염분 스트레스가 둥근전복 Haliotis discus discus의 유리아미노산 조성에 미치는 영향

양현성(Hyun-Sung Yang),박경일(Kyung-Il Park),홍충희(Choong-Hee Hong),최광식(Kwnag-Sik Choi) 한국수산과학회 양식분과 2008 韓國養殖學會誌 Vol.21 No.4

유사도 비교 모듈을 이용한 Tracking By Detection 모델 설계

양현성 ( Hyun-sung Yang ),정세훈 ( Se-hoon Jung ),심춘보 ( Chun-bo Sim ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2

현대 컴퓨터 비전 분야에서는 객체 추적이 중요한 연구 주제 중 하나다. 기존 Tracking By Detection 방식은 실시간 추적 속도와 Tracklet을 유지할 수 있는 정보 전달의 한계를 가지고 있다. 본 연구에서는 유사도 비교 모듈을 기반으로 Tracking By Detection 모델을 설계하고자 한다. 탐지 모델은 Anchor를 사용하지 않는 CenterNet을 사용하고 탐지된 값에 유사도 비교 알고리즘을 적용하여 객체 탐지와 객체 추적을 동시에 수행하는 모델을 제안한다. 제안하는 방법은 Occlusion으로 인한 객체 정보 손실을 완화하고, 새로운 객체 및 장애물에 대해 강건할 것으로 사료된다.

객체 추적 성능향상을 위한 Heatmap Detection 및 Transformer 기반의 MOT 모델 설계

양현성 ( Hyun-sung Yang ),심춘보 ( Chun-bo Sim ),정세훈 ( Se-hoon Jung ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.1

베타 3 - 아드레날린 수용체의 유전자형이 고혈당증 유발에 미치는 영향

오현희(Hyun-hee Oh),최선미(Sun-Mi Choi),양현성(Hyun-Sung Yang),김길수(Kil-Soo Kim),윤유식(Yoo-Sik Yoon) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.1

한국인 남녀 530명을 대상으로 β3-AR의 유전자 다형성이 비만과 혈당의 증가에 미치는 영향을 연구한 결과 연구대상자들의 평균 연령은 26.55±0.31세이었고, 남성이 9.1%, 여성이 90.9%이었다. β3-AR의 유전자 다형성의 분포는 WW형 0.75, WR형 0.22, RR형 0.03이었고, BMI 25 ㎏/㎡를 기준으로 하여 정상군에서 WW, WR, RR형의 빈도수는 각각 0.75, 0.23, 0.02이었고, 비만군에서는 각각 0.76, 0.21, 0.03이었다. 유전자 다형성에 따라 혈당은 WR+RR형에서 WW형에 비해 유의적으로 증가하였다(p=0.001). 혈당 6.105 mmol/L을 기준으로 β3-AR의 유전자 다형성의 빈도수를 분석한 결과 WR+RR형의 빈도수가 고혈당군에서는 35.6%이었고 정상혈당 군에서는 23.3%으로 변이형의 빈도가 고혈당군에서 유의적으로 높았다(p=0.011). 혈당에 따라 비만도와 체지방율은 고혈당군에서 유의적으로 증가하였다(p=0.044, 0.046). HDL 콜레스테롤은 정상혈당군에서 유의적으로 증가하였고(p=0.006), 중성지방은 고혈당군에서 유의적으로 증가하였다(p=0.000). 혈당의 증가에 가장 영향을 미치는 지표를 분석하기 위해 다단계 로지스틱 회귀분석한 결과 중성지방(p=0.000), 혈중 알부민(p=0.008), β3-AR의 유전자 다형성(p=0.011), HDL 콜레스테롤(p=0.059) 순으로 나타났다. 특히 중성지방의 증가와 β3-AR의 유전자의 WR+RR형은 고혈당의 유발 위험율을 각각 2.165배, 2.015배 증가시키고, HDL 콜레스테롤의 증가는 위험율을 0.491배 감소시키는 결과를 보인다. 각각의 유전자 다형성 군에서 혈당과 BMI, WHR, 체지방량의 상관성을 분석한 결과에서 정상군에서는 비만의 판정지표인 BMI, WHR, 체지방량과 혈당이 유의적인 정의 상관관계를 나타내었으나 변이형인 WR, RR형에서는 이들 변수간에 상관성이 보이지 않았다. 결과적으로 β3-AR 유전자의 변이형에서 혈당은 증가하였고, 고혈당에서는 체지방 및 중성지방이 증가하였고, HDL 콜레스테롤은 감소하였다. 또한 고혈당과 변이형의 빈도는 유의적인 상관성을 나타내었다. 따라서 β3-AR 유전자의 변이형은 혈당과 혈중 지질의 조성변화에 영향을 미치며 이는 고혈당의 위험성을 예견할 수 있는 독립적인 지표로 나타났다. This study was conducted to examine the effects of β3-adrenergic receptor polymorphism on the blood glucose level and obesity in 530 volunteers, who attended a weight loss program in a local obesity clinic. The age differences in total subjects and the distribution of male and female were 26.55±0.31 yr, 9.1% (n=48), 90.9% (n=492). The genotype distribution of β3-AR gene polymorphism were WW type 75%, WR type 22% and RR type 3%. Among many parameters, fasting blood glucose was significantly higher in WR+RR type (p=0.001) compared with WW type. When the subjects were divided into two groups by 6.105 mmol/L of the fasting blood glucose level, the frequency of hyperglycemia was 23.3% in WW type subjects, while there was a increase to 35.6% in WR+RR type subjects (p=0.011, χ²-analysis). When hyperglycemia group was compared with normoglycemia group, obesity index (p=0.044), %body fat (p=0.046) and TG (p=0.000) were significantly higher, and HDL (p=0.006) was significantly lower in the hyperglycemia. When all of the above factors were included in stepwise logistic regression analysis to find risk factors of hyperglycemia, the results were that the odds ratio for hyperglycemia were 2.015 (p=0.011) for WR+RR type of β3-AR gene, 2.165 (p=0.000) for TG and 0.419 (p=0.059) for HDL cholesterol. There was a significantly positive correlation between the blood glucose vs BMI, WHR, body fat in the WW type (r=0.099, 0.119, 0.082). However, in the WR and RR type there were no significance between the blood glucose vs BMI, WHR, body fat. These data suggest that the WR+RR genotype of β3-AR has a very strong association with increased blood glucose level and might be a significant risk factor for hyperglycemia among Korean subjects.

