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A magnetostrictive self-powered biosensor based on Au-BaTiO3-FeGa & PDMS
Qiang Zhang,Meng Xu,Yan Liu,Chunyan Zhang,Rui Zhang,Zhiyuan Fu,Jianlong Ji,Riguang Zhang,Shengbo Sang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-
Piezoelectric flexible sensors have been used to detect biomolecules such as sweat and glucose because oftheir passive, simple structure and high sensitivity. This paper proposes a novel flexible piezoelectric Au-BaTiO3-FeGa & PDMS biosensor in which magnetostrictive deformation amplifies the surface stress generatedby biomolecules combining on the thin film. The modification process of bovine serum albumin(BSA) binding with the sensor was initially determined by the first principles approach. Then, the sensingmechanism was verified by finite-element simulation. Based on the simulation results, flexible Au-BaTiO3-FeGa & PDMS biosensors were prepared, modified, and measured. The structure, modification,and detection of the sensors were analyzed by digital microscopy, Fourier transform infrared spectrometry(FTIR), atomic force microscopy (AFM), and scanning electron microscopy (SEM). The responses ofthe biosensors detecting different BSA solution concentrations under magnetic fields were then investigated. Experimental results indicate that the biosensor has the highest sensitivity under a magnetic fieldof 30 mT.
Potential Therapeutic Targets for the Primary Gallbladder Carcinoma: Estrogen Receptors
Zhang, Ling-Qiang,Zhang, Xiu-De,Xu, Jia,Wan, Yong,Qu, Kai,Zhang, Jing-Yao,Wang, Zhi-Xin,Wei, Ji-Chao,Meng, Fan-Di,Tai, Ming-Hui,Zhou, Lei,Liu, Chang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Gallbladder carcinoma, the most frequent malignant neoplasm of the biliary tract system, has always been considered to feature late clinical presentation and diagnosis, limited treatment options and an extremely poor prognosis. In recent years, while the incidence of gallbladder cancer has appeared to be on the increase, the available treatment methods have not greatly improved survival of the affected patients. Thus, exploring new therapeutic targets for this devastating disease is an urgent matter at present. Epidemical studies have demonstrated that the incidence of gallbladder carcinoma exhibits a distinct gender bias, affecting females two to three times more than males, pointing to crucial roles of estrogen. It is well known that estrogen acts on target tissues by binding to estrogen receptors (ERs), which are mainly divided into three subtypes, $ER{\alpha}$, $ER{\beta}$ and $ER{\gamma}$. $ER{\alpha}$ and $ER{\beta}$ appear to have overlapping but also unique even opposite biological effects. As important pathogenic mediators, ERs have been considered to relate to several kinds of tumors. In gallbladder carcinoma tissue, ERs have been shown to be positively expressed, and ERs expression levels are associated with differentiation and prognosis of this cancer. Nevertheless, the exact mechanisms of estrogen inducing growth of gallbladder carcinoma remain poorly understood. On the base of the current investigations, we deduce that estrogen participates in promotion of gallbladder carcinoma by influencing the formation of gallstones, stimulating angiogenesis, and promoting abnormal proliferation. Since ERs mediate the carcinogenic actions of estrogen in gallbladder, and therapy targeting ERs may provide new directions for gallbladder carcinoma. Therefore, it should be stressed that ERs are potential therapeutic targets for gallbladder carcinoma.
