Information Security in the Age of Algorithms

Fei Yang(Fei Yang),Xuan Luo(Xuan Luo) 아시아사회과학학회 2023 Jornal of Asia Social Science Vol.10 No.1

Algorithms are now widely used in all areas of social life, building a new social picture and reality. As a technology based on big data modelling and analysis, algorithms are embedded in all aspects of information production and distribution by means of technology, and become an important force in the construction of information environment. Under the algorithmic logic of information dissemination, the visible and invisible are in fact influenced by the algorithm as an authoritative mediator and mediator. From Daniel Dayan's 'visibility' perspective, this paper examines the risks posed by algorithms in three areas: the risk of passive disclosure of personal privacy, the use and control of personal data by profit-seeking algorithms, and the polarisation of information cocoons and circles. The information security risk brought by algorithms is attempted to be tackled and improved from several aspects, such as constructing a 'trinity' information security strategy system; adhering to the mainstream value orientation and highlighting the rational balance of “tool-value” of algorithms; and bringing into play multiple mechanisms together with effects.

A DISTRIBUTED OPTICAL FIBER SENSOR FOR MONITORING STRUCTURAL INTEGRITY

Luo Fei,Tao Jie,박동창,김광수 한국항공우주학회 1995 한국항공우주학회 학술발표회 논문집 Vol.- No.-

RNAi-Mediated Gene Silencing of Trcot1 Induces a Hyperbranching Phenotype in Trichoderma reesei

Fei Gao,Mengzhu Li,Weiquan Liu,Yingguo Bai,Tu Tao,Yuan Wang,Jie Zhang,Huiying Luo,Bin Yao,Huoqing Huang,Xiaoyun Su 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.2

Trichoderma reesei is the major filamentous fungus used to produce cellulase and there is huge interest in promoting its ability to produce higher titers of cellulase. Among the many factors affecting cellulase production in T. reesei, the mycelial phenotype is important but seldom studied. Herein, a close homolog of the Neurospora crassa COT1 kinase was discovered in T. reesei and designated TrCOT1, which is of 83.3% amino acid sequence identity. Functional disruption of Trcot1 in T. reesei by RNAi-mediated gene silencing resulted in retarded sporulation on potato dextrose agar and dwarfed colonies on minimal medium agar plates containing glucose, xylan, lactose, xylose, or glycerol as the sole carbon source. The representative mutant strain, SUS2/Trcot1i, also displayed reduced mycelia accumulation but hyperbranching in the MM glucose liquid medium, with hyphal growth unit length values decreased to 73.0 μm/tip compared to 239.8 μm/tip for the parent strain SUS2. The hyperbranching phenotype led to slightly but significantly increased cellulase secretion from 24 to 72 h in a batch culture. However, the cellulase production per unit of mycelial biomass was much more profoundly improved from 24 to 96 h.

Deregulated Expression of Cry1 and Cry2 in Human Gliomas

Luo, Yong,Wang, Fan,Chen, Lv-An,Chen, Xiao-Wei,Chen, Zhi-Jun,Liu, Ping-Fei,Li, Fen-Fen,Li, Cai-Yan,Liang, Wu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Growing evidence shows that deregulation of the circadian clock plays an important role in the development of malignant tumors, including gliomas. However, the molecular mechanisms of gene chnages controlling circadian rhythm in glioma cells have not been explored. Using real time polymerase chain reaction and immunohistochemistry techniques, we examined the expression of two important clock genes, cry1 and cry2, in 69 gliomas. In this study, out of 69 gliomas, 38 were cry1-positive, and 51 were cry2-positive. The expression levels of cry1 and cry2 in glioma cells were significantly different from the surrounding non-glioma cells (P<0.01). The difference in the expression rate of cry1 and cry 2 in high-grade (grade III and IV) and low-grade (grade 1 and II) gliomas was non-significant (P>0.05) but there was a difference in the intensity of immunoactivity for cry 2 between high-grade gliomas and low-grade gliomas (r=-0.384, P=0.021). In this study, we found that the expression of cry1 and cry2 in glioma cells was much lower than in the surrounding non-glioma cells. Therefore, we suggest that disturbances in cry1 and cry2 expression may result in the disruption of the control of normal circadian rhythm, thus benefiting the survival of glioma cells. Differential expression of circadian clock genes in glioma and non-glioma cells may provide a molecular basis for the chemotherapy of gliomas.

