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과민성장증후군 환자의 정전가미이진탕(正傳加味二陳湯) 투여(投與) 1례(例)
김회영,남효익,손현수,박상무,Kim, Hoi-Young,Nam, Hyo-Ik,Son, Hyun-Soo,Park, Sang-Moo 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.2
The irritable bowel syndrome(IBS) is the most common gastrointestinal disorder in clinical practice and is characterized by abdominal pain associated with a chronic disturbance of defecation. The subject is a-69-year-old man who has abdominal pain, chronic diarrhea. anorexia. general weakness and has been diagnosed as irritable bowel syndrome. We diagnosed this patient as the Gastrointestinal Phlegm(食痰) and prescribed Jengjengamiyijin-tang (Zhengchuanjiaweierchen-tang). In the result, we had improvement of his symptoms.
정전가미이진탕(正傳加味二陳湯)이 흰쥐의 위배출능(胃排出能)에 미치는 영향(影響)
김회영,손현수,임성우,남효익,Kim, Hoi-Young,Son, Hyun-Soo,Lim, Sung-Woo,Nam, Hyo-Ik 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2
Background & Objective : The herbal medicine JGT has been used for the treatment of functional dyspepsia, generally categorized as a gastric disease. However, its effect and mechanism are not yet well known. Therefore, the effects of JGT on gastric emptying in rats was investigated to know its effectiveness and mechanism. Methods : Gastric emptying effect was measured by the number of glass beads expelled from the stomach within an hour after glass beads and test drugs were administered. In another series of experiments to evaluate the mechanisms of JGT under delayed conditions, the rats were treated with atropine sulfate Results : Intragastric administration of JGT significantly increased gastric emptying of glass beads Under the gastric emptying delayed with atropine sulfate, JGT insignificantly increased gastric emptying of glass beads. Conclusions : These suggest that JGT has a significant effect to stimulate gastric emptying. Results are indicative of JGT as an especially effective remedy for dysmotility-like functional dyspepsia with impaired reservoir function such as gastric adaptive relaxation.
익명의 알코올 중독자 모임의 불안, 우울에 대한 효과 연구
김회영 ( Hoi Young Kim ),손현수 ( Hyun Soo Son ),강지홍 ( Ji Hong Kang ),심소라 ( So Ra Shim ),박보라 ( Bo Ra Park ),김지훤 ( Ji Hwon Kim ),김태헌 ( Tae Heon Kim ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.2
Objectives: This study was performed to assess the benefits of Alcoholics anonymous program for anxiety and depression of alcoholics. And we investigate Sasang constitution in Alcoholics Anonymous(A.A.) members to study relation between alcoholic and constitution. Methods: 21 members of A.A. groups in korea who agreed to the purpose of this study were selected. We evaluated anxiety by BAI, depression by BDI-Ⅱ and sasang constitution by QSCCⅡ+. Results: The research result is as follows. 1. Eighteens of 21 A.A. members are men and the rest are women. First alcohol drinking age(mean) is 15. Getting alcohol drunk age(mean) is 20.9. 2. The duration of alcohol drinking before A.A. participation(mean) is 20.2 years. The duration of giving up drinking after A.A. participation(mean) is 26.5 months. 3. A.A. program significantly reduced anxiety of A.A. members from 10.43±1.37(mean±S.E.)(light anxiety) to 6.86±1.24(normal). 4. A.A. program significantly reduced depression of A.A. members from 4.14±1.14(mean±S.E.)(normal) to 2.33±0.75(normal) in the statistics, but it does not have the meaning clinically. 5. Sasang constitution classification result was Taeum group 10 people(47.6%), Soyang group 9 people(42.9%), Soeum group 2people(9.5%), Taeyang group 0 people(0%), Taeum group and Soyang group were relatively more than Soeum group. Conclusions: Participation in the A.A. program reduce anxiety and depression of A.A. members. This research provide data on positive effect of A.A program and may prove that the self-help program(A.A.) can help to maintain long term sobriety and improve the quality of life of its members.
Guillain-Barre Syndrome으로 진단받은 환자의 비증(痺證) 치험 2례
남효익,김회영,김지원,최은영,Nam, Hyo-Ik,Kim, Hoi-Young,Kim, Ji-Won,Choi, En-Young 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Guillain-Barre Syndrome is a disorder caused by nerve inflammation. The inflammation damages portions of the nerve cells, resulting in pain, numbness, muscle weakness or paralysis and sensory loss. The damage can also leads to denervation (killing the axon part of the nerve cell), which stops nerve function entirely. Without the axon, messages cannot be transferred from one nerve cell to another, but the causes and mechanism of this syndrome are unknown. This is a clinical report about two patients diagnosed with Guillain-Barre Syndrome. The patients, a 54-year-old woman and a 37-years-old man, had pain, and weakness in both legs and arms. After about 4 weeks of Korean medicine and acupuncture treatment, most of their symptoms improved. Therefore, Korean traditional therapy has potential for treatment of Guillain-Barre Syndrome.
