염증성 장질환 환자에서 Azathioprine 사용방법에 따른 골수억제 부작용의 빈도

현경희 ( Kyung Hee Hyun ),이석호 ( Suck Ho Lee ),신재민 ( Jae Min Shin ),박동일 ( Dong Il Park ),이창균 ( Chang Kyun Lee ),신정은 ( Jeong Eun Shin ),은창수 ( Chang Soo Eun ),허규찬 ( Kyu Chan Huh ),황보영 ( Young Hwangbo ) 대한장연구학회 2012 Intestinal Research Vol.10 No.3

Background/Aims: The most important adverse effect of azathioprine (AZA) is bone marrow toxicity (BMT). Many physicians have preferred a gradual dose increment (GDI) policy for the prevention of BMT. The aim of this study was to evaluate the efficacy of GDI for the prevention of AZA-induced BMT in inflammatory bowel disease (IBD) patients. Methods: The medical records of IBD patients who received AZA in 6 university hospitals were reviewed. The patients were divided into two groups: the GDI group (initial dose <1.5 mg/kg, gradually increased to a therapeutic dose) and the non-GDI group (initial therapeutic dose ≥2 mg/kg). Results: A total of 308 patients were enrolled (male to female ratio, 1:2.3; mean age, 34.91±14.19 years; ulcerative colitis, 43.5%; Crohn`s disease, 55.2%; and intermediate colitis, 1.3%). The overall incidence of BMT was 16.2% (50/308). BMT developed most frequently between fourth to eighth week (26%, 13/50). The rate of BMT of the non-GDI group was significantly higher than that of the GDI group (27.5%, 11/40 vs. 14.6%, 39/268, P=0.038). A multivariate analysis showed that the only factor related to BMT was a non-GDI policy (P=0.036; odds ratio, 2.41; 95% confidence interval, 1.06-5.49). Conclusions: A GDI policy could be useful for reducing AZA-induced BMT in Korean IBD patients. (Intest Res 2012;10:244-250)

기도상피세포에서 식물 에센셜 오일의 인터루킨-8 분비억제 효과

현경희 ( Kyung Hee Hyun ),김윤섭 ( Youn Seup Kim ),서정근 ( Jeung Keun Suh ),한성환 ( Sung Hwahn Hahn ),김도형 ( Do Hyung Kim ),박재석 ( Jae Suk Park ),지영구 ( Young Koo Jee ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4

Background: Neutrophil is an important inflammatory cell in severe asthma and associated with steroid-resistance in asthma therapy. In addition, interleukin (IL)-8 is a key chemokines recruiting and activating neutrophils. Methods: The aim of this study was to explore the therapeutic potential of aromatherapy using essential oils derived from plant extracts in asthma treatment. Essential oils from citron, pine tree, Chamaecyparis pisifera, and Chamaecyparis obtusa were extracted by water-steam distillation. The promoter activity and secretion of IL-8 were measured by using luciferase assay and enzyme-linked immunosorbent assay after pretreatment in tumor necrosis factor-α stimulated A549 and human bronchial epithelial cells (BEAS-2B) cell lines with diluted essential oils. Results: IL-8 transcription was suppressed with 1 : 500 concentration of each essential oil (P<0.05). IL-8 secretion in A549 cell was suppressed with 1 : 1,000 or higher concentrations of oils except from citron (P<0.05). IL-8 secretion in BEAS-2B cells was decreased after exposure to 1 : 500 concentration of pine tree, Chamaecyparis pisifera and 1 : 2,000 or higher concentrations of Chamaecyparis obtusa (P <0.05). Conclusion: Essential oils from pine tree and Chamaecyparis obtusa may have a therapeutic potential for asthma by regulating neutrophil-mediated inflammation. (Korean J Asthma Allergy Clin Immunol 2011;31:272-280)

내일로 여행자 대상 정보 서비스 디자인을 위한 인스타그램 해시태그 분석

현경희(Hyun Kyung-Hee),한나라(Han Nara),장선희(Jang Sun-Hee) 한국디자인학회 2017 한국디자인학회 학술발표대회 논문집 Vol.2016 No.10

내일로 여행자 대상 정보 서비스 디자인을 위한 인스타그램 해시태그 분석

현경희(Hyun Kyung-Hee),한나라(Han Nara),장선희(Jang Sun-Hee) 한국디자인학회 2017 한국디자인학회 학술발표대회 논문집 Vol.2017 No.06

성인 환자에서 자궁근종 수술 후 장유착증과 동반된 Yersinia enterocolitica 장염 1예

현경희 ( Kyung Hee Hyun ),전승민 ( Soung Min Jeon ),김형준 ( Hyung Joon Kim ),이준혁 ( Joon Hyuk Lee ),김배환 ( Bae Hwan Kim ),신현덕 ( Hyun Duk Shin ),신정은 ( Jeong Eun Shin ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6

