실내 위치 측위를 통한 D2D 통신 성공 확률 (Opportunity Probability) 측정 및 예측

한규원(Kyuwon Han),남혜린(Hyelin Nam),박지훈(Jihoon Park),성명훈(Meonghoon Seong),김성륜(Seong-Lyun Kim) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2

본 논문에서는 실내 측위를 진행하고, 그 결과를 바탕으로 D2D 통신 성공 확률인 Opportunity probability (OP)를 예측 및 측정하여 그 값을 비교하는 실험을 소개한다. 실내 측위를 위해서 스마트폰의 관성 측위 센서와 이를 보정하기 위한 딥러닝 네트워크, 그리고 WiFi RTT를 융합한 측위 기법이 사용되었다. 그 결과 OP값을 중위값 90% 이상으로 예측하는 데 성공하였다.

천궁의 혈액순환과 항산화적 효과

박영철,이선동,허용,김현수,이인선,Park Yeong-Chul,Lee Sun-Dong,Heo Yong,Kim Hyun-Soo,Lee In-Seon 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

Ligusticum Chuanxiong and its components were reviewed in terms of pharmacodynamic mechanisms. Three components of about 40 chemical components in Chuanxiong tetramethylpyrazine, ferulinolol and Butylidenephthalide have mainly been studied for its pharmacodynamic mechanisms which are focused on the increase in blood flow and anti-oxidative stress. The mechanisms for the effects of Chuanxiong on the increase in blood flow can be summarized as four ways, 1) anti-coagulation 2) blocker of ${\beta}1$ adrenergic receptor 3) cellular control of Ca++ level 4) collagen synthesis. Chuanxiong also showed the effectiveness on free radical-induced injury. It seems that its effectiveness is also related to the mechanisms for the increase in blood flow.

한약의 안전성 등급화를 위한 evidence-based approach : Human equivalent dose-based the margin of safety

박영철,이선동,Park, Yeong-Chul,Lee, Sundong 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.3

This study was aimed to develop a new formula for herbal medicine-safety classification in terms of evidence-based medicine. Recently, human equivalent dose(HED)-based therapeutic index was developed for herbal medicine-safety classification by transforming $LD_{50}$ to HED. However, the use of the $ED_{50}$ and $LD_{50}$ to derive the therapeutic index may be misleading as to safety, depending on the slope of the dose-response curves for therapeutic and lethal effects. To overcome this deficiency, HED-based MOS(Margin of Safety)was developed and suggested in this study. The HED-based MOS developed by using $LD_1$, changing to ALD(approximate lethal dose), and $ED_{99}$. The HED-based MOS seems to be more useful and safer than HED-based therapeutic index since its values for several herbal medicines are basically two times less than the values from HED-based therapeutic index. Thus, HED-based MOS can be a good example of Evidence-based approach for herbal medicine-safety classification.

A phase 1/2a, dose-escalation, safety and preliminary efficacy study of oral therapeutic vaccine in subjects with cervical intraepithelial neoplasia 3

박영철,오영택,MOON-HEE SUNG,Hong-Gyu Park,김태진,조치흠,박종섭,이재관 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6

Objective: Persistent infection of HPV increases the chance of carcinoma in situ of cervixthrough stages of cervical intraepithelial neoplasia (CIN) 1, 2, and 3, and finally progressesinto cervical cancer. We aimed to explore the safety and efficacy of BLS-M07 which is orallyadministered agent expressing human papillomavirus (HPV) 16 E7 antigen on the surface ofLactobacillus casei in patients with CIN 3. Methods: Patients with CIN 3 were recruited in our clinical trial. Reid Colposcopic Index(RCI) grading and serum HPV16 E7 specific antibody production were used to evaluateefficacy of BLS-M07. In phase 1, BLS-M07 was administered orally, 5 times a week, on weeks1, 2, 4, and 8 with dosages of 500 mg, 1,000 mg, and 1,500 mg. In phase 2a, patients weretreated with 1,000 mg. The primary endpoints were the safety and the pathologic regressionon colposcopic biopsy. Results: Nineteen patients were enrolled in the CIN 3 cohort. In phase 1, no patientsexperienced dose limiting toxicity. No grade 3 or 4 treatment-related adverse events or deathswere observed. At 16 weeks after treatment, RCI grading was improved and serum HPV16E7 specific antibody production increased (p<0.05). Six of 8 (75%) patients with CIN 3 werecured in phase 2a. Conclusions: Oral immunization with BLS-M07 increases production of serum HPV16 E7specific antibody which induces protective humoral immunity. The safety of this oral vaccinewas proved and could be a competitive non-surgical therapeutic agent of CIN 3. Trial Registration: ClinicalTrials.gov Identifier: NCT02195089

도서관인의 명암(明暗) - 독서명문대학을 꿈꾸는 숭실대학교 독서인재프로그램

박영철,Park, Yeong-Cheol 한국도서관협회 2012 圖協會報 Vol.53 No.7

식이요법으로 위염치료를

박영철,Park, Yeong-Cheol 한국건강관리협회 1989 건강소식 Vol.13 No.1

숙지황(Rehmannia glutinosa)의 약리작용과 독성

박영철,이기용,백낙민,손혜영,국윤범,이선동,Park, Yeong-Chul,Lee, Gi-Yong,Baek, Lag-Min,Son, Hye-Young,Kook, Yoon-Boom,Lee, Sun-Dong 대한한의학방제학회 2011 大韓韓醫學方劑學會誌 Vol.19 No.1

