토끼에서 enrofloxacin과 enrofloxacin acetate의 比較藥物動態學

윤효인,박승춘,김창식,김민규,최기섭,신광순,박종일,조준형,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

This study was designed to examine the in vitro antibacterial activities and pharmacokinetics of enrofloxacin acetate (ENFXA) and enrofloxacin (ENFX). Two enrofloxacins had wide spectrum antibacterial activities against Gram positive and negative bacteria, and mycoplasma, showing potent antibacterial activities with low MICs (0.05-3.33 ㎍/㎖ for Gram positives, 0.002 ㎍/㎖ for Gram negatives and 0.02 ㎍/㎖ for mycoplasma). In order to investigate the profiles of two formulations of enrofloxacin we studied comparative pharmacokinetics of them in rabbits. Five rabbits were given 5 ㎎/㎏ body weight of each enrofloxacin formulation intravenously (i.v.) and orally (p.o.) in a cross-over study. Pharmacokinetic parameters of both formulations were calculated by the use of PCNONLIN, a computer program. Their bioavailibility in rabbits, the means of the area under the curve (AUC). After oral administration of each formulation in rabbits, the mean elimination half-lives (t_1/2,ke) were 3.25h (ENFX) and 4.32 h (ENFXA), and mean AUC 4.27 ㎍·h/㎖ (ENFX) and 6.21 ㎍·h/㎖ (ENFXA). Both enrofloxacin formulations seemed to have good tissue distribution and penetration as indicated by large volume of distribution: 4.76 1/㎏ for ENFX and 7.23 1/㎏ for ENFXA. With the results obtained in this study, ENFXA could be used in place of ENFX in rabbits.

우리 나라 보건관리대행서비스 평가 연구

하은희,조수헌,김선민,주영수,한상환,하미나,권호장,홍윤철,김창엽 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

Group occupational health service programme started in 1990 is one of the measures to cope with limited human and financial resources in occupational health. The programme has expanded rapidly to include 52 institutions, private as well as public, all over the country. In spite of its potential impact on health of employees and practice of occupational health in small and medium sized industries, comprehensive evaluation in terms of quality has not been tried. This study has aims to develop the criteria to assess the quality of newly developed group occupational health service programme, and to investigate the quality of institutions, and finally to develop policies for the quality improvement. 1) Criteria development : By defining occupational health services, in particular for small and medium sized industries, as one of the primary health care, followings are included as core elements of qualitative occupational health programme; accessibility, continuity, comprehensiveness, technical quality, intersectoral collaboration, emphasis on preventive services, community participation, and adequacy. Again each element is divided into five major components of national health system infrastructure developed by the World Health Organization; development of health resources, organized arrangement of resources, delivery of health care, economic support, and management. In turn, each component is categorized into three aspects of quality assessment, structure, process and outcome. Expert panel selected several criteria for each category to evaluate the programme. Criteria were modified according to each group of interviewees, to produce two sets of questionnaire, one for chief operating officer and another for nurses in the institutions, and the chief operating officer and workers in the workplace. 2) Subject : Of all 52 institutions, 25 voluntarily participated in the survey. At individual institution, chief operating officer and practicing nurses were interviewed in depth. After intensive education for interviewees, every interviewees, every interview was performed with standardized guideline and questionnaire. The quality of the 'Group occupational health service programme' was found to be lower than expected. Especially in continuity, comprehensiveness, technical quality, community participation and adequacy, lower quality in structural aspect was commonly identified throughout all the institutions,. Quality in terms of accessibility and continuity highly varied among institutions., To improve quality of the programme, more comprehensive and systematic programme such as accreditation has to be introduced. In addition, human resources, governmental fund and information systems for individual workers are to be developed. As a long range plan, integration of occupational health services into the national health systems and pooling of financial resources and planned allocation should be considered.

Reducing Phosphorus Release from Paddy Soil by Coal Ash and Phospho-Gypsum Mixture

Lee, Chang Hoon,Lee, Yong Bok,Lee, Hyub,Ha, Byung Yun,Kim, Pil Joo 한국환경농학회 2005 한국환경농학회지 Vol.24 No.1

As a silicate source to rice, a coal ash was selected and mixed with phosphor-gypsum (50:50, wt wt^(-1)) to reduce the potential of boron toxicity and to supply calcium element We expected that high con-tent of calcium in this mixture might convert water-soluble phosphorus to less soluble forms and then reduce the release of soil phosphorus to surface runoff. The mixture was applied with the rate of 0, 20, 40, and 60 Mg ha^(-1) in paddy soil (Nagdong series, a somewhat excessively drained loamy fine sand) in Daegok, Jinju, Korea The mixture reduced significantly water-soluble phosphorus (W-P) in the surface soils by shifting from W-P and Fe-P to Ca-P and Al-P during whole rice cultivation. In contrast with W-P, plant available phosphorus increased significantly with the mixture application due to high content of phosphorus and silicate in the mixture. The mixture of coal ash and phosphor-gypsum (50:50, wt wt^(-1)) would be a good alternative to reduce a phosphorus export in rice paddy soil together with increasing rice yields.

