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헬리코박터 관련 소화성궤양 환자에서 위산펌프길항제 사용이 요소호기검사 결과에 미치는 영향
옥주현 ( Ju Hyun Oak ),정우철 ( Woo Chul Chung ),정성훈 ( Sung Hoon Jung ),최강현 ( Kang Hyun Choi ),김은정 ( Eun Jung Kim ),강봉구 ( Bong Koo Kang ),강보라미 ( Bo Ra Mi Kang ),공시은 ( Si Eun Kong ),백창렬 ( Chang Nyol Paik ),이 대한소화기학회 2011 대한소화기학회지 Vol.57 No.1
Background/Aims: Revaprazan (Revanex(R)) is a novel proton pump inhibitor (PPI) that has a somewhat different effect on proton pump compared with the other PPI`s, also (called as `acid pump antagonist`). We aimed to examine the false negative rate of (13)C-urea breath test (UBT) in the patients with Helicobacter pylori (H. pylori) associated peptic ulcer disease who were treated with revaprazan and evaluate the anti-urease activity of revaprazan. Methods: Total 55 patients were enrolled in this study. They received EGD examination between January 2009 and December 2009 and diagnosed histologically as H. pylori associated peptic ulcer disease. All patients took revaprazan only. Three patients were excluded because of underlying chronic disease and inappropriate breath sampling. The remaining 52 patients had UBT at 0, 2 and 4 weeks of revaprazan use. After 2 weeks of the cessation of revaprazan, they had the fourth UBT. Results: At 2 and 4 weeks, the false negative rates of UBT were 5.8% and 23.1%, respectively (p=0.05). After 2 weeks of the cessation, the cases of the false negative result were five. Four out of five patients had prolonged negative results on two or three successive tests, and baseline (13)C difference value did not predict the false negative results. Conclusions: False negative results of UBT were common and increased with prolonged use of acid pump antagonist. As PPI, it had also anti-urease activity and most patients (47/52, 90.4%) reverted to positive results by 2 weeks after the cessation of taking the medication. (Korean J Gastroenterol 2011;57:8-13)
Kang Ki-Woon,Ko Ju-Young,Lee Hyunghee,Shin Seung Yong,Lee Wang Soo,Hong Joonhwa,Kim Sang-Wook,Lee Seong-Kyu,Oak Min-Ho 대한의학회 2022 Journal of Korean medical science Vol.37 No.9
Background: Pericardial fat (PF) is highly associated with cardiovascular disease but the effectiveness of surgical resection of PF is still unknown for myocardial mitochondrial structure and function in acute myocardial infarction (AMI) with obesity. The aim of this study was to demonstrate the difference in myocardial mitochondrial structure and function between obese AMI with additionally resected PF and those without resected PF. Methods: Obese rats with 12-week high fat diet (45 kcal% fat, n = 21) were randomly assigned into 3 groups: obese control, obese AMI and obese AMI with additionally resected PF. One week after developing AMI and additional resection of PF, echocardiogram, myocardial mitochondrial histomorphology, oxidative phosphorylation system (OXPHOS), anti-oxidative enzyme and sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) in the non-infarcted area were assessed between these groups. Results: There was significant improvement of systolic function in AMI with PF resection compared with the AMI group in the echocardiogram. Even though the electron microscopic morphology for the mitochondria seems to be similar between the AMI with PF resection and AMI groups, there was an improved expression of PGC-1α and responsive OXPHOS including NDUFB3, NDUFB5 and SDHB are associated with the ATP levels in the AMI with PF resection compared with those in the AMI group. In addition, the expression levels of antioxidant enzymes (MnSOD) and SERCA2 were improved in the AMI with PF resection compared with those in the AMI group. Conclusion: Surgical resection of PF might ameliorate myocardial mitochondria dysfunction in obese AMI.