장화다리지지대(boot support leg holder)를 사용한 복강경수술에서 발생한 신경학적 합병증 5예

방현철 ( Hyun Chul Bang ),김진영 ( Jin Young Kim ),송태훈 ( Tae Hun Song ),양현성 ( Hyun Sung Yang ),이채형 ( Chae Hyeong Lee ),박현수 ( Hyun Soo Park ),박진우 ( Jin Woo Park ),윤상호 ( Sang Ho Yoon ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.9

쇄석위 자세는 산부인과 수술 시 흔히 취하는 자세로 하지의 신경 손상이 드물지만 언제나 발생할 수 있다. 신경학적 합병증의 발생기전은 명확하지 않으나 대부분은 수술 중 부적절한 자세유지로 인한 신경의 손상으로 인해 생기는 것으로 알려져 있다. 경미한 신경 손상은 자발적인 회복이 가능하지만 심할 경우 회복이 늦어지거나 영구적인 손상을 일으킬 수 있다. 쇄석위 자세에서 무릎지지대를 쓸 경우 신경의 압박, 저관류의 증가, 수술 중 체위변경의 어려움으로 인해 본원에서는 장화다리지지대를 사용하여 수술을 시행하였다. 그럼에도 불구하고 본 저자들은 장화다리지지대를 사용한 쇄석위 자세에서 신경학적 합병증 5예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Lithotomy position has often been used in gynecologic surgeries. Nerve injury of lower extremities may be rare but can happen anytime during the surgeries. The pathogenesis of neurologic complications is not clear, but most of the neurologic complications are known to occur due to improper posture during surgery, Minor nerve injuries can recovered spontaneously, but severe injuries can cause slow recovery or permanent damage. The usage of generic knee support may cause compression to the nerves and increases the risk of hypoperfusion and difficulty in the change of posture during surgery, so in our hospital we have used a boot support leg holder during the surgery. Nevertheless, we experienced five cases of neurologic complication during a lithotomy position with usage of a boot support leg holder. Therefore we report these cases with review of literature.

