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분극전계가 모포트로픽 상경계 부근의 PZT 세라믹스의 공진주파수의 온도의존성에 미치는 영향
梁正普(Jung-Bo Yang),梁完碩(Wan-Seok Yang),李開明(Gae-Myoung Lee) 대한전기학회 2008 전기학회논문지 Vol.57 No.7
Poling is an important process in fabricating PZT ceramic devices such as filters and resonators and activates piezoelectricity to sintered PZT ceramics. Tolerance of the operating frequency of these devices is tightly required in applications. And a factor to attribute the tolerance is the temperature dependence of the resonance frequency of PZT ceramics. In this paper the relationship of poling strength and temperature dependence of resonance frequency of PZT specimens was studied. The Pb(Zr0.53Ti0.47)O₃ ceramics were fabricated and the poling strengths were chosen to be 0.5, 1.5, 2.5 and 3.5 [㎸/㎜]. The dielectric constant of the specimen poled in poling strength 0.5 [㎸/㎜] was less than that of unpoled specimen and the specimen poled in higher electric field had the higher dielectric constant. (002) peak in X-ray diffraction patterns of the specimens increased as poling strength increased. And the change of resonance frequency of the specimens according to the variation of temperature was measured. Resonance frequency of all specimens increased as the temperature increased. The specimen poled in higher electric field had the smaller positive temperature coefficient of resonance frequency. The effect that temperature coefficient of resonance frequency becomes smaller is obtained when Zr mole in PZT composition equation increase. Controlling the poling strength is believed to be a method to adjust the temperature stability of resonance frequency of the PZT ceramic devices.
양정보 ( Jung Bo Yang ),강병헌 ( Byung Hun Kang ),고영복 ( Young Bok Ko ),박찬준 ( Chan Joon Park ),유헌종 ( Heon Jong Yoo ),이윤이 ( Yun Ee Lee ),강길전 ( Kil Chun Kang ),노흥태 ( Heung Tae Noh ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
목적 : 임신전, 임신중의 인구학적, 임상적 특성을 통해 전자간증을 예측할 수 있는 요소를 결정하였다. 연구 방법 : 1998년 1월에서 2002년 12월까지 충남대학교 산부인과에서 전자간증으로 진단되어 분만을 시행한 산모 279명을 환자군으로 하여 의무기록 분석을 통해 후향적 환자-대조군 연구를 시행하였다. 대조군으로는 2002년 1월에서 12월 사이에 본원에서 분만을 시행한 산모중 무작위 추출을 통해 364명을 선정하였다. 각각의 연구대상에서 나이, Objective : To assess several variables that are known as the risk factor of preeclampsia. Methods : We have studied with 279 pregnant women who were diagnosed with preeclampsia and went through delivery in Chungnam University from January, 1998 to Decemb
김보연 ( Bo Youn Kim ),양정보 ( Jung Bo Yang ),이민아 ( Min A Lee ),고영복 ( Young Bok Ko ),이기환 ( Ki Hwan Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.2
Vesicovaginal fistula (VVF) is one of the most serious surgical complication in gynecologic surgery. Surgical approach to repair this condition can be performed by transvaginal or transabdominal. However, laparoscopic repair of VVF may be an alternative surgical method. We present four cases of VVF treated with transperitoneal laparoscopic technique. Laparoscopic repair is a feasible, safe and efficacious minimally invasive approach for the management of VVF. We believe that this method provides excellent results and may result in lower morbidity, shorter hospital stay, and quicker recovery than the abdominal or transvaginal approaches.
현석환 ( Suk Hwan Hyun ),양정보 ( Jung Bo Yang ),박상도 ( Sang Do Park ),이종선 ( Jong Seon Lee ),이기환 ( Ki Hwan Lee ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.1
Vaginal evisceration is a rare but life threatening complication of gynecologic surgery. Most of them occur after abdominal or vaginal hysterectomy. The incidence after laparoscopic hysterectomy is unknown. The incidence of evisceration in the patients undergoing laparoscopic hysterectomy in our hospital was 0.1 %. The rapid recovery after laparoscopic hysterectomy, compared with abdominal hysterectomy, is widely acknowledged. Swift return to everyday activities and early resumption of intercourse could predispose to rupture of vaginal vault. Upon discharge, patients undergoing laparoscopic hysterectomy should be given careful instructions to avoid coitus until complete healing of vaginal vault. We described three cases of vaginal evisceration after laparoscopic hysterectomy including a review of the literature.