Objectives : Rehmannia glutinosa has been used extensively in Korean traditional medicine. Although thorough clinical trials are lacking, Various pharmacological actions for Rehmannia glutinosa has been identified newly using animal models. In addition, it was reported that reactive intermediates, potentially causing toxic effects, was isolated from one of components in Rehmannia glutinosa. In this article, it is purposed for explanation and introduction of new studies for Rehmannia glutinosa in terms of pharmacological action and toxicology. Methods : New studies for Rehmannia glutinosa were reviewed and summarized in terms of pharmacological action and toxicity. Results and Conclusions : Rhmannia glutinosa and its components including iridoids, saccharides, as well as amino acid, showed a variety of pharmacological actions on the blood system, immune system, endocrine system, cardiovascular system and the nervous system. In addition, it was identified that aucubin, one of major components of Rhmannia glutinosa was biotransformed to reactive intermediates by ${\beta}$-glycosidase and acid-hydrolysis, resulting in forming aucubigenin- albumin adduct. Even if a lot of new pharmacological actions has been identified, it should be considered for Rhmannia glutinosa to contain the material producing reactive intermediates which may induce the side effects.

한약의 독물동태학적 특성

박영철,신헌태,이선동,Park, Yeong-Chul,Shin, Heon-Tae,Lee, Sun-Dong 대한예방한의학회 2011 대한예방한의학회지 Vol.15 No.2

Toxicokinetics of Korean Traditional Medicines(TKM) is the description of what rate TKM will enter the body and what happens to it once it is in the body in terms of toxicology. However, it is not easy to understand TKM toxicokinetics because of various factors such as a mixture of 2-30 kinds of herbal materials containing thousands of chemicals, and complex chemical properties. For these reasons, little is known about toxicokinetics of TKM. This study was aimed to characterize and review the absorption, distribution and metabolism of korean traditional medicines in a view of toxicokinetics. For this aim, some of korean traditional medicines were reviewed on a basis of drug-drug interaction, biotransformation and intestinal metabolisms by bacteria. As the factors affecting mainly on toxicokinetics of TKM, individual herbal material's degree of lipophilicity and metabolic rate, and decoction components according to different kinds of herbal materials were considered. Other factors such as intestinal pH and bacterial activity for metabolism affecting on TKM toxicokinetics, especially in small intestine. It would be a better way for improving the adverse or poor effects caused by TCM if the factors affecting on toxicokinetics of TKM is considered.

건축분야 임대형 민자사업 협상단계 쟁점 분석에 관한 연구

박영철,이건,이현철,고성석,Park, Yeong-Cheol,Lee, Gun,Lee, Hyun-Chul,Go, Seong-Seok 한국건설관리학회 2009 한국건설관리학회 논문집 Vol.10 No.5

본 연구는 BTL사업 실시협약을 위한 협상단계에서의 쟁점이 되는 항목의 분석 및 그 발생 원인을 찾아보고 해결방안을 제시하고자 하였다. 이에 기 수행되었거나 또는 수행중인 협상에서 논의되고 쟁점화 되는 항목에 관하여 주무관청과 사업참여자를 대상으로 협상참여 주체들이 인식하고 있는 쟁점화정도를 분석하였다. 또한 협상단계 각 분야별 쟁점항목들의 계층 분석방법을 통한 쌍대비교를 통해 가중치를 산정하고 그 쟁점화정도를 정량적으로 도출하였다. 최종적으로 1차 계층의 6개 협상분야 중 4개 분야에 대한 발생원인 각 2개, 2개 분야에 대한 발생원인 각 1개를 도출한 후 그에 대한 해결방안을 제시하였다. This study aimed to find major issues on negotiations of the BTL project, to analysis the degree, and to investigate the underlying cause and propose solutions. Data were collected from authorities in charge and the companies which have participated in BTL projects. Also, the weights of major issues were analyzed using Analytic Hierarchy Process method(AHP), which uses pair-wise comparison between variables, and the degree of them were listed in the quantitative way. As a result, 4 part had each 2 reasons and others had one reason among 6 negotiation parts of first step. In addition, the solutions were indicated.

한약재의 대사 및 독성의 기전과 예방

박영철,김종봉,이선동,Park, Yeong-Chul,Kim, Jong-Bong,Lee, Sun-Dong 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.1

In recent years, there has been a globally increasing application of herbal medicines and dietary supplements to treat various chronic diseases and to promote health. However, there are increasing clinical reports on the organ toxicities associated with consumption of herbal medicines. In general, most xenobiotics are metabolized by Phase I reaction(the main enzyme : cytochrome P450) and Phase II reaction. However, reactive oxygen species, free radicals and electrophils are produced inevitably during xenobiotics metabolism. These toxic species and metabolites are increased whenever the endogenous substances and enzymes for Phase II reaction not available. In addition, herbal-drug interactions are pharmacokinetic, with most actually or theoretically affecting the metabolism of the affected product by way of the cytochrome P450 enzymes. This review updated the knowledge on metabolic activation of herbal components and its clinical and toxicological implications. Also, the possible way for preventing the side-effects by herbal-medicine use was suggested.