscopic thyroidectomy (BABA) and a conventional open thyroidectomy (CT) for papillary thyroid carcinomas. Methods: We retrospectively reviewed the medical records of 299 papillary thyroid cancer patients who had a total thyroidectomy between January 2008 and December 2011. We grouped the patients into two groups: BABA (n=70) and CT (n=229). We analyzed age, tumor size, operation time, the number of preserved and removed parathyroid glands, amount and duration of seroma drainage, pain score, hypocalcemia symptoms, and serum total calcium level in both the BABA and CT groups. Results: We observed a younger age (under 45 years old) (P=0.000), smaller tumor size (P=0.000), longer operation time (P=0.000), larger amount of drainage (P=0.000), longer duration of drainage (P=0.007), and larger pain score (P=0.000) in the BABA group. Of the 70 patients that received an endoscopic thyroidectomy, we preserved all four parathyroid glands in 56 patients (78.6%). Of the 229 patients that received an open thyroidectomy, we preserved all four parathyroid glands in 141 patients (61.6%, P=0.004). Conclusion: BABA results in more extensive tissue damage over a longer period of time than CT. However, BABA was an excellent method for preserving parathyroid glands when compared with CT for thyroid carcinoma. Thus, it seems to be feasible performing BABA when it matches the indications. (Korean J Endocrine Surg 2012;12: 0-101)
대용량 정보처리기술을 통한 U-City 통합플랫폼 개선방안에 관한 연구
홍재주,이병노,이준형,원동현,Hong, Jaejoo,Lee, Byungno,Lee, Junhyeong,Won, Donghyun 한국공간정보학회 2015 한국공간정보학회지 Vol.23 No.3
It was necessary for us to establish a U-City Integrated platform to handle information and to operate the processes in order to solve various social problems in the modern cities and environment. As time has passed, we have confronted to difficulty in handling massive data with limited storage and computing environment and in not satisfying all the new requirements and on time information from the publics. The bigger the cost of the operation of the platform got, the more doubts to keep and invest more to upgrade it arose. Here, we investigated the limitations of the U-city platforms and analyzed the additional requirements and each function of the platform. In order to meet the requirement, we applied new technologies to deal with massive data and suggested the infrastructure of computing environment. We will be expecting the cost decreasing effects and the benefit increasing effects from the enhancement of U-City platform. 현대도시와 환경에서 발생하는 여러 종류의 사회문제를 해결하기 위한 목적으로 다양한 정보를 처리하고 운영하는 U-City 통합플랫폼이 도입되었다. 시간이 지나감에 따라 더 많은 자료를 처리해야 하는 어려움과 더불어 제한된 자원으로 적시의 필요한 정보를 찾는 사용자들의 요구를 만족시켜야 하는 어려움에 직면하게 되었다. 플랫폼의 운영비가 더 증가하면 할수록, 이를 유지하고 지속적인 투자를 해야 하는가에 대한 우려가 거세졌다. 이에 우리는 기존의 플랫폼의 한계점을 집어보고, 새로운 요구가 무엇인지 분석하고 기능 등을 개선하고자 하는 항목을 도출하였다. 이를 위해, 대용량 데이터를 처리할 수 있는 새로운 기술을 적용하였으며 전산환경의 기반을 제시하였다. U-City 통합플랫폼의 고도화로 비용절감의 효과와 편익 증가를 기대한다.
윤성준 ( Sungjun Yoon ),정현이 ( Hyeonyi Jeong ),박병노 ( Byungno Park ),김용운 ( Yongun Kim ),김혜수 ( Hyesu Kim ),박재봉 ( Jaebong Park ),손병구 ( Byungkoo Son ),김태욱 ( Taewook Kim ),문영범 ( Youngbum Mun ),이선동 ( Sundong Le 한국암석학회·(사)한국광물학회 2020 광물과 암석 (J.Miner.Soc.Korea) Vol.33 No.4
국내 폐슬레이트 발생량은 매년 증가 추세로 지정매립장 용량이 한계에 다다르고 있어 슬레이트를 대용량으로 안전하고 저렴하게 처리함과 동시에 재활용할 수 있는 방법이 필요하다. 이에 대한 대안으로 시멘트 소성로를 이용한 폐슬레이트 열처리 방법을 들 수 있다. 이 연구에서는 플라즈마를 이용하여 시멘트 소성로의 고온 환경을 모사할 수 있는 중간 규모(pilot scale)의 장치를 개발하고 이를 이용하여 폐슬레이트 내석면의 비활성화 및 시멘트 원료로의 재활용 가능성을 확인하고자 하였다. 중간규모 실험 장치는 플라즈마 토치를 이용하여 실제 소성로와 동일한 조건을 가지도록 1/50로 축소·제작하였다. 실험조건은 시멘트 소성로의 소성 시간과 동일하게 20분간 200-2,000℃까지 100℃ 간격으로 온도를 상승시키며 폐슬레이트의 비활성화 실험을 실시하였다. 플라즈마 고온반응기를 이용하여 열처리한 폐슬레이트의 XRD, PLM, TEM-EDS 분석결과, 1,500℃ 이상의 온도에서 슬레이트 내 백석면이 고토감람석으로 광물 상전이가 일어나 비활성화되고 시멘트 구성 광물인 라나이트(Ca<sub>2</sub>SiO<sub>4</sub>)가 형성됨을 확인하였다. 이 연구 결과는 추후 시멘트 소성로를 이용하여 대용량의 슬레이트를 경제적이고 안전하게 처리함과 동시에 시멘트 원료로 재활용할 수 있는 방안에 대한 기초자료로 활용할 수 있을 것으로 사료된다. The capacity of the designated landfill site for asbestos-containing waste is approaching its limit because the amount of asbestos-containing slate is increasing every year. There is a need for a method that can safely and inexpensively treat asbestos-containing slate in large capacity and at the same time recycle it. A cement kiln can be an alternative for heat treatment of asbestos-containing slate. We intend to develop a pilot scale device that can simulate the high temperature environment of a cement kiln using a high temperature plasma reactor in this study. In addition, this reactor can be used to inactivate asbestos in the slate and to synthesize one of the minerals of cement, to confirm the possibility of recycling as a cement raw material. The high-temperature plasma reactor as a pilot scale experimental apparatus was manufactured by downsizing to 1/50 the size of an actual cement kiln. The experimental conditions for the deactivation test of the asbestos-containing slate are the same as the firing time of the cement kiln, increasing the temperature to 200-2,000℃ at 100℃ intervals for 20 minutes. XRD, PLM, and TEM-EDS analyses were used to characterize mineralogical characteristics of the slate before and after treatment. It was confirmed that chrysotile [Mg<sub>3</sub>Si<sub>2</sub>O<sub>5</sub>(OH)<sub>4</sub>] and calcite (CaCO<sub>3</sub>) in the slate was transformed into forsterite (Mg<sub>2</sub>SiO<sub>4</sub>) and calcium silicate (Ca<sub>2</sub>SiO<sub>4</sub>), a cement constituent mineral, at 1,500℃ or higher. Therefore, this study may be suggested the economically and safely inactivating large capacity asbestos-containing slate using a cement kiln and the inactivated slate via heat treatment can be recycled as a cement raw material.