비인강암의 임상적 고찰과 예후인자

배창훈,서영중,예상백,최영호,김용대,송시연 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.1

본 연구에서는 1993년 1월부터 2002년 12월까지 10년간 비인강암으로 진단받은 환자 54예를 환자의 의무기록과 전화상담을 통하여 후향 적으로 분석하여 비인강암의 임상적인 특징과 생존율에 미치는 인자에 대하여 알아보고자 하였다. 환자의 연령분포는 16~78세로 평균 연령은 46.9세였다. 40대(26.0%)와 50대(27.8%)에서 호발하였으며, 남자가 여자보다 3.5배 많았다. 경부 종물을 주소로 내원한 환자가 30예(55.5%)로 가장 많았으며, 조직학적 유형은 WHO 제3형이 29예(53.7%)로 가장 많은 분포를 나타내었다. 조직학적 유형에 따른 5년 생존율은 제1형은 40.0% 제 2형은 45.5% 제 3형은 54.1%였다. 비인강암의 발생위치는 Rosenmu¨ller fossa를 포함한 측벽에서 35예(64.8%)로 가장 많이 발생하였다. 진단 시 Ⅲ, Ⅳ기의 진행된 병기군이 79.6%로 비인강암은 비교적 늦게 발견됨을 알 수 있었다. 전체적인 5년 누적 생존율은 46.5%였으며, 초기 병기군과 진행된 병기군의 5년 누적 생존율은 각각 58.3%, 44.2%로 초기 병기군의 생존율이 높은 것을 알 수 있었으나 통계학적 의의는 없었다. 원격전이의 경우 17예(31.5%)에서 발생 하였으며 골, 폐, 뇌, 척추, 간 등의 순서였다. 원발 부위의 완전관해 후 6예(11.1%)에서 국소 재발하여 다시 방사선치료를 시행하거나 항암화학요법과 방사선치료를 병행하여 치료하였다. 이상의 결과에서 보면 비인강암은 50대의남자에서 호발하며, 국내에서는 WHO 제 3형이 가장 빈발한다는 것을 알 수 있었다. 또한 TNM 병기는 비인강암의 생존율을 예측하는데 적절하지 않다고 생각되며, 생존율과 연관된 인자를 찾기 위해 향후 더 많은 연구가 시행되어야 하며 그에 따라 새로운 분류법이 제시되어야 할 것으로 사료된다. Background: Nasopharyngeal cancer is a rare disease with a relatively poor prognosis because it tends to be diagnosed at an advanced stage. The aim of this study was to establish the clinical characteristics of nasopharyngeal cancer. Materials and Methods: The medical records of 54 patients with nasopharyngeal cancer from January 1993 to December 2002 were reviewed retrospectively. Forty one cases were male (75.9%) and thirteen were female (24.1%). The average age was of 46.9 (range 16 to 78 years) years. The majority of patients (79.6%) were diagnosed in the advanced stage. The most common complaints were a neck mass (55.5%) and the WHO type 11I (53.7%) was the most frequent histological type. Results: The cumulative survival rate for a 5-year period was 46.5% and the T stage, N stage, pathologic type, and clinical stage were not significantly related to the survival rate. Sixteen of 54 (31.5%) cases presented with a distant metastasis of the bone, lung, brain, spine, and liver, and six cases (11.1%) presented with a locoregional recurrence. Conclusion: TNM staging is not appropriate for predicting survival rate of nasopharyngeal carcinoma patients. Therefore, a newer staging system, which includes new factors, is needed to predict the prognosis.

GG-10 : Predictors of success with postoperative voiding trials after incontinence surgery

( Ye Jin Park ),( Yeo Jung Moon ),( Su Yeon Park ),( Soo Rim Kim ),( Sei Kwang Kim ),( Sang Wook Bai ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

We identified predictors of passing a voiding trial after incontinence surgery and examined of successful performance on a voiding trial was maintained. A total of 125 women scheduled for transobturator tape(TOT) at Yonsei university health system were enrolled from January 2010 until December 2012. Patients underwent TOT with another surgery such as hysterectomy, perineorrhaphy were excluded. Medical history included hypertension, diabetes mellitus(DM), cerebrovascular accident(CVA) and spinal disease. Voiding trials were performed the next day of operation after removal of foley catheter, with less than a half volume void after more than a 300 ml considered passing. Residual urine was checked by nelaton catheterization. A total of 118 participants passed the first voiding trial. Univariate analysis identified nine potential predicting variables for passing the first voiding trial. From these nine variables, significant differences for passing the first voiding were identified in the patients with aged, DM or CVA. Those three variables were analyzed with multiple regression to examine the dependency of them. There was no significant difference between the patients over fifty years old and the patients below fifty years old. There was increased odds ratio(OR) with DM(OR:7.5;95% confidence intervals, CI:1.34-42.16) or CVA(OR:10.7; 95% CI:1.41-81.01) for passing the first voiding trial. The patients with DM, CVA were more likely to fail postoperative voiding trials after incontinence surgery which suggests that preoperative counseling and education on CIC are needed on women with such risk factors before incontinence surgery.

