대전 도덕봉과 백운봉의 산림군락 분류

김효정,이미정,지윤의,안승만,이규석,송호경 한국환경생물학회 2002 환경생물 : 환경생물학회지 Vol.20 No.3

본 연구는 계룡산국립공원의 지류인 도덕봉과 백운봉의 산림식생을 대상으로 식물사회학적 방법에 의해 산림군락을 분류하고 이 지역의 식생 현황 파악과 국립공원관리에 필요한 기초자료를 제공하고자 하였다. 식물사회학적 방법으로 89개 조사구를 분석한 결과, 신갈나무군락, 졸 참나무군락, 굴 참나무군락, 소나무군락, 서어나무군락, 리기다소나무-곰솔군락으로 구분되었다. 신갈나무군락은 해발고가 가장 높고 경사가 급한 지역에 분포하였으며,졸참나무군락은 해발고가 비교적 낮고 경사가 급한 지역에 분포하였다. 그리고 굴참나무군락은 신갈나무군락에 비해 해발고가 낮은 남사면의 건조한 지역에 분포하고 있었다. 소나무군락은 해발고가 비교적 높고 폭이 좁은 건조한 능선 부위에 분포하고 있으며, 서어나무군락은 주로 남사면 계곡부의 중부에 분포하고 있었 다. 그리고 리기다-곰솔군락은 조림군락이다. This study was carried out to classify forest vegetation community of Dodeokbong and Baekwunbong in Gyeryongsan. Employing the releve method of Dierssen, 89 plots were sampled. Forest community was classified into Quercus mongolica community, Quercus serrata community, Quercus variabilis community, Pinus densiflora community, Carpinus laxiflora community, and Pinus rigida-Pinus thunbergii community. Quercus mongolica community was found in high altitude and steep area, Quercus serrata community in relatively low altitude and steep slope area, and Quercus variabilis in southern arid and low area compared with Quercus mongolica community. Pinus densiflora community is present in relatively high altitude and narrow arid ridge area. And, Carpinus laxiflora community is mainly distributed in southern valley area. Pinus rigida-Pinus thunbergii community is planted community.

ISC3를 이용한 서울시 대기질 모델링

정일래,권오열,안효승,문인수 서울産業大學校 1999 논문집 Vol.49 No.2

In this study ISC3(Industrial Source Complex Ver.3) model is applied to Seoul area (1) to evaluate the applicability of ISC3 by comparing the model results and the measured results under control of Seoul City Government and Han-River Environmental Management Office, and (2) propose the direction of future air pollution management of Seoul area by looking at contributing intensity of point, line and area sources, of which each has different dispersion characteristics, to the air quality. The results of the study, of which pollutant is SO₂ and the year is 1996, are summarized as follows. First, the model results are very similar to those of the measured, showing the regression coefficient(except 4 data of which errors are big) is 0.72 in case of 10 meters height of area source and 0.71 in case of 5 meters height of area source. Therefore ISC3 is judged to be applicable to Seoul area of which comprises of a variety of source types and topographically rolling terrains. Second, for Seoul area, total SO₂emissions are 31.4% from the point sources and the rest 68.6% from the area sources, while contributing weights are 17.39% from the point sources and 82.61% from the area sources in case of 10 meters height of area source, and 16.15% from the point sources and 83.85% from the area sources in case of 5 meters height of area source. Therefore the area sources impact surface concentrations much more than the point sources. Interpreting the second result in terms of contributing intensities which we define the ratio of surface concentration X area and source emissions, contributing intensities of Seoul area are 0.55 for point sources and 1.20 for area sources in case of 10 meters height of area source, and 0.51 for point sources and 1.22 for area sources in case of 5 meters height of area source. Thus the contributing intensity of area sources appears to be approximately as twice as that of point sources. Overall results show that the control of area sources is more urgent and effective than that of point sources in view point of air quality management of SO₂.

과거 영상자료를 이용한 해안선 정보 추출

안승효(Ahn, Seung Hyo),최현(Choi, hyun),김기홍(Kim, Gi Hong) 한국측량학회 2020 한국측량학회 학술대회자료집 Vol.2020 No.7

도로정보 3차원 가시화

안승효(Ahn, Seung Hyo),김기홍(Kim, Gihong) 대한토목학회 2023 대한토목학회 학술대회 Vol.2023 No.10

폭발하중을 받는 철근콘크리트 부재의 붕괴해석을 위한 침식 기준

안효승(Ahn, Hyo Seung),김한수(Kim, Han Soo),안재균(Ahn, Jae Gyun) 한국콘크리트학회 2013 한국콘크리트학회 학술대회 논문집 Vol.2013 No.10

