충주 지역에서 10년간 급성심근경색의 임상관찰에 대한 연구

박봉안,류하근,이종혁,김인숙,류주성,유재등,이용구,문언수,김형수 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Background: The current treatments of acute myocardial infarct(AMI) Include noninvasive method using thrombolytics and invasive methods such as primary percutaneous transluminal coronary angioplasty(PTCA) and coronary artery bypass graft(CABG)surgery. Although there are many studies comparing the effectiveness of noninvasive and invasive methods, when large clinical centers, 20% of totar hospitals, were excluded, most middle-sized hospitals lacked personnels and facilities for the invasive methods. Thus they opted for the noninvasive methods. Therefore, in this study, the clinical characteristics of AMI patients and the results of thrombolytic & conservative treatment were observed. Method: 137 patients with acute myocardial infarct, who visited KonKuk University Medical Center, ChoongJu Hospital during Sept. 1990 to Sept. 1999 were analysed retrospectively using medical records. Result: The sexual compositions of patients were 63.5% male, and 36.5% female. The mean age for male patients were 56±12.9, and for female patients 68.7±9.6 (p<0.05). The mean age for female patients was significantly older than male patients. The patients in the thrombolytic treatment group had mortality rate of 6.25% which is lower than that of the conservative treatment group at 12% (p>0.05). Conclusion: Although in our study, small number of acute myocardial infarct patients caused the statistical insignificance, rapid revascularization by thrombolytic therapy within 6 hours of onset of symptoms improved mortality rate and early ambulation. And we had good results on AMI with thrombolytic agent in ChungJu including near rural area as primary emergency hospital. Therefore a prospective research with greater number of subjects is needed to develop better treatments for AMI.

균체외 다당류를 생산하는 균주의 분리 및 배양조건

박석규,손봉수,문주석 순천대학교 기초과학연구소 1993 基礎科學硏究誌 Vol.4 No.-

For the screening of a highly viscous exopolysaccharide, a bacterium strain was isolated from soils and identified as Bacillus sp. SFN-83 accroding to the morphological, cultural and physiological properties. The optimum concentration of carbon and nitrogen sources were 1% sucrose and 0.3% ammonium vanadate. At the condition, exopolysaccharide production and product yield were 6.73g/l and 67.3%, respectively.

뇌수술 시 과호흡과 만니톨의 투여가 뇌혈류와 뇌산소대사에 미치는 영향

김지헌,김경식,문봉기,조경기,신용삼,이영주,김진수 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: There are therapies to lower intracranial pressure (ICP) including head elevation, hyperventilation, diuretics injection, intravenous mannitol, hypothermia, cerebrospinal fluid drainage, and cerebral resection in neurosurgical patients. However in recent reports, hyperventilation followed by mannitol administration may lead to cerebral ischemia. Therefore, we investigated the effect of 0.5-1.0 g/kg mannitol administration on jugular venous oxygen saturation (SjVO_2) and cerebral arterial-jugular venous oxygen content difference (AVDO_2) at PaCO_2 25-30 mmHg and 35-40 mmHg in patients undergoing neurosurgery. Methods: we studied 17 patients undergoing neurosurgery in the Ajou University Hospital. Anesthesia was induced with fentanyl, midazolam, thiopental, and vecuronium, and maintained with )_2-Air-Isoflorane, a continuous infusion of fentanyl, and vecuronium. Patients were divided into two groups. Group 1 (n = 10) which is PaCO_2 25-30 mmHg and Group 2 (n = 7) which is PaCO_2 35-40 mmHg by controlling ventilator. Measurements of SjVO_2 and AVDO_2 in following time intervals: Ⅰ = preinjection of mannitol, Ⅱ = postinjection 20 minutes of mannitol, Ⅲ = postinjection 40 minutes of mannitol were obtainde for each group. 0.5-1.0 g/kg mannitol was administered intravenously just at duramater opening. Results: Hemodynamics and hematologics were not significantly different among the two groups. SjVO_2 of each group are as follows; Group 1; Ⅰ (70.3 ± 8.1%), Ⅱ (66.3 ± 6.9%), Ⅲ (69.1 ± 7.9%) and Group 2; Ⅰ (78.6 ± 7.4%), Ⅱ (75.1 ± 8.1%), Ⅲ (76.0 ± 11.2%), Hyperventilation significantly decreased SjVO_2- AVDO_2 was not significantly different but SjVO_2 in Ⅱ was significantly decreased compared with Ⅰ and Ⅲ in Group 1 (20% patients). Conclusions: Mannitol produced a change of SjVO_2 during hyterventilation. Therefore, intravenous mannitol during hyperventilation should be given cautiously according to the patients status because it may cause cerebral ischemia in critical patients. (Korean J Anesthediol 2002; 43: 462~467)

