New Hanger Design Approach of Tied-Arch Bridge to Enhance Its Robustness

Wenqing Wu,Hao Wang,Yan-Jie Zhu,Jiangyu Yu,Hao Zhao,Hui Zhang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.11

As the crucial components among the tied-arch bridge, the local failure of hangers may trigger a progressive collapse through the entire tied-arch bridge. However, the current design guidance as regards hangers still lacks consideration of structure robustness under an extreme hazard. To improve the structural robustness of tied-arch bridge under extreme conditions, a new hanger design method is proposed, which is termed as asymmetric parallel double-hanger system. Based on Miner’s linear cumulative damage law, an analysis on the fatigue life of the double-hanger system was conducted to verify the feasibility of the proposal, and then a dynamic time-history analysis was employed to simulate the transitory fracture impact due to one or more hangers fracturing. According to the simulation results, the structural robustness is greatly enhanced with asymmetric parallel-double hanger system design, when compared with single hanger system design. When one or more hangers reveal local damage, it will not trigger a progress failure to the whole structure in particular. Several practical suggestions of bridge system’s load-carrying capacity are also put forward for the future arch bridge design at the end of this paper.

The effect of volume conservation based on nucleon scattering analysis for W isotopes

Du Wenqing,Zhao Xiuniao,Sun Weili,Soukhovitskiĩ E. Sh. 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.6

On the basis of soft-rotor model, a good description of nucleon scattering on tungsten and neighboring nuclei was achieved in J. Phys. G: Nucl. Part. Phys. 48, 075101 (2021), and the nuclear volume conservation condition was introduced. The effect of volume conservation on calculations for tungsten isotopes is further investigated by defining the ratio R for cross sections, scattering angular distributions and analyzing powers. The results show that the volume conservation effect cannot be ignored. This effect is more significant in the low-energy region of cross sections and at extrema of angular distributions. Comparison between the calculated results and existing nuclear data evaluations in different evaluated nuclear data libraries is shown.

SOX12 Promotes Thyroid Cancer Cell Proliferation and Invasion by Regulating the Expression of POU2F1 and POU3F1

Zhenxi Su,Wenqing Bao,Guanghua Yang,Jianping Liu,Bin Zhao 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.6

Purpose: SOX12 is overexpressed in many cancers, and we aimed to explore the biological function and mechanism of SOX12 inthyroid cancer. Materials and Methods: We first analyzed the expression of SOX12 in thyroid cancer using data in The Cancer Genome Atlas. Immunohistochemistryand qRT-PCR were performed to identify SOX12 expression in thyroid cancer tissue and cells. Thyroid cancercells were transfected with small interfering RNA targeting SOX12, and cellular functional experiments, including CCK8, woundhealing, and Transwell assays, were performed. Protein expression was examined by Western blot analysis. A xenograft model wasdeveloped to evaluate the effect of SOX12 on tumor growth in vivo. Results: SOX12 expression was increased in thyroid cancer tissue and cells. SOX12 promoted cell proliferation, migration, and invasionand accelerated tumor growth in vivo. The expression of PCNA, Cyclin D1, E-cadherin, Snail, MMP-2, and MMP-9 was affectedby SOX12 knockdown. Bioinformatic analysis showed that SOX12 could interact with the POU family. SOX12 knockdown inhibitedthe expression of POU2F1, POU2F2, POU3F1 and POU3F2, and SOX12 expression showed a positive correlation with POU2F1,POU3F1, and POU3F2 expression in clinical data. POU2F1 and POU3F1 were able to reverse the effect of SOX12 knockdown onthyroid cancer cells. Conclusion: SOX12 affects the progression of thyroid cancer by regulating epithelial-mesenchymal transition and interacting withPOU2F1 and POU3F1, which may be novel targets for thyroid cancer molecular therapy.

Understanding and Leading Through Crises: The Contingency Theory and Beyond

Yan Jin,Wenqing Zhao Korean Academic Society For Public Relations 2023 Asian Journal of Public Relations Vol.6 No.1

Based on the essentials of the Korean Academic Society for Public Relations (KASPR) 2022 Distinguished Lecture given by Dr. Glen T. Cameron and Dr. Yan Jin, this conceptual piece provides an overview of the contingency theory of strategic conflict management, its application to research, and future directions, with a focus on the theory-practice interconnections of the contingency theory in public relations across multiple contexts. How the contingency theory has been and can be further applied to advancing crisis communication and conflict management research and practice in Asia is further discussed.

