Focal adhesion kinase and src expression in premalignant and malignant skin lesions

( Ju Yeon Choi ),( Jae Yun Lim ),( Han Saem Kim ),( Jung Min ),( Jung In Kim ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Chong Won Choi ),( Yoon Hwan Kim ),( Jin Hee Sohn ),( Hyunjoo Lee ),( Won Serk Ki 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Focal adhesion kinase (FAK) and Src are non-receptor tyrosine kinases. FAK and Src play a critical role in inducing malignant transformation in tumor cells. Objectives: We performed immunohistochemical staining for total and phosphorylated forms of FAK and Src, to evaluate the role of FAK and Src in the development of premalignant and malignant skin lesions. Methods: A total of 59 facial skin samples (30 actinic keratoses, 10 Bowen``s diseases, 13 squamous cell carcinomas and six perilesional skins) were immunohistochemically stained for Ki-67, total (t) and phosphorylated (p) form of FAK and Src. Methods: A total of 59 facial skin samples (30 actinic keratoses, 10 Bowen``s diseases, 13 squamous cell carcinomas and six perilesional skins) were immunohistochemically stained for Ki-67, total (t) and phosphorylated (p) form of FAK and Src. Results: Cells positive for t-Src, p-Src-y530, t-FAK and pFAK-s722 were detected in premalignant intra-epithelial lesions (PELs) and squamous cell carcinomas (SCCs), but not in the perilesional skin. There was a tendency towards high correlation between Ki-67 and t-FAK or pFAK-s722, suggestive of the active role of FAK in cell proliferation. Conclusion: Our findings of higher t-Src and p-Src-y530 positive cells in PELs, as compared to SCCs (with higher Ki-67 level), are suggestive of the other role of Src in tumor formation and progression, which requires further investigation.

비닐系廢플라스틱의 利用에 關한 硏究

韓元熙,周赫鍾,孟琦錫 嶺南大學校 工業技術硏究所 1975 연구보고 Vol.3 No.1

Wasted plastics were collected and selected through the specific gravity method, the combustion method and coloring reaction method, and these methods showed to us various physical properties of wasted plastics. Degradation of wasted plastics was carried out by the thermodegradation method and the catalytic degradation in the presence of catalystes; Al₂O₃, Bentonite and Kaoline. Generally, these materials showed the affects of lowering decomposition temperature of wasted plastics and those of increasing the yield of recovery oil. Bentonite brought the best result of these catalystes. It was possible to polymerize the recovery oil extracted from the decomposed oil of P.S. collected below 180℃ and from that of PMMA collected below 270℃. Out of the polymers of good qualities, products compared with the other wasted plastics could be obtained. The recovery oils extracted from P.P, P.E., P.S. and P.M.M.A. had high calories and low flash points enough to be utilized as liquid fuel. Prepolymers of P.S. and P.M.M.A. are able to be used as coating material for metal.

Tabes Dorsalis의 핵자기공명영상 및 전기생리학적 소견

권기한,김성민,권석범,이병철,조광호,주정희 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

FEM에 의한 Al07075/CFRP 적층재의 탄성계수 해석

윤한기,안광주,김연겸,박준수 東義大學校産業技術開發硏究所 1998 産業技術硏究誌 Vol.12 No.-

As for the properties on both the aluminum and the CFRP which are used to make A17075/CERP multi-layered hybrid composites, CRALL(carbon reinforced aluminum laminate). For CRALL specimen, FEM analysis is compared with experimental results. It is shown that the rule of mixture is well agreed with experiment result in A/C 0001 layered 1 ply. However, differences are conceivable in A/C 0003 and A/C and A/C 0005 because of the effect of fiber volume fraction. In the A/C 0001 specimen case, the elastic modulus of the unnotched and circular notched CRALL specimen by FEM analysis are agreed with the experimental results, but that of A/C 0003 and A/C 0005 specimens had high CFRP volume fraction doesn't agree with experimental results.

韓國에 있어서의 道路交通의 變動에 關한 地理學的 硏究

徐贊基,韓柱成 慶北大學校 1978 論文集 Vol.25-26 No.-

In this thesis an attempt puts to grasp the spatial variation of the road density, the factors of the road density variation, to clarify a spatial regularity and a regional structure of the road network. A statistical Yearbooks of 1960 and 1970 by each province(Do) were used as basic data. And city(Shi) and county(Gun) were taken for unit area. The spatial variation of the road density in 1960 and 1970 were studied through the linear, quadratic, cubic, and quartic equation of trend-surface analysis. While among the 9 variables which would be expected to affect the road density, 4 factors of the spatial variation were selected through the correlation analysis. By these 4 variables a multiple regression equation was constructed for the model of road density variation. And the residuals from the regression were calculated and the distribution of anomaly was studied to estimate the significance of the local factors. Finally, to study a regional structure of the network each regional connectivity and the connection of a regional traffic was analysed through the graph theory, and accessibility and dispersion were measured by shortest-path matrix. Through the above procedure the findings were as follows: (1) The Southwestern part of the Jeonra Bug Do appeared the peak of the trend-surface in the road density in 1960. The Honam region including the Chungcheong Nam Do is characterized by the road intensive area, the Central region, the road extensive area, the Yungnam region, transitional area in 1960. (2) Over the whole country in 1960' the road development is continued, and the road density in 1970 about 10% than that of 1960. From 1960 to 1970 the peak area of trendsurface of road density moved from the Southwestern part of the Jeonra Bug Do to the Southeastern part of Gyeongsang Bug Do, and the Southern Korea could keep a balance of road density among the Honam and the Yungnam regions. This balance suggests the eastward road diffusion in 1960-1970. On the other hand the regional structure is changed into the Yungnam region as a road intensive, the Central region, road extensive, the Honam region including the Chungcheong Nam Do, the transitional area. (3) The basic factors of spatial variation of the road density in Korea are degree of land slope, population density, surplus of rice and distance from the urban center of the tributary area. And these 4 factors expains 75% of the spatial variation of the road density in Korea of which degree of land slope is the most important factor. The spatial variation of road density in Korea could explain by gravity model and landform condition basically, though in reality the factors are more complicated than the other countries. Finally the road system of Korea reflects centralized administrative system which the regional connectivity is low, the centralization is high.

