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서정길,김찬희,배윤정,문호성,김근용,박희연,윤호동,김창훈,변대석,홍용기,박남규 한국어병학회 2003 한국어병학회지 Vol.16 No.3
Mastoparan B (MPB)는 벌독으로부터 정제된 양친매성α-helical 구조를 취하면서 14개의 아미노산 잔기로 구성된 염기성 항균성 펩타이드로서 여러 가지 생물막과 작용한다. 본 연구에서는 우리 나라 연안의 적조 (HABs, harmful algal blooms)를 일으키는 4종의 적조생물 (Alexandrium tamarense, Chattonella catenatum)에 대한 MPB의 살조효과를 조사하였다. MPB의 4종의 적조생물에 대한 살조효과는 31.3㎍/㎖에서 세포의 lysis또는 ecdysis와 같은 형태로 현미경으로 관찰할 수 있었다. 또한 MPB는 C. marina 및 C. polykridorides에 대해서 A. tamarense와 G. catenatum보다 더욱 강한 살조효과를 나타내었다. 이러한 MPB의 HABs에 대한 살조효과연구는 새로운 살조물질을 개발하기 위한 자료가 될 것으로 생각된다. Mastoparan B (MPB), an antimicrobial cationic peptide isolated from the venom of the hornet Vespa basalis, is a basic amphipathic a-helical peptide composed of fourteen amino acid residues. In this study, we have investigated the algicidal effect of MPB against hatmful algae blooms (HABs) casative Alexandrium tamarense, Chattonella marina, Cochlodinium polykrikoides and Gymnodinium catenatum. The algicidal effect of MPB showed in the concentration of 31.3 ㎍/㎖ to 500 ㎍/㎖ against 4 HAB species and observed cell lysis or cell ecdysis by microscopy. MPB reacted more sensitive to C. marina and C.polykrikoides than A. tamarense and G. catenatum. The algicidal study of MPB against HABs will provides much insight into development of new algicidal substances.
α-클로로-α-(메틸티오)아세톤을 이용한 벤조푸란 유도체의 합성
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1
Benzofuran ring을 포함하는 다수의 화합물이 생리활성을 발현하는 의약품으로 개발되어있고 아울러 Benzofuran ring의 모핵 구조를 가진 천연물로서 천식, 위궤양 및 고혈압 등에 유용한 물질도 알려져 있다. Benzofuran ring의 합성법 중 대표적인 예로는 고온에서 arylalkyl ether의 cyclodehydration, aryloxyacetone의 탈수제에 의한 cyclization 및 o-allylphenol 류의 오존분해와 cyclization을 경유하는 방법과 (2-methoxyphenyl)ethynes을 2,4,6-trimethylpyrideine 중 lithium iodide로 처리하는 방법이 보고된바 잇다 .이들 제법은 출발물질의 합성이 용이하지 않고, 고온과 강산성의 격렬한 방응조건을 요구하고 있다.
2-Chloro-2-(methylthio)acetophenone을 이용한 2-페닐벤조[b]퓨란 유도체의 합성
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
It is well known that 2-arylbenzo[b]furan derivatives are occured in natural products such as Styrax obassia, Sophora tomentosa, and Krameria ramosissima. In the course of our search on the carbon-carbon bond formation utilizing 1-acyl-l-thiocarbocationic intermediates, we showed that the reaction of substituted phenols with α-chloro-α-(methylthio)acetone (1) in the presence of Lewis acid provided a convenient method for the 2-methylbenzo[b]furans (3) through the reductive desulfurization of the resulting products (2) (Scheme 1). The present paper describes the one-step synthesis for 2-phenylbenzo[b]furan derivatives from the reaction of phenol or cresol isomers with 2-chloro-2-(methylthio) acetophenone in the presence of zinc chloride. Many procedures have been reported for the preparation of 2-phenylbenzofuran ring. Among them, the most frequently employed method is based upon the cyclodehydration reaction of aryloxyacetone moiety with standard dehydrating reagents(H₂SO₄, ZnCl₂, POCl₃, KOH or PPA).
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
황원자가 α-탄소상의 양이온을 안정화시키는 성질을 가짐은 널리 보고되어있다. 이 α-thiocarbocations를 이용한 탄소-탄소결합형성반응에 관한 연구의 일환으로서, 저자동은 Scheme 1처럼 Friedel-Crafts반응 또는 Pummerer반응조건하에서 발생되어지는 황원자와 acyl기(nitrile기를 포함)에 인접한 탄소양이온(1-acyⅠ-1-thiocarbocations)과 방향족 화합물로부터 arylacctic acid와 arylacetone 및 arylacetonitrile의 간편한 합성법을 개발하였다. 또한 1-acyⅠ-1-thiocarbocations를 적용하여 phenylacetic acid의 모핵구조를 포함하는 소염제인 aryalkanoic acid의 제법을 보고하였다.