Multi-point displacement monitoring of bridges using a vision-based approach

Ye, X.W.,Yi, Ting-Hua,Dong, C.Z.,Liu, T.,Bai, H. Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.20 No.2

To overcome the drawbacks of the traditional contact-type sensor for structural displacement measurement, the vision-based technology with the aid of the digital image processing algorithm has received increasing concerns from the community of structural health monitoring (SHM). The advanced vision-based system has been widely used to measure the structural displacement of civil engineering structures due to its overwhelming merits of non-contact, long-distance, and high-resolution. However, seldom currently-available vision-based systems are capable of realizing the synchronous structural displacement measurement for multiple points on the investigated structure. In this paper, the method for vision-based multi-point structural displacement measurement is presented. A series of moving loading experiments on a scale arch bridge model are carried out to validate the accuracy and reliability of the vision-based system for multi-point structural displacement measurement. The structural displacements of five points on the bridge deck are measured by the vision-based system and compared with those obtained by the linear variable differential transformer (LVDT). The comparative study demonstrates that the vision-based system is deemed to be an effective and reliable means for multi-point structural displacement measurement.

Modeling and experimental studies of ammonia absorption in a spray tower

Shichao Ye,Jie Zhu,Zhenhua Liu,Jie Bai,Yunfeng Yang,Qin Peng 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.1

We did an experimental study on ammonia absorption in a spray tower. The kinetic characteristics of droplets were investigated by considering the forces acting on a droplet. The gas-phase mass transfer coefficient was deduced with the Colburn analogy method. A simplified model for predicting NH3 capture with a spray tower has been presented based on mass transfer and ionic equilibrium, which was successfully validated against experimental data. The influences and the sensitivity analysis of main operating parameters on the absorption efficiency were analyzed. As the most sensitive parameter, the mean droplet diameter was obtained by fitting experimental data with an empirical correlation. The distributions of two typical process parameters along the absorber were also simulated. Decreasing the pH value of absorbent is an effective but restrictive way to strengthen the mass transfer rate on account of insufficient liquid-side resistance.

암모니아 표면처리 된 질소 도핑 TiO2 광촉매의 합성 및 광분해반응

김예솔 ( Ye Sol Kim ),배병철 ( Byong Chol Bai ),이영석 ( Young Seak Lee ) 한국공업화학회 2012 공업화학 Vol.23 No.3

암모니아를 이용하여 질소가 도핑된 광촉매를 제조하고 이에 따른 가시광 광촉매 활성효과를 알아보았다. 질소 도핑 된 TiO2 광촉매가 태양광영역에서 분해되는 정도를 확인하기 위해서 태양광에 조사하에 메틸렌블루 염료분해 실험을 수행하였다. SEM 이미지 분석결과 질소가 도핑된 TiO2 광촉매의 응집 입자가 감소함을 알 수 있었고, XRD 결과 600 ℃에서 열처리된 질소 도핑 TiO2 광촉매는 아나타제 구조와 루타일이 존재하고 있음을 알 수 있었다. 또한, X선 광전 자 분광기 분석을 통하여 암모니아 반응시간에 따라서 TiO2 광촉매에 N의 조성 증가를 알 수 있었다. TiO2 광촉매의 질소 도핑에 의하여 메틸렌블루에 대한 광분해 효과가 도핑되지 않은 시료에 비해 증가하였다. 또한 질소 도핑은 TiO2 광촉매의 결정에도 영향을 주었다. Nitrogen doped TiO2 photocatalysts were prepared by ammonia for exploring the visible light photocatalytic activity. To explore the visible light photocatalytic activity of the nitrogen doped TiO2 photocatalyst, the removal of methylene blue dye was investigated under the sunlight. SEM images showed that the flocculated particle sizes of N-doped TiO2 decreased due to the reaction with ammonia. XRD patterns demonstrated that the samples calcined at temperatures up to 600 ℃ and doped with nitrogen using ammonia clearly showed rutile as well as anatase peaks. The XPS results showed that the nitrogen composition onto TiO2 increased according to the reaction time with ammonia. Photocatalytic activity of the nitrogen doped TiO2 was better than that of undoped TiO2. Nitrogen doping onto the TiO2 also affected the crystal type of TiO2 photocatalyst.

