Holstein 종의 우유 단백질형과 산유량에 관한 연구

신인식,유제현 ( In Sik Shin,Jae Hyun Yoo ) 한국낙농학회 1990 韓國酪農學會誌 Vol.12 No.1

Spargue-Dawley 랫드를 이용한 구미강활탕의 급성독성 연구

신인식,김정훈,하혜경,서창섭,이미영,이호영,이준경,이남헌,이진아,이설림,허정임,신현규,Shin, In-Sik,Kim, Jung-Hoon,Ha, Hye-Kyung,Seo, Chang-Seob,Lee, Mi-Young,Lee, Ho-Young,Lee, Jun-Kyoung,Lee, Nam-Hun,Lee, Jin-Ah,Lee, Sul-Lim,Huh, Jung-Im 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1

Objectives : This study was conducted to evaluate the acute toxicity and safety of Gumiganghwal-tang (Jiuweiqianghou-tang) in Sprague-Dawley rats though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the $LD_{50}$ of Gumiganghwal-tang (Jiuweiqianghou-tang) was considered to be over 2000 mg/kg body for both sexes.

치은섬유아세포의 MMP 발현에 대한 Nitric Oxide의 영향

신인식,윤상오,정현주,고정태,Shin, In-Sik,Yoon, Sang-Oh,Chung, Hyun-Ju,Koh, Jung-Tae 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.2

It has been suggested that increased number and activity of phagocytes in periodontitis lesion results in a high degree of reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, nitric oxide and peroxynitrite. There are few reports on the relationship between ROS and MMPs expressions in gingival fibroblast. We studied to elucidate whether and how ROS, especially nitric oxide affects the MMP expression. Human gingival fibroblasts and HTl080 cells (human fibrosarcoma sell line as reference) were grown in DMEM supplemented with 10 mM HEPES, 50 mg/L gentamicin, and 10% heat inactivated fetal bovine serum with addition of various reactive oxygen species (ROS). Culture media conditioned by cells were examined by gelatin zymography. HT1080 cells expressed proMMP-2 and proMMP-9, but human gingival fibroblasts (HGF) produced only proMMP-2. Hydrogen peroxide upregulated MMP-9 expression in HT1080 cells, whereas in human gingival fibroblast SNP treatment showed marked increase in MMP-2 level compared to other ROS. These results suggest that the effects of ROS on MMPs expressions are cell-type specific. RT-PCR for MMP-2 and TIMP-2 m-RNA were performed using total RNA from cultured cells under the influence various kinase inhibitors. In HT1080 cells, treatment with FPTI III (Ras processing inhibitor) and LY294002 (PI3-kinase inhibitor) resulted in inhibition of MMP-2 and MMP-9 expressions, suggesting that Ras/P13-kinase pathway is important for MMPs expression in HT1080 cells. In gingival fibroblasts, treatment with FPTI III and PDTC (NF-kB inhibitor) showed marked decrease in MMP-2 regardless of the of SNP , suggesting that Ras/NF-kB could be the key pathway for NO-induced MMP-2 expression in gingival fibroblasts. This study showed that ROS, especially nitric oxide, could be the critical mediator of periodontal disease progression through control of MMP-2 expression in gingival fibroblasts possibly via Ras/NF-kB pathway.

Spargue-Dawley 랫드를 이용한 방풍통성산의 급성독성 연구

신인식,김정훈,하혜경,서창섭,이미영,허정임,신현규,Shin, In-Sik,Kim, Jung-Hoon,Ha, Hye-Kyung,Seo, Chang-Seob,Lee, Mee-Young,Huh, Jung-Im,Shin, Hyeun-Kyoo 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objectives : This study was conducted to evaluate the acute toxicity and safety of Bangpungtongsung-san (Fangfengtongsheng-san) in Sprague-Dawley rat though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Bangpungtongsung-san (Fangfengtongsheng-san) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Bangpungtongsung-san (Fangfengtongsheng-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the $LD_{50}$ of Bangpungtongsung-san (Fangfengtongsheng-san) was considered to be over 2000 mg/kg body for both sexes.