Tyrosinase Inhibitory Xanthones from Cudrania tricuspidata
오상석,서은진,김회영,류영배,이진환,갈상완,박기훈,Oh, Sang-Seok,Seo, Eun-Jin,Kim, Hoi-Young,Ryu, Young-Bae,Lee, Jin-Hwan,Gal, Sang-Wan,Park, Ki-Hun Korean Society of Life Science 2007 생명과학회지 Vol.17 No.4
꾸지뽕나무(Cudrania tricuspidata(Carr.) Bureau) 뿌리껍질에서 3종의 xanthones 화합물을 분리하였으며, 분광학적인 자료를 바탕으로 cudraxanthone L (1), cudraxanthone D (2), 그리고 cudraxanthone M (3)으로 구조동정되었다. 분리된 화합물을 L-tyrosine이 기질로 작용할 때 tyrosinase 저해 활성을 측정한 결과 cudraxanthone M (3)의 $IC_{50}$ 값이 $16.5{\mu}M$로 가장 높은 저해 효능을 보였으며, kinetic type은 uncompetitive inhibition로 저해 상수($K_i$)는 $1.6{\mu}M$로 측정되었다. 또한 이 화합물은 $20{\mu}M$의 농도에서 lag time이 310초로 측정 되어 대조화합물인 kojic acid와 유사한 저해능을 나타내었다. The methanolic roots bark extract of Cudrania tricuspidata (Carr.) Bureau was chromatographed, which yielded three xanthones 1-3 by tyrosinase inhibitory activity-guided fractionation. The structures were fully characterized by analysis of physical and spectral data. Among them, furano prenylxanthone 3, never reported as tyrosinase inhibitor, showed potent activity with $IC_{50}$ value of $16.5{\mu}M$, and appeared to inhibit the polyphenol oxidase activity of tyrosinase in an uncompetitive inhibitor($K_i=1.6{\mu}m$) when L-tyrosine was used as a substrate. Moreover, potent inhibitor furano prenylxanthone 3 had an extended lag time of 310 sec at $20{\mu}M$, while lag time of kojic acid as positive control was prolonged with 350 sec at the same concentration.
우상지(右上肢) 단마비(單痲痺)가 주증(主症)인 풍비 환자의 만금탕가미방(萬金湯加味方) 투여 호전 1례
정병주,우성호,김병철,김용호,서호석,황규동,장하정,남효익,김회영,김진원,Jeong, Byeong-Ju,Woo, Sung-Ho,Kim, Byung-Chul,Kim, Yong-Ho,Seo, Ho-Seok,Hwang, Gyu-Dong,Jang, Ha-Jeong,Nam, Hyo-Ick,Kim, Hoi-Young,Kim, Jin-Won 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1
Background : Monoplegia is the paralysis of a limb. It is commonly caused by an injury to the cerebral cortex, and rarely caused by injury to the internal capsule, brain stem, or spinal cord. Most problems with cerebral cortex is derived from the occlusion of a brain cortex blood vessel due to thrombus or embolus. Objectives : This study is to see if there is a significance in thermal differences of acupoints in diagnosis and treatment of monoplegia on an upper extremity to test the validity of acupuncture and herbal treatment for it. Methods : By using Digital Infrared Thermographic Imaging(DITI), thermal differences$({\Delta}T)$ of acupoints on the upper extremity in a patient with monoplegia on the right upper extremity were measured after an attack of the disease. By giving Mangeum-tang(萬金湯) and treating the patient with acupuncture. the temperature changes of the upper extremity were examined through DITI and improvement was observed. Results : Compared with the left arm which suffered no such injury, the right recovered about 80% of sensation, and the grade of monoplegia improved from Grade O to Grade V. Also, the temperatures of right palmar-dorsal hand and the region of Weiguan(外關, Waiguan, TE5) were $1^{\circ}C$ and $1.45^{\circ}C$ higher than the same left region on admission day, but the thermal differences$({\Delta}T)$ narrowed to $0.5^{\circ}C$ by the last day. Conclusions : Results suggest that DITI screening is a reliable method of prognosis and that the time required for treatment can be estimated through this method in cases of monoplegia to an upper extremity. Also, progress in treatment is reflected in thermal differences of acupoints of the monoplegic upper extremity in accordance with the theory of meridian. This supports a role for acupuncture and herbal treatment for monoplegia.