Characterization of the TAK1 gene in Apis cerana cerana (AccTAK1) and its involvement in the regulation of tissue-specific development

( Fei Meng ),( Ming Jiang Kang ),( Li Liu ),( Lu Luo ),( Bao Hua Xu ),( Xing Qi Guo ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.3

TGF-β activated kinase-1 (TAK1) plays a pivotal role in developmental processes in many species. Previous research has mainly focused on the function of TAK1 in model organisms, and little is known about the function of TAK1 in hymenoptera insects. Here, we isolated and characterized the TAK1 gene from Apis cerana cerana. Promoter analysis of AccTAK1 revealed the presence of transcription factor binding sites related to early development. Real-time quantitative PCR and immunohistochemistry experiments revealed that AccTAK1 was expressed at high levels in fourth instar larvae, primarily in the abdomen, in the intestinal wall cells of the midgut and in the secretory cells of the salivary glands. In addition, AccTAK1 expression in fourth instar larvae could be dramatically induced by treatment with pesticides and organic solvents. These observations suggest that AccTAK1 may be involved in the regulation of early development in the larval salivary gland and midgut. [BMB reports 2011; 44(3): 187-192]

Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis

Luo Kui,Wang Zhifei,Zhuang Kai,Yuan Shishan,Liu Fei,Liu Aihua 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Increased focus has been placed on the role of histone deacetylase inhibitors as crucial players in subarachnoid hemorrhage (SAH) progression. Therefore, this study was designed to expand the understanding of SAH by exploring the downstream mechanism of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in SAH. The expression of TDP-43 in patients with SAH and rat models of SAH was measured. Then, western blot analysis, immunofluorescence staining, and transmission electron microscope were used to investigate the in vitro effect of TDP-43 on a neuronal cell model of SAH established by oxyhemoglobin treatment. Immunofluorescence staining and coimmunoprecipitation assays were conducted to explore the relationship among histone deacetylase 1 (HDAC1), heat shock protein 70 (HSP70), and TDP-43. Furthermore, the in vivo effect of HDAC1 on SAH was investigated in rat models of SAH established by endovascular perforation. High expression of TDP-43 in the cerebrospinal fluid of patients with SAH and brain tissues of rat models of SAH was observed, and TDP-43 accumulation in the cytoplasm and the formation of inclusion bodies were responsible for axonal damage, abnormal nuclear membrane morphology, and apoptosis in neurons. TDP-43 degradation was promoted by the HDAC1 inhibitor SAHA via the acetylation of HSP70, alleviating SAH, and this effect was verified in vivo in rat models. In conclusion, SAHA relieved axonal damage and neurological dysfunction after SAH via the HSP70 acetylation-induced degradation of TDP-43, highlighting a novel therapeutic target for SAH.

Fabric Defect Detection Using Adaptively Tuned Gabor Filters

Luo Jie,Hu Quan,Bi Mingde,Ao Fei 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.8

A new fabric defect detection algorithm base on Gabor filters is proposed. The spectral characteristics of both fabric texture and defects are analyzed. Gabor wavelet which can be considered as a bank of Gabor filters are used for the decomposition of fabric image. Based on spectral characteristics of fabric texture and defects, a new tuning method of Gabor wavelet is proposed to enhance the energy of defective region and attenuate the energy of normal texture. Decomposition images from different scales and orientations are fused into a single one to emphasize the presence of different kinds of defects. For comparison, the performance of proposed method as well as other two other defect detection methods using Gabor filters is evaluated with typical fabric defect samples. The experiment results obtained indicate that the proposed method is more effective than the other two.

