Can Opinion Leader Influences the Purchase Intension of Online Consumer

Fei Meng,Jianliang Wei 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.1

With the role which opinion leader plays in e-WOM(word of mouth) generation and communication comes more and more important, its influence on online consumer purchase intension become a hot issue for industry and academics. Based on the concept model constructed and scale designed in our previous studies, a questionnaire is used in this paper for data collection. Then, structural equation model is adopted for fitting and path analysis, and found that: In all 14 hypotheses, 9 of them have significant positive correlation, which verified that variants including professional knowledge, product involvement, interactive, functional value, emotional value influence purchase intension virtually via trust. And at the same time, professional, product involvement and visual clue impact purchase intension directly. Moreover, homophily has positive moderating effect on correlation between professional knowledge and purchase intension, as well as in the relationship of product involvement and purchase intension.

ACOX1 destabilizes p73 to suppress intrinsic apoptosis pathway and regulates sensitivity to doxorubicin in lymphoma cells

( Fei-meng Zheng ),( Wang-bing Chen ),( Tao Qin ),( Li-na Lv ),( Bi Feng ),( Yan-ling Lu ),( Zuo-quan Li ),( Xiao-chao Wang ),( Li-ju Tao ),( Hong-wen Li ),( Shu-you Li ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.9

Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid β-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. Currently, there is no information about the function of ACOX1 in lymphoma. In this study, we found that upregulation of ACOX1 promoted proliferation in lymphoma cells, while downregulation of ACOX1 inhibited proliferation and induced apoptosis. Additionally, overexpression of ACOX1 increased resistance to doxorubicin, while suppression of ACOX1 expression markedly potentiated doxorubicin-induced apoptosis. Interestingly, downregulation of ACOX1 promoted mitochondrial location of Bad, reduced mitochondrial membrane potential and provoked apoptosis by activating caspase-9 and caspase-3 related apoptotic pathway. Overexpression of ACOX1 alleviated doxorubicin-induced activation of caspase-9 and caspase-3 and decrease of mitochondrial membrane potential. Importantly, downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. Also, overexpression of ACOX1 significantly reduced stability of p73 protein thereby reducing p73 expression. Thus, our study indicated that suppression of ACOX1 could be a novel and effective approach for treatment of lymphoma. [BMB Reports 2019; 52(9): 566-571]

Characterization of the TAK1 gene in Apis cerana cerana (AccTAK1) and its involvement in the regulation of tissue-specific development

( Fei Meng ),( Ming Jiang Kang ),( Li Liu ),( Lu Luo ),( Bao Hua Xu ),( Xing Qi Guo ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.3

TGF-β activated kinase-1 (TAK1) plays a pivotal role in developmental processes in many species. Previous research has mainly focused on the function of TAK1 in model organisms, and little is known about the function of TAK1 in hymenoptera insects. Here, we isolated and characterized the TAK1 gene from Apis cerana cerana. Promoter analysis of AccTAK1 revealed the presence of transcription factor binding sites related to early development. Real-time quantitative PCR and immunohistochemistry experiments revealed that AccTAK1 was expressed at high levels in fourth instar larvae, primarily in the abdomen, in the intestinal wall cells of the midgut and in the secretory cells of the salivary glands. In addition, AccTAK1 expression in fourth instar larvae could be dramatically induced by treatment with pesticides and organic solvents. These observations suggest that AccTAK1 may be involved in the regulation of early development in the larval salivary gland and midgut. [BMB reports 2011; 44(3): 187-192]

중국 자동차 산업의 역물류 네트워크 최적화에 관한 연구

남몽비(Meng-fei Nan),최요(Yao Cui),장몽택(Meng-ze Zhang) 한국물류학회 2023 물류학회지 Vol.33 No.3

Analysis of delay compensation in real-time dynamic hybrid testing with large integration time-step

Fei Zhu,Jin-Ting Wang,Feng Jin,Yao Gui,Meng-Xia Zhou 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.14 No.6

With the sub-stepping technique, the numerical analysis in real-time dynamic hybrid testing is split into the response analysis and signal generation tasks. Two target computers that operate in real-time may be assigned to implement these two tasks, respectively, for fully extending the simulation scale of the numerical substructure. In this case, the integration time-step of solving the dynamic response of the numerical substructure can be dozens of times bigger than the sampling time-step of the controller. The time delay between the real and desired feedback forces becomes more striking, which challenges the well-developed delay compensation methods in real-time dynamic hybrid testing. This paper focuses on displacement prediction and force correction for delay compensation in the real-time dynamic hybrid testing with a large integration time-step. A new displacement prediction scheme is proposed based on recently-developed explicit integration algorithms and compared with several commonly-used prediction procedures. The evaluation of its prediction accuracy is carried out theoretically, numerically and experimentally. Results indicate that the accuracy and effectiveness of the proposed prediction method are of significance.

Accuracy analysis of spatial multi-loop mechanism effected by paired bearings support joint clearance

Fei Lin,Chuanzhi Chen,Jinbao Chen,Meng Chen 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.3

The primary objective of this work is to present a three-dimensional (3D) clearance model of the paired bearings support joint (PBS-joint) and address the influence of PBSjoint clearance on the accuracy of the spatial multi-loop mechanism. Through the synthetic use of the vector and homogeneous coordinate transformation methods, the 3D clearance model of the PBS-joint is obtained on the basis of the static balance condition. When clearance is equated as a spatial virtual link, the error space solution models of serial mechanism and single-loop mechanism are developed respectively according to the Denavit-Hartenberg method and the geometric closure condition. The error space standardization solution model of the multi-loop mechanism is then presented through improving the low-layer loop sequence description method of the topological structure relations. Finally, the application in the basic loop mechanism is demonstrated to discuss the procedures adopted in this work and the influence of the PBS-joint clearance. Results show that the PBS-joint clearance may cause the error on the point with a 3D deviation transmission path to deviate the normal distribution. Moreover, the plane-joint clearance model may not yield an accurate analysis of the spatial mechanism.