백일주 양조중 맛성분의 변화

박석규,박필숙,손봉수,문주석 순천대학교 기초과학연구소 1993 基礎科學硏究誌 Vol.4 No.-

Changes in taste components of Backilju, an old Korean cleraed rice wine, were investigated. During brewing, pH and titratable acidity of mash were decreased or increased in the range of 3.41→3.81 and 8.62→6.74, respectively. The final product of Backilju filtrate, fermented for 100 days, contained 0.36% reducing sugar, 2.68% total sugar, 606.6 ㎎% total acid, 2.5 ㎎% volatile acid and 22.9㎎ solid/ml extract. Major volatile components analized by GC/MS methods were 3-methyl-1-butanol acetate, 4-decanol and dimethyl disulfide. Calcium(20.26ppm) was the most abundant, followed by magnesium(3.19ppm) and zinc(1.87ppm). Nucleotides and their related compounds were inosine(0.12→0.44 mM/ml), ADP(0.16→0.33 mM/ml) and hypoxanthine(0.33→0.04 mM/ml). Compared with other Korean traditional Yakju, Backilju contained more total acid and mineral but less sugar and volatile acid.

폐결핵으로 오인된 SIADH를 동반한 편평상피 세포폐암 1예

김순제,류하근,김선두,이길도,박봉안,류주성,유재등,김인숙,신현준,문언수 대한노인병학회 1999 Annals of geriatric medicine and research Vol.3 No.4

Heat-map visualization of gas chromatography-mass spectrometry based quantitative signatures on steroid metabolism

Moon, Ju-Yeon,Jung, Hyun-Jin,Moon, Myeong Hee,Chung, Bong Chul,Choi, Man Ho Springer-Verlag 2009 Journal of the American Society for Mass Spectrome Vol.20 No.9

<P>Abnormalities in steroid hormones are responsible for the development and prevention of endocrine diseases. Due to their biochemical roles in endocrine system, the quantitative evaluation of steroid hormones is needed to elucidate altered expression of steroids. Gas chromatographic-mass spectrometric (GC-MS) profiling of 70 urinary steroids, containing 22 androgens, 18 estrogens, 15 corticoids, 13 progestins, and 2 sterols, were validated and its quantitative data were visualized using hierarchically clustered heat maps to allow “steroid signatures”. The devised method provided a good linearity (<I>r</I><SUP>2</SUP> > 0.994) with the exception of cholesterol (<I>r</I><SUP>2</SUP> = 0.983). Precisions (% CV) and accuracies (% bias) ranged from 0.9% to 11.2% and from 92% to 119%, respectively, for most steroids tested. To evaluate metabolic changes, this method was applied to urine samples obtained from 59 patients with benign prostatic hyperplasia (BPH) versus 41 healthy male subjects. Altered concentrations of urinary steroids found and heat maps produced during this 70-compound study showed also differences between the ratios of steroid precursors and their metabolites (representing enzyme activity). Heat maps showed that oxidoreductases clustered (5<I>β</I>-reductase, 3<I>β</I>-HSD, 3<I>β</I>-HSD, and 17<I>β</I>-HSD, except for 20<I>β</I>-HSD). These results support that data transformation is valid, since 5<I>β</I>-reductase is a marker of BPH and 17<I>β</I>-HSD is positively expressed in prostate cells. Multitargeted profiling analysis of steroids generated quantitative results that help to explain correlations between enzyme activities. The data transformation and visualization described may to be found in the integration with the mining biomarkers of hormone-dependent diseases.</P>