글루코스와 피부르산염의 농도가 조절된 DMEM과 Vero 세포를 이용한 무혈청 적응용 배양액의 개발에 관한 연구
김주환 ( Ju Hwan Kim ),서영석 ( Young Seok Seo ),송해범 ( Hai Bun Song ),양정보 ( Jung Bo Yang ),이경은 ( Kyung En Lee ),이기환 ( Ki Hwan Lee ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.2
목적: 본 연구는 글루코스와 피부르산염이 조절된 DMEM을 이용해 Vero 세포를 배양한 후 무혈청 적응용 배양액 (Serum-free Vero cell conditioned medium, SF-VCM)을 얻어 생쥐의 착상 전 생쥐 배아의 체외발달에 미치는 효과를 보기 위해 수행되었다. 연구 방법: 총 846개의 2-세포기 배아를 4~5주령의 ICR 계통 생쥐로부터 얻었다. 글루타민만 함유되어 있는 DMEM (DMEM-G)과 글루타민, 글루코스 및 피부르산염을 함유하고 있는 DMEM (DMEM-GGP)을 각각 3:1 (#1), 1:1 (#2) 및 1:3 (#3)의 비율로 혼합한 배양액을 제조하였다. Vero 세포 단층이 형성된 배양용기에 DMEM #1 배양액을 각각 10 mL, 30 mL 및 50 mL 씩넣어 48시간 배양 후 회수하여 보관하였다가 사용하였으며, 각각의 배양액에 생쥐배아를 배양하여 48시간 및 96시간에 발달을 비교하였다. 또한 20% 난포액을 함유하고 있는 DMEM #2 배양액을 Vero 세포와 공배양한 군을 대조군으로 하여 각각 DMEM #1, #2 및 #3 배양액으로 제조된 3가지 SF-VCM에도 생쥐배아를 배양하여 발달을 서로 비교하였다. Vero 세포와의 공배양군을 제외하고 모든 실험군에는 10% SSS를 첨가하여 사용하였다. 결과에 대한 유의성 검증은 Chi-square test를 이용하였고, P 값이 0.05 이하일 때 유의한 차이가 있는 것으로 판정하였다. 결과: DMEM #1 배양액 30 mL를 넣은 군에서 각 단계 발달률 (상실배아≤: 97.2%, 주머니배≤: 97.2%, 탈출 주머니배≤: 82.2%)이 다른 실험군들에 비해 유의하게 높게 나타났다 (P<0.05). Vero 세포와의 공배양과 다양한 SF-VCM에서 생쥐 배아의 체외배양 효과를 비교한 결과에서는 DMEM #1 배양액으로 제조된 SF-VCM #1 실험군 (Group I)에서 각 단계별 발달률 (상실배아≤: 98.1%, 주머니배≤: 97.1%, 탈출 주머니배≤: 81.7%)이 다른 실험군들에 비해 높게 나타났으며, 배양 96시간 후탈출 주머니배 이상으로의 발달에서는 대조군 (67.6%)보다 유의하게 높은 발달률을 나타내었다 (P<0.05). 결론: Vero 세포 단층이 형성된 배양용기에 DMEM #1 배양액을 사용하여 SF-VCM을 제조하는 경우 250 mL 플라스크에 30mL의 용량으로 배양하는 것이 가장 효과적이며, 이는 다른 농도의 배양액에 비해 더 높은 체외 발달률을 유도 할 수 있어 사람의 시험관 아기 시술에서 응용해 볼 만한 가치가 있을 것이라 사료된다. Objective: The purpose of this study was to examine in vitro development of early preimplantation mouse embryos in various kind of serum-free conditioned media (SF-VCM) manufactured from DMEM cultured with Vero Cells. Methods: A total of 846 two-cell mouse embryos were cultured in different kind of SF-VCM. SF-VCMs were divided into SF-VCM-10, -30 and -50 by media volume using DMEM #1 media, and divided into SF-VCM #1, #2 and #3 by controlled concentration of glucose and pyruvate (manufactured by DMEM #1: mixed three volume of DMEM-G (DMEM with glutamine without glucose and pyruvate) and one volume of DMEM-GGP (DMEM with glutamine, glucose, pyruvate), #2: mixed same volume of DMEM-G