당뇨황반부종에 대한 트리암시놀론의 유리체강내 주입술과 테논낭하 주입술의 비교

권순재,신재필,김시열.Soon Jae Kwon. M.D.. Jae Pil Shin. M.D.. Si Yeol Kim. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.1

`Purpose: To retrospectively evaluate the clinical effect of intravitreal (IVT) and posterior subtenon (PSTT) triamcinolone acetonide (TA) injection in diabetic macular edema. Methods: Fifty eyes of 43 patients with diabetic macular edema (DME) were included. Twenty-two eyes in the IVT group received 4 mg/0.1 ml intravitreal TA injections and 26 eyes in the PSTT group received 40 mg/1.0 ml subtenon TA injections. LogMAR visual acuity and intraocular pressure (IOP) were measured and, using OCT, central macular thickness (CMT) and total macular volume (TMV) were also measured before and 1, 3, and 6 months postoperatively. Results: Both groups showed significant decreases in the mean CMT and TMV. The mean CMT in the IVT group was significantly thinner than that of the PSTT group 1 month postoperatively. The percentage reduction in CMT and TMV were also greater in the IVT group than the PSTT group 1 month postoperatively. Both groups showed significant improvements in mean visual acuity, with no significant difference between the two groups. However, at 1-month postoperative improvement in visual acuity was significantly greater in the IVT group than the PSTT group. The mean IOP in the IVT group was also greater than that in the PSTT 1 month postoperatively. Conclusions: Both injections caused a significant increase in visual acuity and a decrease in CMT and TMV. The effect was more pronounced in the IVT group. However, the PSTT injection also appeared to be a safe and effective technique for the treatment of DME.`

뚜렛 증후군을 가진 15세 소아에서 발생한 양측성 망막박리

권순재,이진영,신재필,Soon Jae Kwon,Jin Young Lee,Jae Pil Shin 대한안과학회 2012 대한안과학회지 Vol.53 No.11

Purpose: To report a case of bilateral retinal detachment in a 15-year-old child with Tourette syndrome. Case summary: A 15-year-old child treated for Tourette syndrome for 4 years presented with decreased visual acuity of several days in duration. The fundus of the right eye was not observed due to lens opacity and posterior synechiae. The B-scan of the right eye showed funnel-shaped densely reflective echoes connected to the optic disc, suggesting a total retinal detachment. Fundus examination of the left eye revealed an inverted retinal flap, which covered the posterior pole. During vitrectomy of the left eye, a ciliary body detachment anterior to a giant retinal tear extending 360 degrees was observed. In addition, an inverted flap covering 2 superior retinal quadrants was observed. A perfluorocarbon liquid was injected to unfold the tear’s inverted flap, and silicone oil tamponade was performed. Conclusions: Self-induced and repeated periocular trauma induced by motor tics of Tourette syndrome can result in bilateral retinal detachment. Regular ophthalmic examinations are helpful for early detection of ocular complications including periocular trauma induced by motor tics of Tourette syndrome.

외상후스트레스장애 환자에 대한 음악요법의 적용 일례

권순재,양종철,박태원,정영철,정상근,Kwon, Soon-Jae,Yang, Jong-Chul,Park, Tae-Won,Chung, Young-Chul,Chung, Sang-Keun 대한불안의학회 2012 대한불안의학회지 Vol.8 No.1

Music therapy had been widely used in the area of psychiatry. However recently, participation of psychiatrist has been decreased, due to recent trends of emphasizing biological psychiatry and rapid effectiveness of pharmacotherapy. A 46 years old male PTSD patient was admitted to psychiatric ward. He has suffered from PTSD symptoms, such as intrusive distressing recollection of his past traffic accident, social avoidance, insomnia and depression. Music therapy, which is conducted by a psychiatrist and a music therapist, was applied. This case suggests the positive role of music therapy in treatment of PTSD and emphasizes the importance of participation of psychiatrist, as an organizer during music therapy.

정보시스템에서 재미의 하위유형 개발

권순재 ( Soon Jae Kwon ) 한국정보시스템학회 2017 情報시스템硏究 Vol.26 No.1

본 연구의 목적은 기존의 정보시스템 및 심리학에서 사용한 재미의 개념을 분석하여, 정보시스템 사용자들이 느끼는 재미모형의 유형에는 어떠한 것들이 있는지를 살펴보는 것이다. 이를 위하여 기존문헌연구를 통하여 재미를 구성하는 29개의 항목을 개발하고 이를 검증하여 이 중 15개 항목을 선정하였다. 이후 다시 실증분석 후 재미를 구성하는 하위요인을 사회성, 만족감, 성취감, 열광적 4개의 1차 하위차원으로 정의하였다.