Streptococcus constellatus에 의한 경막 외 농양이 동반된 화농성 척추염 1예
안홍대,박재찬,서종구,김진용,김수연,박윤수,서일혜,조용균 대한감염학회 2008 감염과 화학요법 Vol.40 No.5
We report a case of vertebral osteomyelitis with epidural abscess caused by Streptococcus constellatus. The patient was present with fever, back pain, and dyspnea for 1 week. The patient was previously healthy and did not have any predisposing factor. After evaluation, the patient was diagnosed as Streptococcus constellatus vertebral osteomyelitis. He was successfully treated with surgical debridement and antibiotic therapy. To the best of our knowledge, this is the first case of S. constellatus vertebral osteomveltis with epidural abscess to be reported in Korea.
개심술(開心術)의 임상적 고찰 : 치험 200예 200 Cases
최형호,서홍주,임영혁,김정중,배대양,이석기,임진수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2
Background and Objectives: Two hundred cases of the open heart surgery due to congenital and acquired heart disease were done using the cardiopulmonary bypass in the Department of Thoracic and Cardiovascular surgery, Chosun University Hospital from November, 1980 to June, 2001. Material and Methods: The number of congenital heart disease was 132 cases. 68 cases were acquired heart disease. 'The age of the congenital heart disease was from 22 days to 45 years. In the acquired heart disease, the age was from 14 to 72 years. Result: Congenital heart disease consisted of 113 congenital acyanotic heart disease, 19 congenital cyanotic heart disease. Corrective operation was done for congenital heart disease with 4. 5 % operative mortality. Of 68 cases acquired heart disease, 44 patients were valvular heart disease, 3 cardiac tumors, 9 ischemic heart diseases, 12 aortic dissections and etc. The operative mortality was 13%. Conclusion: The postoperative complications were appeared in 68 cases and the complications were wound infection, occipital alopecia, low cardiac output syndrome, arrhythmia, septicemia etc. The mortality after open heart surgery was 15 cases and the causes of death were low cardiac output syndrome, septicemia, respiratory failure and left ventricle rupture.
고혈압·당뇨병 신규 환자 발견 이후 지역사회 협력을 통한 등록관리가 치료순응도 및 혈압 및 혈당 조절에 미치는 영향
홍두호(Duho Hong),서화정(Hwa-jeong Seo),강경희(Kyoung-hee Kang),김은주(Eun-ju Kim),임정수(Jeong-Soo Im),오대규(Dae-kyu Oh),임준(Jun Yim) 한국농촌의학 지역보건학회 2008 농촌의학·지역보건 Vol.33 No.3
인천광역시의 2개 지방자치단체에서 고혈압과 당뇨병의 관리를 위해 민간의료기관과 함께 만든 만성질환등록관리체계의 효과를 평가하였다. 만성질환등록관리체계에 등록관리가 이루어지고 있는 군이 미등록군에 비해 치료순응도와 혈압 및 혈당의 조절 정도가 좋은지를 평가하였다. 자료분석은 로짓회귀모형을 구축하여 이루어졌고, 다단계 변수 선택법을 사용하여 교차비와 95% 신뢰구간을 구하였다. 연구결과 등록관리군이 미등록군에 비해 치료순응도가 5.5배 높았고, 혈압 및 혈당의 조절이 3.78배 더 잘 되었다. 향후 이러한 효과가 인천광역시 전체 사업으로 확대된 후에도 지속되는지를 평가할 필요가 있다. Objectives : Incheon metropolitan city has set a model program of community partnership for hypertensive or diabetic patients detection and follow-up since 2005. This study examines the effects of the model on the compliance and the control of blood pressure or blood sugar level Methods : Telephone-surveys were done for 140 persons selected from 408 patients who were detected newly as hypertensive or diabetic patients at Gangwha-Gun and Seo-Gu in Incheon between January 1st and August 31th in 2006, and finally completed in 110 patients(78.6%). Survey questionnaires included socio-demographic(age, gender, and educational level), health behavioral (smoking, drinking, physical activity, and diet), and therapy-related (registration state, compliance, blood pressure or blood sugar control) variables. Odds ratio and 95% CI were derived from logistic regression model. Results : Registered group exhibited high compliance and well managed blood pressure or blood sugar level. The odds ratio of registration were 5.55(95% CI:1.83~16.89) for compliance and 3.78(95% CI:1.43~9.99) for blood pressure or blood sugar control after adjusting for age, gender, disease, and area Conclusions : It is independently related to compliance and blood pressure or blood sugar control whether the patient is registered or not. To control hypertension or diabetes mellitus in terms of compliance and control state, a community-based registration program through community partnership could be a powerful tool.
신생아에 심한 심부전증을 일으킨 선천성 뇌동정맥 기형: 풍선 색전 요법을 시도한 1례
박인숙,김영휘,홍창의,조영국,서대철,박영일 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2
Cerebral arteriovenous malformation is a rare cause of congestive heart failure in neonates and is known to carry a very poor prognosis even wish prompt recognition and aggressive treatment. We recently encountered a 2-day-old male neonate with huge cerebral arteriovenous malformation who presented with intractable heart failure. Despite aggressive medical treatment and partial embolization with detachable balloon, baby died of severe hearts failure. Since there is no report of percutaneous balloon embolization in a neonate with this lesion in Korean literature, we wish to present our experience in one such neonate. Also we believe this is the first report of color Doppler findings in cerebral arteriovenous malformation in Korean literature.