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최선택,은종렬,임상우,김봉준,이헌주,구미진,최준혁 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1
Background: Cholestatic hepatitis is failure of bile to reach the duodenum with hepatocellular damage and no demonstrable obstruction of the major bile ducts. The prognosis is usually good with recovery in less than 4 weeks after withdrawal of the offending drug. However, a prolonged course lasting over 3 months is possible and, in rare cases, progression to ductopenia with development of a vanishing bile duct syndrome occurs. A differential diagnosis with other causes of Chronic liver disease is needed. Materials and Methods: From January 1991 through Jaunary 2000, 14 patients diagnosed as cholestatic hepatitis by liver biopsy were inclouded. The possible causative drug, clinical features, laboatory findings, and progression of cholestatic hepatitis were evaluated. The semiquantitative study of liver lesions was performed by two independent observers. Results: Causes of cholestatic hepatitis are 5 cases of oriental medicine, 3 cases of anti-tuberculosis medication, 1 case of ticlopidine and antibiotics and 4 cases of unknown causes. The clinical features of cholestatic hepatitis were jaundice, itching, urine color change, and general weakness. During 6 to 30 months, LFT of 5 patients showed prolonged elevation. Elevated total cholesterol ≥250 mg/dL in 6 patients, pheripheral blood eosinophilia in 5 patients, auto-antibody positive in 6 patients were observed respectively. The biopsies showed intralobular bilirubinostasis with a mixed portal inflammatory infiltration. Conclusion: In cholestatic hepatitis. durations of abnormal LFT are variable regardless of causative drugs. If cholestatic hepatitis progresses toward chronic course, viral hepatitis, primary biliary cirrhosis, and autoimmune hepatitis should be differentially diagnosed and sequential liver biopsies are needed.
쇼핑호스트에 대한 의사인간관계가 홈쇼핑 TV에 대한 태도 및 구매의도에 미치는 영향 : 지각된 위험과 지각된 혜택의 매개효과를 중심으로
주지혁,최명일,김봉철 한국방송광고공사 2008 광고연구 Vol.0 No.80
Home-shopping in cable TV is considered as one of the important channels by innovative changes for the shopping. In this process, shopping hosts take a great portion, but they are not weighted in other studies. This study explores various emotions for the shopping hosts in the field of parasocial interaction and examines how those emotions affect to purchase intention. Also, the study can see over how perceived risk, perceived benefit, and attitude for the CATV home-shopping have an impact on the purchase intention. In the result, as parasocial interaction with shopping-hosts would grow, perceived risk for home-shopping is reduced, meanwhile perceived benefit is grown. Perceived risk can mediate purchase intention, and perceived benefit also can moderate attitude for homeshopping and purchase intention. It could mean that consumers can have positive image for CATV home-shopping under the conditions that parasocial interaction with shopping-hosts would be grown. The result can show that CATV home-shopping should attempt to establish parasocial interaction in order to take upper hands against open markets and internet shopping malls.
Choi, Jin Bong,Yoon, Byung Il,Kim, Su Jin,Cho, Hyuk Jin,Hong, Sung-Hoo,Choi, Yeong Jin,Kim, Sae Woong,Hwang, Tae-Kon,Lee, Ji Youl 대한비뇨기과학회 2011 Investigative and Clinical Urology Vol.52 No.2
<P><B>Purpose</B></P><P>We examined changes in the clinicopathologic characteristics of renal cell carcinoma (RCC) in the past 25 years and aimed to obtain indicators for its diagnosis and treatment.</P><P><B>Materials and Methods</B></P><P>The medical records of 563 patients with confirmed primary RCC after surgical treatment from 1985 to 2010 at Seoul St. Mary's Hospital were retrospectively reviewed. Patient and tumor characteristics were compared over 3 time periods (period 1: 1985-1994, period 2: 1995-2004, period 3: 2005-2010).</P><P><B>Results</B></P><P>Period 1 included 65 patients, period 2 included 183 patients, and period 3 included 315 patients, showing an exponential growth in the number of patients. Frequency was highest in the late 50s age group. The review of clinical symptoms showed that incidental diagnosis increased significantly. The tumor size at diagnosis gradually decreased and the proportion of small tumors less than 4 cm increased remarkably. Concerning tumor spread, organ-confined tumors (T<SUB>1-2</SUB>N<SUB>0</SUB>M<SUB>0</SUB>) increased and distant metastasis decreased. Histologically, the clear cell type made up the greatest proportion, about 90% in each period, but subtypes besides the clear cell type increased over the study period. The rate of nephron-sparing surgery increased, and exophytic masses were the most common.</P><P><B>Conclusions</B></P><P>Our review of the recent 25 year's worth of data on RCC from Seoul St. Mary's Hospital showed that the incidental diagnosis of RCC increased over the study period in accordance with the development of screening tests. Tumor size decreased in accordance with the progress in imaging modalities. In the future, multicenter research will be needed to analyze the characteristics of whole renal cancer in Korea.</P>
Bong-Hyuk Choi,Yu-Hee Kim,In-Sook Ahn,Jung-Heun Ha,Jae-Min Byun,Myoung-Sool Do 한국영양학회 2009 Nutrition Research and Practice Vol.3 No.2
In our previous study, we have shown that berberine has both anti-adipogenic and anti-inflammatory effects on 3T3-L1 adipocytes, and the anti-adipogenic effect is due to the down-regulation of adipogenic enzymes and transcription factors. Here we focused more on anti-inflammatory effect of berberine using real time RT-PCR and found it changes expressions of adipokines. We hypothesized that anti-adipogenicity of berberine mediates anti-inflammtory effect and explored leptin as a candidate mediator of this signaling. We studied this hypothesis by western blot analysis, but our results showed that berberine has no effect on the phosphorylations of STAT-3 and ERK which have important roles on leptin signaling. These results led us to conclude that the anti-inflammatory effect of berberine is not mediated by the inhibition of leptin signal transduction. Moreover, we have found that berberine down-regulates NF-κB signaling, one of the inflammation-related signaling pathway, through western blot analysis. Taken together, the anti-inflammatory effect of berberine is not mediated by leptin, and berberine induces anti-inflammatory effect independent of leptin signaling.