Peroxisome Proliferator-Activated $Receptor-{\gamma}$ 2 $(PPAR{\gamma}2)$ Pro12Ala (P12A) 유전자 다형성이 한국여성의 체지방분포에 미치는 영향

김길수,최선미,양현성,윤유식,신승우,Kim, Kil-Soo,Choi, Sun-Mi,Yang, Hyun-Sung,Yoon, Yoo-Sik,Shin, Seun-Uoo 한방비만학회 2004 한방비만학회지 Vol.4 No.1

Objectives: The effects of peroxisome proliferator-activated receptor ${\gamma}2\;(PPAR{\gamma}2)$ Pro12Ala (P12A) polymorphism on body mass index (BMI) and type 2 diabetes are well documented; however, until now, only a few studies have evaluated the effects of this polymorphism on body fat distribution. This study was conducted to elucidate the effects of this polymorphism on computed tomography (CT)-measured body fat distribution and other obesity-related parameters in Korean female subjects. Methods & Results: The frequencies of $PPAR{\gamma}2$ genotypes were: PP type, 93.0%; PA type, 6.8%; and AA type, 0.2%. The frequency of the A allele was 0.035. Body weight (P .012), BMI (P .012), and waist-to-hip ratio (WHR) (P .001) were significantly higher in subjects with PA/AA compared with subjects with PP. When body composition was analyzed by bioimpedance analysis, lean body mass and body water content were similar between the 2 groups. However, body fat mass (P .003) and body fat percent (P .025) were significantly higher in subjects with PA/AA compared with subjects with PP. Among overweight subjects with BMI of greater than 25, PA/AA was associated with significantly higher abdominal subcutaneous fat (P .000), abdominal visceral fat (P .031), and subcutaneous upper and lower thigh adipose tissue (P .010 and .013). However, among lean subjects with BMI of less than 25, no significant differences associated with $PPAR{\gamma}2$ genotype were found, suggesting that the fat-accumulating effects of the PA/AA genotype were evident only among overweight subjects, but not among lean subjects. When serum lipid profiles, glucose, and liver function indicators were compared among overweight subjects, no significant difference associated with $PPAR{\gamma}2$ genotype was found. Changes in body weight, BMI, WHR, and body fat mass were measured among overweight subjects who finished a 1-month weight lose program of a hypocaloric diet and exercise; no significant differences associated with $PPAR{\gamma}2$ genotype were found. Conclusions: The results of this study suggest that the $PPAR{\gamma}2$ PA/AA genotype is associated with increased subcutaneous and visceral fat areas in overweight Korean female subjects, but does not significantly affect serum biochemical parameters and outcomes of weight loss programs.

트레드 블록을 고려한 타이어의 잔류 복원 토크 및 마찰 에너지에 대한 유한 요소 해석

김기운(Kee-Woon Kim),정현성(Hyun-sung Jeong),조진래(Jin-Rae Cho),양영수(Young-Soo Yang) 한국자동차공학회 2004 한국 자동차공학회논문집 Vol.12 No.4

베타 2-아드레날린 수용체의 유전자 변이형이 비만도에 미치는 영향

김길수 ( Kil Soo Kim ),오현희 ( Hyun Hee Oh ),최선미 ( Sun Mi Choi ),양현성 ( Hyun Sung Yang ),배정환 ( Jung Hwan Bae ),윤유식 ( Yoo Sik Yoon ) 한방비만학회 2003 한방비만학회지 Vol.3 No.1

Objectives: The lipolytic effects of catecholamines in adipose tissue are mediated by members of adrenergic receptors. This study was conducted to examine the effects of β2-AR Gln27Glu (Q27E) polymorphism on obesity indices and risk among obesity clinic patients. Methods: 532 subjects, 38 men and 494 women, who attended a weight loss program in a local obesity clinic were analyzed. Height, weight, BMI, WHR and obesity index were measured or calculated. Body composition was measured by bio-impedance analysis. Genotype of β2-AR polymorphism in codon 27 was analyzed by PCR-RFLP method. Serum concentrations of fasting glucose, total and HDL cholesterol, and triglyceride were determined by autobiochemical analyzer. Results: The Genotype distributions of β2-AR gene were QQ type 81.3%, QE type 17.9% and EE type 8%. Therefore, the frequency of E allele of β2-AR gene was 0.170 in the total subjects. The frequency of the β2-AR variant genotype(QE+EE) was significantly higher in obese group(BMI>25) compared with non-obese group(p=0.027). Weight was significantly higher in variant(QE+EE) type compared with normal(QQ) type in total subjects(p=0.001), male(p=0.022) and female(p=0.013). BMI, obesity index and WHR were also significantly higher in QE+EE type. Body fat mass was significantly higher in QE+EE type in total subjects(p=0.005) and female(p=0.027). When forward stepwise regression analysis was used to create a model of risk predictors of obesity(BMI>25), QE+EE type of β2-AR gene was found to be a significant risk factor for obesity (p=0.042, ORs 1.597). Conclusions: QE+EE genotype of β2-AR was associated with increased obesity indices and might be a significant risk factor for obesity.