Junbo Zhang,Shuanghong Yin,Fei Guo,Ren Meng,Chuangfu Chen,Hui Zhang,Zhi-qiang Li,Qiang Fu,Huijun Shi,Shengwei Hu,Wei Ni,Tiansen Li,Ke Zhang 한국미생물학회 2014 The journal of microbiology Vol.52 No.8
Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. However, the current Brucella abortus vaccines (S19 and RB51) are deficient; they can cause abortion in pregnant animals. Moreover, when the vaccine S19 is used, tests cannot differentiate natural from vaccinated infection. Therefore, a safer and more potent vaccine is needed. A Brucella abortus 2308 ery promoter mutant (Δery) was constructed to overcome these drawbacks. The growth of the Δery mutant was significantly attenuated in macrophages and mice and induced high protective immunity in mice. Moreover, Δery induced an anti-Brucellaspecific IgG (immunoglobulin G) response and stimulated the expression of interferon-gamma (INF-γ) and interleukin-4 (IL-4). Furthermore, the expression of EryA antigen allowed for the serological differentiation between natural and vaccinated infection in mice. These results indicate that the Δery mutant is a potential attenuated live vaccine candidate against virulent Brucella abortus 2308 (S2308) infection.
THE BIG WORD EFFECT: IMPACT OF USING BIG WORDS ON BACKERS’ FUNDING BEHAVIOR IN CROWDFUNDING
Qiang Zhang,Yeyi Liu,Yuanyuan Liu,Dionysius Ang 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Crowdfunding is an increasingly popular fundraising tool where project creators solicit capital from potential backers in return for monetary rewards or presales of products/services. Potential backers in crowdfunding are looking for potential cues to reduce uncertainty and predict new venture success when making their capital contributions. To increase their funding success, project creators strategically use project descriptions as a marketing tool to attract potential backers and funding.
Qiang Zhang,Cheng Li,Qiang Guo,Ming Min,Yanning Wang,Binsong Jiang 한국자원공학회 2017 Geosystem engineering Vol.20 No.5
The conventional strain-softening behaviors which assume the strength parameters as the functions of the plastic strain have been studied using various methods. However, rock-like materials have also been found to manifest pressure-dependent behavior for both elastic and plastic rock masses. The realization of the radial stress was found to be continuous, and gradually increased from supporting stress to in situ stress for the circular openings under hydrostatic pressure. The radial stress was spaced as numbers of sections, and each annulus was considered as an ideal plastic rock mass. The close-formed analytical solutions of each annulus can be easily obtained. Therefore, using the displacement continuum and stress boundary conditions, the dimensionless radius corresponding to the spaced radius could be derived. The radial stress and plastic shear strain at the inner radius of the outer adjacent annulus were employed to describe the material property evolution law. Then, the radii could be recursively obtained. Finally, for the conventional strain-softening rock masses, the pressure-dependent elastic rock and elasto-plastic coupling strain-softening rock masses were employed to validate the proposed approach. In this study, having completed the above steps, it was concluded that the results were in accordance with the numerical methods.
( Qiang Zhang ),( Yujuan Li ),( Fangxue Xu ),( Mengmeng Zheng ),( Xiaozhi Xi ),( Xuelan Zhang ),( Chunchao Han ) 한국균학회 2017 Mycobiology Vol.45 No.2
Different endophytes isolated from the seeds of Sophora flavescens were tested for their ability to produce matrine production. Response surface methodology (RSM) was applied to optimize the medium components for the endophytic fungus. Results indicated that endophyte Aspergillus terreus had the ability to produce matrine. The single factor tests demonstrated that potato starch was the best carbon source and the combination of peptone and NH<sub>4</sub>NO<sub>3</sub> was the optimal nitrogen source for A. terreus. The model of RSM predicted to gain the maximal matrine production at 20.67 μg/L, when the potato starch was 160.68 g/L, peptone was 24.96 g/L and NH<sub>4</sub>NO<sub>3</sub> was 2.11 g/L. When cultured in the optimal medium, the matrine yield was an average of 20.63 ± 0.11 μg/L, which was consistent with the model prediction. This study offered an alternative source for the matrine production by endophytic fungus fermentation and may have far-reaching prospect and value.