지역농협의 상대적 효율성 평가를 위한 투입,산출변수 선정에 관한 고찰 -DEA 모형을 중심으로-

신인식 ( In Sik Shin ),최경식 ( Kyung Sik Choi ),남기포 ( Gi Pou Nam ) 한국협동조합학회 2011 韓國協同組合硏究 Vol.29 No.2

DEA is a linear programming for evaluation of comparative efficiency and inefficiency among some units that use multiple inputs for multiple outputs. The purpose of this paper is to review the evaluation of efficiencies by DEA model and the selection of appropriate input and output variables. As a result of this study, I suggest the input and output variables for using the DEA model are as follows; Firstly, selected input variables are the real estate for business, total personnel number including regular and irregular works, per capita, sale and maintenance cost, members of cooperatives and immeasurable items, etc.. Secondly, selected output variables are the volume of credit business, the volume of economic business, effective contract volume of insurance, gross profit, immeasurable items (members satisfaction), etc..

이동통신사 TV광고의 기호학적 분석

신인식 ( Shin In Sik ) 한국디자인트렌드학회 2006 한국디자인포럼 Vol.14 No.-

최근 한국 사회는 “정보강국”이라는 슬로건 아래 정보화 사회를 지향하고 있으며 현재 이동통신 사업은 업체간 과다경쟁으로 인하여 광고에 대한 의존도가 그 어느 때보다 높아지고 있다. 이동통신 광고는 이동통신에 관한 수용자의 인식을 확대시키고, 가입자를 유치하는 데 결정적으로 기여하므로 사업자들은 소비자에게 자사의 이미지를 어필하기 위하여 참신하고 독창적인 아이디어로 광고를 제작하고 있다. 본 연구는 이동통신사의 광고를 연구대상으로 광고 텍스트에 내재된 숨은 의미를 기호학적 분석방법을 통하여 파악해봄으로써 기업이 광고를 통하여 소비자에게 부여하고자하는 문화적 가치를 알아보고자 하는 것을 연구의 목적으로 하였으며 국내 3개 이동통신사의 TV광고를 대상으로 기호학적 분석방법을 통하여 광고의 의미구성 방식이 지니는 이데올로기적 성격을 알아보았다. 본 연구는 TV광고 텍스트에 내재되어 있는 의미에 관하여 분석, 광고 텍스트에 내재되어 있는 이데올로기에 대하여 파악해 본 것에 학문적 의의가 있다. Currently, the Korean society is striving for an information-based society under the slogan of “Information Superpower.” With this, excessive competition among mobile telecomm companies is forcing these firms to depend on advertisement more than ever. Since mobile telecomm advertisements play a key role in increasing public awareness of products or services and in inducing new customers, telecomm companies are producing creative and original advertisements to appeal their images to consumers. The purpose of this research is to search for the kinds of cultural virtues companies are trying to relay to consumers, by analyzing the semiotic meanings hidden between the lines of the messages in the advertisements presented by telecommunications firms. Also, ideological characteristics of advertisement semiotics were analyzed by reviewing TV advertisements representing 3 Korean telecommunications companies. This research focused on finding the ideological foundations embedded in TV advertisement messages.