임신 제3삼분기에 aspartate transaminase/alanine transaminase (AST/ALT) 상승을 동반한 소장폐색

박준호 ( Jun Ho Park ),윤상호 ( Sang Ho Yoon ),전동수 ( Dong Su Jeon ),양현성 ( Hyun Sung Yang ),이채형 ( Chae Hyeong Lee ),박현수 ( Hyun Soo Park ),민응기 ( Eung Gi Min ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.6

The intestinal obstruction during pregnancy is rare but early diagnosis and treatment is essential. This disease can be diagnosed very late because the presenting symptoms such as nausea, vomiting and abdominal pain are often seen in normal pregnancies and most pregnant women avoid radiologic examinations. Moreover, this disease can be accompanied by high aspartate transaminase/alanine transaminase (AST/ALT) which can be also found in acute fatty liver of pregnancy or preeclampsia, and it makes diagnosis to be much delayed. If the diagnosis were delayed much, maternal and perinatal mortality would be increased highly. Therefore, the previous record of abdominal surgery or above mentioned symptom should be considered as the intestinal obstruction, and simple abdominal x-ray for early diagnosis and prompt operation step are critical. We present a case of small bowel obstruction accompanied with high AST/ALT during pregnancy which had the history of previous cesarean section with a brief review of the literature.

Peroxisome Proliferator-Activated Receptor-γ 2 (PPARγ2) Pro12Ala (P12A) 유전자 다형성이 한국여성의 체지방분포에 미치는 영향

김길수 ( Kil Soo Kim ),최선미 ( Sun Mi Choi ),신승우 ( Seung Uoo Shin ),양현성 ( Hyun Sung Yang ),윤유식 ( Yoo Sik Yoon ) 한방비만학회 2004 한방비만학회지 Vol.4 No.1

Objectives : The effects of peroxisome proliferator-activated receptor γ2 (PPARγ2) Pro12Ala (P12A) polymorphism on body mass index (BMI) and type 2 diabetes are well documented; however, until now, only a few studies have evaluated the effects of this polymorphism on body fat distribution. This study was conducted to elucidate the effects of this polymorphism on computed tomography (CT)-measured body fat distribution and other obesity-related parameters in Korean female subjects. Methods & Results : The frequencies of PPARγ2 genotypes were: PP type, 93.0%; PA type, 6.8%; and AA type, 0.2%. The frequency of the A allele was 0.035. Body weight (P .012), BMI (P .012), and waist-to-hip ratio (WHR) (P .001) were significantly higher in subjects with PA/AA compared with subjects with PP. When body composition was analyzed by bioimpedance analysis, lean body mass and body water content were similar between the 2 groups. However, body fat mass (P .003) and body fat percent (P .025) were significantly higher in subjects with PA/AA compared with subjects with PP. Among overweight subjects with BMI of greater than 25, PA/AA was associated with significantly higher abdominal subcutaneous fat (P .000), abdominal visceral fat (P .031), and subcutaneous upper and lower thigh adipose tissue (P .010 and .013). However, among lean subjects with BMI of less than 25, no significant differences associated with PPARγ2 genotype were found, suggesting that the fat-accumulating effects of the PA/AA genotype were evident only among overweight subjects, but not among lean subjects. When serum lipid profiles, glucose, and liver function indicators were compared among overweight subjects, no significant difference associated with PPARγ2 genotype was found. Changes in body weight, BMI, WHR, and body fat mass were measured among overweight subjects who finished a 1-month weight lose program of a hypocaloric diet and exercise; no significant differences associated with PPARγ2 genotype were found. Conclusions : The results of this study suggest that the PPARγ2 PA/AA genotype is associated with increased subcutaneous and visceral fat areas in overweight Korean female subjects, but does not significantly affect serum biochemical parameters and outcomes of weight loss programs.1)