Prevalence, Incidence, Comorbidity, and Mortality Rates of Ossification of Posterior Longitudinal Ligament in the Cervical Spine: A Nested Case-Control Cohort Study

Moon, Bong Ju,Choi, Sun Kyu,Shin, Dong Ah,Yi, Seong,Kim, Keung Nyun,Yoon, Do Heum,Ha, Yoon Elsevier 2018 World neurosurgery Vol.117 No.-

<P><B>Objective</B></P> <P>To evaluate prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL) using data from a 12-year national cohort of 1,025,340 Korean people.</P> <P><B>Methods</B></P> <P>A nested case-control cohort study was performed from 2002 to 2013 using the insurance claims database provided by the National Health Insurance Service. We examined prevalence and incidence of cervical OPLL. Age- and sex-matched control subjects were randomly extracted, with 10 times the number of OPLL cases. Differences in sex, comorbidity, and relative survival rate compared with control subjects were assessed.</P> <P><B>Results</B></P> <P>Cumulative prevalence was 20,960 per 1,025,340 people for 12 years. Annual incidence was approximately 199–371 per 1 million people. Overall crude mortality rate was 7.64%. Relative survival rate of OPLL cases was not significantly different from control cases. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases (<I>P</I> < 0.001). Additionally, between dead and surviving patients among OPLL cases, all comorbidities correlated more significantly with death (<I>P</I> < 0.001). Furthermore, between surgery and nonsurgery cases of OPLL, diabetes, hypertension, and renal disease (<I>P</I> < 0.05) were significantly associated with surgery.</P> <P><B>Conclusions</B></P> <P>Annual incidence of OPLL was 199–371 per 1,025,340 people for 10 years. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases. Especially, diabetes, hypertension, and renal disease were associated with patients with OPLL who underwent surgery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Prevalence, incidence, comorbidity, and mortality of cervical spine OPLL was analyzed in a nested case-control cohort study. </LI> <LI> Cumulative prevalence was 20,960 per 1,025,340 people for 12 years. </LI> <LI> Annual incidence of OPLL was 199–371 per 1,025,340 people for 10 years. </LI> <LI> Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease were associated significantly with OPLL. </LI> <LI> Diabetes, hypertension, and renal disease were associated with patients with OPLL who underwent surgery. </LI> </UL> </P>

Prevalence, Distribution, and Significance of Incidental Thoracic Ossification of the Ligamentum Flavum in Korean Patients with Back or Leg Pain : MR-Based Cross Sectional Study

Bong Ju Moon,구성욱,김성준,김근수,조용은,진동규 대한신경외과학회 2015 Journal of Korean neurosurgical society Vol.58 No.2

Objective : Thoracic ossification of the ligamentum flavum (OLF) is a relatively rare disease. Because of ambiguous clinical symptom, it is difficult for early diagnosis of OLF and subsequent treatment can be delayed or missed. Therefore, the purpose of this study is to comprehensively assess the prevalence and distribution of thoracic OLF by magnetic resonance imaging (MRI) and coexisting spinal disease in Korean patients with back pain or leg pain. Methods : The sample included 2134 Korean patients who underwent MRI evaluation for back pain. The prevalence and distribution of thoracic OLF were assessed using lumbar MRI with whole spine sagittal images. Additionally, we examined the presence of coexisting lumbar and cervical diseases. The presence of thoracic OLF as well as clinical parameters such as age, sex, and surgery were retrospectively reviewed. Results : The prevalence of thoracic OLF in total patients was 16.9% (360/2134). The prevalence tended to increase with aging and was higher in women than in men. The lower thoracic segment of T10–11 was the most frequently affected segment. Of the 360 patients with OLF, 31.9% had coexisting herniated thoracic discs at the same level. Approximately 74% of the patients with OLF had coexisting lumbar and cervical disease. Nine (2.5%) of 360 OLF patients underwent surgery for thoracic lesion. Conclusion : The prevalenceof thoracic OLF was relatively higher than those of previous reports. And coexisting lumbar and cervical disease were very frequent. Therefore, we should check coexisting spinal diseases and the exact diagnostic localization of ossification besides lumbar disease.

