관상동맥질환 환자에서 척수마취로 시행한 요추의 척추 추간판 절제술 : 증례보고 A case report

김유경,양홍석,임정길,이청,신진우 대한정맥마취학회 2003 정맥마취 Vol.7 No.4

Study on Female Consciousness of Jin Renshun`s Short Stories

김염 ( Jin Yan ) 한국중국어문학회 2014 中國文學 Vol.81 No.-

김인순은 “70년대에 출생한 작가” 중 “절제미”의 서사에 능한 대표적인 여류작가이다. 70년대 생의 다른 여류작가들과는 달리, 그녀의 소설은 여성의 신체를 통한 욕망의 관능적 표출을 절제하였다. 그녀의 소설은 현대사회에서 남성중심주의와 직접적인 충돌, 저항 대신 `가면`을 쓰고 자신의 욕망을 간접적으로 표출하는 여성상을 그리는 데 집중하였고, 전통적인 가부장제 사회의 폐단을 가장 잘 보여주는 조선시대를 배경으로 하는 고전적인 텍스트에 대한 재구성을 통하여 가부장제의 억압에 반항하는 도발적인 여성상을 표출하였다. 남성들은 거의 다 무기력한 형상으로 등장하며 집단적인 “거세” 양상을 보이고 있다. Jin Renshun is a representative female writer skilled in restrained narration from the group of “writers born in 1970s”. Unlike other female writers in the same group, she refrains herself from exposing women`s figures to express the desire. Her works tend to shape the images of women who masquerade themselves while satisfying their desires to avoid direct conflicts with male-controled system in modern society, or, build images of women who directly resist tyranny of patriarchy system by reconstructing classical texts of the Joseon Dynasty period which reflect the malady of traditional patriarchy society. Almost all the male characters show powerlessness and “castration” in her works.

Understanding and Leading Through Crises: The Contingency Theory and Beyond

Yan Jin,Wenqing Zhao Korean Academic Society For Public Relations 2023 Asian Journal of Public Relations Vol.6 No.1

Based on the essentials of the Korean Academic Society for Public Relations (KASPR) 2022 Distinguished Lecture given by Dr. Glen T. Cameron and Dr. Yan Jin, this conceptual piece provides an overview of the contingency theory of strategic conflict management, its application to research, and future directions, with a focus on the theory-practice interconnections of the contingency theory in public relations across multiple contexts. How the contingency theory has been and can be further applied to advancing crisis communication and conflict management research and practice in Asia is further discussed.

Understanding and Leading Through Crises: The Contingency Theory and Beyond

( Yan Jin ),( Wenqing Zhao ) 한국PR학회 2023 AJPR Vol.6 No.1

Based on the essentials of the Korean Academic Society for Public Relations (KASPR) 2022 Distinguished Lecture given by Dr. Glen T. Cameron and Dr. Yan Jin, this conceptual piece provides an overview of the contingency theory of strategic conflict management, its application to research, and future directions, with a focus on the theory-practice interconnections of the contingency theory in public relations across multiple contexts. How the contingency theory has been and can be further applied to advancing crisis communication and conflict management research and practice in Asia is further discussed.

Potential Predictors of Sensitivity to Pemetrexed as First-line Chemotherapy for Patients with Advanced Non-Squamous NSCLCs

Lu, Yan-Yan,Huang, Xin-En,Xu, Lin,Liu, De-Gan,Cao, Jie,Wu, Xue-Yan,Liu, Jin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: Pemetrexed (PEM) is effective in first-line treatment for patients with non-squamous non-small cell lung cancer (NSCLC). However there are currently no definitive determinants to certify which patients could benefit from PEM. To improve the efficacy of PEM combined with platinum as first-line therapy for advanced non-squamous NSCLC, we conducted this retrospective study to detect potential determinants of this regimen. Methods: We recruited 109 patients with advanced non-squamous NSCLC who received PEM with a platinum as first-line therapy from June 2006 to February 2013 in Jiangsu Cancer Hospital. Multiple variables (age, sex, smoking, degree of cell differentiation, hemoglobin, platinum drugs combined, positions of metastasis) were selected. Logistic regression analysis was used to analyse relationships between these variables and tumor response. Result: In univariate analysis, we found that age and platinum significantly influenced the results of PEM therapy (P<0.05). In multivariable analysis, no factors were independently significant. Conclusion: Our analysis did not suggest that the age, sex, metastasis of liver or other organs, hemoglobin, smoking history and pathological differentiation are associated with the response of PEM. We should conduct further analyses with larger sample size to reconfirm this issue.

