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The Combined Effect of Caffeine and Ornithine on the Mood of Healthy Office Workers
Akane Misaizu,Takeshi Kokubo,Kyoko Tazumi,Masaya Kanayama,Yutaka Miura 한국식품영양과학회 2014 Preventive Nutrition and Food Science Vol.19 No.4
Caffeine is widely consumed and well known for stimulating the central nervous system. When developing new foods and beverages that contain caffeine, it is important to explore the potential synergistic effects of consuming amino acids and other food ingredients with caffeine on humans. Given the physiological pathways affected by the amino acid ornithine, consumption of ornithine with caffeine may have synergistic effects. The purpose of the present study was to examine the effect of consuming caffeine with ornithine in humans. The study used a randomized, placebo-controlled, double-blinded crossover design. The subjects were all healthy office workers who ingested the placebo, 100 mg caffeine, or 100 mg caffeine plus 200 mg ornithine in the morning and completed questionnaires about their mood. Office workers who consumed the combination of caffeine and ornithine had higher mood ratings 8 h after consumption than office workers who consumed caffeine alone. The results of the present study suggest that there is a unique synergistic effect between caffeine and ornithine on the mood of healthy office workers and that ornithine may potentiate the effects of caffeine.
Akane Uemichi,Riku Machida,Shigehiko Kaneko 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.춘계 No.-
The present study propose an evaluate formula based on the n-τ model for combustion oxcillation fueled by methane and hydrogen in a micro turbine combustor. Instead of a constant value of the pressure-interaction index n (in the previous study, usually n = 0.05), we use a modified index n; which was calculated with considering a relationship between laminar flame speed and heat release rate, in which laminar flame speed was calculated by software based on chemical kinetics. Acoustic instabilities were obtained by this evaluation formula and were compared with the experiment results. As a result, the evaluation formula proposed in this study can predict more accurately than the previous one.
Akane ODA 한국직업자격학회 2017 한국직업자격학회 학술대회 Vol.2017 No.10
The purpose of this paper is to analyze the characteristic of the higher vocational education in Japan by focusing on the logic that each committee had in the discussion on establishing “Universities of Applied Sciences”. The discussion was located as the reforms of universities finally, but it had also been that on establishing the new institution to have existing colleges of vocational education move there in the middle of the discussion. Especially, the specialized training college which isn’t the formal school stipulated in the article 1 of the School Education Law has desired to move to the new institution which is located as non-university and become the formal school in the article 1 of the School Education Law. However, they couldn’t realize because the new institution is located within the system of university finally. Hereafter, colleges of implementing vocational education newly should improve to their systematic position.
Kubota, Akane,Ito, Shogo,Shim, Jae Sung,Johnson, Richard S.,Song, Yong Hun,Breton, Ghislain,Goralogia, Greg S.,Kwon, Michael S.,Laboy Cintró,n, Dianne,Koyama, Tomotsugu,Ohme-Takagi, Masaru,Prune Public Library of Science 2017 PLoS genetics Vol.13 No.6
<▼1><P>Photoperiod is one of the most reliable environmental cues for plants to regulate flowering timing. In <I>Arabidopsis thaliana</I>, CONSTANS (CO) transcription factor plays a central role in regulating photoperiodic flowering. In contrast to posttranslational regulation of CO protein, still little was known about <I>CO</I> transcriptional regulation. Here we show that the CINCINNATA (CIN) clade of class II TEOSINTE BRANCHED 1/ CYCLOIDEA/ PROLIFERATING CELL NUCLEAR ANTIGEN FACTOR (TCP) proteins act as <I>CO</I> activators. Our yeast one-hybrid analysis revealed that class II CIN-TCPs, including TCP4, bind to the <I>CO</I> promoter. TCP4 induces <I>CO</I> expression around dusk by directly associating with the <I>CO</I> promoter <I>in vivo</I>. In addition, TCP4 binds to another flowering regulator, GIGANTEA (GI), in the nucleus, and induces <I>CO</I> expression in a <I>GI</I>-dependent manner. The physical association of TCP4 with the <I>CO</I> promoter was reduced in the <I>gi</I> mutant, suggesting that GI may enhance the DNA-binding ability of TCP4. Our tandem affinity purification coupled with mass spectrometry (TAP-MS) analysis identified all class II CIN-TCPs as the components of the <I>in vivo</I> TCP4 complex, and the <I>gi</I> mutant did not alter the composition of the TCP4 complex. Taken together, our results demonstrate a novel function of CIN-TCPs as photoperiodic flowering regulators, which may contribute to coordinating plant development with flowering regulation.</P></▼1><▼2><P><B>Author summary</B></P><P>For plant adaptation to seasonal environments, a crucial developmental event is flowering, as proper timing of flowering affects reproductive success. Although plants monitor various environmental parameters to optimize this timing, photoperiod information is important for plants to regulate seasonal flowering time, because changes in photoperiod occur in a predictable manner throughout the year. The model plant <I>Arabidopsis thaliana</I> responds to photoperiodic changes and flowers under long-day conditions. Based on genetic analyses using mutants defective in the photoperiodic flowering response, we learned that the transcription factor referred to as CONSTANS (CO) plays a central role in regulating the timing of flowering by directly controlling the expression of florigen (flowering-inducing substrate) gene. Long-day afternoon expression of <I>CO</I> is critical for this regulation; however, we had limited knowledge of <I>CO</I> transcriptional regulation. Here we identified that a group of plant-specific transcription factors belonging to the <I>TCP</I> gene family function as novel <I>CO</I> transcriptional activators. We demonstrated that TCP transcription factors regulate <I>CO</I> transcription together with known regulators of <I>CO</I>. Our results imply that plants utilize multiple transcription factors to precisely coordinate the expression of the key regulator gene, <I>CO</I>, which will directly affect flowering time.</P></▼2>