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백서의 신경병증성 통증모델의 척수감각신경세포에 대한 NMDA 수용체 길항제 및 NOS 억제제의 영향
이강창(Kang Chang Lee),최유선(Yu Sun Choi),이환봉(Hwan Bong Lee),박승택(Seung Taeck Park) 대한통증학회 2002 The Korean Journal of Pain Vol.15 No.1
N/A Background: In order to evaluate the effect of N-methyl-D-aspartate (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (APV), nitric oxide synthase (NOS) inhibitor, and aminoguanidine (AGH) on rat spinal sensory neurons from the neuropathic pain animal model. Methods: Cell viability, amount of neurofilament by immunocytochemistry, and rate of protein synthesis were measured after spinal motor neurons of rats were incubated with various concentrations of APV or AGH for 48 hours. Results: Cell viability of spinal sensory neurons from the neuropathic pain model was remarkably decreased compared with the control. Regarding their protective effect, both APV and AGH significantly increased cell viability, amount of neurofilament and rate of protein synthesis, compared to experimental groups with untreated APV or AGH in spinal sensory neurons. Conclusions: The present study suggests that NMDA receptor, reactive nitrogen species (RNS), and No are involved in neuropathic pain.
Bupivacaine을 이용한 미추마취후 전신반응 증례보고
이강창,김태요 圓光大學校 醫科學硏究所 1987 圓光醫科學 Vol.3 No.1
The authors had an experience of a severe convulsion and hypoxic patient who had caudal block with 20ml of 0.5% bupivacaine ( total 100 ㎎) in order to have operation for the anal fistula. These complications were developed just after injection of 0.5% bupivacaine in to the sacral hiatus. This patient was treated completely without sequale . Nextday, operation had done under the general anesthesia.
소아환자의 수술후 P.R.N 근주와 PCA의 제통효과의 비교
이강창(Kang Chang Lee) 대한통증학회 1998 The Korean Journal of Pain Vol.11 No.1
N/A Background: The postoperative pain in children and adolescents is most commonly managed by intramuscular injections of NSAIDs or opioids. This approach may result in fluctuating plasma drug levels and cycles of pain, comfort, and sedation. Patient-controlled analgesia(PCA) is a method of analgesia administration that consists of a computer- driven pump with a button that the patient may press to administer a small dose of analgesic drug. Materials & Methods: Forty ASA physical status 1 or 2 children and adolescents were divided into two groups. In the PRN group, patients received intramuscularly diclofenac(Valentac®) on a p.r.n. basis. The PCA group patients received a mixture of nalbuphine and ketorolac by WalkMed®PCA infusor. Analgesic efficacy was evaluated with NRS(numerical rating scale) and Faces Pain Rating Scale. The side effects were evaluated. Results: The patients of PCA group had less pain than those of PRN group. Complications were similar in both group. Conclusions: PCA with nalbuphine and ketorolac is a safe and effecfive methods of pain relief in children and adolescents after surgery, and is better accepted than intramuscular injections.
Glucose Oxidase로 손상된 대뇌신경세포에 대한 Herba Epimedii의 영향에 관한 연구
이강창,옥순인,김상수,김봉룡,이재규,오연균,최대호,박승택,김용익,백은경,황상구,류도곤,전병훈 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.3
To elucidate the neurotoxicity of glucose oxidase(GO) in cultured cerebral neurons derived from neonatal mouse cytotoxicity was measured by MTT assay after cultured cells were grown for 4 hours in the media containing 1∼40mU/ml concentrations of GO. In addition, the neuroprotective effect of Herba Epimedii was measured by MTT assay in these cultrures. Cell viability was positively decreased in a dose-dependent manner after exposure of cultured mouse cerebral neurons to 20mU/ml GO for 4 hours. In the neuroprofective effect of Herba Epimedii on GO-mediated toxicity, Herba Epimedii prevented the GO-induced neurotoxicity in these cultures. From these results, it suggests that Epimedii is effective in prevetion of the neurotoxicity induced by GO.
Carrageenan에 의해 유발된 백서 비복근의 염증성 근육통이 건에 미치는 영향
이강창,이용석,이은미,허후만 대한통증학회 2004 The Korean Journal of Pain Vol.17 No.01
Background: It has been suggested that muscle pain may induce skeletal muscle tendon damage, but the mechanism of this process is not known. The purpose of this study was to investigate gastrocnemius muscle tendon damage on Sprague-Dawley rats after inducing inflammatory muscle pain with carrageenan. Methods: Rats were anesthetized with sevoflurane. Muscle pain was induced by injecting 0.1 ml of carrageenan into the gastrocnemius muscle. Rats were killed on 48 hours after carrageenan injection. Muscle tendons were fixed in 10% neural buffered formalin (NBF), dehydrated, embedded, and sectioned at 4μm. Sections were then stained with phosphotungstic acid hematoxylin (PTAH), mounted, and observed under a light microscope. Results: Carrageenan-induced inflammatory muscle pain was associated with reduced tendon fiber and fibroblast numbers. Conclusions: This finding suggests that carrageenan-induced inflammatory muscle pain damages the gastrocnemius muscle tendon in the rat by reducing tendon fiber and fibroblast numbers.
The Effects of Systemic Morphine to Analgesic Level in Spinal Anesthesia
이강창,김태요,윤재승,이의상,Lee, Kang-Chang,Kim, Tai-Yo,Yun, Jae-Seung,Lee, Eui-Sang The Korean Journal of Pain 1995 The Korean Journal of Pain Vol.8 No.1
척추마취는 국소마취제를 지주막하강에 주입하여 척수신경 전근과 후근을 차단하는 방법으로 하복부나 하지 수술 뿐 아니라 만성 통증과 암성 통증의 치료에도 이용되고 있는데 마취시간이나 제통시간의 연장 및 적절한 피부분절의 마취나 진통의 달성은 척추마취에서 중요한 사항이다. 본 연구에서는 morphine정주가 척추마취에 어떤 영향을 주는지 알아보기 위해 척추마취하에서 하지 수술을 받은 40명의 환자를 대상으로 척추마취를 시행한 80분에 척추마취 레벨, 수축기 및 이완기 혈압, 맥박 그리고 호흡수를 조사한후 morphine 10 mg을 정맥내로 주사후 20분후에 척추마취 레벨과 혈압, 맥박, 호흡수를 조사하여 다음과 같은 결과를 얻었다. 1) 척추마취 레벨은 morphine 투여진 $T_{7.5{\pm}0.32}$에 비해 morphine 투여 20분후에 $T_{6.0{\pm}0.31}$로 의의있게 상승하였다 (p<0.005). 2) 수축기 및 이완기 혈압과 맥박수는 morphine투여전과 투여후에 의의있는 변화가 없었다. 3) 호흡수는 morphine 투여전에 비해 투여후 감소가 있었다(p<0.005). 이상의 결과로 척추마취하에서 수술을 시행할 때나 통증치료시 전신적으로 morphne을 투여하여 마취와 진통부위를 넓일 수 있을 것으로 사료된다.