모바일 휴대용 단말기의 지속적 이용에 있어서 기기애착 개념의 역할에 관한 연구

권순재 ( Soon Jae Kwon ),채성욱 ( Sung Uk Chae ) 한국정보시스템학회 2009 情報시스템硏究 Vol.18 No.3

압저항 연성해석을 통한 고충격 미소가속도계의 최적설계 및 성능 비교

권순재(Soon Jae Kwon),한정삼(Jeong Sam Han) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10

In order to detect a high impact that occurs at earth-penetration weapons, piezoresistive micro accelerometers are generally used because of its structural sturdiness. In this paper, structural optimization for piezoresistive micro accelerations was introduced to improve its performances from initial designs. In the optimization formulations, the following sensor performances are considered; maximum stress level, resonant frequencies, and sensor sensitivity calculated by piezoresistive-structural coupled-field analysis. We adopted two reference models: (1) a piezoresistive type silicon micromachined high-shock accelerometer with a bonded hinge structure and (2) a silicon micromachined shock accelerometer with twin-mass-plate structure. Several optimization with different formulations are performed for the examples and their optimum results are compared and discussed.

토마토페이스트소스첨가 멸치( Engraulis japonica ) 육젓필레통조림의 제조 및 특성

권순재 ( Soon Jae Kwon ),이재동 ( Jae Dong Lee ),윤문주 ( Moon Joo Yoon ),박진효 ( Jin Hyo Park ),제해수 ( Hae Soo Je ),공청식 ( Cheung Sik Kong ),노윤이 ( Yu Ni Noh ),김정균 ( Jeong Gyun Kim ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6

This study was investigated for the purpose of obtaining basic data for application to the canning process of salt-fermented anchovy Engraulis japonica fillet using tomato paste. The salt fermented anchovy fillet was prepared by fermenting anchovy fillet with salt 15% at 5 for 15 days and then cold air drying the salt-fermented anchovy fillet for 1 h at 16±1. The dried salt-fermented anchovy fillet 85 g was filled with 60 g of tomato paste sauce (tomato paste 42%, gum guar 1.0%, salt 2.0%, starch syrup 2.0%, cooking wine 1%, water 52%) and seamed by vacuum seamer in 301-3 can, then sterilized at Fo 9 and 11 min in a steam system retort at 121, respectively. The factors such as chemical composition, pH, total volatile basic nitrogen (TVB-N), amino-N, color value (L, a, b), texture profile, thiobarbituric acid (TBA) value, sensory evaluation and viable bacterial count of the canned salt-fermented anchovy fillet were measured. Texture value of the product sterilized at Fo 11 min was higher than at Fo 9 min condition. In both sterilized cans, the viable bacterial counts were not detected. There was no remarkable difference in physicochemical between sterilization conditions. As a result of sensory evaluation, most sensory evaluation inspector judged that it was difficult to distinguish the sensory difference of both products sterilized at Fo 9 min and at 11 min. The results showed that sterilization of Fo 9 min was more desirable than that of Fo 11 min to prepare canned salt-fermented anchovy fillet using tomato paste sauce, because this condition is more economical.

인체 전립선 암세포에서 Methyl Gallate의 항암효과

권순재(Soon Jae Kwon),이주혜(Ju Hye Lee),김재용(Jae Yong Kim),문광덕(Kwang Deog Moon),이성태(Sung Tae Yee),서권일(Kwon Il Seo) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.3

