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재발성 또는 난치성 소세포폐암에 대한 topotecan, vincristine 복합요법
안효승 ( Hyo Seung Ahn ),원혜진 ( Hye Jin Won ),이효락 ( Hyo Rac Lee ),유영진 ( Young Jin Yuh ),김성록 ( Sung Rok Kim ) 대한내과학회 2007 대한내과학회지 Vol.72 No.6
목적: 항암화학요법에 불응하거나 또는 관해 후 재발된 소세포폐암 환자를 대상으로 topotecan과 vincristine 복합화학요법의 효과와 안전성에 대하여 알아보기 위하여 연구를 시행하였다. 방법: 조직학적으로 증명된 소세포폐암 환자로 이전 항암화학요법에 불응하거나 관해 후 재발된 환자를 대상으로 연구를 진행하였다. 치료는 topotecan 1.5 mg/m2/day를 3일간, vincristine 1.5 mg/m2 (maximum 2 mg)를 홀수 주기에는 2일간, 짝수 주기에는 1일간 투여하였다. 이 치료는 감내할 수 없는 독성이 발생하거나 병변이 진행될 때까지 3주 간격으로 반복하였다. 결과: 총 19예가 이 연구에 등록 되었다. 등록된 환자 연령의 중앙값은 63세이었다. 평가 가능한 19예 중 3예에서 부분관해가 관찰되어 반응률은 15.8% (95% 신뢰구간: 0~32.5%)이었다. 생존기간의 중앙값은 199일이었고, 진행까지의 기간 중앙값은 51일이었다. 전체 52회의 치료 중 NCI-CTC 3도 이상의 백혈구감소가 25.0%, 호중구감소가 11.5%에서 나타났다. NCI-CTC 2도의 신경독성이 15.4%에서 관찰되었으나 치료와 연관된 사망은 관찰되지 않았다. 결론: 난치성 또는 재발성 소세포폐암에서 topotecan과 vincristine 복합화학요법은 효과가 있었고 안전하였다. 그러나 topotecan 단독요법과의 비교연구가 필요하다고 생각된다. Background: Small cell lung cancer (SCLC) is a chemotherapy-sensitive tumor. However, the duration of response is usually short and most patients experience relapses. Topotecan is commonly used for treatment of these patients. Nevertheless, the response rate of topotecan as a single regimen is only about 20% and the resulting severe myelosuppression is troublesome. Vincristine is also an active agent, and it does not compromise the marrow function. In this background, we evaluated the efficacy and toxicities of topotecan and vincristine combination chemotherapy. Methods: Patients with pathologically confirmed SCLC refractory to or recurrent after platinum-based chemotherapy were eligible for this study. The treatment regimen was as follows; topotecan 1.5 mg/m2/day IV bolus on day 1, 2 and 3 and vincristine 1.5 mg/m2 (maximum 2 mg on day 1 (on every cycle)) and day 2 (on odd cycles only). This regimen was repeated every 3 weeks. The efficacy was evaluated in terms of response rate, time to progression and overall survival duration. The toxicities were assessed according to NCI-CTC version 3.0. Results: A total of 19 patients were entered into this study. The median age was 63 years (range 43-85 years). Partial response was obtained for 3 patients (response rate 15.8%, 95% CI: 0-32.5%). The median time to progression and survival duration was 51 days and 199 days, respectively. For a total of 52 cycles of treatment, grade 3 or 4 neutropenia and thrombocytopenia were observed in 25.0% and 11.5% of the patients, respectively. Grade 2 neurotoxicities were observed in 15.4% of the patients. There was no treatment-related mortality. Conclusions: The topotecan and vincritine combination is active and safe for patients with recurrence or refractory SCLC. However, the benefit of adding vincristine to topotecan needs to be confirmed in further studies. (Korean J Med 72:632-638, 2007)
김한수(Kim, Han-Soo),안효승(Ahn, Hyo-Seung),안재균(Ahn, Jae-Gyun) 대한건축학회 2014 大韓建築學會論文集 : 構造系 Vol.30 No.3
Erosion is fundamentally a numerical technique to overcome the problems such as large numerical errors or abrupt termination of analysis which are associated with the excessive element distortions in finite element analysis. In this paper, erosion was utilized to represent cracks and failures in the reinforced concrete structures subjected to blast or impact loads. The erosion criteria for the realistic blast simulation were suggested by comparing experiment results and numerical analysis results. Instantaneous effective strain of 0.1 was proposed as a reference erosion criteria value to show the closest failure shape to the blast experiments of reinforced concrete beams and slabs.
철근콘크리트 건물의 폭파 해석을 위한 간략 모델링 방법
김한수(Kim, Han-Soo),안재균(Ahn, Jae-Gyun),안효승(Ahn, Hyo-Seung) 대한건축학회 2012 大韓建築學會論文集 : 構造系 Vol.28 No.7
A new material model that can show similar structural behavior under the blast load to the precise model with reinforcement and concrete was proposed to enable the progressive collapse simulation of a tall building. Von Mises yield model was applied to represent the ductile behavior of reinforced concrete and the yield strength, failure strength and elastic modulus were determined through repetitive comparisons of the analysis results from the precise model with fine mesh and the simple model with coarse mesh. The damage distribution of the simple model with the proposed material model was quite similar to the precise model though the number of elements of the simple model was a small fraction of the precise model. The proposed modeling method can be applied effectively to the blast analysis of tall buildings.
원혜진 ( Hye Jin Won ),한성훈 ( Seong Hoon Han ),박혜경 ( Hye Kyeong Park ),안효승 ( Hyo Seung Ahn ),임현민 ( Hyun Min Lim ),김정연 ( Jung Yeon Kim ),최원충 ( Won Choong Choi ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.4
Wegener`s granulomatosis is an uncommon disease that is characterized by granulomatous necrotizing vasculitis affecting small vessels. It typically targets the upper and lower respiratory tract and the kidney, but gastrointestinal involvement is rare. A 41-year-old man who has been already diagnosed with Wegener`s granulomatosis by nasal cavity biopsy was admitted with bloody diarrhea and high fever. He had discontinued taking the immunosuppressive medication. His colonoscopic finding revealed colitis and ulcer lesions which biopsies show vasculitis and ill-defined granuloma. Therefore he was treated with systemic steroid and improved dramatically.