동결견 치료에 관한 임상적 연구

변재영,안수기 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

Clinical studies were done on 80 persons who were treated with the acupuncture therapy frozen shoulder. The following results are obtained. 1. Distribution of sex: male(28 persons), female (52persons). 2. Cuses of illness : work(40 persons), unknown origin(32 persons). 3. Duration of illness : less than 1 month (28 persons), 1-3 month(22 persons), 3-6months(20 persons). 4. Distribution of occupational : housewife(10 persons), unemployed(22 persons), farmer(16 persons). 5. Distribution according to number of times of treatment rate : 3 weeks (32 persons), 2weeks(14 persons), 4 weeks(10 persons). 6. The classification of abduction disturbance before treatment were GI group 14 persons, GII group 46 persons, GIII group 20 persons. After treatment were GI group 41 persons, GII group 30 persons, GIII group 9 persons. 7. The classification of HBST disturbance before treatment were GI group 10 persons, GII group 51 persons, GIII group 19 persons. After treatment were GI group 39 persons, GII group 28 persons, GIII group 13 persons. 8. The classification of MWT disturbance before treatment were GI group 25 persons, GII group 37 persons, GIII group 18 persons. After treatment were GI group 44 persons, GII group 25 persons, GIII group 1 person.

天安삼거리公園基本計劃에 關한 硏究

安奉遠,李錫孫,姜喆基,林秀眞,金恩一 경희대학교 1988 造景論叢 Vol.1 No.1

The goal of this study is to propose a plan for the construction of Chonan Samgori park. Present this park is designated a neighborhood park of Chonan city. This park is located on the point of traditionally important traffic point linked to Samnam province. And, this place is where the perspective experience of history and culture, which is a unique folk related activities. The site which covers about 96,000㎡is located about 4 km from the cityhall of Chonan city. This basic idea of this plan is to reconstruct the ancient culture and traditional way of life which is rapidly disappearing, to offer the place of education of vernacular culture, to give the recreation place to be a center where city dwellers release and enjoy. Facilities of this park are divided into five groups according to function such as support facilities, folk facilities, play facilities, educational and cultural facilities, and landscape facilities. Design principles are established as follows; to provide the folk park with identity, effectively to admit the folk-related activities, to maintain a functional linkage between facilities. The frame works for final master plan are Landuse plan, Circulation plan, Planting Plan, Facility plan.

色盲의 치료에 대한 臨床的 考察

安秀基 圓光大學校 韓醫學硏究所 1996 원광한의학 Vol.6 No.1

The most important theory of color vision was Young-Helmholtz theory. According to the theory, there are three different types of cones, each of watch responds maximally to different color, one type responding maximally to red, another to green, and another to blue. The subject of this study is investigation of possibility on the Therpy of Color Blindness by acupuncture. The 32 patients of color blindness who were treated by acupuncture therapy became the object of this study. The patients consisted mainly of young man and student because they wanted to conquer restriction on employment. Degree of Color Blindness on the first medical examination is split into three level, the most seriouse level group responds grade Ⅲ that was appared in 18 patients, the middle seriouse group responds grade Ⅱ that was appared in 11 patients, the slight group responds grade Ⅰ that was appared in 3 patients. After the treatment was operated, the group of grade Ⅲ patients(18 numbers) were changed into 5 patients of grade Ⅲ, 3 patients of grade Ⅱ, 8 patients of grade Ⅰ, 2 patients of recovered group(Normal) by the acupunture, the group of grade Ⅱ patients (11 numbers) were changed into 3 patients of non-effective group, 4 patients of grade Ⅰ, 4 patients of recovered group (Normal), the group of grade Ⅰ(3 numbers) were changed into 1 patient of non-effective group, 2 patients df recovered group(Normal). The total result of the treatreamt were that poor result was appear in 9 patients, good result as appear in 15 patients, excellent result of normal was appear in 8 patients. These result suggests that acupuncture treatment could be applied on Color Blindness effectively.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

류마치스성 제1-2경추 아탈구 : 증례보고 Report of A Case

송상현,윤수한,조기홍,안영환,안영민,조경기 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Authors report a case of one-stage transoral decompression and posterior fusion in rheumatoid atlantoaxial subluxation. A 63-year-old man developed a rheumatiod atlantoaxial subluxation with mild weakness of all extremities which developed relatively suddenly 3 months after the initial symptom of neck pain. Skeletal traction followed by transoral decompression and occipitocervical fusion was performed on the same day. Postoperative course has been uneventful and revealed favorable fusion state of occipito-atlanto-axis. The pertinent literature on theumatoid atlanto-axial subluxation is reviewed and discussed.

뇌동맥류의 진단에 대한 전산화단층촬영 뇌혈관조영술과 고식적 뇌혈관조영술의 비교

송상현,윤수한,안영환,안영민,조기홍,조경기,김선용,서정호 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Cerebral angiography has been essential for the diagnosis of the intracranial aneurysms but. is sometimes accompanied by serious complications. Resolution of CT angiography was up-graded greatly to represent the three-demensional structure of vesseles since helical CT had been introduced. We have compared 26 cases of CT angiography and 28 cases of conventional angiography in terms of specificity and sensitivity for the diagnosis detectable aneurysm diameter. configurational diagnosis and diagnostic confidency. All results showed no statistical difference between CT angiography and conventional angiography. These should suggest that CT angiography could be replaced with conventional angiography for the diagnosis of ruptured aneurysms and even of unruptured aneurysms. resulting in the introduction of first screening modality of unruptured aneurysms.