재발성 또는 난치성 소세포폐암에 대한 topotecan, vincristine 복합요법

안효승 ( Hyo Seung Ahn ),원혜진 ( Hye Jin Won ),이효락 ( Hyo Rac Lee ),유영진 ( Young Jin Yuh ),김성록 ( Sung Rok Kim ) 대한내과학회 2007 대한내과학회지 Vol.72 No.6

목적: 항암화학요법에 불응하거나 또는 관해 후 재발된 소세포폐암 환자를 대상으로 topotecan과 vincristine 복합화학요법의 효과와 안전성에 대하여 알아보기 위하여 연구를 시행하였다. 방법: 조직학적으로 증명된 소세포폐암 환자로 이전 항암화학요법에 불응하거나 관해 후 재발된 환자를 대상으로 연구를 진행하였다. 치료는 topotecan 1.5 mg/m2/day를 3일간, vincristine 1.5 mg/m2 (maximum 2 mg)를 홀수 주기에는 2일간, 짝수 주기에는 1일간 투여하였다. 이 치료는 감내할 수 없는 독성이 발생하거나 병변이 진행될 때까지 3주 간격으로 반복하였다. 결과: 총 19예가 이 연구에 등록 되었다. 등록된 환자 연령의 중앙값은 63세이었다. 평가 가능한 19예 중 3예에서 부분관해가 관찰되어 반응률은 15.8% (95% 신뢰구간: 0~32.5%)이었다. 생존기간의 중앙값은 199일이었고, 진행까지의 기간 중앙값은 51일이었다. 전체 52회의 치료 중 NCI-CTC 3도 이상의 백혈구감소가 25.0%, 호중구감소가 11.5%에서 나타났다. NCI-CTC 2도의 신경독성이 15.4%에서 관찰되었으나 치료와 연관된 사망은 관찰되지 않았다. 결론: 난치성 또는 재발성 소세포폐암에서 topotecan과 vincristine 복합화학요법은 효과가 있었고 안전하였다. 그러나 topotecan 단독요법과의 비교연구가 필요하다고 생각된다. Background: Small cell lung cancer (SCLC) is a chemotherapy-sensitive tumor. However, the duration of response is usually short and most patients experience relapses. Topotecan is commonly used for treatment of these patients. Nevertheless, the response rate of topotecan as a single regimen is only about 20% and the resulting severe myelosuppression is troublesome. Vincristine is also an active agent, and it does not compromise the marrow function. In this background, we evaluated the efficacy and toxicities of topotecan and vincristine combination chemotherapy. Methods: Patients with pathologically confirmed SCLC refractory to or recurrent after platinum-based chemotherapy were eligible for this study. The treatment regimen was as follows; topotecan 1.5 mg/m2/day IV bolus on day 1, 2 and 3 and vincristine 1.5 mg/m2 (maximum 2 mg on day 1 (on every cycle)) and day 2 (on odd cycles only). This regimen was repeated every 3 weeks. The efficacy was evaluated in terms of response rate, time to progression and overall survival duration. The toxicities were assessed according to NCI-CTC version 3.0. Results: A total of 19 patients were entered into this study. The median age was 63 years (range 43-85 years). Partial response was obtained for 3 patients (response rate 15.8%, 95% CI: 0-32.5%). The median time to progression and survival duration was 51 days and 199 days, respectively. For a total of 52 cycles of treatment, grade 3 or 4 neutropenia and thrombocytopenia were observed in 25.0% and 11.5% of the patients, respectively. Grade 2 neurotoxicities were observed in 15.4% of the patients. There was no treatment-related mortality. Conclusions: The topotecan and vincritine combination is active and safe for patients with recurrence or refractory SCLC. However, the benefit of adding vincristine to topotecan needs to be confirmed in further studies. (Korean J Med 72:632-638, 2007)

Paeonol Exerts Anti-angiogenic and Anti-metastatic Activities through Downmodulation of Akt Activation and Inactivation of Matrix Metalloproteinases

Kim, Seung-Ae,Lee, Hyo-Jeong,Ahn, Kwang Seok,Lee, Hyo-Jung,Lee, Eun-Ok,Ahn, Kyoo-Seok,Choi, Seung-Hoon,Jung, Soo-Jin,Kim, Ji Young,Baek, Namin,Kim, Sung-Hoon Pharmaceutical Society of Japan 2009 Biological & pharmaceutical bulletin Vol.32 No.7

