Heterogeneity of Invasive Ductal Carcinoma: Proposal for a Hypothetical Classification

Baik Hyeon Jo,Yi Kyeong Chun 대한의학회 2006 Journal of Korean medical science Vol.21 No.3

조직병리학적 분류에 따른 침윤성 유관상피암의 임상양상

조백현(Baik-Hyeon Jo),허민희(Min Hee Hur),이해경(Hae Kyung Lee),강성수(Sung Soo Kang),이성공(Sung Kong Lee),전이경(Yi Kyeong Chun),김의정(Yee Jung Kim),김혜선(Hye Sun Kim),홍성란(Sung Ran Hong),김희숙(Hy Sook Kim),이지현(Jee Hyun Lee 대한외과학회 2003 Annals of Surgical Treatment and Research(ASRT) Vol.64 No.6

Suppressed Gastric Mucosal TGF-β1 Increases Susceptibility to H. pylori-Induced Gastric Inflammation and Ulceration: A Stupid Host Defense Response

( Yunjeong Jo ),( Sang Uk Han ),( Yoon Jae Kim ),( Ju Hyeon Kim ),( Shin Tae Kim ),( Seong-jin Kim ),( Ki-baik Hahm ) 대한소화기기능성질환·운동학회 2010 Gut and Liver Vol.4 No.1

Background/Aims: Loss of transforming growth factor β1 (TGF-β1) exhibits a similar pathology to that seen in a subset of individuals infected with Helicobacter pylori, including propagated gastric inflammation, oxidative stress, and autoimmune features. We thus hypothesized that gastric mucosal TGF-β1 levels could be used to determine the outcome after H. pylori infection. Methods: Northern blot for the TGF-β1 transcript, staining of TGF-β1 expression, luciferase reporter assay, and enzyme-linked immunosorbent assay for TGF-β1 levels were performed at different times after H. pylori infection. Results: The TGF-β1 level was markedly lower in patients with H. pylori-induced gastritis than in patients with a similar degree of gastritis induced by nonsteroidal anti-inflammatory drugs. There was a significant negative correlation between the severity of inflammation and gastric mucosal TGF-β1 levels. SNU-16 cells showing intact TGF-β signaling exhibited a marked decrease in TGF-β1 expression, whereas SNU-638 cells defective in TGF-β signaling exhibited no such decrease after H. pylori infection. The decreased expressions of TGF-β1 in SNU-16 cells recovered to normal after 24 hr of H. pylori infection, but lasted very spatial times, suggesting that attenuated expression of TGF-β1 is a host defense mechanism to avoid attachment of H. pylori. Conclusions: H. pylori infection was associated with depressed gastric mucosal TGF-β1 for up to 24 hr, but this apparent strategy for rescuing cells from H. pylori attachment exacerbated the gastric inflammation. (Gut Liver 2010;4:43-53)

Epidemiological Study of Outbreak of Gastroenteritis Associated with Norovirus and Astrovirus in Busan, Korea

Hee Soo Koo(구희수),Hyeon Cheol Jo(조현철),Hyung Suk Baik(백형석) 한국생명과학회 2016 생명과학회지 Vol.26 No.9

2016년 3월, 부산 D대학 인근 음식점에서 모임을 한 후, 설사, 구토를 호소하는 환자들이 발생하였다. 역학조사팀은 설사 환자 및 해당 음식점 조리종사자에 대한 분변 검체를 수집하였고 해당 음식점 주방에서 식품용수에 대한 채수도 진행하였다. 인체 검체 42건에서 노로바이러스 16건, 아스트로바이러스 8건이 검출되었으며, 노로바이러스의 경우는 GI, GII genogoup 모두 검출되었으며, GI.3, GI.4, GII.4, GII.13, GII.17, GII.21로 6가지 다양한 유전자형의 분포를 확인하였다. 아스트로바이러스의 경우 Type 5과 Type 2의 유전자형 분포양상을 확인하였다. 또한 노로바이러스와 아스트로바이러스가 복합 감염된 3 케이스도 포함되어 있었다. 노로바이러스는 전세계적으로 GII.4형이 유행하고 있고, 최근에는 GII.17형이 출현하고 급증하는 동향에 따라 본 연구에서도 GII.17형이 가장 우세하였으며, 아스트로바이러스 경우는 국내에서 우세한 유전자형인 Type 1인 것과는 차이가 있는 사례였다. 특히, 부산지역에서 아스트로바이러스가 식중독 발생의 원인이 된 경우는 이번이 첫 사례여서 본 연구를 통하여 부산지역의 식중독 발생에 새로운 발생 양상을 파악하는 매우 특징적 결과를 얻었다. This paper studies an infection of norovirus and astrovirus in outbreaks in Korea. In March 2016, gastroenteritis outbreaks occurred in Busan. 522 students of three departments at university D had meeting at a restaurant near the university. Some of them had symptom such as diarrhea, vomiting. Epidemiological, laboratory and environmental investigations were performed to identify the agents of the outbreaks. Fecal specimens were collected from 35 students and 7 food handlers to identify causative viral agents. Norovirus genogroup GI and GII were detected from diarrhea patients. Astrovirus was also detected from some of them. In particular, these outbreaks were the first occurrence associated with astrovirus in Busan. Total of 42 samples were collected, and 24 samples resulted in positive to norovirus (16 cases) and astrovirus (8 cases). To identify the molecular genetic information of norovirus, we carried out sequences analysis of the detected strains. Norovirus genotypes were classified into GI.3, GI.4, GII.4, GII.13, GII.17 and GII.21. Astrovirus genotypes were seven astrovirus type 5 and one astrovirus type 2. We performed environmental investigation about water at the kitchen, but norovirus and astrovirus were not detected. The statistical analysis was conducted to evaluate the association between illness and risk factors. The results of this study may contribute to accumulate more the epidemiological data and develop the public health and hygiene.

