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청상보하탕(淸上補下湯)으로 호전된 위증환자 치험(治驗) 1례(例)
송광규,조동희,최해윤,김종대,전귀옥,Song, Kwang-Kyu,Cho, Dong-Hee,Choi, Hae-Yun,Kim, Jong-Dae,Jeon, Kwi-Ok 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.3
Wei symptom is muscle relaxation to the point of no contraction and occurs in the limbs. Several cases have led to death. This is a clinical report of a Wei symptom patient diagnosed with impairment of body fluid due to lung heat(肺熱傷津). This patient was treated with Chungsangboha-tang(Qingshangbuxia-tang) and had significant improvement in Wei symptom. Results suggest that oriental medicine is an effective treatment for Wei symptom. But more clinical case reports are needed.
인삼양영탕(人蔘養榮湯)이 비소세포 폐암세포(NCI-H520) 이식 마우스에서 항암 및 면역 활성에 미치는 영향
송광규,곽민아,김종대,Song, Kwang-Kyu,Kwak, Min-A,Kim, Jong-Dae 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1
Objectives : The object of this study was to observe anticancer and related immunomodulatory effects of Insamyangyoung-tang extracts (ISYYTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Methods : Three different dosages of ISYYTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from 11 days after tumor cell inoculation. Six groups, which are intact control, tumor bearing control, 5-fluorouracil (FU) 30 mg/kg, ISYYTe 50 mg/kg, ISYYTe 100 mg/kg, ISYYTe 200 mg/kg, each of 8 mice per group were used in the present study. Changes on the body weight, tumor volume and weight, lymphatic organ (spleen and popliteal lymph node), serum interferon (IFN)-${\gamma}$ levels, splenocytes NK cell activity and peritoneal macrophage activities, splenic tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-10 contents were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. Results : As results of ISYYTe 50, 100 and 200 mg/kg treatment, decreases in the tumor volumes and weights were detected. At histopathological observations, decreases of tumor cell volumes in tumor masses were dose-dependently decreased mediated by increases of apoptosis among tumor cells by treatment of all three different dosages of ISYYTe. As results of tumor cell inoculation, marked decreases of spleen and popliteal lymph node weights, serum IFN-${\gamma}$, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents and splenocytes were observed with histopathological atrophic changes of spleen and popliteal lymph nodes. Conclusions : Over 50 mg/kg of ISYYTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory effects. Although relatively lower anticancer effects were observed in ISYYTe 200 mg/kg treated mice as compared with 5-FU 30 mg/kg treated mice, there are no meaningful favorable immunomodulatory effects were observed after 5-FU treatment in the present study.
보중익기탕가미방(補中益氣湯加味方)으로 호전된 만성 방광염 환자 처험1례 -IPSS 변화를 중심으로-
박송기,송광규,전귀옥,조동희,신현철,강석봉,권은희,Park, Song-Kee,Song, Kwang-Kyu,Jeon, Kwi-Ok,Cho, Dong-Hee,Shin, Hyeon-Cheol,Kang, Seok-Bong,Kwon, Eun-Hee 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2
Objectives: This study was designed to evaluate the effects of an oriental medicine therapy, namely Bojoongikkitang-gamibang, on a chronic cystitis patient. Methods: The clinical data was analyzed on a patient with chronic cystitis due to Bigiheoyak(脾氣虛弱) and Junggihaham(中氣下陷) whose main symptoms were urinary disturbances, such as urgency, weak stream, hesitancy and nocturia, etc. The patient visited twice at the internal medicine department of Dae-Gu Hanny University Dae-Gu Oriental Medicine Hospital on May 20, and on June 3, 2004 and was only treated with herbal medicine(Bojoongikkitang-gamibang). Results: After treatment, improvement was seen in the subsection of the International Prostate Symptom Score(IPSS). Conclusions: This study suggests that Bojoongikkitang-gamibang is significantly effective in treatment of a chronic cystitis.