Yersinia enterocolitica infection in adults in Korea is reported rarely. Therefore, the possibility of Yersinia infection as a cause of abdominal pain may be overlooked. Because its clinical features are similar to those of acute appendicitis or other diseases that require operations, Yersinia enterocolitis should be diagnosed before surgery. We recently experienced a case of Y. enterocolitica enterocolitis accompanied by postoperative colonic adhesion. A 39-year-old female patient with a 5-year history of asymptomatic uterine myoma underwent transabdominal hysterectomy due to abdominal pain. However, the pain worsened. On CT, diffuse swelling of the right colon and adhesion of the sigmoid colon with luminal narrowing were found. Colonoscopy showed multiple aphthous ulcers with mucosal hyperemia from the cecum to the sigmoid colon. Multiplex PCR with stool specimens, a hemagglutination test for Y. enterocolitica O:3, and tissue culture were positive for Y. enterocolitica. After fluids and antibiotic therapy, her symptoms were relieved. (Korean J Med 2012;83:757-763)

증례 : 혈액종양 ; 소화기계 및 호흡기계에 발생한 이시성 4중복암

김용현 ( Yong Hyun Kim ),박건우 ( Keon Woo Park ),이순일 ( Soon Il Lee ),임도형 ( Do Hyoung Lim ),이현숙 ( Hyun Suk Lee ),현경희 ( Kyung Hee Hyun ) 대한내과학회 2012 대한내과학회지 Vol.82 No.1

한 사람에서 다발성으로 악성종양이 발생하는 다발 원발암은 1889년 Billroth에 의해 처음 발표되었다. 최근 들어 악성종양에 대한 점진적인 진단 및 치료기술의 발달로 다발 원발암의 발생률은 증가되는 추세이다. 국내에서도 3중복암에 대한 몇몇 증례 보고가 있었으나 4중복암에 대한 발표는 드물다. 최근 저자들은 69세 남자에게서 발생한 이시성 4중 복암-폐, 식도, 성문, 하인두-을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Multiple primary neoplasms, defined as the occurrence of multiple malignant neoplasms in the same individual, were first reported by Billroth in 1889. With gradual improvements in diagnostics, and the early detection and effective treatment of malignant neoplasms, the prevalence of multiple primary neoplasms seems to be increasing. Although there have been several reports of triple primary neoplasms in Korea, cases of quadruple neoplasms are rare. Recently, we diagnosed a 69-year-old male with primary neoplasms in the Lung, esophagus, vocal cords, and hypopharynx. The authors report this rare case of four metachronous primary neoplasms and provide a review of the Literature. (Korean J Med 2012;82:110-114)

뚜렷한 신경학적 증상 없이 통풍성 관절염만으로 발현된 hypoxanthine-guanine phosphoribosyltransferase (HPRT) 완전 결핍증 (Lesch-Nyhan 병) 1례

권병운 ( Byung Won Kwon ),현경희 ( Kyung Hee Hyun ),한진형 ( Jin Hyung Han ),김소미 ( So Mi Kim ),이상석 ( Sang Seok Lee ),추영광 ( Young Kwang Choo ),이은경 ( Eun Kyoung Lee ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.1

Lesch-Nyhan disease is a very rare X-linked recessive disorder characterized by mental retardation, spasticity resembling cerebral palsy, choreoathetosis, self-mutilation and hyperuricemia. Self-mutilative behavior is a hallmark of the disease. The underlying defect is a deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT). We report on a fourteen-year-old boy, who manifested gouty arthritis and mild renal insufficiency with Lesch-Nyhan disease, lacking self-mutilative behavior in spite of undetectable HPRT activity. Though there were several reports about some cases of Lesch-Nyhan disease in the past Korean literature, the cases were classic forms with definite neurological manifestation. As far as we know, this is the first case of Lesch-Nyhan disease without self-mutilation in Korea.