Study on Very Fast Transient Overvoltage of Closing No-load China UHV Transmission Demonstration Project Jindongnan-Nanyang-Jingmen 1000 kV Transmission Lines

Bo Ye,Ming Li,Biao Bai,Gefei Qiu 보안공학연구지원센터(IJGDC) 2014 International Journal of Grid and Distributed Comp Vol.7 No.3

MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN?

( Xing Ming Ye ),( Wen Dong Bai ),( Hua Yu Zhu ),( Xiao Zhang ),( Ying Chen ),( Lei Wang ),( An Gang Yang ),( Jing Zh Ao ),( Lin Tao Jia ) 생화학분자생물학회 2014 BMB Reports Vol.47 No.5

HER2-overexpressing breast cancers are characterized byfrequent distant metastasis and often develop resistance aftershort-term effective treatment with the monoclonal antibodydrug, trastuzumab. Here, we found that the oncogenic miRNA,miR-221, inhibited apoptosis, induced trastuzumab resistanceand promoted metastasis of HER2-positive breast cancers. Thetumor suppressor PTEN was identified as a miR-221 target;overexpression of PTEN abrogated the aforementionedmiR-221-induced malignant phenotypes of the cells. Thesefindings indicate that miR-221 may promote trastuzumabresistance and metastasis of HER2-positive breast cancers bytargeting PTEN, suggesting its role as a potential biomarker forprogression and poor prognosis, and as a novel target fortrastuzumab-combined treatment of breast cancers.[BMB Reports 2014; 47(5): 268-273]

Nucleocapsid Amino Acids 211 to 254, in Particular, Tetrad Glutamines, are Essential for the Interaction Between the Nucleocapsid and Membrane Proteins of SARS-Associated Coronavirus

Fang, Xiaonan,Ye, Lin-Bai,Zhang, Yijuan,Li, Baozong,Li, Shanshan,Kong, Lingbao,Wang, Yuhua,Zheng, Hong,Wang, Wei,Wu, Zhenghui The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.5

GST pull-down assays were used to characterize the SARS-CoV membrane (M) and nucleocapsid (N) interaction, and it was found that the amino acids 211-254 of N protein were essential for this interaction. When tetrad glutamines (Q) were replaced with glutamic acids (E) at positions of 240-243 of the N protein, the interaction was disrupted.

Gene Expression Profiles of HeLa Cells Impacted by Hepatitis C Virus Non-structural Protein NS4B

Zheng, Yi,Ye, Lin-Bai,Liu, Jing,Jing, Wei,Timani, Khalid A.,Yang, Xiao-Jun,Yang, Fan,Wang, Wei,Gao, Bo,Wu, Zhen-Hui Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.2

By a cDNA array representing 2308 signal transduction related genes, we studied the expression profiles of HeLa cells stably transfected by Hepatitis C virus nonstructural protein 4B (HCV-NS4B). The alterations of the expression of four genes were confirmed by real-time quantitative RT-PCR; and the aldo-keto reductase family 1, member C1 (AKR1C1) enzyme activity was detected in HCV-NS4B transiently transfected HeLa cells and Huh-7, a human hepatoma cell line. Of the 2,308 genes we examined, 34 were up-regulated and 56 were down-regulated. These 90 genes involved oncogenes, tumor suppressors, cell receptors, complements, adhesions, transcription and translation, cytoskeletion and cellular stress. The expression profiling suggested that multiple regulatory pathways were affected by HCV-NS4B directly or indirectly. And since these genes are related to carcinogenesis, host defense system and cell homeostatic mechanism, we can conclude that HCV-NS4B could play some important roles in the pathogenesis mechanism of HCV.

Multi-point displacement monitoring of bridges using a vision-based approach

X.W. Ye,Ting-Hua Yi,C.Z. Dong,T. Liu,H. Bai 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.20 No.2

To overcome the drawbacks of the traditional contact-type sensor for structural displacementmeasurement, the vision-based technology with the aid of the digital image processing algorithm hasreceived increasing concerns from the community of structural health monitoring (SHM). The advancedvision-based system has been widely used to measure the structural displacement of civil engineeringstructures due to its overwhelming merits of non-contact, long-distance, and high-resolution. However,seldom currently-available vision-based systems are capable of realizing the synchronous structuraldisplacement measurement for multiple points on the investigated structure. In this paper, the method forvision-based multi-point structural displacement measurement is presented. A series of moving loadingexperiments on a scale arch bridge model are carried out to validate the accuracy and reliability of thevision-based system for multi-point structural displacement measurement. The structural displacements offive points on the bridge deck are measured by the vision-based system and compared with those obtainedby the linear variable differential transformer (LVDT). The comparative study demonstrates that thevision-based system is deemed to be an effective and reliable means for multi-point structural displacementmeasurement.