Protective Effect of Baicalin against Multiple Ultraviolet B Exposure-mediated Injuries in C57BL/6 Mouse Skin

Bing-rong Zhou,Dan Luo,Wen-li Liu 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.2

Multiple exposures to solar ultraviolet (UV) radiation cause critical damage to skin that may lead to the development of several cutaneous disorders including skin cancer. Protection against sun-induced damage is therefore a highly desirable goal. Chemoprevention via plantbased agents may be a useful approach for the prevention? of UV-induced neoplasia. In this study, we assessed (1) whether baicalin protected against multiple UVB exposure-mediated damage in skin of C57BL/6 mice and (2) the underlying mechanisms. C57BL/6 mice were topically pretreated with baicalin (1 mg/cm^2 skin area/mouse/100 μL acetone) and were exposed to UVB 30 min later (180 mJ/cm^2, on alternate days × 10 exposures). The animals were sacrificed 24 h after the last UVB exposure. Skin edema, histopathology changes, Ki-67, PCNA, and COX-2 were assessed to determine UVB induced damage. Multiple exposures of C57BL/6 mice to UVB resulted in an increase in skin edema and hyperplasia. Topical application of baicalin prior to UVB radiation resulted in a significant inhibition of Ki-67, PCNA and COX-2 expression. These protective effects of baicalin may also inhibit UVB-induced skin carcinogenesis. Based on this data, we suggest that baicalin could be developed as an agent for the management of conditions elicited by multiple UV exposures, including skin cancer.

A Novel Method of Reducing the Cogging Torque in SPM Machine with Segmented Stator

Li-Bing Jing,Lin Liu,Rong-Hai Qu,Qi-Xing Gao,Zheng-Hao Luo 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

The method of stator segmentation is generally taken to enhance the electromagnetic performance of surface-mounted permanent magnet (SPM) machine and reduce its production cost. Based on the model with single slot, the expressions of cogging torque in machine with uniform or non-uniform segmentations are deduced and the optimal combination is given. Moreover, this paper discusses a structured skewing method and put forward a novel stator structure model to reduce the cogging torque in segmented permanent magnet machine. The model can reduce the cogging torque amplitude by shifting a proper angle of slot-opening. The shifting angle formula for analysis can also be suitable for other permanent machine with segmented stator. Finally the results of finite element simulation are given to prove that the method is effective and feasible.

Structure and Properties of Polyimide (BTDA-TDI/MDI co-polyimide) Fibers Obtained by Wet-Spinning

Hong Bing Xiang,Zhong Huang,Li Qi Liu,Lei Chen,Jing Zhu,Zu Ming Hu,Jun Rong Yu 한국고분자학회 2011 Macromolecular Research Vol.19 No.7

BTDA-TDI/MDI (P84, synthesized by the condensation of 2,4-diisocyanato-1-methylbenzene and 1,1' -methylenebis(4-isocyanatobenzene) with 5,5'-carbonylbis(l,3-isobenzofurandione)) co-polyimide fibers were prepared by wet-spinning. The basic spinning conditions were found from the studies of dope viscosity, ternary phase diagrams, coagulation value, and precipitation value. The effect of the coagulation bath composition on the morphology of as-spun fibers was investigated and a theoretical approach was used to understand the coagulation phenomena. Scanning electron microscopy (SEM) showed that the cross-sectional shape of the fiber deviated more from an ellipse shape with the increasement of N-methyl-2-pyrrdidinone (NMP) content. The surface and cross section morphology of the as-spun fibers was also analyzed by the rate of diffusion and phase separation. The as-spun fibers were treated in heating tubes without drawing at different temperatures. The gravimetric analysis spectra showed that the BTDA-TDI/MDI co-polyimide fibers, which had been heat treated at 350 and 400 ℃, possessed better thermal properties than the as-spun fibers, a large weight loss was observed only above 550 ℃. Heat treatment of the fibers resulted in relatively high tensile strength and modulus. The fibers spun in Bath C (70/30, NMP/water, wt/wt)and Bath D (80/20, NMP/water, wt/wt) showed better thermal properties and higher tensile strength.