은교산과 Ciprofloxacin의 병용투여가 Streptococcus pneumoniae 호흡기감염에 미치는 영향
이상준,전귀옥,송광규,최해윤,김종대,Lee, Sang-Jun,Jeon, Kwi-Ok,Song, Kwang-Kyu,Choi, Hae-Yun,Kim, Jong-Dae 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
In order to evaluate the in vivo synergic effect of Eunkyo-san which was a traditional poly-herbal formula has been used in the treatment of respiratory diseases in Korea, with quinolone antibiotics, ciprofloxacin (CPFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with S. pneumoniae ATCC 6303. The obtained results were as follows: In CPFX groups, the viable bacterial numbers were significantly decreased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly decreased compared to that of control group in CPFX groups, and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In CPFX groups, the LSA (luminal surface of alveoli $\%$) were significantly increased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. According to these results, it is considered as the in vivo antibacterial activity of CPFX was dramatically increased by concomitant use of Eunkyo-san against S. pneumoniae ATCC 6303 infection of respiratory tract.
박송기,권은희,송광규,전귀옥,신현철,강석봉,문정환,Park, Song-Gi,Kwon, Eun-Hee,Song, Kwang-Kyu,Jeon, Kwi-Ok,Shin, Hyun-Cheol,Kang, Seok-Bong,Moon, Jung-Hwan 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia which results from one or both of decreased insulin secretion and increased insulin resistance. Chronic hyperglycemia causes damage to the eyes, kidneys, nerves, heart and blood vessels. The major goal in treating diabetes mellitus is controlling elevated blood sugars without causing abnormally low levels of blood sugar. A 67-year-old woman was admitted with hyperglycemia, thirst, Lt. leg numbness and both leg weakness. The patient was diagnosed as So-gal(消渴) due to dry ness-heat based on yin-deficiency(陰虛燥熱) through oriental medicine and NIDDM through western medicine. The patient was treated with oriental and western medicines. Specifically herbal medicine(Gamijihwangtang), acupuncture, moxa theraphy were used as well as oral medications. Clinical symptoms improved and hyperglycemia dramatically stablized.
담훈(痰暈)환자의 임상적 고찰과 복부 적외선 체열촬영의 의의
박미연,최해윤,김종대,송광규,Park, Mee-Yeon,Choi, Hae-Yun,Kim, Jong-Dae,Song, Kwang-Kyu 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.2
To make a objective diagnosis of Dam Hun(痰暈), we investigated the 63 patients with Dam Hun(痰暈) and 34 normal people as control group. we compared the thermal difference between Chon-jung(CV17 ) and Chung-wan(CV12 中脘), Chon-jung(CV17 ) and Gwan-won(CV4 關元) and we compared the thermal difference of Yang-mun(ST21 梁門), Chun_chu(ST25 天樞), Su-do(ST28 水道), too. All 63 patients had dizziness and GI trouble. They had the symptom - fatigue, nausea vomitting, head heaviness, indigestion, cold limbs, headache, heart burn, constipation, diarrhea, anorexia. And some had edema, numbness, insomnia, palpitation, facial flushing, dysuria, ringing. Considering the average temparature of Chon-jung(CV17 ), Chung-wan(CV12 中脘), Gwan-won(CV4 關元), Yang-mun(ST21 梁門), Chun-chu(ST25 天樞), Su-do(ST28 水道) between the patients group and the control group, the patients group were lower than the control group except for Chon-jung(CV17 ), Gwan-won(CV4 關元), but the statistical significance was not. Considering the thermal difference of Chon-jung(CV17 ) and Chung-wan(CV12 中脘), Gwan-won(CV4 關元), Yang-mun(ST21 梁門), Chun-chu(ST25 天樞), Su-do(ST28 氷道) between the patients group and the control group, the temparature deviation of Chon-jung(CV17 ) and Chung-wan(CV12 中脘), Chon-jung(CV17 ) and Yang-mun(ST21 梁門) was significant. We suggest that coldness of upper abdomen is significant in diagnosis of Dam Hun(痰暈).