당뇨황반부종에 대한 트리암시놀론의 유리체강내 주입술과 테논낭하 주입술의 비교

권순재,신재필,김시열.Soon Jae Kwon. M.D.. Jae Pil Shin. M.D.. Si Yeol Kim. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.1

`Purpose: To retrospectively evaluate the clinical effect of intravitreal (IVT) and posterior subtenon (PSTT) triamcinolone acetonide (TA) injection in diabetic macular edema. Methods: Fifty eyes of 43 patients with diabetic macular edema (DME) were included. Twenty-two eyes in the IVT group received 4 mg/0.1 ml intravitreal TA injections and 26 eyes in the PSTT group received 40 mg/1.0 ml subtenon TA injections. LogMAR visual acuity and intraocular pressure (IOP) were measured and, using OCT, central macular thickness (CMT) and total macular volume (TMV) were also measured before and 1, 3, and 6 months postoperatively. Results: Both groups showed significant decreases in the mean CMT and TMV. The mean CMT in the IVT group was significantly thinner than that of the PSTT group 1 month postoperatively. The percentage reduction in CMT and TMV were also greater in the IVT group than the PSTT group 1 month postoperatively. Both groups showed significant improvements in mean visual acuity, with no significant difference between the two groups. However, at 1-month postoperative improvement in visual acuity was significantly greater in the IVT group than the PSTT group. The mean IOP in the IVT group was also greater than that in the PSTT 1 month postoperatively. Conclusions: Both injections caused a significant increase in visual acuity and a decrease in CMT and TMV. The effect was more pronounced in the IVT group. However, the PSTT injection also appeared to be a safe and effective technique for the treatment of DME.`

외상후스트레스장애 환자에 대한 음악요법의 적용 일례

권순재,양종철,박태원,정영철,정상근,Kwon, Soon-Jae,Yang, Jong-Chul,Park, Tae-Won,Chung, Young-Chul,Chung, Sang-Keun 대한불안의학회 2012 대한불안의학회지 Vol.8 No.1

Music therapy had been widely used in the area of psychiatry. However recently, participation of psychiatrist has been decreased, due to recent trends of emphasizing biological psychiatry and rapid effectiveness of pharmacotherapy. A 46 years old male PTSD patient was admitted to psychiatric ward. He has suffered from PTSD symptoms, such as intrusive distressing recollection of his past traffic accident, social avoidance, insomnia and depression. Music therapy, which is conducted by a psychiatrist and a music therapist, was applied. This case suggests the positive role of music therapy in treatment of PTSD and emphasizes the importance of participation of psychiatrist, as an organizer during music therapy.

뚜렛 증후군을 가진 15세 소아에서 발생한 양측성 망막박리

권순재,이진영,신재필,Soon Jae Kwon,Jin Young Lee,Jae Pil Shin 대한안과학회 2012 대한안과학회지 Vol.53 No.11

Purpose: To report a case of bilateral retinal detachment in a 15-year-old child with Tourette syndrome. Case summary: A 15-year-old child treated for Tourette syndrome for 4 years presented with decreased visual acuity of several days in duration. The fundus of the right eye was not observed due to lens opacity and posterior synechiae. The B-scan of the right eye showed funnel-shaped densely reflective echoes connected to the optic disc, suggesting a total retinal detachment. Fundus examination of the left eye revealed an inverted retinal flap, which covered the posterior pole. During vitrectomy of the left eye, a ciliary body detachment anterior to a giant retinal tear extending 360 degrees was observed. In addition, an inverted flap covering 2 superior retinal quadrants was observed. A perfluorocarbon liquid was injected to unfold the tear’s inverted flap, and silicone oil tamponade was performed. Conclusions: Self-induced and repeated periocular trauma induced by motor tics of Tourette syndrome can result in bilateral retinal detachment. Regular ophthalmic examinations are helpful for early detection of ocular complications including periocular trauma induced by motor tics of Tourette syndrome.