and DMEM-GGP and #3: mixed one volume of DMEM-G and three volume of DMEM-GGP, respectively). Experimental groups were mainly added 10% SSS, and 20% hFF was added to only Control group co-cultured with Vero cells. Development of embryos was observed every 24 hours. Results between different groups were analyzed using Chi-square test, and considered statistically significant when P-value was less than 0.05. Results: In vitro developmental rate by each cleavage stages of mouse embryos cultured in SF-VCMs with a various volumes were significantly (P<0.05) higher in SF-VCM-30 (morula≤: 97.2%, Blastocyst (BL)≤: 97.2%, Hatching BL≤: 82.2%) than other groups. In the rate of development on in vitro co-culture vs. a various SF-VCMs manufactured by DMEM controlled concentration of glucose and pyruvate, Group I (SF-VCM #1) was higher than other groups in each cleavage stages (morula≤: 98.1%, Blastocyst (BL)≤: 97.1%, hatching BL≤: 81.7%, respectively). Moreover, specially, in the developmental rate into the hatching blastocyst ≤after 96 hours in vitro culture, Group I (81.7%) was significantly higher than control group (67.6%, P<0.05). Conclusion: SF-VCM #1 manufactured by volume of 30 mL DMEM #1 media cultured in vitro for 48 hours in 250 mL flask was the most effective on in vitro developmental rate of mouse preimplantation embryos. Therefore, it is expected that SF-VCM #1 has application to human IVF-ET.
이민아 ( Min A Lee ),현석환 ( Suk Whan Hyun ),황순호 ( Soon Ho Hwang ),신관섭 ( Kwan Seop Shin ),양정보 ( Jung Bo Yang ),이진구 ( Jin Goo Lee ),손성경 ( Sung Kyong Son ),이윤이 ( Yun Ee Rhee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10
Meckel Gruber syndrome consisting of an occipital encephalocele, polycystic kidney disease and polydactyly is a rare autosomal recessive disorder with a recurrence risk of 25%. Targeted ultrasonography in late embryonic or early fetal stages of pregnancy has great importance in diagnosis and management of affected pregnancy in high risk groups due to incomplete genetic mapping of meckel syndrome gene (MKS). We present a case of prenatal diagnosis at 14 weeks` gestational age of Meckel Gruber syndrome in a woman, who experienced same disorder in her previous pregnancy.