Time Trends of Ovarian Cancer Incidence in China

Wang, Bing,Liu, Shu-Zheng,Zheng, Rong-Shou,Zhang, Fang,Chen, Wan-Qing,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

The aim of this study was to examine the trend of ovary cancer incidence from 1999 to 2010 in China and predict the burden up to 2020. Crude incidence, age specific incidence and age-adjusted incidence rates were calculated. Joinpoint regression was performed to obtain estimated annual percentages and Bayesian age-period-cohort modeling was used to predict the incidence rate until the year 2020. In China, the crude rate of ovary cancer was 7.91/100,000 and the age-adjusted rate was 5.35/100,000 overall during period 1999-2010. The rates in urban regions were higher than in rural regions. A significant rising trend during 1999-2006 was followed by a drop during 2006-2010 in age-adjusted rates for urban females. In contrast, constant rise was observed in rural women. The decrease in ovary cancer of urban areas tended to be restricted to women aged 50 years and younger. In contrast, increases of ovary cancer in rural areas appeared in virtually all age groups. Although the age-adjusted incidence rate for ovary cancer was predicted to be reduced after year 2011, the crude rate was likely to be relative stable up to 2020. The burden of ovary cancer in China will continue to be relative stable due to the aging population.

A Novel Method of Reducing the Cogging Torque in SPM Machine with Segmented Stator

Jing, Li-Bing,Liu, Lin,Qu, Rong-Hai,Gao, Qi-Xing,Luo, Zheng-Hao The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

The method of stator segmentation is generally taken to enhance the electromagnetic performance of surface-mounted permanent magnet (SPM) machine and reduce its production cost. Based on the model with single slot, the expressions of cogging torque in machine with uniform or non-uniform segmentations are deduced and the optimal combination is given. Moreover, this paper discusses a structured skewing method and put forward a novel stator structure model to reduce the cogging torque in segmented permanent magnet machine. The model can reduce the cogging torque amplitude by shifting a proper angle of slot-opening. The shifting angle formula for analysis can also be suitable for other permanent machine with segmented stator. Finally the results of finite element simulation are given to prove that the method is effective and feasible.

XPD Lys751Gln and Asp312Asn Polymorphisms and Gastric Cancer Susceptibility: A Meta-analysis of Case-control Studies

Yin, Qing-Hua,Liu, Chuan,Hu, Jian-Bing,Meng, Rong-Rong,Li, Lian,Wang, Ya-Jie Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: Published data regarding the association between xeroderma pigmentosum group D (XPD) Lys751Gln and Asp312Asn polymorphisms and gastric cancer susceptibility havew been inconclusive. This meta-analysis was therefore performed toobtain a more precise estimation of any relationship. Materials and Methods: A comprehensive literature search was conducted to identify all case-control studies of Lys751Gln and Asp312Asn polymorphisms and susceptibility to gastric cancer. Summary odds ratios (ORs) and its 95% confidence intervals (95% CIs) were calculated using a random-effects model with the software STATA (version10.0). Results: A total of 12 case-control studies including 3,147 cases and 4,736 controls were included. Overall, no significant associations were found in some models (for Lys751Gln: Lys/Gln vs Lys/Lys: OR=1.144, 95% CI=0.851-1.541, Gln/Gln vs Lys/Lys: OR=1.215, 95% CI = 0.740-1.955, dominant model: OR=1.137, 95% CI=0.818-1.582; recessive model: OR=1.123, 95% CI=0.765-1.650; for Asp312Asn: Asp/Asn vs Asp/Asp: OR=1.180, 95% CI=0.646-2.154, dominant model: OR=1.380, 95% CI = 0.812-2.346), but significantly elevated susceptibility was found for Asp312Asn polymorphism in some models (Asn/Asn vs Asp/Asp: OR=2.045, 95% CI=1.254-3.335, recessive model: OR=1.805, 95% CI =1.219-2.672), for the additive model, the XPD Lys751Gln and Asp312Asn polymorphisms were not significantly associated with gastric cancer susceptibility. In stratified analyses, significantly elevated susceptibility was found for some models in the Chinese population. Conclusion: This meta-analysis suggested the XPD Asp312Asn polymorphism might be a potential biomarker of gastric cancer susceptibility in overall population, while both XPD Lys751Gln and Asp312Asn polymorphisms might be risk factors of gastric cancer susceptibility in Chinese.