한국과 일본의 공익광고 디자인에 관한 비교 연구

신인식 ( Shin In Sik ) 한국디자인트렌드학회 2007 한국디자인포럼 Vol.15 No.-

공익광고 텍스트에는 수용자를 설득시키고 광고의 효율성을 제고하기 위한 다양한 크리에이티브 전략이 내재되어 있지 않으면 안 된다. 표현방식에 있어서 이러한 크리에이티브 전략은 사회 구성원을 대상으로 사회변화를 주관, 형성, 통제하고자 하는 공익광고 고유의 목적 달성을 위한 매우 중요한 요인으로 작용할 것이다. 그러므로 이 분야에 관한 연구의 중요성은 점차 증가하고 있는 실정이며 국가 간 비교 연구를 통한 새로운 전략의 모색도 표현전략을 다양화하여 수용자의 동의를 얻어내는데 중요한 역할을 할 것으로 기대된다. 이러한 관점에서 한국과 정치, 경제, 사회, 문화적으로 밀접한 관계에 있는 일본의 공익광고와 한국의 공익광고를 비교분석하여 양국 공익광고의 역사적 배경과 광고표현 전략의 차이점, 그리고 국가별 공익광고의 특성을 파악해 보는 작업은 지금까지의 공익광고의 커뮤니케이션전략의 틀을 파악해 보고, 앞으로 효율적인 광고 집행을 위한 계획수립을 위하여 의미있는 연구라고 할 수 있다. The texts in public service advertising should contain diverse creative strategies for persuading consumers and enhancing the efficiency of advertisement. Such creative strategies in a way of expression will work as a significant factor for reaching the unique goal of public service advertising which is dedicated to control, form and control social changes aimed at social members. Therefore, the importance of research into this field has increased gradually, and it is supposed to play a crucial role in obtaining approval of receptors consumers by diversifying expression strategies in pursuit of new strategies through a comparative study among nations. From this perspective, it may be meaningful to identify the characteristics of public service advertising by country as well as the historic background of Korean and Japanese public service advertising and differences between their strategies of expressing advertisements, by comparing and analyzing Japanese public service advertising and Korean public service advertising which are closely coupled economically, socially, and culturally, and to establish plans for executing efficient advertising in the future.

일본 TV공익광고의 시각적 요소와 언어적 요소의 상관관계에 관한 연구

신인식(Shin Insik) 한국디지털디자인학회 2009 디지털디자인학연구 Vol.9 No.3

공익광고는 광범위한 목표 수용자 즉 공공을 대상으로 계획적인 커뮤니케이션을 통하여 일정한 시간 내에 그들의 생각을 공공의 이익에 맞게 유도하고 궁극적으로 의도하는 태도변화를 이끌어 내는데 그 목적이 있다. 지금까지 우리나라 공익광고는 탄생 초기에 국가의 시책을 강요하거나 정권이 국민을 조직화하고 이데올로기를 강요하는 부정적 수단으로 사용되기도 하였으나 사회적 문제에 대한 관심을 제고시키고 실천하게 함으로써 우리 사회의 공익추구와 사회통합을 위한 핵심적 역할을 수행한 순기능이 더욱 크다고 할 수 있겠다. 공익광고가 사회구성원의 가치체계와 의식을 변화시키고 사회적 문제 해결을 추구하는 본래의 목적을 달성하기 위해서는 목표 수용자를 설득하고 행동으로 전이시킬 수 있는 다양한 전략들이 광고 텍스트에 내재되어 있어야 한다. 본 연구에서는 일본의 공익광고 텍스트에 내재되어 있는 광고 표현 전략을 분석해 보고 향후 우리나라 공익광고의 커뮤니케이션 방향을 모색해 보는 것을 연구의 목적으로 하였다. 일본의 TV공익광고를 연구의 대상으로 하였고 텍스트 내의 시각적 요소와 언어적 요소의 연관성의 정도를 파악해 보기 위하여 영상 이미지와 언어의 상관관계를 직접적 연관 축어적 연관 간접적 연관 무관의 4가지 유형으로 나누어 분석하였고 그 결과를 중심으로 일본 TV공익광고의 표현 전략에 대하여 알아보았다. Public Service Advertising aim to direct the thoughts of the public toward the public benefit and to ultimately draw their intended changes in attitude within a certain time through planned communication targeting the public namely a broad range of target consumers. Korean public service advertising was once employed as a negative means to force the execution of national policies enable the regime to organize its people and to force ideology at its birth; however to date they have performed more positive functions in order to portray a crucial role in the pursuit of the public benefit of our society and in social integration. In order for public service advertising to achieve their original goals of changing the value system and awareness of the members of society and pursuing social problem-solving various strategies that will be able to persuade target consumers and convert them to behave should be inherent in advertising text. The purpose of this study is to analyze advertising expressive strategies inherent in Japanese public service advertising text and to seek the direction of forthcoming Korean public service advertising communication. The study aimed at Japanese TV public service advertising as a research target. And then in order to identify the level of correlation between visual factors and lingual factors within text the study classified the correlation between video image and language into four types: direct matching literal matching only indirect reference and irrelevant and analyzed them. Focusing on the analyzed results the study looked into the expressive strategies of Japanese TV public service advertising.