불임을 동반한 중증 자궁내막증 환자에서 수술 후 임신에 미치는 요인에 관한 연구
유헌종 ( Heon Jong Yoo ),고영복 ( Young Bok Ko ),박찬준 ( Chan Jun Park ),김도영 ( Do Young Kim ),양정보 ( Jung Bo Yang ),신관섭 ( Kwan Seop Shin ),현석환 ( Suk Hwan Hyun ),황순호 ( Soon Ho Hwang ),이기환 ( Ki Hwan Lee ),강길전 ( 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.9
태변복막염으로 진단된 환아의 산전진단 및 출생 후 임상경과에 대한 고찰
강병헌 ( Byung Hun Kang ),노흥태 ( Heung Tae Noh ),이윤이 ( Yun Ee Rhee ),이기환 ( Ki Hwan Lee ),고영복 ( Young Bok Ko ),양정보 ( Jung Bo Yang ),이경은 ( Kyung Eun Lee ),이건우 ( Kun Woo Lee ),이민아 ( Min A Lee ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.2
목적: 생후 태변성 복막염으로 진단된 신생아의 산전 초음파 소견과 생후 임상적 경과와 예후를 알아보고자 하였다. 연구 방법: 생후 수술로서 태변성 복막염으로 확진된 신생아와 산모의 의무기록을 토대로 산전 초음파 소견, 생후 이학적 및 방사선학적 소견, 수술 소견, 수술 후 예후에 관해 조사하였다. 결과: 14명의 신생아가 생후 수술로서 태변성 복막염으로 확진되었고, 이 중 8예는 분만 직전 산전 초음파상 복수와 함께 석회화 및 확장성 장팽창 또는 고에코성 장 루프 소견을 보여 산전에 진단이 가능하였고, 6예에서는 산전 초음파에서 복수 소견만을 보였다. 출생 후 수술까지의 평균기간은 2.2±0.6일이었고, 1예에서 출생 당일에 수술을 받았는데, 소장의 이상회전과장 염전, 감돈으로 인한 소장 천공이 동반되어 있었고, 11예에서 회장의 폐쇄와 천공이, 3예에서 공장의 폐쇄와 천공이 있었으며, 산전 초음파 소견에 따른 차이는 없었다. 회장루 조성술과 이차적인 장 문합술을 받은 경우가 4예가 있었으나, 모든 환아의 생존율은 100%였고 수술 후 6개월의 추적 관찰에서 특별한 합병증 없이 정상적인 성장 발달을 보였다. 결론: 생후 태변성 복막염으로 진단된 모든 경우에 전형적인 산전 초음파 소견을 보이는 것이 아니므로 산전에 복수 소견만을 보이는 경우에도 태변성 복막염의 가능성을 고려해야 한다. 태변성 복막염을 지닌 신생아들의 생존율이 아주 높았으며 이는 여러 임상과의 정확하고 신속한 협진을 통해 가능했다고 생각되며 본원의 자료가 향후 산전상담에 도움이 되었으면 한다. Objective: To detect meconium peritonitis for the fetal period is important for prenatal counseling. The aim of this study was to evaluate prenatal ultrasound finding for diagnosing meconium peritonitis and postnatal clinical course and outcomes. Methods: The prenatal and postnatal medical records of all patients to our institutions with confirmed meconium peritonitis were reviewed, with emphasis on prenatal ultrasound findings, postnatal investigations, operative findings, outcomes of meconium peritonitis. Results: Fourteen fetuses were confirmed to have meconium peritonitis at birth by operation. Eight cases were diagnosed correctly because of prenatal ultrasound showing ascites and calcification/dilated or hyperechoic bowel loops. In the other 6 cases, prenatal ultrasound showed only ascites. One patient was operated on first day of life and its intra-operative finding was malrotation of small bowel, volvulus with strangulation, perforation and jejunal atresia. Most cases were operated on 2nd or 3rd day of life. Intra-operative findings were ileal atresia and perforation in 11 cases and jejunal atresia and perforation in 3 cases. Four patients underwent ileostomy but all patients survived and prospered. Conclusion: All patients do not present typical prenatal ultrasound findings of meconium peritonitis. Therefore, even in pregnancies associated with isolated ascites, meconium peritonitis should be taken into consideration. Favorable outcome of intrauterine meconium peritonitis is reassuring in prenatal counselling and stems from multidisplinary team approach.
MRKH 증후군에서 골반복막피판을 이용한 복강경보조 질 성형술 6예
박상도 ( Sang Do Park ),이종선 ( Jong Seon Lee ),이건우 ( Geon Woo Lee ),이경은 ( Kyung Eun Lee ),고영복 ( Young Bok Koh ),양정보 ( Jung Bo Yang ),이기환 ( Ki Hwan Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.11
Vaginal agenesis is rare gynecologic condition, and the most common etiology is Mayer-Rokitansky-Kster-Hauser (MRKH) syndrome, characterized by the absence of uterus and vagina and presence of normal ovaries and tubes. In such patients, the evaluation for associated malformations as well as careful non-surgical and surgical approach are essential. The neovaginoplasty is an important issue for these patients in regard of functional and psychological standpoint. There are many options available for creation of neovagina. We report six cases of laparoscopic assisted neovaginoplasty using pelvic peritoneal flap.