A Hybrid Optimization Algorithm for Traveling Salesman Problem Based on Geographical Information System for Logistics Distribution

Wei Gu,Yong Liu,Li-Rong Wei,Bing-Kun Dong 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.3

This paper presents a hybrid algorithm for traveling salesman problem. The algorithm is a combination of the genetic algorithm and simulated annealing algorithm; in other words, it is a hybrid algorithm. The combination overcomes the deficiencies of the two algorithms when acting separately. The real distance between customers has been used on the basis of geographical information system (GIS) in order to make the result more suitable in real-life. The algorithm has tested on the examples of international standards. We made a comparison with the result of second nearest neighbor algorithm and genetic optimization algorithm. The test showed that the algorithm proposed in this paper has improved the results.

Performance of Hepatitis B Core-Related Antigen Versus Hepatitis B Surface Antigen and Hepatitis B Virus DNA in Predicting HBeAg-positive and HBeAg-negative Chronic Hepatitis

Zhan-qing Zhang,Yan-bing Wang,,Wei Lu,,Dan-ping Liu,,Bi-sheng Shi,,Xiao-nan Zhang,,Dan Huang,,Xiu-fen Li,,Xin-lan Zhou,,Rong-rong Ding, 대한진단검사의학회 2019 Annals of Laboratory Medicine Vol.39 No.1

Background: We examined changes in hepatitis B core-related antigen (HBcrAg) during the four sequential phases of chronic hepatitis B virus (HBV) infection: hepatitis B e antigen (HBeAg)-positive chronic infection (EPCI) and hepatitis (EPCH), followed by HBeAg-negative chronic infection (ENCI) and hepatitis (ENCH). We compared the performance of serum HBcrAg, hepatitis B surface antigen (HBsAg), and HBV DNA in predicting EPCH and ENCH.

Modeling of low viscosity oil-water annular flow in horizontal and slightly inclined pipes: Experiments and CFD simulations

Yi-Xin Pan,Hong-Bing Zhang,Rong-Hua Xie,Xing-Bin Liu,Min Wang 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.10

To characterize the effect of pipe inclination, low viscosity, flow rate and inlet water cut on annular flow pattern, a low viscosity oil-water two-phase annular flow in horizontal and slightly inclined (+1o, +3o and +5o) pipes with diameter of 20 mm has been experimentally investigated. A modified VOF model based on the CFD software package FLUENT was used to predict the in-situ oil fraction and pressure drop. The experimental data indicate that annular flow appears at a medium-high water cut. The slip ratio increases with flow rate increase but decreases with increasing water cut. The changes are more significant as the degree of inclination increases. Pressure drop is strongly dependent on flow rate, as it increases rapidly as inlet flow rate increase. Good agreement between the experimental data and calculated results of slip ratio and pressure drop was obtained.

Correlation between rearing temperature and the dual cellulolytic system of Coptotermes formosanus Shiraki and its intestinal microenvironment

Wen-Hui Zeng,Zhi-Qiang Li,Bing-Rong Liu,Qiu-Jian Li,Jun-Hong Zhong 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.1

The lower termite, Coptotermes formosanus Shiraki, is an important model species for studying the dual cellulolytic system of termites. The effect of rearing temperature on the interaction between the intestinal symbiont community and the host in lignocelluloses digestion was investigated by assaying the activity and gene expression of cellulase, and monitoring the population size of intestinal protozoan community, which was followed by rearing C. formosanus at a temperature gradient (15–37 °C) for 3 d. The results showed that the rearing temperature of C. formosanus had a much greater impact on cellulase activity and gene transcription of the intestinal symbiont than on the host. The transcriptional variations of endogenous and symbiotic cellulase genes presented mutual complement and restrained when C. formosanus living in high temperature environment (32 and 37 °C). Additionally, the optimum survival temperature of Pseudotrichonympha grassii Koidzumi (22 °C) was found lower than that of Holomastigotoides mirabile Koidzumi (28 °C) and Spirotrichonympha leidyi Koidzumi (28 °C).The optimum rearing temperature for cellulase activity and protozoan survival of C. formosanus was found much lower than its optimum temperature for feeding. These findings provide a novel glimpse into host-symbiotic mutualism in lower termite digestion.