변형된 측방 접근법으로 시행한 무시멘트형 인공고관절 전치환술에서 알루미나 관절면을 사용한 티타늄 테이퍼형 스템의 최소 5년 추시 결과

윤필환(Pil Whan Yoon),정현장(Hyeon Jang Jeong),이지호(Ji-Ho Lee),강승백(Seung-Baik Kang),이재협(Jae Hyup Lee),조현철(Chris H. Jo),한혁수(Hyuk Soo Han),이승환(Seung Hwan Rhee),김지형(Jihyeung Kim),윤강섭(Kang Sup Yoon) 대한정형외과학회 2012 대한정형외과학회지 Vol.47 No.4

목적: 변형된 측방 접근법으로 시행한 무시멘트형 인공고관절 전치환술에서 알루미나 관절면을 사용한 티타늄 테이퍼형 스템의 최소 5년추시 결과를 평가해 보고자 한다. 대상 및 방법: 단일 병원, 단일 집도의에 의해 인공고관절 전치환술을 시행 받은 102명, 120예를 대상으로 후향적 분석을 시행하였다. 남자가 53명, 여자가 49명이었고, 평균 연령은 54세였으며, 추시 기간은 평균 5.9년이었다. Harris 고관절 점수와 대퇴부 동통 및 파행 유무를 조사하여 임상 결과를 평가하고, 수술 후 시행한 방사선 사진으로 인공관절 삽입물의 고정 상태를 평가하였다. 결과: 평균 Harris 고관절 점수는 수술 전 46점에서 최종 추시 때 94점으로 호전되었다. 2예에서 활동 시 대퇴부 동통을 호소하였고, 4예에서 경도의 파행이 관찰되었다. 최종 추시 방사선 사진상 대퇴 스템은 모든 예에서 안정된 골성 고정이 확인되었다. 합병증으로 수술 후 3예에서 고관절 탈구가 발생하였고, 2예에서 squeaking이 발생하였다. 결론: 저자들의 방법으로 시행한 무시멘트형 인공고관절 전치환술의 최소 5년 이상 추시 결과, 환자의 연령과 근위 대퇴골의 형태와 상관없이 만족스러운 임상 및 방사선학적 결과를 확인할 수 있었다. Purpose: The purpose of the current study is to evaluate the clinical and radiographic outcomes of primary total hip arthroplasty (THA) using a single titanium tapered stem with alumina bearing, which was performed through a modified direct lateral approach. Materials and Methods: One hundred twenty consecutive primary THAs were performed in 102 patients, and retrospectively reviewed. There were 53 men and 49 women of mean age 54 years, and all patients were followed for a minimum follow-up period of 5 years (range, 5-8.1 years). Clinical outcomes assessment consisted of calculation of the Harris hip score (HHS), and evaluation of the presence of thigh pain or limp. Sequential radiographs were evaluated for implant migration, osteolysis, reactive line, cortical hypertrophy, or evidence of component loosening. Results: At the final follow-up, the mean preoperative HHS of 46 points improved to 94 points; and activity-related thigh pain occurred in two hips, and mild limps in four hips. There was no evidence of implant migration, osteolysis, or component loosening. Audible squeaking was present in two hips, without pain and radiographic abnormality. Dislocation occurred in three hips. Conclusion: The minimum 5-year results of titanium tapered stem with alumina bearing in cementless primary THA, using a modified direct lateral approach, were encouraging.