축협사업과 축산농가소득의 연관성 분석

신인식 ( Shin Insik ),김기환 ( Kim Gihwan ) 농협대학교 협동조합경영연구소 2021 협동조합경영연구 Vol.54 No.-

본 연구는 축산농가소득과 축협사업과의 연관성을 분석하여 향후 축협사업이 농업 및 농가소득증대에 기여하는 방안을 모색해 보고자 하였다. 이에 본 연구에서 사용된 축협사업통계는 자료의 일관성을 위하여 통합농협 이후인 2001년부터 2018년까지의 자료를 이용하여 생산함수를 확장하여 분석을 실시하였다. 분석결과를 정리해보면 다음과 같다. 첫째, 자본집약도는 농업 및 농가소득에 정(+)의 영향을 미친다. 둘째, 경제사업 중 판매사업, 마트사업과 기타사업, 교육지원사업은 축산업에 종사하는 농업 및 농가소득에 정(+)의 영향을 미치는 것으로 나타났다. 셋째, LASSO 분석에서는 판매사업과 교육지원사업이 축산업에 종사하는 농업인의 소득에 유의한 영향을 미치는 것으로 나타났다. 종합하여 보면 축협의 사업 중 판매사업과 마트 사업 및 교육지원 사업은 농가소득에 긍정적인 영향을 미치나, 신용사업은 통계적으로 유의한 영향을 확인하지 못하였다. This study analyzes the impact of livestock cooperative businesses on farm income growth. Livestock cooperative businesses have been trying to find ways to contribute to increases in farm income. The data in this study dates from 2001 to 2018. The results of the analysis are as follows. First, capital intensity has a positive effect on agricultural and farm household income. Second, in the economy business of livestock cooperatives, the purchase business has a positive effect on agricultural income. Third, LASSO analysis showed that the sales and the education support business of livestock cooperatives had a significant effect on the income of farmers engaged in the livestock industry. In summary, the economic business and the education and guidance business of the livestock cooperatives have a positive impact on farm income. However, in the case of the credit business, the statistical significance was not confirmed.

농업의 4차 산업화에 따른 농지ㆍ농업ㆍ농업인의 개념 및 농협 조합원 자격에 관한 고찰

신인식 ( Shin In-sik ),김기환 ( Kim Gi-hwan ) (사)한국협동조합학회 2021 韓國協同組合硏究 Vol.39 No.3

본 연구는 농업의 4차 산업화에 따른 농지 및 농업에 대한 개념을 논의한 후 이에 따른 농업인의 개념을 재정립하고, 이를 기준으로 4차 산업화에 부응하는 농협의 조합원 자격기준을 검토하였다. 먼저 농지와 농업 그리고 농업인의 개념 변화 방향을 요약하면 다음과 같다. 첫째, 전통적인 토경 개념의 농지에서 탈피하여 생산목적 개념의 농지로 접근하여야 한다. 둘째, 농업의 개념을 포괄적으로 농산물을 생산하는 산업으로 확장하여야 한다. 셋째, 농업인의 개념 확장이 필요하다. 마지막으로 앞서 언급한 개념 변화에 발맞추어 농협 조합원 자격에 관한 재설정이 필요하다. 이에 대한 변경 방안은 다음과 같다. 첫째, 농지 규모에 대한 세부 내용의 변경이 필요하다. 둘째, 농업 종사자에 범위 확대가 필요하다. 셋째, 새로운 품목 농업협동조합의 설립 및 중소기업협동조합과의 연계가 필요하다. After discussing the concept of farmland and agriculture following the 4th industrialization of agriculture, this study reestablished the concept of a farmer and tried to review the membership criteria of the Agricultural Cooperatives in response to the 4th industrialization based on this. The direction of change in farmland, agriculture, and farmer concepts is summarized as follows. First, it is necessary to break away from the traditional concept of land farming and approach the farmland with the concept of inclusiveness. Second, the concept of agriculture should be comprehensively expanded to an industry that produces agricultural products. Third, the concept of farmers also needs to be expanded. Lastly, according to the change in the concept mentioned above, it is necessary to re-examine the qualifications for membership in the NACF. The change plan for this is as follows. First, it is necessary to change the contents of the farmland scale. Second, it is necessary to expand the scope of farmers. Third, it is necessary to establish a new agricultural cooperative and link with the small and medium-sized enterprises cooperative.