양수 DNA를 이용한 취약 X 증후군의 산전진단

김광준(Gwang Jun Kim),김석영(Suk Young Kim),황병철(Byung Cheul Hwang),박환용(Whan Yong Park),최유덕(Yu Duk Choi),황유진(Yu Jin Whang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3

N/A Background : The fragile X syndrome is the most common cause of inherited mental retardation, is almost always caused by abnormal CGG trinucleotide amplication within the FMR1(fragile X mental retardation) gene located in Xq27.3. Methods : DNA samples were obtained from the amniotic fluids of known carrier mother and 35 mothers without risk factors of the fragile X syndrome. Polymerase chain reaction(PCR) and Southern blot analysis were performed to evaluate the number of CGG repeats in the FMR1 gene. Results : The DNA samples from the carrier mother gave a large fragment over 300 repeats by PCR. All 35 control samples showed fragments sized under 35 repeats. Conclusion : Prenatal diagnosis of the fragile X syndrome could be done with mid-trimester amniotic fluid using PCR and Southern blot method.

SK-OV-3 상피성 난소암세포주에서 선택적 COX-2 억제제인 celecoxib가 paclitaxel에 의한 세포자멸사에 미치는 영향

안윤걸 ( Yun Gul Ahn ),김성수 ( Sung Soo Kim ),전완주 ( Wan Joo Chun ),황병철 ( Byung Cheul Hwang ),송영준 ( Young Jun Song ),소은정 ( Eun Jung Soh ),황종윤 ( Jong Yun Hwang ),조준식 ( Jun Sik Cho ),이동헌 ( Dong Heon Lee ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.7

정상 단태아 임신과 동반된 Hyperreactio luteinalis 1 예

김광준(Gwang Jun Kim),이광범(Kwang Beom Lee),황병철(Byung Cheul Hwang),조현이(Hyun Yee Cho) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6

Hyperreactio luteinalis is a rare disease characterized by marked cystic enlargement of the ovary due to multiple benign theca lutein cyst. The cause of this disease is not well known but is believed to be induced by high serum levels of human chorionic gonadotropins (hCG). It occurs usually in gestational trophoblastic disease, multiple pregnancies, and rarely in normal pregnancy. In nature, hyperreactio luteinalis is a benign condition. Therefore, the appropriate management is conservative, but surgical intervention is definitely indicated to remove infarcted tissue, control hemorrhage, or decrease androgen production in virilized patients. Here we report a case of hyperreactio luteinalis which was diagnosed at 11 weeks gestation. Lower abdominal pain was developed and progressed. Emergent right wedge oophorectomy and left salpingoophorectomy was performed due to probable torsion of left ovarian cyst and the pregnancy maintained. Theca lutein cysts were confirmed on pathologic examination.

자연분만일 예측에 있어서 초음파측정법과 최종생리일 산출법의 비교

김석영(Suk Young Kim),임승욱(Seung Ug Lim),김광준(Gwang Jun Kim),이지성(Ji Sung Lee),황병철(Byung Cheul Hwang),최유덕(Yu Duk Choi) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5

N/A Objectives : To evaluate whether the day of delivery for women with regular menstrual history was predicted best from the last menstrual period (LMP), crown rump length (CRL) and or biparietal diameter (BPD). Methods : All of 561 women had estimated the day of delivery by LMP, CRL in the first trimester (In case of 217 women, it was available) and BPD in the second trimester. The accuracy of each method in predicting the day of delivery was determined. Those who were delivered after the spontaneous onset of labor were included. Differences among these methods were evaluated with nonparametric tests. Results : The percentage of women who delivered within 3 days of the estimated day of delivery was 254(45.3%) and 216(38.5%) of the women with pregnancies by BPD and LMP, respectively. And within 7days of the estimated day were 408(72.7%), 390(69.5%) of the women from BPD and the LMP. In the women, the BPD estimate was significantly better predictor within the 7days of the day of delivery than LMP estimate (p=0.027). Compared to LMP estimate, CRL and BPD estimates seemed to be advanced the day of delivery about 2.6 days in CRL, and 0.9 days in BPD (p=0.004, p=0.034). But we could not find any advantage of the CRL measurement in first trimester than single BPD measurement in the second trimester for the predictor of the day of delivery. Conclusions : When the difference between the methods in predicting the day of delivery was less than 7 days, the BPD measurement was better than the last menstrual period.

임신 중 체중증가가 제왕절개 후 자연분만(VBAC)의 성공여부에 미치는 영향

오현명 ( Hyun Myeong Oh ),안옥주 ( Ok Joo Ahn ),이순표 ( Soon Pyo Lee ),이경훈 ( Gyoung Hoon Lee ),박혜원 ( Hey Won Park ),황병철 ( Byung Cheul Hwang ),노정희 ( Jung Hee Rho ),김석영 ( Suk Young Kim ) 대한주산의학회 2008 Perinatology Vol.19 No.3