Deep traps and enhanced photoluminescence efficiency in nonpolar a-GaN/InGaN quantum well structures

Polyakov, A. Y.,Jang, Lee-Woon,Jo, Dong-Seob,Lee, In-Hwan,Smirnov, N. B.,Govorkov, A. V.,Kozhukhova, E. A.,Hyeon Baik, Kwang,Hwang, Sung-Min American Institute of Physics 2012 JOURNAL OF APPLIED PHYSICS - Vol.111 No.3

Cr-Mo 강의 피로강도에 미치는 열처리의 영향

조환종,이길홍,백승남,이효복,추현식,이현규,강조원,박창선,고제만 조선대학교 생산기술연구소 1983 生産技術硏究 Vol.1983 No.-

After Quenching C_(r)ㅡM_(o) steel, the Variations of tensile strength and hardness with the tempering temperature and the effects of tempering temperature and tufftrided treatment on fatigue strength were investigated. The results obtained in this study were as follows : 1. Tensile strength and hardness decreased as the tempering temperature increased, but elongation increased slightly. 2. Fatigue strength increased as the tempering temperature decreased, therefore equations of 3), 5), 6), were effected between fatigue limit and vickers hardness and proportional relation between fatigue strength and hardness even above Hv 400 was effected. 3. Fatigue strength of the specimens tufftrided was higher than that of specimen ternpered at 600℃ after quenching, but lower than that of specimens tempered at 150℃, 300℃ and 450℃.

2000년대 초에 유행한 Orientia tsutsugamushi에 의한 간염

박재일,한성희,조승철,조용현,홍상모,이학현,윤혜련,양선영,윤재훈,윤영섭,문지용,조경란,백상현,손주현,김태화,이동후 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3

목적: Orientia tsutsugamushi 감염은 삼림에 서식하는 매개충인 진드기(Leptotrombidium)의 유충이 우연히 사람의 피부를 통하여 전파되어 생기는 급성 발열 질환이다. 저자들은 지난 3년 동안 쯔쯔가무시병으로 진단된 환자들에서 간 기능 이상을 확인하고 가을철 간염환자의 감별진단 특히 non-A, non-B, non-C 간염의 진단에 주의를 환기하고자 관찰 결과를 보고하는 바이다. 대상과 방법: 한양대학교 서울병원과 구리병원에 2000년 10월부터 2002년 11월까지 hemagglutinin법으로 쯔쯔가무시병으로 진단된 환자 22명을 조사 대상으로 삼아 그 진료기록을 조사하였다. 결과: 남녀 비는 1:3.4로 여자가 많았다. 연령(범위 31-83세)은 56.4±2.6(평균±표준오차)세였다. 입원시기는 9월 23일부터 11월 15일 사이였고 10월 중순 이후 11월 상순 사이가 제일 많았다. 증상은 발열이 21예로 가장 많았고, 근육통 13예, 관절통 12예, 오한 6예, 피부발진 6예 순이었다. 잠복기는 7-9일이 10예로 가장 많았고 13-15일이 4예, 10-12일 3예, 3일 이내 3예, 4-6일 2예였다. ALT(범위 18-345 IU/L)는 93.2±17.3 IU/L(평균±표준오차)였고, AST(범위 34-255 IU/L)는 92.5±11.7 IU/L, GGTP (범위 19-251 IU/L)는 132.2±14.5 IU/L로 상승하였지만 혈중 총 빌리루빈은 정상이었다. 모든 환자들은 doxycycline 투여로 호전되었다. 결론: Orientia tsutsugamushi 감염은 대부분, 경도의 간 기능 이상을 동반하므로 특히 가을철 간 기능 이상을 보이는 열성 질환 환자들에게서 다른 간 질환과 감별해야 할 질환으로 인지하는 것이 중요하다. Background/Aims: Orientia -tsutsugamushi infection is an acute febrile disease due to the accidental transmission through human skin of forest dwelling vector Leptotrombidium larva. The authors observed liver dysfunctions in patients diagnosed with tsutsugamushi disease (Scrub typhus) in the past 3 years and report the data in the hope of bringing attention to this disease in the differential diagnosis of autumn-season hepatitis, especially of non-A, non-B and non-C hepatitis. Methods: Medical records of 22 patients diagnosed with tsutsugamushi disease by the hemagglutinin method between October 2000 and November 2002 were reviewed. Results: Female gender was dominant in the ratio of 3.4:1. Mean age was 56.4±2.6. Admission was between 23rd September and 15th November with the peak between mid October and early November. Fever, being the most common symptom, was observed in 21 cases, myalgia in 13, arthralgia in 12, chills in 6, and skin rash in 6. An incubation period of 7-9 days was most common (10 cases), 13-15 days (4), 10-12 days (3), within 3 days (3), and 4-6 days (2). Average ALT, AST and GGTP were increased to 93.2±17.3 IU/L (18±345 IU/L), 92.5±11.7 IU/L (34-255 IU/L) and 132.2±14.5 IU/L (19-251 IU/L), respectively, but total bilirubin was normal. All the patients improved with doxycycline therapy. Conclusions: since it usually shows liver dysfunction, it is important to take Orientia tsutsugamushi into consideration in differential diagnosis of autumn-season, febrile hepatic disease.(Korean J Hepatol 2003;9:198-204)