마이크로 엔드밀링에서 음향방출 신호를 이용한 상태감시

정연식,강익수,김전하,강명창,김정석,안중환 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

Ultraprecision machining and MEMS technology have been taken more and more important position in machining of microparts. Micro endmilling is one of the prominent technology that has wide spectrum of application field ranging from macro parts to micro products. Also, the method of micro-grooving using micro endmilling is used widely owing to many merit, but has problems of precision and quality of products due to tool wear and tool fracture. This investigation deals with state monitoring using acoustic emission(AE) signal in the micro-grooving. Characteristic evaluation of AE raw signal, AE hit and frequency analysis for state monitoring is also presented in the paper.

저전력의 플립-플롭과 클럭 드라이버 설계

양윤주,하영철,송정근,홍창희 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1

본 논문에서는 VLSI 전체 전력소비에 있어 비중이 높은 클럭 시스템의 전압 스윙 폭을 줄여 전력소비를 감소시킬 수 있는 저전압 클럭용 플립플롭을 제안한다. 제안된 플립플롭이 저전압 스윙 클럭으로도 동작함을 증명하고 이 플립플롭과 연계하기 위한 실제 전압 폭 감소 클럭 드라이버를 설계하였으며, 이 클럭 드라이버에 의해 기존의 클럭 드라이버에서 발생하는 전력소비를 1/4가량 감소시킬 수 있음을 설명했다. 본 논문에서 제시하는 플립플롭과 클럭 드라이버간의 연계동작과 소비전력 감소 효과는 SPLICE simulation을 통해 검증하였다.

Tocopherol 投與가 家兎의 增體 및 飼料利用性에 미치는 影響

林鍾佑,尹昌鉉,河正基,朴琦緖 진주농과대학 1970 진주농과대학 연구논문집 Vol.- No.9

本 試驗은 Tocopherol이 家兎의 增體 및 飼料利用性에 미치는 影響을 究明하기 위해 雌兎 20頭, 雄兎20頭 計 40頭를 8週間 試驗하였던바 다음과 같은 結果를 얻었다. 1. 日當 增體量에 있어서는 處理區間에 1% 水準의 有意性이 認定되었으며 T₂區가 14.68g, T₁區가 13.17g로서 對照區보다 優秀하였으나 T₃區는 對照區보다 좋지 않았다. 2. 飼料攝取量에 있어서는 處理區間과 性別間에 1%水準의 高度의 有意性이 認定되었고 T₂區, T₁區가 對照區보다 飼料攝取量이 많았으나 T₃區는 對照區보다 不良했다. 3. 飼料利用率에 있어서는 處理區에 있어서 別다른 差가 認定되지 않았다. This experiment was conducted to study the effects of Tocopherol on gain weight, feed consumption and feed conversion of growing rabbits. Twenty male and twenty female rabbits of Japanese white breed used for 8 weeks. The results obtained from this study may be summarized as follows: 1. There was found a highly significant difference(P<0.01) for daily gain weight between treatments. T₂lot with 14.68g and T₂lot with 13.17g had higher daily gain weight than its of control lot. But T₃lot had lower daily gain weight than its of control lot. 2. In feed consumption there were highly significant differences (P<0.01) between treatments and sex. T₂lot and T₁lot had more feed intake than its of control lot. But T₃lot had lower feed intake than its of control lot. 3. The difference in feed conversion was found insignificant between treatments.