A study of multi-layer multi-pass laser depositing with 316L stainless steel wire

Fei Yan,Yuanqing Luo,Chunming Wang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.4

In this article, laser metal-wire depositing was conducted on 316 L stainless steel. Microstructures and mechanical properties of deposited samples were carefully studied employing an optical microscope (OM), scanning electron microscope (SEM) and other methodologies. A well-formed product was successfully acquired by means of process optimization including multi-layer single-pass and single-layer multi-pass laser deposition. The structures of multi-layer multi-pass deposited samples exhibited the characteristics of epitaxial column growth. The resulting ferrite at grain boundaries (GBs) revealed a subgrain structure. The brand structures between adjacent layers were composed of tiny cellular and columnar grains, meaning unexpected metallurgical bonding. The average hardness was 222 HV and no much fluctuation occurred in tested samples. The maximum tensile strength and elongation of deposited samples reached 110 % and 140 % of rolled samples, respectively. The uniformlydistributed dimples at the fracture proved that laser depositing product had good plasticity and ductility.

Inferring Single Nucleotide Polymorphisms in MicroRNA Binding Sites of Lung Cancer-related Inflammatory Genes

He, Fei,Zheng, Ling-Ling,Luo, Wen-Ting,Yang, Rong,Xu, Xiao-Qin,Cai, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Single nucleotide polymorphisms located at microRNA (miRNA)-binding sites are likely to affect the expression of miRNA targets and may contribute to the susceptibility of humans to common diseases. Here 335 candidate lung cancer-related inflammatory genes were selected according to the existing literature and database. We identified putative miRNA-binding sites of 149 genes by specialised algorithms and screened SNPs in the 3'UTRs of these genes. By calculating binding free energy, we sorted 269 SNPs on the basis of the possibility of prediction. The proposed approach could help to easy the identification of functionally relevant SNPs and minimize the workflow and the costs.

Genome-Wide Association Analysis to Search for New Loci Associated with Lifelong Premature Ejaculation Risk in Chinese Male Han Population

Wang Fei,Luo Defan,Chen Jianxiang,Pan Cuiqing,Wang Zhongyao,Fu Housheng,Xu Jianbing,Yang Meng,Mo Shaowei,Zhuang Liying,Ye Liefu,Wang Weifu 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.2

Purpose: Genetic factors play an indispensable role in the pathogenesis of lifelong premature ejaculation (LPE). The suscep-tibility genes/SNPs that have been discovered are very limited and can only explain part of the genetic effects of LPE. There-fore, discovering more genetic polymorphisms associated with the occurrence and development of LPE will help reveal the pathogenesis of LPE. Materials Materials and and Methods:Methods: We conducted a genome-wide association study of LPE in 486 Chinese male Han people (cases and controls). We used Gene Titan multi-channel instrument and Axiom Analysis Suite 6.0 software for genotyping. Imputation was performed by IMPUTE2 software and the 1000 Genomes Project (Phase3) was used as reference for haplotype. Finally, logistic regression analysis was performed on all loci that passed the quality control. The odds ratio and 95% confidence in-terval were calculated to determine the association between each SNPs and Chinese male Han population LPE risk. Results:Results: The results showed that a total of 33 genetic variants in 13 genes (LACTBL1 , SSBP3 , ACOT11 , LINC02486 , TMEM154, LINC01098, NONE, HCG27, HLA-C, TNFSF8, TNC, FAM53B, SULF2) have a suggestively significant genome-wide association with LPE risk (p<5×10-6). Conclusions:Conclusions: This study is the first to conduct a GWAS on LPE in Chinese male Han population 33 genetic polymorphisms have a suggestive genome-wide association with LPE risk. This study have provided data supplement for the genetic loci of LPE risk, and laid a scientific foundation for the pathogenesis and the targeted therapy of LPE.