Understanding and Leading Through Crises: The Contingency Theory and Beyond

( Yan Jin ),( Wenqing Zhao ) 한국PR학회 2023 AJPR Vol.6 No.1

Based on the essentials of the Korean Academic Society for Public Relations (KASPR) 2022 Distinguished Lecture given by Dr. Glen T. Cameron and Dr. Yan Jin, this conceptual piece provides an overview of the contingency theory of strategic conflict management, its application to research, and future directions, with a focus on the theory-practice interconnections of the contingency theory in public relations across multiple contexts. How the contingency theory has been and can be further applied to advancing crisis communication and conflict management research and practice in Asia is further discussed.

NOVEL HIERARCHICAL NANORODS OF SILICON-DOPED Bi2O2CO3 AND ITS PHOTOCATALYTIC ACTIVITY

Peng Sun,MINDONG CHEN,YUNXUAN ZHAO,JUAN XU,WENQING YAO,YONGFA ZHU,FEI TENG,YUJIAN JIN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.8

The silicon-doped Bi2O2CO3 nanorods with the interesting hierarchical structure are synthesized by a simple hydrothermal method. The samples are characterized by XRD, X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), high-resolution transmission electron microscopy (HRTEM), Ultraviolet-visible diffuse refectance spectra (UV-DRS) and nitrogen sorption isotherms. It is found that with the increase of silicon content, the XRD peak of the sample significantly shifts toward a low diffraction angle and the particle morphologies change from nanosheets, nanoflowers to hierarchical nanorods. Moreover, the silicon-doped Bi2O2CO3 hierarchical nanorods exhibit improved photocatalytic degradation activities for different types of dyes under simulated solar light irradiation. The improved activity has been mainly attributed to the unique hierarchical nanorods structure and the formation of Si–O–Bi bonds.

Down‑regulation expression of TGFB2‑AS1 inhibits the proliferation, migration, invasion and induces apoptosis in HepG2 cells

Wenrong Liu,Ruiping Huai,Yin Zhang,Shuquan Rao,Lili xiong,Ruofan Ding,Canquan Mao,Wenqing Zhao,Tao Hao,Qingqing Huang,Zhiyun Guo 한국유전학회 2019 Genes & Genomics Vol.41 No.8

Background Hepatocellular carcinoma (HCC) is the leading cause of cancer mortality and without effective prognosis. Previous study has been confirmed that the abnormal expression of long non-coding RNAs (lncRNAs) TGFB2-AS1 was involved in tumorigenesis. However, the biological functions of TGFB2-AS1 in hepatocellular carcinoma (HCC) remain largely unclear. Objective We comprehensively assess the clinical significance of TGFB2-AS1 and investigate the biological functions of TGFB2-AS1 on HCC HepG2 cells. Methods We firstly confirmed the expression of TGFB2-AS1 between tumor and normal tissues using public available transcriptome data. We analyzed the clinical significance of TGFB2-AS1 using the TCGA HCC datasets. The biological functions of TGFB2-AS1 on HCC HepG2 cells were explored by multiple in vitro assays. Results We found that TGFB2-AS1 was remarkably increased in HCC tissues (P = 0.00148) and exhibited a potential predictive marker for HCC, with an area under curve (AUC) of 0.708 (P = 0.0034) using the fifty pairs of matched HCC tissues of TCGA. Besides, higher expression of TGFB2-AS1 in HCC tissues was identified as being positively associated with advanced tumor (P = 0.012) and disease stage (P = 0.009) in 355 HCC cases using independent sample nonparametric test. Downregulation of TGFB2-AS1 expression significantly restrained proliferation (P < 0.01) and impaired colony formation (P < 0.05). Furthermore, TGFB2-AS1 depletion remarkably promoted the apoptosis of HepG2 cells (P < 0.05) and inhibited migration and invasion (P < 0.01). Conclusion Taken together, these findings suggested that TGFB2-AS1 might serve as a potential therapeutic target for HCC.