Effects of Allogeneic Blood Transfusion in Patients with Stage II Colon Cancer

Meng, Jin,Lu, Xiao-Bo,Tang, Yuan-Xin,Sun, Gong-Ping,Li, Xin,Yan, Yi-Fei,Liang, Gao-Feng,Ma, Si-Ping,Li, Xiao-Xia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

The aim of the present study was to determine whether allogeneic red blood cell transfusions showed a deleterious effect and what might be preoperative risk factors for blood transfusion in patients with TNM stage II colon cancer. Total 470 patients who fulfilled inclusion criteria were selected for a further 10-year follow-up study. We found that there were statistical significance between non-transfused and transfused group in mortality (P=0.018), local recurrence (P=0.000) and distant metastasis (P=0.040). Local recurrence and distant metastasis between 1 to 3 units and more than 3 units group did not show any significant differences. There was no difference in survival rate between non-transfused and 1 to 3 units group (log rank=0.031, P=0.860). The difference between different blood transfusion volume in transfused patients was found (78.77% vs 63.83%, P=0.006). Meanwhile, the significant difference of survival rate was existed between non-transfused group and more than 3 units group (84.83% vs 63.83%, P=0.002 ). Univariate analysis showed the following 3 variables to be associated with an increased risk of allogeneic blood transfusions: preoperative CEA level (P<0.05), location of tumor (P<0.01) and diameter of tumor (P<0.01). Multivariate analysis revealed that location of tumor and diameter of tumor are two independent factors for requirement of perioperative transfusions. Therefore, allogeneic transfusion increase the postoperative tumor mortality, local recurrence and distant metastasis in patients with stage II colon cancer. The postoperative tumor mortality, local recurrence and distant metastasis were not associated with the blood transfusion volume. The blood transfusion volume was associated with the survival rate. Location of tumor and diameter of tumor were the independent preoperative risk factors for blood transfusion.

An Energy-Efficient Mobility-Supporting MAC Protocol in Wireless Sensor Networks

Fei Peng,Meng Cui 한국통신학회 2015 Journal of communications and networks Vol.17 No.2

Although mobile applications are an essential characteristic of wireless sensor networks, most existing media access control (MAC) protocols focus primarily on static networks. In these protocols, fixed periodic neighbor discovery and schedule updating are used to connect and synchronize neighbors to provide successful data transmission; however, they cannot adapt to mobile speed variation and degrade the network performance dramatically. In this paper, we propose a mobile-supporting mechanism for MAC protocols, in which the decision to update the neighbors of a mobile node is made adaptively according to the mobile speed. Analysis and simulation results demonstrate that the mechanism efficiently avoids the disconnection of amobile node fromits neighbors and achieves a better performance as compared with fixed periodic neighbor discovery.

Neurotrophic Artemin Promotes Motility and Invasiveness of MIA PaCa-2 Pancreatic Cancer Cells

Meng, Ling-Xin,Chi, Yu-Hua,Wang, Xiang-Xu,Ding, Zhao-Jun,Fei, Li-Cong,Zhang, Hong,Mou, Ling,Cui, Wen,Xue, Ying-Jie Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Objective: To analyze the capacity of neurotrophic artemin to promote the motility and invasiveness of MIA PaCa-2 pancreatic cancer cells. Methods: MIA PaCa-2 was cultured in vitro and studied using transwell chambers for motility and invasiveness on treatment with different concentrations of aArtemin or its receptor $GFR{\alpha}3$ were also determined. Expression of matrix metalloproteinase-2 (MMP-2) and epithelial cadherin (E-cadherin) was quantified using RT-PCR and Western blotting. Results: MIA PaCa-2 pancreatic cancer cell motility and invasiveness was significantly increased with artemin and its receptor $GFR{\alpha}3$ with dose dependence (P<0.01). MMP-2 production was also significantly increased (t = 6.35, t = 7.32), while E-cadherin was significantly lowered (t = 4.27, t = 5.61) (P <0.01). Conclusion: Artemin and its receptor $GFR{\alpha}3$ can promote pancreatic cancer cell motility and invasiveness and contribute to aggressive behavior. The mechanism may be related to increased expression of MMP-2 molecule and down-regulation of E-cadherin expression.

A Hierarchical Single-Surface Model for an Unsaturated Soil-Structure Interface

Fei Peng,Xin Li,Meng-fan Lv,Yong-Hui Li,Yuan-Cheng Guo 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.6

In this paper, according to the shear test of the interface between unsaturated soil and steel plate, the modified apparent roughness is used to describe interface roughness. And considering the influence of matrix suction and interface roughness, the stress variable is constructed to improve the yield and plastic potential functions. Then a modified hierarchical single-surface elastoplastic interface constitutive model (HISS-Unsaturated-Int model) is set up. The finite element calculation of HISS-Unsaturated-Int model is achieved by compiling and calling the user subroutine FRIC of ABAQUS. The interface shear test between unsaturated soil and structure with different water contents and the pull-out shear test between unsaturated soil and soil nail are simulated. The calculation results are consistent with those of experiments, which shows the modified interface constitutive model can effectively predict the shear mechanical properties of soil-structure interface under different soil moisture content, normal stress and interface roughness.