L1210 세포에 대한 약용 식물의 세포독성 검색

배기환,민병선,도동선,김남수,양기종,안병준 충남대학교 약학대학 의약품개발연구소 1992 藥學論文集 Vol.8 No.-

For the research of cytotoxic natural products, 50 medicinal plants were extracted with benzene and methanol, separately, and screened against L1210 cells. From the results(Table I), 6 samples showed cytotoxicity both in benzene and methanol extracts of 17 samples in benzene extracts and 3 samples in methanol extracts, respectively. Generally, the cytotoxicity exhibited high frequency (34%) in benzene extract but low frequency in methanol extract(6%), it meant that active cytotoxic components had less polarity. ED_50 values less than 10 ㎍/㎖ were observed in 17 medicinal plants.

태양전지로부터 은 회수를 위한 친환경 공정 연구

안성수(Ahn Sung-Soo),이준규(Lee Jun-Kyu),안영수(Ahn Young-Soo),강기환(Kang Gi-Hawn),장효식(Chang Hyo-Sik),이진석(Lee Jin-Seok) 한국태양에너지학회 2021 한국태양에너지학회 논문집 Vol.41 No.6

In this study, a solution capable of leaching silver (Ag) from solar cells in an environment-friendly manner was presented, and a leaching effect according to the concentration was evaluated. Generally, a nitric acid (HNO₃) solution is used to leach Ag. However, it often causes environmental pollution owing to its high toxicity and the nitrous oxide (NOx gas) generated during the process, thus requiring considerable development. Accordingly, Ag leaching behavior according to the concentration was confirmed by mixing sulfuric acid (H₂SO₄) and hydrogen peroxide (H₂O₂) solutions. After this process, the optimal concentration condition was derived by confirming the Ag leaching effect through inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analyses of the leachate. Additionally, Ag removal in the recovered scrap to which the optimal concentration condition was applied was confirmed using scanning electron microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDS). Conclusively, as the H₂SO₄ and H₂O₂ mixed solution concentration increased, the Ag leaching effect tended to increase, and the optimal condition derived from the analysis reached a level capable of replacing the HNO₃ solution.

음향튜브를 이용한 폴리머 재료의 수중 음향 특성 평가

안경수(Kyeong Soo Ahn),강창기(Chang Gi Kang),윤우원(Woo Won Youn),윤진민(Jin Min Youn),김수연(Soo Yeon Kim) 제어로봇시스템학회 2011 제어로봇시스템학회 합동학술대회 논문집 Vol.1 No.2

수중에서 사용되는 음향재는 입사되는 음을 흡수하거나 음을 반사시키는 역할을 한다. 일반적으로 수중 음향재료는 기공이 주입된 점탄성 폴리머가 많이 사용된다. 점탄성 모재를 가지는 폴리머는 높은 Damping 특성으로 음의 급격한 공진 거동을 감소시켜주고 재료내의 기공이 입사되는 음을 반사 및 산란시켜 음의 손실을 가져온다. 투과 손실(Transmission Loss)성능은 재료에 입사되는 음파의 입사파와 투과파를 사용하여 다음과 같이 정의 된다. TL= -10log10(It/Io) 국내에서 재료의 투과손실 성능 측정은 일반적으로 음향수조를 이용하고 있으니 심해에서의 압력에 대한 환경소건의 한계로 해외 선진국에서는 압력음향수조를 이용하고 있다. 본 논문에서는 수중환경을 모사하기 위해 압력과 조절이 가능하도록 개발한 주중 음향튜브(water-filled acoustic pulse tube)를 이용하여 기공 주입한 폴리머의 음향 특성을 평가하고자 한다.

Long-term outcomes of liver resection for multiple hepatocellular carcinomas: Single-institution experience with 187 patients

Soo-Young Lee,Chul-Soo Ahn,Young-In Yoon,Sung-Gyu Lee,Shin Hwang,Ki-Hun Kim,Deok-Bog Moon,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Gil-Chun Park 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.4

Backgrounds/Aims: Surgical resection for the treatment of multiple hepatocellular carcinomas (HCCs) is controversial. This study aimed to evaluate the clinical and oncological outcomes after liver resection in patients with multiple HCCs. Methods: Clinicopathological and survival data of 187 patients who underwent curative resection for multiple HCCs between June 2004 and December 2016 at Asan Medical Center, Seoul, South Korea were retrospectively reviewed. The prognostic factors for recurrence and survival were identified using univariate and multivariate analyses. Results: Of the 187 patients, 153 (81.8%) had two nodules, 23 (12.3%) had three nodules, and 11 (5.9%) had more than three nodules. Multiple tumors were located in the ipsilateral lobe in 163 (87.2%) patients. Anatomical resection, non-anatomical resection, and both types of resections were performed in 81.3%, 8.0%, and 10.7% patients, respectively. Recurrence occurred in 133 (71.1%) patients, and the mean time to recurrence after surgery was 34.2 months. Independent risk factors for tumor recurrence in multivariate analyses were indocyanine green retention rate at 15 min ≥15%, preoperative alpha-fetoprotein level ≥400 ng/ml, and total tumor diameter ≥6 cm. The 1-, 3-, 5-, and 10-year disease-free survival rates were 94.1%, 81.7%, 69.7%, and 39.4%, respectively, and the 1-, 3-, 5-, and 10-year survival rates were 93.5%, 74.2%, 64.9%, and 38.8%, respectively. Conclusions: Our experience shows that liver resection can be considered a first-line treatment option for selected patients with multiple HCCs who have well-preserved liver function.