<P>Paeonol (2′-hydroxy-4′-methoxyacetophenone) is known to possess anti-inflammatory and anti-proliferative activities. Recently there is evidence that anti-inflammatory agents may be useful in the setting of angiogenesis-related diseases. Thus in the present study the anti-angiogenic activity of paeonol and its mechanism were investigated <I>in vitro</I> and <I>in vivo</I>. Paeonol significantly inhibited proliferation of basic fibroblast growth factor (bFGF)-stimulated human umbilical vein endothelial cells (HUVECs). Paeonol also significantly inhibited migration and tube formation of bFGF-stimulated HUVECs <I>in vitro</I>. In addition, paeonol significantly suppressed neovessel formation on bFGF-treated chick chorioallantoic membrane (CAM) and disrupted bFGF-induced neovascularization in Matrigel plug assay <I>in vivo</I>. Furthermore, paeonol downregluated Akt phosphorylation in bFGF-stimulated HUVECs and reduced expression of matrix metalloproteinases-2 and -9 in HT1080 human fibrosarcoma cells. The Akt inhibitor LY294002 synergistically potentiated paeonol-induced inactivation of Akt and vascular endothelial growth factor in bFGF-treated HUVECs. Taken together, these findings suggest that paeonol can be a potent suppressor of angiogenesis and metastasis partially through inhibition of Akt signaling pathway and matrix metalloproteinase activity.</P>

A new approach of digital PCR system for non-invasive prenatal screening of trisomy 21

Lee, Seung Yong,Kim, Seung Jun,Han, Sung-Hee,Park, Joon Soo,Choi, Hyo Jung,Ahn, Jeong Jin,Oh, Moon-Ju,Shim, Sung Han,Cha, Dong Hyun,Hwang, Seung Yong Elsevier 2018 Clinica chimica acta Vol.476 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Non-invasive prenatal screening (NIPS) of trisomy 21 (T21) using digital PCR (dPCR) with several advantages will be very effective. Here, we developed a dPCR system for T21 screening which allows high sensitivity and real-time diagnosis and thus overcome sequence based analysis.</P> <P><B>Methods</B></P> <P>Cut-off value was established using DNA extracted from all 157 T21 negative samples including 47 pregnant woman samples and 3 T21 positive pregnant woman samples extracted from 4 different sample types. To increase the portion of the cell-free fetal DNA (cffDNA) in maternal cell-free DNA (cfDNA), a size selection method was devised. We evaluated the clinical reliability of NIPS using dPCR through analysis of 877 pregnant woman samples.</P> <P><B>Results</B></P> <P>We could demonstrate the possibility of NIPS using dPCR performed by applying cut-off value and size selection method. The overall accuracy was derived at 99.66% using 877 pregnant woman plasma samples.</P> <P><B>Conclusion</B></P> <P>Our results showed that dPCR can meet the requirements for NIPS for T21. It is relatively inexpensive, easy to use in a screening method and compatible with ethical concerns regarding access to nucleotide sequence information. This study may be a basic data for the development of population-wide screening for T21 in pregnant women.</P> <P><B>Highlight</B></P> <P> <UL> <LI> NIPS for trisomy 21 using dPCR is easy to apply and results are obtained quickly </LI> <LI> We have developed the technology using digital PCR to screening for trisomy 21 </LI> <LI> We evaluated the accuracy of development technology using clinical samples </LI> <LI> This technique can be extended to the detection of other aneuploidies using cfDNA </LI> </UL> </P>

Comparison of the effects of maxillary protraction using facemask and miniplate anchorage between unilateral and bilateral cleft lip and palate patients.

Ahn, Hyo-Won,Kim, Keun-Woo,Yang, Il-Hyung,Choi, Jin-Young,Baek, Seung-Hak Angle Orthodontists Research and Education Foundat 2012 The Angle orthodontist Vol.82 No.5

<P>To determine the difference in the effects of facemask with miniplate (FM-MP) anchorage on maxillary protraction in growing cleft patients between unilateral (UCLP) and bilateral cleft lip and palate (BCLP) groups.</P>

마미총 부위에 발생한 척수관내 말초 신경상피종 : 증례 보고 Case Report

안용봉,이종수,이승재,박효일 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.10-11

An unusual case of intraspinal peripheral neuroepithelioma arising from the cauda equina is reported. The patient, a 21-year old female, suffered from low back pain with radiation to the posterior aspect of both legs. Myelographic, computed tomographic scan and magnetic resonance imaging studies of lumbosacral spine showed the intradural extramedullary mass lesion on the L3-S1 level which was excised surgically, but recurred rapidly. It could be diagnosed by the histopathologic findings. The postoperative radiotherapy and chemotherapy were administered. We report this rare case with review of the literatures.