옥주현 ( Ju Hyun Oak ),정우철 ( Woo Chul Chung ),정지한 ( Ji Han Jung ),김진동 ( Jin Dong Kim ),이정록 ( Jeong Rok Lee ),백창렬 ( Chang Nyol Paik ),이강문 ( Kang Moon Lee ),조규도 ( Kyu Do Cho ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.1
Carcinosarcoma of the esophagus is a rare malignancy accounting for approximately 1-2% of all esophageal neoplasms. It presents as a bulky intraluminal polypoid lesion mainly in the mid to lower esophagus, which harbors both carcinomatous and sarcomatous components histologically. It often presents relatively early because of its rapid intraluminal growth. We report the case of a 69-year-old man who had suffered from dysphagia for 1 month. He was previously admitted to the hospital due to corrosive esophagitis caused by ingestion of acetic acid. Endoscopy and radiological studies revealed a bulky polypoid mass with superficial ulcerations and mucosal friability, measuring 10 cm in length approximately, in the mid-esophagus. Subtotal esophagectomy with esophagogastrostomy was done. Microscopically it was composed of sarcomatous component intermingled with squamous cell carcinoma. Immunohistochemical stains reveal cytokeratin, 34βE12, and p63 positivity in the nests of carcinoma, and desmin and vimentin positivity in the spindle cells of sarcomatous stoma. (Korean J Gastroenterol 2008;52:42-47)
Chronic Alcohol Consumption Results in Greater Damage to the Pancreas Than to the Liver in the Rats
Lee, Seong-Su,Hong, Oak-Kee,Ju, Anes,Kim, Myung-Jun,Kim, Bong-Jo,Kim, Sung-Rae,Kim, Won-Ho,Cho, Nam-Han,Kang, Moo-Il,Kang, Sung-Koo,Kim, Dai-Jin,Yoo, Soon-Jib The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.4
Alcohol consumption increases the risk of type 2 diabetes. However, its effects on prediabetes or early diabetes have not been studied. We investigated endoplasmic reticulum (ER) stress in the pancreas and liver resulting from chronic alcohol consumption in the prediabetes and early stages of diabetes. We separated Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type-2 diabetic animal model, into two groups based on diabetic stage: prediabetes and early diabetes were defined as occurrence between the ages of 11 to 16 weeks and 17 to 22 weeks, respectively. The experimental group received an ethanol-containing liquid diet for 6 weeks. An intraperitoneal glucose tolerance test was conducted after 16 and 22 weeks for the prediabetic and early diabetes groups, respectively. There were no significant differences in body weight between the control and ethanol groups. Fasting and 120-min glucose levels were lower and higher, respectively, in the ethanol group than in the control group. In prediabetes rats, alcohol induced significant expression of ER stress markers in the pancreas; however, alcohol did not affect the liver. In early diabetes rats, alcohol significantly increased most ER stress-marker levels in both the pancreas and liver. These results indicate that chronic alcohol consumption increased the risk of diabetes in prediabetic and early diabetic OLETF rats; the pancreas was more susceptible to damage than was the liver in the early diabetic stages, and the adaptive and proapoptotic pathway of ER stress may play key roles in the development and progression of diabetes affected by chronic alcohol ingestion.
( Seong-hee Kim ),( Yong-man Kim ),( Ju-hyeon Nam ),( Yeong-tak Kim ),( Jong-hyeok Kim ),( Dae-sik Suh ),( Jeong-yeol Park ),( Shin-hwa Lee ),( Ju-hee Kim ),( Ji-hoon Lee ),( Oak-ju Kang ),( Dae-yeon 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: The controversy between the proponents of radical pelvic surgery and those of radiotherapy for primary treatment in early cervical cancer still exists for a long time. The aim of this study is to demonstrate the efficacy of radical hysterectomy as primary treatment in non-bulky node-positive early cervical patients. Methods: Patients that were diagnosed with cervical cancer and received RH at Asan Medical Center between January 2013 and December 2015 were identified from an electronic database at our center, and their medical records were reviewed retrospectively. The eligibility criteria for patients inclusion in this study were as follows: previously untreated; pathologically diagnosed cervical cancer; an age of 20-80 years at the time of surgery; laparoscopic or open radical hysterectomy with pelvic and/or para-aortic lymphadenectomy; clinical tumor or MIR tumor size under 4cm and lymph node positive in imaging study. Patients whose cell type was small cell carcinoma or neuroendocrine carcinoma, who underwent neoadjuvant chemotherapy, or who had other coexisting malignancies were excluded. Results: Of the 53 patients, 6 patients (11.3%) were recurred, and 4 patients were died among the recurred patients. 15 patients (28.3%) were not received any adjuvant therapy after radical hysterectomy. 2years overall survival was 93%, and 3years overall survival was 90% in non-bulky lymphadenopathy cervical cancer patients. 2years recurrence-free survival rate was 86%. 15 patients (28.3%) were not received any adjuvant therapy after radical hysterectomy. Conclusion: In non-bulky lymphadenopathy cervical patients who received radical hysterectomy as primary treatment, it presented good overall survival and recurrence-free survival rates. It was single-arm study. The necessity of multicenter prospective randomized controlled comparative study between radical pelvic surgery and radiotherapy as primary treatment in high risk early cervical cancer was highly required.
환자용 사상체질설문지(SSCQ-P) 축소화에 관한 연구
정종훈,전수형,나영주,강석환,동상옥,이시우,김규곤,김종원,김상혁,Jeong, Jong-Hun,Jeon, Soo-Hyung,Na, Young-Ju,Kang, Seok-Hwan,Dong, Sang-Oak,Lee, Si-Woo,Kim, Kyu-Kon,Kim, Jong-Won,Kim, Sang-Hyuk 사상체질의학회 2014 사상체질의학회지 Vol.26 No.4
Objectives This study was performed to make a short-form of Sasang Constitution Questionnaire for Patient(SSCQ-P). Methods In order to select important questions of SSCQ-P, we got advice from 10 professors of Oriental Medicine. As a result, we chose 37 questions. In addition, we selected 69 questions which had been used more than 12 times in SSCQ-P as the variable. We used some statistical methods to reduce questions. Finally, a total of 40 questions were selected. To find diagnostic accuracy rate of this short-form, discriminant analysis was performed. We used 1378 cases which was collect ed from February 2008 to June 2013 by online system(Sasang-medi data which has selected by web site, http://www.sasangmedi.or.kr), and 68 cases which was collected from November 2006 to September 2007 by the research "Construction of a biological information collection system for the Constitutional scientific diagnosis"(Korea Constitutional Multicenter Bank data, KCMB data) Results We made a short-form of SSCQ-P consisting of 40 questions. Diagnostic accuracy rate of short-form is 66.18% using Sasang-medi data, and 42.65% using KCMB data. Conclusions More cases are needed to improve the diagnostic accuracy rate of this short-form.