목적: 임신 중 체중증가가 VBAC의 성공여부에 미치는 영향을 체질량지수(Body Mass Index, MRI)를 이용하여 그 상관관계를 조사하였고, 과도한 체중증가가 VBAC 성공에 risk factor로 작용하는지를 알아보고자 하였다. 방법: 2001년 1월부터 2006년 12월까지 본원에서 VBAC을 시도한 산모 112명을 대상으로 하여 성공군 92명(82.1%), 실패군 20명(17.9%)의 임상적 특정을 비교하였다. 산모의 신장기록이 없던 36명을 제외한 76명의 산모들을 대상으로 분만일에서 마지막으로 측정한 체중을 기준으로 MRI를 구하여 receiver-operating characteristic (ROC) curve를 통해서 VBAC성공을 예측할 수 있는 최적의 MRI 값을 알아보았다. 또한 정상과 과체중을 구분 짓는 MRI 26 미만과 MRI 26 이상을 기준으로 나누어 각각의 임상적 특정을 조사하였고 임신 중 체중의 증가에 따른 각 임상적 변수간의 차이를 회귀분석을 통하여 알아보았다. 한편 VBAC성공군 실패군 사이의 각 변수간 차이는 Chi-square검정, 및 Fisher`s exact test을 이용하여 비교하여 p<0.05을 의미 있는 것으로 하였다. 결과: 1. VBAC의 성공군과 실패군 간의 임상적인 특징을 보면 임신 중 산모의 체증증가가 성공군 1l.2±3.7 kg, 실패군 13.2±4.7 kg으로 통계적으로 유의한 차이를 보이는 것으로 나타났다(p<0.05). 2. VBAC성공을 예측할 수 있는 MRI값의 유용성에 대한 검사에서 MRI 26을 기준으로 한 것은 통계적으로 유의하지 않음을 알 수 있었다(p=0.837). 3. MRI 26 미만의 정상체중군에서 과체중군보다 산전진찰 방문 횟수가 더 많았고, 산모의 출생시 체중이 더 가벼웠으며, 산모의 임신기간 중 체중증가가 더 작았으며, 촉진제 사용 빈도도 낮았던 것으로 나타났다. 또한 신생아 출생체중도 더 가벼웠다. 결론: MRI값은 VBAC성공을 예측할 수 있는 지표로 사용하는 데는 제한적이라는 것을 알 수 있었다. 하지만 임신기간 중 체중증가가 상대적으로 적은 산모에서 VBAC의 성공률 높일 수 있는 여러 임상적 특정을 보인다는 것을 확인하였고 이러한 사실을 객관화시킬 수 있는 적절한 예측지표의 개발이 필요할 것으로 사료된다. Purpose: To examine the relationship between weight gain and the success of VBAC by using body mass index (BMI). To examine the relationship between weight gain and the success of VBAC by using body mass index (BMI). Methods: The study compared clinical features taken from 112 patients who tried VBAC at our institute from January 2001 through December 2006. There were divided into two groups: 92 patients for the success (82.1 %) and 20 patients for the failure group (17.9%). Excluding 36 patients with no BMI data, we constructed Receive-operating characteristics (ROC) curve to make the optimum BMI value for the prediction of success of VBAC. Based on the BMI 26 or more, two groups of patient were surveyed the interrelation between weight gain and success of VBAC. Results: Between success and failure group, the weight gain during pregnancy showed significant differences which are 11.2±4 kg of the success group and 13.2±5 kg of the other one (p<0.05). A survey on the availability of the BMI date to estimate success of VBAC, the criteria with the standard BMI 26 is not statistically valuable (p=0.837). By comparing normal weight and overweight based on BMI 26, some factors showed statistically significant discrepancies: number of prenatal visit, maternal weight gain, maternal weight at the time of delivery, use of oxytocin and birth weight. Conclusion: BMI value of 26 has limitations in using as an estimate criteria on success of VBAC. Patients, however, who had relatively small scale of weight gain, showed significant clinical factors to increased success rate of VBAC.

소아 및 청소년기에서 난소종물에 대한 임상병리학적경험

최병철(Byoung Cheol Choi),임승욱(Seung Ug Lim),엄기남(Gi Nam Eom),송경철(Gyung Chel Song),이종민(Jong Min Lee),김광준(Gwang Jun Kim),김석영(Suk Young Kim),이순표(Soon Pyo Lee),이지성(Ji Sung Lee),황병철(Byung Cheul Hwang),박찬용(Chan 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

N/A Objective : The purpose of this study was to review the incidence, clinicopathological feature, treatment, outcome in the series of childhood and adolescence with ovarian mass. Patients and Methods : Retrospective reviews of the medical recordings for 116 patients with ovarian mass under the age of twenty years old who were admitted, operated and confirmed with histopatholgical study at the department of obstetric and gynecology, Gachon medical school, Inchon, Korea for 8 years from Jan. 1993 till Dec. 2000. Results : Of 116 the patients who underwent surgical treatment, the incidence of malignant ovarian tumors was 15 cases(12.9%). If ovarian neoplasm alone are considered, the rate of malignancy increases to 17.6%. The frequency of ovarian malignancies correlated inverㅎsely with patient age. In the 0-10 age group ,40% had malignancies, as compared with 20.3% in the 11-15 age group and 15.3% in the 16-20 age group. On histopathological classification, the tumors originated from germ cell tumors were 55.2%, epithelial cell tumors were 40%, and sex-cord stromal tumors were 4.7%. According to FIGO classification of malignant ovarian tumor, stage I(80%) was most common, followed stage IV(13.3%), stage II(6.6%) and III(0%). 13 of the 15 malignant ovarian tumors, unilateral salpingoophorectomy was done in an attempt for reproductive organ conservation; 2 cases of stage IV disease were treated with hystrectomy, bilateral salpingoophorectomy and omentectomy. On follow up, only two ovarian malignancy stage IV died within 3 months and another is well. Conclusion : The frequency with which ovarian meoplasms malignancy in the under 20 age group is 17.6%. Because of their malignant potential in young girl, prompt evaluation and treatment is imperative.