經典的解構予重構 - 龍賢重的 『白雪春香傳』予金仁順的『春香』 比較硏究 -

김염 ( Yan Jin ) 한국문학언어학회(구 경북어문학회) 2015 어문론총 Vol.63 No.-

한국의 문화원형으로 자리 잡은 “춘향 이야기”는 여러 가지 예술 형식으로 거듭 재탄생되고 있다. 소설 영역에서 이해조의 『옥중화』, 최남선의 『고본 춘향전』,이광수의 『일설 춘향전』, 안수길의 「이런 춘향」, 최인훈의 「춘향뎐」, 임철우의 「옥중가」, 김주영의 『외설 춘향전』에 이어 한국 신인작가 용현중의 장편소설 『백설춘향전』과 중국 조선족 작가 김인순의 『춘향』이 “춘양 이야기”의 현대적 변용에 가담하였다. 『백설춘향전』은 춘향 이야기와 백설 공주 이야기, 장옥정·최숙빈에 관한 궁중비화를 절묘하게 결합하여 춘향이 궁중 의녀로, 왕의 여인으로 거듭나는 새로운 이야기를 탄생시켰고 『춘향』은 신비롭고 환상적인 분위기 속에서 여인의 유토피아-향사에서 절대 권력을 행사하는 향부인과 속세에 물젖지 않은 춘향의 초월적인 삶을 그렸다. 두 작품은 각각 남성시각과 여성시각에 입각하여 춘향의 열녀 이미지를 벗기고 여성의식이 뚜렷한 정체성을 획득한 여성으로 재탄생 시킴과 동시에 이몽룡과 변학도의 인물성격 및 기능을 재구성하고 주변 인물들에 대한 재조명과 새로운 설정을 통해 이야기의 새로운 전개를 담보하였다. 두 작품은 한중 양국의 서로 다른 상상력과 미학적 추구를 바탕으로 『춘향전』에 대한 해체와 재구성을 통한 경전의 적극적인 생산적 수용을 실현하였다. The Chunhyang story which is the archetype of the Korean culture has been reproduced into various artistic forms. Speaking of the reproduction in the form of short stories and novels, there are Lee Hae-jo``s The flower in prison, Choi Nam-seon``s The ancient version of Chunhyangjeon, Lee Gwang-su``s One saying of Chunhyangjeon, Ann Su-gil``s Such a Chunhyang, Choi In-hun``s Chunhyangdyeon, Lym Cheol-u``s The song sung in prison, and Gim Ju-yeong``s Outside saying of Chunhyangjeon. Recently, a budding writer Yong Hyeon-jung``s The Snow White Chunhyang and Korean Chinese writer Jin Renshun``s Chunhyang have joined the process. The Snow White Chunhyang created a brand new story of a girl growing into a female doctor and the lover of the King, combining the Chunhyang story with the story of The Snow White and behind-the-scenes story of Jang Ok-jung and Choi Sukbin. Chunhyang portrayed the transcendent lives of Lady Xiang who has the super power and Chunhyang who is isolated from the secular society in the women``s Utopia mysteriously and fantasticly. The two works uncovered the virtuous image of Chunhyang,recreated the character into an independent woman who has a clear self-identification, reshaped the characteristics of Lee Mong-rong and Byeon Hak-tto, reviewed the outsiders and reorganized the function of them to create a new story from a male perspective and female one. The reproductive acceptance of the two works is based on different imagination and aesthetic pursuit of different cultures the authors belong to.

Phase II Study on Javanica Oil Emulsion Injection (Yadanzi^®) Combined with Chemotherapy in Treating Patients with Advanced Lung Adenocarcinoma

Lu, Yan-Yan,Huang, Xin-En,Cao, Jie,Xu, Xia,Wu, Xue-Yan,Liu, Jin,Xiang, Jin,Xu, Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Purpose: To investigate the efficacy and safety of Javanica oil emulsion injection (Yadanzi$^{(R)}$) combined with pemetrexed and platinum (PP) for treating patients with advanced lung cancer. Patients and Methods: From June 2011 to June 2013, we recruited 58 patients with advanced lung cancer, and divided them into two groups. Twenty eight patients received Yadanzi$^{(R)}$ (from ZheJiang Jiuxu Pharmaceutical Co., Ltd.) together with PP chemotherapy (combined group), while the others were given only PP chemotherapy (control group). After two cycles of treatment, efficacy and safety of treatment were evaluated. Results: The overall respnse rate [(CR+PR+SD)/(CR+PR+SD+PD)] of the combined group was higher than that of control group (89.7% vs. 86.2%, p>0.05). Regarding rate of life improvement, it was 82.8% in combined group, and 51.7% in the control group (p<0.05). In terms of side effects, leukopenia in combined group was less frequent than that in control group (p<0.05). More patients in the control group were found to suffer liver toxicity. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced lung adenocarcinoma. It can improve the quality of life and reduce the possibility of leukopenia. Further clinical trials with a large sample size should be conducted to confirm whether addition of Yadanzi$^{(R)}$ to chemotherapy could increase the response rate, reduce toxicity, enhance tolerability and improve quality of life for patients with advanced lung cancer.