노마딕 환경에서 유비쿼터스 시스템이 사용자의 의사결정에 미치는 영향

권순재(Kwon, Soon-Jae) 대한경영학회 2010 大韓經營學會誌 Vol.23 No.3

소아청소년 집단에서 집단 따돌림의 유병률과 이와 관련된 정신병리 현상

권순재(Soon-Jae Kwon),박태원(Tae Won Park),박선희(Seon Hee Park),양종철(Jong-Chul Yang),정영철(Young-Chul Chung),정상근(Sang-Keun Chung) 대한소아청소년정신의학회 2012 소아청소년정신의학 Vol.23 No.3

Objectives:This study examined the current prevalence rate of school bullying and its related psychopathology. Methods:A total of 3,550 elementary/middle school students and their parents were recruited for this study. A self-report questionnaire on perpetration and victimization in school bullying was used for collection of data regarding prevalence and the present state of school bullying. For evaluation of associated psychopathology, self report forms, including the Children’s Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), attention-deficit hyperactivity disorder Rating Scale (ARS), Korean-Child Behavior Checklist (K-CBCL), Korean-Youth Self Report (K-YSR), and the Korean Eppendorf Schizophrenia Inventory (K-ESI) were applied. Samples were classified according to four subtype groups (control, victim, perpetrator, and victim-perpetrator) and characteristics of each group were compared. Results:Overall, the prevalence rate for bullying perpetration was 64.4% and the prevalence rate for bullying victimization was 63.4%, indicating involvement of more than half of students in school bullying. Bully-victims reported high social immaturity and depressive and suicidal tendency, whereas bully-perpetrators reported less social immaturity and more externalizing problems. Among the subtype groups, the victim-perpetrator group showed the most prominent depressive/anxiety tendency and behavioral problems. Conclusions:Both victimization and perpetration of bullying are common problems for child and adolescent groups and several psycho-social problems were found to be related. The results of this study will guide direction of future study and development of strategies for prevention of bullying.

인체 전립선 암세포에서 Methyl Gallate의 항암효과

권순재(Soon Jae Kwon),이주혜(Ju Hye Lee),김재용(Jae Yong Kim),문광덕(Kwang Deog Moon),이성태(Sung Tae Yee),서권일(Kwon Il Seo) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.3

본 연구에서는 MG의 RC-58T/h/SA#4 인체 전립선 암세포에 대한 증식 억제 및 apoptosis 유도효과에 대하여 확인하였다. MG는 RC-58T/h/SA#4 세포의 증식을 농도 의존적으로 억제하였다. 이러한 MG에 의한 RC-58T/h/SA#4 세포의 사멸이 apoptosis에 의해 일어나는지를 sub-G1 함량측정 및 Hoechst 33258 염색을 이용하여 확인하였다. 그 결과 MG를 처리한 군의 sub-G1의 함량이 대조군에 비하여 증가하였으며, methyl gallate를 처리한 군에서 핵의 응축과 apoptotic body 형성을 Hoechst 33258 염색을 통하여 관찰할 수 있었다. 또한 RC-58T/h/SA#4 세포에서 MG가 유도하는 apoptosis의 기전을 확인하기 위하여 다양한 실험을 실시하였다. MG는 DNA의 분절량 증가 및 caspase 활성을 유도하였으며, 활성화된 caspase-8, -9 및 -3에 의해 PARP와 Bid 단백질의 분절을 발현시켰으며, Bcl-2 family 단백질의 발현에 영향을 미쳐 apoptosis를 유도하였음을 확인하였다. 한편 환경호르몬인 dioxin과 bisphenol A를 다양한 농도로 처리한 결과 각각 1 nM, 0.1 μM 농도에서 가장 높은 전립선 암세포 과다증식을 유도하였으며, 이를 바탕으로 MG를 농도별로 처리한 결과 환경호르몬에 의해 유도된 인체 전립선 암세포의 증식을 농도 의존적으로 억제시켰다. 본 연구 결과 MG는 RC-58T/h/SA#4 전립선 암세포에서 apoptosis 유도를 통한 암세포 성장 억제효과를 가지고 있음을 확인하였으며, 환경호르몬에 의해 유발될 수 있는 암에 대해서도 유사한 보호효과를 가지고 있음을 증명하였다. In this study, we investigated the anticancer activity of methyl gallate (MG), which is the major biologically active component of Galla Rhois, in RC-58T/h/SA#4 human prostate cancer cells. MG inhibited cell proliferation in a dose-dependent manner. Cell death induced by MG increased the population of cells in sub-G1 phase, formation of apoptotic bodies, nuclear condensation, and DNA fragmentation. Apoptosis induced by MG was associated with activation of initiator caspases-8 and -9 as well as effector caspase-3. Endocrine disruptors such as dioxin and bisphenol A increased growth of RC-58T/h/SA#4 cells in charcoal-treated FBS (cFBS) medium. Cell proliferation was highest upon treatment with 1 nM and 0.1 μM dioxin and bisphenol A, respectively. MG also dose-dependently inhibited cell proliferation in RC-58T/h/SA#4 cells treated with endocrine disruptors. These results indicate that MG exerts anticancer effects on RC-58T/h/SA#4 primary human prostate cancer cells.