Adaptive Neural Finite-time Trajectory Tracking Control of MSVs Subject to Uncertainties
Qiang Zhang,Meijuan Zhang,Renming Yang,Namkyun Im 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.6
This paper provides two finite-time trajectory tracking control schemes for marine surface vessels (MSVs) which are influenced by dynamic uncertainties and unknown time-varying disturbances. Neural networks (NNs) are applied to reconstruct the vehicle’s dynamic uncertainties, and the sum of upper bound of approximation error and external unknown disturbances is estimated by designing an adaptive law. According to the backstepping technique and finite-time stability theory, a finite-time trajectory tracking control scheme is presented. Further, to decrease the conservatism of the presented control scheme caused by estimating the upper bound, a multivariate sliding mode finite-time disturbance observer (MSMFTDO) is designed to estimate the unknown external disturbances and the part that is not completely reconstructed by NNs, and then a MSMFTDO-based adaptive neural finite-time trajectory tracking control law is designed. Rigorous theoretical analyses are provided to prove that,owing to the developed finite-time trajectory tracking control strategies, all the signals of the closed-loop trajectory tracking control system are bounded, and that the actual trajectory of MSVs is able to track the reference trajectory in finite time. Simulation results illustrate the effectiveness of the developed schemes.
Zhang, Zhi-Qiang,Kim, Young-Min,Song, Soo-Chang American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.38
<P>Intravenous (IV) route is the most commonly used drug-delivery approach. However, the targeting efficiency to tumor through IV delivery is usually less than 10%. To address this limitation, we report a new systemic delivery method utilizing injectable and quadruple-functional hydrogels to improve targeting efficiency through passive, active, and magnetic targeting, and hydrogel-controlled sustained release. The hydrogels consist of a folate/polyethylenimine-conjugated poly(organophosphazene) polymer, which encapsulates small interfering RNA (siRNA) and Au-Fe<SUB>3</SUB>O<SUB>4</SUB> nanoparticles to form a nanocapsule (NC) structure by a simple mixing. The hydrogels are localized as a long-term “drug-release depot” after a single subcutaneous injection and sol-gel phase transition. NCs released from the hydrogels enter the circulatory systems and then target the tumor through enhanced permeability and retention/folate/magnetism triple-targeting, over the course of circulation, itself prolonged by the controlled release. In vivo experiments show that 12% of NCs are successfully delivered to the tumor, which is a considerable improvement compared to most results through IV delivery. The sustained targeting of gold to tumor enables two cycles of photothermal therapy, resulting in an enhanced silencing effect of siRNA and considerable reduction of tumor volume, which we are unable to achieve via simple intravenous injection.</P> [FIG OMISSION]</BR>
Zhang Yun-Ying,Guo Jin-Meng,Wei Zhi-Qiang,Zhang Xiao-Tong,Liu Si-Ruo,Guo Hui-Fang,Dong Shuanglin 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.2
To better understand the olfactory mechanism of Mythimna loreyi, a worldwide migratory pest, we for the first time conducted a large scale identification of olfactory-related genes and investigation of their sex expression profiles by transcriptomic analysis. A total of 42,832 unigenes were obtained by transcriptome sequencing, as sembly and annotation, with an average length of 1,229 bp and N50 of 2,086 bp. In particular, 138 olfactoryrelated genes were identified by homologous blasting, including 33 odorant binding proteins (OBPs), 16 che mosensory proteins (CSPs), 63 odorant receptors (ORs), 24 ionotropic receptors (IRs) and two sensory neuron membrane proteins (SNMPs). Further, by using differential gene expression (DGE) and fragments per kilobase per million fragments (FPKM) values to compare the transcript levels between female and male antennae, we found that 22 olfactory-related genes (9 OBPs, one CSP and 12 ORs) were sex biased, with 10 genes being male biased and 12 genes female biased. In addition, sex and tissue expression profiles determined by qPCR of 15 selected genes confirmed the reliability of sex expression profiles obtained by the transcriptomic analysis, and demonstrated that most olfactory-related genes were specifically or primarily expressed in antennae, suggesting their roles in olfaction, while a few genes were highly expressed in other tissues, implying their non-olfaction functions. This study provides an important basis for further functional study of olfactory genes in M. loreyi.