Clinical Observations on Associations Between the UGT1A1 Genotype and Severe Toxicity of Irinotecan

Lu, Yan-Yan,Huang, Xin-En,Wu, Xue-Yan,Cao, Jie,Liu, Jin,Wang, Lin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: Severe toxicity is commonly observed in cancer patients receiving irinotecan (CPT-11) UDPglucuronosyltransferase1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38 but the relationship between UGT1A1 and severe toxicity remains unclear. Our study aimed to assess this point to guide clinical use of CPT-11. Materials and Methods: 89 cancer patients with advanced disease received CPT-11-based chemotherapy for at least two cycles. Toxicity, including GI and hematologic toxicity was recorded in detail and UGT1A1 variants were genotyped. Regression analysis was used to analyse relationships between these variables and tumor response. Results: The prevalence of grade III-IV diarrhea was 10.1%, this being more common in patients with the TA 6/7 genotype (5 of 22 patients, 22.7%) (p<0.05). The prevalence of grade III-IV neutropenia was 13.4%and also highest in patients with the TA 6/7 genotype (4 of 22 patients; 18.2%) but without significance (p>0.05). The retreatment total bilirubin levels were significantly higher in TA6/7 patients (mean, $12.75{\mu}mol/L$) with compared to TA6/6 (mean, $9.92{\mu}mol/L$) with p<0.05. Conclusions: Our study support the conclusion that patients with a $UGT1A1^*28$ allele (s) will suffer an increased risk of severe irinotecan-induced diarrhea, whether with mid-or low-dosage. However, the $UGT1A1^*28$ allele (s) did not increase severe neutropenia. Higher serum total bilirubin is an indication that patients UGT1A1 genotype is not wild-type, with significance for clinic usage of CPT-11.

Phase II Study on Safety and Efficacy of Yadanzi^® (Javanica oil emulsion injection) Combined with Chemotherapy for Patients with Gastric Cancer

Liu, Jin,Huang, Xin-En,Tian, Guang-Yu,Cao, Jie,Lu, Yan-Yan,Wu, Xue-Yan,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Objective: To investigate the efficacy and safety of Yadanzi$^{(R)}$ (Javanica oil emulsion injection) combined with chemotherapy for treatment of patients with advanced gastric cancer. Methods: From January 2011 to December 2012, we recruited 75 patients with advanced gastric cancer, who received javanica oil emulsion injection together with chemotherapy. After two cycles of treatment, efficacy and safety of the combined therapies were evaluated. Results: Overall response rate of 75 patients after treatment was 85.3% (CR+PR+SD). Treatment related side effects were recorded. No treatment related death occurred. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced gastric cancer. Further randomized clinical trials should be conducted to confirm whether the addition of Yadanzi$^{(R)}$ to chemotheraphy could be associated with reduced toxicity, enhanced tolerability and improved quality of life for patients with advanced gastric cancer.

L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

( Hai Yan Zhao ),( Hui Ying Li ),( Jian Jin ),( Ji Zhe Jin ),( Long Ye Zhang ),( Mei Ying Xuan ),( Xue Mei Jin ),( Yu Ji Jiang ),( Hai Lan Zheng ),( Ying Shun Jin ),( Yong Jie Jin ),( Bum Soon Choi ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0

Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on renal fibrosis. This study examined whether LC treatment would provide renoprotection in a rat model of unilateral ureteral obstruction (UUO) and in vitro. Methods: Sprague-Dawley rats that underwent UUO were treated daily with LC for 7 or 14 days. The influence of LC on renal injury caused by UUO was evaluated by histopathology, and analysis of gene expression, oxidative stress, mitochondrial function, programmed cell death, and phosphatidylinositol 3-kinase (PI3K)/ AKT/forkhead box protein O 1a (FoxO1a) signaling. In addition, H₂O₂-exposed human kidney cells (HK-2) were treated with LC. Results: LC treatment inhibited expression of proinflammatory and profibrotic cytokines, and was followed by a significant attenuation of tubulointerstitial inflammation and fibrosis. The increased oxidative stress caused by UUO was associated with mitochondrial dysfunction and excessive apoptosis and autophagy via PI3K/AKT/FoxO1a-dependent signaling, and this was abrogated by administration of LC. In H₂O₂-exposed HK-2 cells, LC decreased intracellular production of reactive oxygen species, and suppressed expression of profibrotic cytokines and reduced the number of apoptotic cells. Conclusions: LC protects against the progression of tubulointerstitial fibrosis in an obstructed kidney.