Anatomical variations of vertebral artery and C2 isthmus in atlanto-axial fusion: Consecutive surgical 100 cases

Moon, Bong Ju,Choi, Kyung Ho,Shin, Dong Ah,Yi, Seong,Kim, Keung Nyun,Yoon, Do Heum,Ha, Yoon Elsevier 2018 Journal of clinical neuroscience Vol.53 No.-

<P><B>Abstract</B></P> <P>VA anomalies in extra- and intraosseous regions of the craniovertebral junction (CVJ) is considered very carefully during the posterior screw fixation for the atlantoaxial instability (AAI). This study aims to compare the incidence and variations of VA anomalies, isthmus and pedicle size of C2 in 100 patients with AAI due to congenital skeletal anomaly (CSA) and acquired disease by using three-dimensional CT angiograms (3D CTA) before surgery. The CSA group contained 48 patients and the acquired disease group consisted of 52. In the CSA group, Os odontoideum was the major cause with 43 patients. The causes of acquired disease were RA in 16 patients and OA in 36 patients. Five patients had the anomalous VA in only CSA group; fenestration 2 patients and persistent first intersegmental (PFIS) artery 3 patients. Between CSA and acquired disease groups, no significant differences were found in the isthmus height, internal height, and pedicle width of C2 except the right internal height that is bigger in CSA group. The high-riding VA (isthmus height <4 mm or internal height <2 mm) had no significant difference between CSA group (27.1%) and acquired disease group (34.6%). However, in acquired disease group, patients with rheumatoid arthritis had smaller left internal height (4.21 ± 1.63 vs. 5.51 ± 1.83 mm) and pedicle width (4.11 ± 1.05 vs. 5.05 ± 1.66 mm) of C2 than those of patients with degenerative osteoarthritis. Therefore, in the case of atlantoaxial fusion, we should contemplate VA anomaly and the high-riding VA, especially in patients with CSA and RA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Five patients had the anomalous VA; fenestration 2 patients and PFIS artery 3 patients. </LI> <LI> VA anomaly and VA dominance may be associated with congenital skeletal anomalies. </LI> <LI> The high-riding VA (isthmus height <4mm or internal height <2mm) had no significant difference between CSA group and acquired disease group. </LI> <LI> Pre-operative 3D-CTA is imperative in the evaluation of patients who require C1-2 fusion for AAI. </LI> </UL> </P>

Prevalence, Distribution, and Significance of Incidental Thoracic Ossification of the Ligamentum Flavum in Korean Patients with Back or Leg Pain : MR-Based Cross Sectional Study

Moon, Bong Ju,Kuh, Sung Uk,Kim, Sungjun,Kim, Keun Su,Cho, Yong Eun,Chin, Dong Kyu The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.46 No.5

Objective : Thoracic ossification of the ligamentum flavum (OLF) is a relatively rare disease. Because of ambiguous clinical symptom, it is difficult for early diagnosis of OLF and subsequent treatment can be delayed or missed. Therefore, the purpose of this study is to comprehensively assess the prevalence and distribution of thoracic OLF by magnetic resonance imaging (MRI) and coexisting spinal disease in Korean patients with back pain or leg pain. Methods : The sample included 2134 Korean patients who underwent MRI evaluation for back pain. The prevalence and distribution of thoracic OLF were assessed using lumbar MRI with whole spine sagittal images. Additionally, we examined the presence of coexisting lumbar and cervical diseases. The presence of thoracic OLF as well as clinical parameters such as age, sex, and surgery were retrospectively reviewed. Results : The prevalence of thoracic OLF in total patients was 16.9% (360/2134). The prevalence tended to increase with aging and was higher in women than in men. The lower thoracic segment of T10-11 was the most frequently affected segment. Of the 360 patients with OLF, 31.9% had coexisting herniated thoracic discs at the same level. Approximately 74% of the patients with OLF had coexisting lumbar and cervical disease. Nine (2.5%) of 360 OLF patients underwent surgery for thoracic lesion. Conclusion : The prevalenceof thoracic OLF was relatively higher than those of previous reports. And coexisting lumbar and cervical disease were very frequent. Therefore, we should check coexisting spinal diseases and the exact diagnostic localization of ossification besides lumbar disease.