Squash 운동이 성인 여성의 호흡순환기능에 미치는 영향

권해주,김태운,고기준,한재웅,이재규 부산대학교 체육과학연구소 2000 體育科學硏究所 論文集 Vol.16 No.-

The purpose of this research was to change the effects of Squash exercise on cardiopulmonary functions of females. The subject group was made up of 10 females (first start to Squash exercise). After a pretest, the subjects were given an 12-weeks Squash exercise program. Then the subjects were given a posttest and cardiopulmonary functions after 12-weeks of the program. The program schedule was made up of 3days per week, 60minutes per day. The significance level was α=0.05. The following results were statistical data of difference between pre and post-test. 1.HRmax was significantly increased. 2.RFmax was significantly increased. 3.VO2 max was significantly increased.

ABC/ABM에 기초한 물류 리엔지니어링

조기조,배주한 慶南大學校 産業經營硏究所 1998 産業經營 Vol.22 No.-

특수형 방사성 동위원소 운반캡슐의 안정성 평가

이주찬,서기석,구정회,방경식,한현수,박성원 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1

특수형 방사성물질 운반캡슐은 국내외의 수송관련 법규에 규정된 기술기준을 만족하도록 설계, 제작되어야 한다. 본 연구의 목적은 하나로에서 생산된 192Ir 특수형 동위원소 운반캡슐의 건전성을 평가하는데 있다. 법규에서 규정된 낙하시험, 타격시험, 굽힘시헝 및 가열시험조건에 대한 안전성 시험을 수행하였으며, 각각의 시험 전후에 누설시험을 수행하였다. 또한, 안전성시험과 더불어 컴퓨터코드를 이용한 전산해석을 수행하여 안전성시험 전에 시험결과에 대한 예측자료로 활용되었다. 낙하시험 및 가열시험 결과 캡슐 표면에서 약간의 흠집과 변형이 발생하였으나, 각각의 시험에서 평가기준이 되는 캡슐의 손상이나 용융 등은 발생하지 않았다. 또한 각 시험 후 수행한 누설시험 결과 누설이 발생하지 않았다. 따라서 특수형 방사성물질 운반캡슐은 법규에서 규정하는 기술기준을 만족하도록 설계, 제작되었음이 입증되었다. All of sealing capsules to transport a special form radioactive material should be designed and fabricated in accordance with the design criteria prescribed in IAEA standards and domestic regulations. The objective of this study is to demonstrate the safety of a shipping capsule for 192Ir special form radioisotope which produceed in the HANARO. The safety tests were carried out for the impact, percussion, bending and heat test conditions. And leakage tests were carried out before and after the each test. Also, the safety analyses were performed using computer codes in order to verify the test results. The capsule showed slight scratches and deformation, and maintained its structural and thermal integrities in all tests without any severe damage or melting. It also met the allowable limits of leakage rate after earth test. Therefore, it has been verified that the capsule was designed and fabricated to meet all requirements for the special form.

旅客移動의 空間的 相互作用에 關한 硏究 : 高速道路의 境遇 A case of expressway traffic

徐贊基,韓柱成 慶北大學校 師範大學 1979 敎育硏究誌 Vol.21 No.-

In this thesis an attempt puts to clarify the spatial structure of the passenger movement on express traffic in Korea. For this purpose ranking and it's structure of nodes and routes, passenger movement model and flow pattern are analysed or builded. In the analysis interaction model, point pattern analysis method, combination analysis method and graph theory are adopted, and 1976 Traffic Statistical Yearbook and the Reports of National Association of Express Traffic Service are used for study data. In this study nodes mean interchanges or cities in which expressway are concentrated. Major findings are as follows: (1) The spatial arrangement of the nodes could express for random pattern which could explain by probability. (2) The traffic areas divided into Capital and Taeback, Busan, Daejeon and Daegu area. (3) While the interrelation between rank and number or length of traffic road is negative, that between rank and flow is positive. And the farther distance from the Capital is, the lower rank of the traffic road is. (4) The basic factors of the spatial interaction on the passenger movement are the product of the population size of origin and destination cities and travel time. And these two factors explain 70% of the spatial variation of the passenger movement. Therefore the passenger movement in Korea could explain considerable proportion effectively by the interaction model, and the elasticity of distance is-0.6797. (5) The functional points of the passenger movement as the terminal centers of traffic flow are the Capital and Busan which are two the largest cities in Korea. Especially among above two functional points former has the largest flow and accessibility. Finally it could difficult to find conspicuously the effect of distance decay function in Korea since relatively small spatial size of the nation.

황색포도구균의 균혈증에서 초기 항생제 치료가 예후에 미치는 영향

김성한,박완범,이기덕,강철인,최영주,김홍빈,박상원,김의석,오명돈,김의종,최강원 대한감염학회 2002 감염 Vol.34 No.5