특성화고 직업영어 교수,학습 모형 개발

김경한 ( Kyong Hahn Kim ),현경희 ( Kyung Hee Hyun ),한소현 ( So Hyun Han ),최수정 ( Soo Jeong Choi ),장명희 ( Myung Hee Jang ) 한국외국어대학교 외국어교육연구소 2015 외국어교육연구 Vol.29 No.2

지금까지 우리나라 특성화고의 직업영어 교육은 영어 교수·학습 원리에 대한 고려 없이 전문교과 내용만을 일대일 번역 식으로 가르치는 수업이 지배적이었다. 또한, 특성화고의 직업영어 교육과정은 1학년 기초영어부터 3학년 직업영어까지 위계적이고 체계적으로 구성된 프로그램이라기보다는 보통 영어 교과와 전문교과가 이원화되어 상호 독립적으로 운영되었다. 특히, 기초영어 과정은 일반계 고등학교의 영어 교과서를 그대로 사용함으로써 학생들의 요구, 수준, 진학 등 특성화고의 현실을 반영하지 못하였다. 이제 일반계고와 차별화되고, 영어 교수·학습 원리에 기반하며, 직업 상황에 필요한 의사소통능력 배양에 초점을 둔 직업영어 교육과정, 교재 및 교수법의 개발이 필요한 시점이다. 본 연구는 이러한 시대적 필요성에 입각하여 특성화고 직업영어 교수·학습 모형을 개발하였다. 본 연구에서 개발한 직업영어 교수·학습 모형은 향후 직업영어 교육과정 및 교재개발에 시사점을 제공할 수 있을 것으로 기대된다. 본 연구에서는 특성화고 직업영어 교수·학습 모형을 개발하기 위해 특수목적영어교수법(ESP), 내용중심교수법(CBI), 의사소통중심교수법(CLT)에서 직업영어교육의 이론적 근거를 찾고, 직업영어 교육과정의 방향과 직업영어 교수·학습의 원칙을 확립하였으며, 이를 바탕으로 직업영어 교수·학습 모형을 개발하고 이에 대해 전문가의 타당도 검사를 받아 모형을 수정하였다. 직업영어 교수·학습 모형의 현장적합성을 검토하기 위해서는 인천광역시 소재 특성화고 1학년 30명을 대상으로 4차시의 시험 수업(pilot study)을 실시하였으며, 이에 대한 교사관찰지 및 학생사후반응지를 분석하고 피드백을 반영하여 최종적으로 직업영어 교수·학습 모형을 완성하였다. The Korean national curriculum for English education has so far focused on improving English instruction in academic high schools, while ignoring the particular language needs of vocational high school students. Few vocational high schools use texts specifically designed for vocational students English as a Foreign Language (EFL) needs. Instead texts are used which focus on translation and vocabulary improvement, which do not enhance communicative skills are used. Therefore, it is imperative that new texts be developed, which focus on the particular communicative skills needed to prepare students for careers in various trades. With this unmet need in mind, this study attempts to develop an instructional model for teaching vocational English in Korean EFL contexts. Ideally, vocational English education should be based on English for Specific Purposes (ESP), Content-Based Instruction (CBI), and Communicative Language Teaching (CLT). Drawing from these three approaches, a vocational English curriculum and instructional model was proposed and trialled in classroom settings. Both teachers and students found the instructional model more effective than the current model. This finding suggests that the instructional model could be effective in training teachers to teach EFL in vocational schools, and thus result in an increase in instruction tailored to the specific needs of students in Korean vocational high schools.

알레르기 ; 천식증상으로 내원한 성인에서 운동유발성 천식과 아토피의 상관관계

한진형 ( Jin Hyung Han ),권병운 ( Byung Woon Kwon ),현경희 ( Kyung Hee Hyun ),김용현 ( Young Hyun Kim ),이현숙 ( Hyun Suk Lee ),김도형 ( Do Hyung Kim ),김윤섭 ( Yon Seop Kim ),박재석 ( Jae Suk Park ),김경묵 ( Kyung Mook Kim ),지 대한내과학회 2011 대한내과학회지 Vol.81 No.6