본 연구에서는 MG의 RC-58T/h/SA#4 인체 전립선 암세포에 대한 증식 억제 및 apoptosis 유도효과에 대하여 확인하였다. MG는 RC-58T/h/SA#4 세포의 증식을 농도 의존적으로 억제하였다. 이러한 MG에 의한 RC-58T/h/SA#4 세포의 사멸이 apoptosis에 의해 일어나는지를 sub-G1 함량측정 및 Hoechst 33258 염색을 이용하여 확인하였다. 그 결과 MG를 처리한 군의 sub-G1의 함량이 대조군에 비하여 증가하였으며, methyl gallate를 처리한 군에서 핵의 응축과 apoptotic body 형성을 Hoechst 33258 염색을 통하여 관찰할 수 있었다. 또한 RC-58T/h/SA#4 세포에서 MG가 유도하는 apoptosis의 기전을 확인하기 위하여 다양한 실험을 실시하였다. MG는 DNA의 분절량 증가 및 caspase 활성을 유도하였으며, 활성화된 caspase-8, -9 및 -3에 의해 PARP와 Bid 단백질의 분절을 발현시켰으며, Bcl-2 family 단백질의 발현에 영향을 미쳐 apoptosis를 유도하였음을 확인하였다. 한편 환경호르몬인 dioxin과 bisphenol A를 다양한 농도로 처리한 결과 각각 1 nM, 0.1 μM 농도에서 가장 높은 전립선 암세포 과다증식을 유도하였으며, 이를 바탕으로 MG를 농도별로 처리한 결과 환경호르몬에 의해 유도된 인체 전립선 암세포의 증식을 농도 의존적으로 억제시켰다. 본 연구 결과 MG는 RC-58T/h/SA#4 전립선 암세포에서 apoptosis 유도를 통한 암세포 성장 억제효과를 가지고 있음을 확인하였으며, 환경호르몬에 의해 유발될 수 있는 암에 대해서도 유사한 보호효과를 가지고 있음을 증명하였다. In this study, we investigated the anticancer activity of methyl gallate (MG), which is the major biologically active component of Galla Rhois, in RC-58T/h/SA#4 human prostate cancer cells. MG inhibited cell proliferation in a dose-dependent manner. Cell death induced by MG increased the population of cells in sub-G1 phase, formation of apoptotic bodies, nuclear condensation, and DNA fragmentation. Apoptosis induced by MG was associated with activation of initiator caspases-8 and -9 as well as effector caspase-3. Endocrine disruptors such as dioxin and bisphenol A increased growth of RC-58T/h/SA#4 cells in charcoal-treated FBS (cFBS) medium. Cell proliferation was highest upon treatment with 1 nM and 0.1 μM dioxin and bisphenol A, respectively. MG also dose-dependently inhibited cell proliferation in RC-58T/h/SA#4 cells treated with endocrine disruptors. These results indicate that MG exerts anticancer effects on RC-58T/h/SA#4 primary human prostate cancer cells.

베이비붐세대의 디지털라이프 지수

권순재 ( Soon Jae Kwon ),김미령 ( Mee Ryoung Kim ) 한국정보시스템학회 2014 情報시스템硏究 Vol.23 No.1

Our study measures the Digital Life Index (DLI) of baby boomers by considering the utilization of digital devices in their everyday life. The study was conducted by implementing the following three-step approach: (1) development of survey questions and data collection; (2) build Digital Life Index (DLI) model and lastly; (3) empirical analysis using the Digital Life Index (DLI). In the first stage in order to develop the survey questions to measure the digital index, two surveys were conducted. For the first preliminary survey, it was done based on the existing literatures which enabled this investigation through FGI analysis involving real professionals. The second survey was conducted by commissioning a specialized external firm. In this survey, a total of 400 data was collected to verify the validity and objectivity of the data sample. The data gathered through the survey questions was used to develop the digital index. Firstly, the appropriate factors were extracted by conducting factor analysis. This factor analysis validates and verifies the factors which are appropriate in measuring Digital Life Index (DLI). The derived factors are broadly divided into five main factors. The first factor describes the possession, purchase and use of digital device (x1). Meanwhile, the second factor describes the digital device’s software (x2) and the third factor describes the participation in utilizing digital device (x3). The fourth factor describes the utilization of digital device in human personal relationship (x4) and lastly, the fifth factor describes the effect of digital device in everyday life and work environment (x5). Secondly, the digital index model was developed. The variables to represent the Digital Life Index (DLI) are χ1t,χ2t,χ3t,χ4t and χ5t. Furthermore, as experience in using the digital index grows overtime, the growth can be represented by the “S” shape. Based on the results, Digital Life Index(DLI) is distributed with the highest point at 90.3 and the lowest point at 25.9.

노마딕 환경에서 유비쿼터스 시스템이 사용자의 의사결정에 미치는 영향

권순재(Kwon, Soon-Jae) 대한경영학회 2010 大韓經營學會誌 Vol.23 No.3