압저항 연성해석을 통한 고충격 미소가속도계의 최적설계 및 성능 비교

권순재(Soon Jae Kwon),한정삼(Jeong Sam Han) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10

In order to detect a high impact that occurs at earth-penetration weapons, piezoresistive micro accelerometers are generally used because of its structural sturdiness. In this paper, structural optimization for piezoresistive micro accelerations was introduced to improve its performances from initial designs. In the optimization formulations, the following sensor performances are considered; maximum stress level, resonant frequencies, and sensor sensitivity calculated by piezoresistive-structural coupled-field analysis. We adopted two reference models: (1) a piezoresistive type silicon micromachined high-shock accelerometer with a bonded hinge structure and (2) a silicon micromachined shock accelerometer with twin-mass-plate structure. Several optimization with different formulations are performed for the examples and their optimum results are compared and discussed.

호텔기업에서의 지식경영 순환활동에 대한 탐색적 접근

권순재(Soon Jae Kwon),노정희(Jeong Hee Noh) 한국호텔외식관광경영학회 2009 호텔경영학연구 Vol.18 No.6

Firms are assumed to have always been oriented toward accumulating and applying knowledge to create economic value and competitive advantage. Researchers as well as practitioners need more rigorous results about such issues, especially how much the knowledge management strategic initiatives may have an influence on the firm`s competitiveness. Despite the importance of tacit knowledge in the hotel industry there is little research about knowledge circulation activity. Most studies have been conducted from the marketing or customers` perspectives. There is a lack of research which investigates the competitive power of the hotel from the viewpoint of knowledge management. We therefore suggest the need for a empirical study which we have defined as four components that can be used to determine the knowledge circulation activities (KCA) knowledge creation, knowledge accumulation, knowledge sharing, knowledge internalization. When KCA efficiency increases, knowledge management efficiency will also expand, enabling firms to become knowledge intensive. In this sense, we need an empirical study adopting statistical approaches due to the existence of abundant knowledge management case studies. To fill this research void, this study proposes a research model testing whether knowledge circulation activities could improve corporate competitiveness. We collected 140 valid questionnaires from participants in knowledge circulation activities in the Hospitality industry and applied a structural equation model using PLS. Empirical results showed that knowledge circulation activities have a positive impact on knowledge management efficiency and finally corporate competitiveness.

인터넷의 지속적 사용의도에서 주관적 안녕감에 대한 탐색적 분석

권순재(Kwon-Soon Jae) 한국IT서비스학회 2009 한국IT서비스학회지 Vol.8 No.4

Although the Internet has been a important communication tool in modern societies, researchers did not pay attention to its' positive impacts on individual's psychological process. The Internet provides users with a unique environment such as visual isolation, non face-to-face communication, and easiness to escape from social influences. This environment enables people to take free action according to their personality and disclose themselves. The findings indicate that individuals' social use of the Internet may reflect their personality. To fill the research void like this, this study proposes a new research model in which well being as well as perceived value are positively linked to satisfaction and continuance to use. The statistical results obtained by applying PLS to the valid 150 questionnaires showed that the well bing has stronger positive influence on satisfaction and continuance to use. Therefore, a practical implication is suggested that the web site need to be designed in a way of arousing users' well bing more strongly.

웹 사이트 플로우(Flow) 측정 방법론 및 시뮬레이션에 대한 연구

권순재 ( Soon Jae Kwon ) 한국지식경영학회 2009 지식경영연구 Vol.10 No.2