목적: 아토피는 천식과 밀접한 관련이 있으며, 천식의 발생과 악화의 위험인자로 알려져 있다. 이 연구에서는 천식으로 내원한 환자들을 대상으로 아토피와 운동유발성 천식사이의 연관성을 알아보고자 하였다. 방법: 2002년 1월부터 2010년 1월까지 천식증상으로 단국 대학교병원 호흡기-알레르기내과를 방문하여 운동유발 검사를 시행한 환자들을 대상으로 하였다. 진단적 검사로 피부단자시험, 메타콜린 기관지유발 검사를 함께 시행하였다. 과거에 흡연을 하였거나 현재 흡연 중인 환자들은 모두 제외하였다. 결과: 총 40명의 성인 환자들을 분석하였다. 기도과민성을 보인 환자는 운동유발성 천식 양성군에서 음성군에 비해 더많았다(85.7 vs. 42.1%, p=0.007). 아토피는 운동유발성 천식군에서 대조군에 비해 더 흔히 관찰되었고(85.7 vs. 47.4%, p=0.017), 아토피 점수(16.5±3.0 vs. 6.5±2.0, p=0.011) 및 아토피 지수(2.1±0.3 vs. 1.0±0.3, p=0.004)는 운동유발성 천식군에서 대조군에 비해 높았다. 총 40명의 환자들 중기도과민성이 있는 26명의 천식 환자들과 기도과민성이 없는 14명의 환자들 각각을 대상으로 운동유발성 천식 유무에 따른 특성을 비교하였다. 26명의 천식 환자들 중 운동유발성천식은 18명(69.2%)에서 관찰되었으며, 이들에서 아토피 빈도, 아토피 점수 및 아토피 지수가 높은 경향이 관찰되었지만 유의한 차이는 없었다. 기도과민성이 없는 14명의 환자들중 운동유발성 천식은 3명(21.4%)에서 관찰되었으며 아토피빈도는 운동유발성 천식 양성군과 음성군 사이에 유의한 차이가 없었으나 아토피 점수(22.3±3.3 vs. 5.9±2.3, p=0.007) 및 아토피 지수(2.3±0.3 vs. 1.0±0.4, p=0.028)는 운동유발성천식 양성군에서 유의하게 높았다. D. pteronyssinus (76.2% vs. 42.1%, p=0.028)와 D. farinae (76.2% vs. 36.8%, p=0.012) 양성률은 운동유발성 천식군에서 대조군에 비해 높았다. 이분형로지스틱회귀분석을 시행한 결과 메타콜린에 대한기도과민성(위험비[OR]: 14.3, 95% 신뢰구간[CI]: 1.86-109.4)과 아토피(OR; 16.9, 95% CI; 2.04- 140.74)는 운동유발성 천식의 유의한 위험인자였다. 결론: 아토피는 운동유발성 천식과 연관된 위험인자로 생각된다. 운동유발성 천식 환자에서 대조군에 비해 D. pteronyssinus와 D. farinae의 양성률이 높아 집먼지진드기 항원이운동유발성 천식의 발생과 악화와 관계가 있을 가능성을 확인하였다. Background/Aims: Atopy is closely related to asthma and is a risk factor for the development and exacerbation of asthma. The aim of this study was to evaluate the association between exercise-induced asthma (EIA) and atopy in adult patients with asthma-like symptoms. Methods: Forty young male patients with asthma-like symptoms were enrolled. Skin prick, methacholine bronchial provocation, and exercise provocation tests were performed. Current and ex-smokers were excluded. Results: Exercise provocation tests were positive in 21 patients (52.5%). Airway hyperresponsiveness (AHR) to methacholine (85.7% vs. 42.1%, p=0.007) and atopy (85.7% vs. 47.4, p=0.017) was found more frequently in patients with EIA than in those without EIA. EIA was significantly associated with atopy score (16.5±3.0 vs. 6.5±2.0, p=0.011), atopy index (2.1±0.3 vs. 1.0±0.3, p=0.004), and positive responses to Dermatophagoides pteronyssinus (76.2% vs. 42.1%, p=0.028) and Dermatophagoides farinae (76.2% vs. 36.8%, p=0.012), but not with positive responses to pollen allergens. AHR to methacholine (odds ratio [OR]: 14.3, 95% confidence interval [CI]: 1.86-109.4) and atopy (OR: 16.9, 95% CI: 2.04-140.74) were significant risk factors for EIA. Conclusions: Atopy was a risk factor for EIA in young adult men, and sensitization to house dust mites was associated with EIA. (Korean J Med 2011;81:723-728)

탄소나노튜브가 첨가된 유황전극을 사용한 리튬/유황 전지의 사이클링에 의한 표면형상변화

진창수 ( Chang Soo Jin ),김기원 ( Ki Won Kim ),박진우 ( Jin Woo Park ),안주현 ( Jou Hyeon Ahn ),신경희 ( Kyung Hee Shin ),안효준 ( Hyo Jun Ahn ),유지현 ( Ji Hyun Yu ),류호석 ( Ho Suk Ryu ),김영철 ( Young Chal Kim ) 대한금속재료학회(구 대한금속학회) 2011 대한금속·재료학회지 Vol.49 No.2

We investigated the surface morphology changes of a lithium/sulfur battery using multi-walled canbon nanotube added sulfur electrode during charge-discharge cycling. The Li/S cell showed the first discharge capacity of 1286 mAh/g-S, which utilized is 71% of the theoretical value. It decreased to 328 mAh/g-S at the 100th cycle, which corresponds to about 19% utilization of the total sulfur in the cathode. The spherical lumps of the reaction product were observed on the surface of the sulfur electrode. This material was verified as lithium sulfide by X-ray diffraction measurement. The pores in the separator were filled with reaction product. Thus the diffusion of the Li+ ion decreased, which resulted in the decreased capacity of the Li/S cell.