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

Genome-Wide Analysis of DNA Methylation before- and after Exercise in the Thoroughbred Horse with MeDIP-Seq

Gim, Jeong-An,Hong, Chang Pyo,Kim, Dae-Soo,Moon, Jae-Woo,Choi, Yuri,Eo, Jungwoo,Kwon, Yun-Jeong,Lee, Ja-Rang,Jung, Yi-Deun,Bae, Jin-Han,Choi, Bong-Hwan,Ko, Junsu,Song, Sanghoon,Ahn, Kung,Ha, Hong-Seok Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.3

Athletic performance is an important criteria used for the selection of superior horses. However, little is known about exercise-related epigenetic processes in the horse. DNA methylation is a key mechanism for regulating gene expression in response to environmental changes. We carried out comparative genomic analysis of genome-wide DNA methylation profiles in the blood samples of two different thoroughbred horses before and after exercise by methylated-DNA immunoprecipitation sequencing (MeDIP-Seq). Differentially methylated regions (DMRs) in the pre-and post-exercise blood samples of superior and inferior horses were identified. Exercise altered the methylation patterns. After 30 min of exercise, 596 genes were hypomethy-lated and 715 genes were hypermethylated in the superior horse, whereas in the inferior horse, 868 genes were hypomethylated and 794 genes were hypermethylated. These genes were analyzed based on gene ontology (GO) annotations and the exercise-related pathway patterns in the two horses were compared. After exercise, gene regions related to cell division and adhesion were hypermethylated in the superior horse, whereas regions related to cell signaling and transport were hypermethylated in the inferior horse. Analysis of the distribution of methylated CpG islands confirmed the hypomethylation in the gene-body methylation regions after exercise. The methylation patterns of transposable elements also changed after exercise. Long interspersed nuclear elements (LINEs) showed abundance of DMRs. Collectively, our results serve as a basis to study exercise-based reprogramming of epigenetic traits.

측두하악 증후군에 대한 침치료 군과 추나치료 군의 임상적 고찰

김태수,김창연,이기하,엄태웅,정영훈,고영탁,Kim, Tae-Soo,Kim, Chang-Yun,Lee, Ki-Ha,Um, Tae-Woong,Jung, Yung-Hoon,Kho, Yung-Tak 척추신경추나의학회 2006 척추신경추나의학회지 Vol.1 No.1

Objectives : The purpose of study was to compare and analyze the effects of the distance Acupuncture and the Chuna on Temporomandibular Disorder. Methods : Clinical studies were done on 31 patients who were treated with Temporomandibular Disorder at Dept. of Acupuncture & Moxibusition of Hospital of Ha-na Oriental Medicine from May 23 2005 to Apr 30 2006. Subjects were divided Into two group, Distance acupuncture group and Chuna group. In Distance acupuncture group, we treated patients with Wijungyug(胃正格) or Damjungyug(膽正格). In Chuna group, we treated patients with Distraction & Translation technique. For evaluating Function of Temporomandibular joint of Patients, we use the Modified Craniomandibular Index(mCMI) before treatment and after 6th treatment. Results : In Mandibular Movement(MM) of patients, the patients of Acupuncture Group were more effective than Chuna group. In TMJ noise(TN) of patients, the patients of Chuna Group were more effective than Acupuncture group. Conclusions : The Distance acupuncture may be better effect on Mandibular Movement and The chuna maybe better effect on TMJ noise.

Tailoring oxidation resistance of Super304H by controlling Mn content

Ha, Heon-Young,Lee, Chang-Geun,Jang, Min-Ho,Kang, Jun-Yun,Young Park, Jun,Lee, Tae-Ho,Hong, Hyun-Uk Elsevier 2019 Corrosion science Vol.146 No.-

<P><B>Abstract</B></P> <P>The effects of Mn on oxidation resistance of Fe-18Cr-8.5Ni-3.5Cu-0.5Nb-0.1C-0.1 N-(0.08–2.05 wt%)Mn alloys were investigated by isothermal oxidation in ambient air at 700 °C for up to 8 weeks. The Mn addition up to 0.44 wt% increased the oxidation resistance, but further addition decreased it, thus the best oxidation resistance was obtained in the alloy with 0.44 wt% Mn. Mn promoted the internal oxidation and changed the Mn and Cr concentrations of the inner oxide layer. The best oxidation resistance of the alloy with 0.44 wt% Mn was attributed to the improved protectiveness of the inner oxide layer having the highest Cr content.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of Mn (0–2 wt%) on oxidation resistance of Super304H were examined. </LI> <LI> Addition of Mn up to 0.44 wt% increased the oxidation resistance. </LI> <LI> Further addition of Mn up to 2.05 wt% accelerated the oxidation. </LI> <LI> The best oxidation resistance was obtained in the alloy with 0.44 wt% Mn. </LI> <LI> Alloying Mn changed Mn and Cr contents of the internal oxide layer. </LI> </UL> </P>