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전이성골암에 의한 통증에 대한 Salmon Calcitonin($Miacalcic^{(R)}$) 비강분무의 효능 및 안정성
이수용,전대근,이종석,김석준,홍석일,최수용,장진대,Lee, Soo-Yong,Jeon, Dae-Geun,Lee, Jong-Seok,Kim, Sug-Jun,Hong, Seok-Il,Choi, Soo-Yong,Jang, Jin-Dae 대한근골격종양학회 1996 대한골관절종양학회지 Vol.2 No.1
Metastaic bone tumors are usually accompanied with severe pain. The treatment modalities for this pain are so variable that patients are sometimes afraid of using them. Salmon calcitonin has a function to increase beta-endorphines followed by increasing the blood level of prostaglandin and thromboxan A2, which results in analgesic effect. This drug also has been known to decrease bone resorption. There were a few reports that parenteral use of salmon calcitonin decrease the pain from metastatic bone tumor. We wanted to know the effectiveness and tolerability of nasal spray of salmon calcitonin in relieving bone pain with metastatic tumor. We analyzed the effectiveness in the aspects of pain, sleep, performance status, mobility, supplementary analgesic use. The biologic effect of salmon calcitonin was analysed with CBC, Ca/P, BUN/Cr, uric acid. Simple radiography, alkaline phosphatase, osteocalcin, pyrilink-K were used as parameters for bone change. Eighteen cases of metastatic bone tumors took nasal spray of salmon calcitonin($Miacalcic^{(R)}$, 200IU/day) for 4 weeks, to relieve bone pain. With Wilcoxon Matched-Pairs Signed Ranks Test, we could find pain decreased significantly at 3 week and mobility become improved at 4 week of salmon calcitonin use. Other parameters didn't show any significant changes. We think the analgesic effect is mainly due to effect not on the local bone lesion but on the central nervous system, and that increased dose of salmon calcitonin can induce earlier and stronger analgesic effect.
윤세문(Sae-Moon Yoon),신민석(Min-Seok Shin),김은준(Eun-Jun Kim),홍석인(Seok-In Hong),권오경(Oh-Kyong Kwon) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
In this paper, a LDO circuit for bio-implantable applications is proposed. Even if the load current increases, the open-loop gain of the amplifier can be maintained by using an additional unit gain buffer, a level-shifter, and a pass transistor. This is done by sensing the amount of output voltage variations and passes it onto a buffer and a level shifter so that the change is suppressed. Consequently, the amplifier accuracy and load regulation have been improved. Simulation results are obtained by HSPICE in a 0.18㎛ CMOS standard technology. When the current at the load increased from OA to 200μA, the open loop gain of the previous regulator dropped from 79㏈ to 21㏈, whereas that of the proposed regulator dropped from 76㏈ to 51㏈.
이재학 ( Jae Hak Lee ),전은정 ( Eun Jung Jun ),최현호 ( Hyun Ho Choi ),홍석인 ( Seok In Hong ),김진일 ( Jin Il Kim ),김재광 ( Jae Kwang Kim ),이연수 ( Youn Soo Lee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
대장에서 전이된 선암은 비강 및 부비동에서 발생하는 장형 선암과 조직학적으로 매우 비슷하여 구분이 어렵다. 대장암으로 전신화학요법을 시행하고 있는 환자에서 코인두에 종양이 발생하여 영상검사와 조직검사, 면역조직화학검사를 시행하였다. 시행한 영상학적 검사에서 장형 선암이 잘 발생하는 비강과 부비동에는 종양이 발견되지 않았다. 조직검사에서는 원발 병소와 병리조직학적으로 비슷한 모습을 보였으며 면역조직화학검사에서 CK20와 CDX-2에서 양성을 나타냈고, CK7은 음성을 나타내어 대장암의 코인두 전이로 진단하였다. 대장에서 전이된 선암과 장형 선암의 감별은 조직 검사만으로는 구분하기가 어렵다. 임상적인 감별이 필요하며 적극적인 영상학적 검사와 면역조직학적검사가 시행되어야 한다. 저자들은 58세 남자 환자에서 대장암의 치료과정에서 발생한 코인두 전이를 경험하고 코인두에서 선암이 발생하였을 경우 대장암의 전이를 고려해야 한다고 생각되어 문헌고찰과 함께 보고한다. Metastatic adenocarcinoma from the gastrointestinal tract to the nasopharynx is rare. The histological morphology of this lesion is indistinguishable from the colonic variant of primary head and neck adenocarcinoma or intestinal-type adenocarcinoma (ITAC) of the nasal cavity. This is a report of metastatic adenocarcinoma of colorectal origin to the nasopharynx in a 58-year-old man who was previously treated for adenocarcinoma of the sigmoid colon. A histopathological study of the specimen from the nasopharynx demonstrated a tumor that was identical to the patient`s previous primary tumor from the colon. There was no tumor mass in the nasal cavity or paranasal sinuses. The nasopharyngeal tissue expressed cytokeratin 20 and CDX-2, but not cytokeratin 7. The patient received palliative radiation after the diagnosis. Distinguishing metastatic adenocarcinoma from the gastrointestinal tract from ITAC can be difficult. The clinical manifestation is important in differentiating these conditions. It is important to recognize these as metastatic lesions because treatment is primarily palliative. (Korean J Med 2011;80:S96-S100)
정수미,김성진,김방울,전상윤,홍석,김행진,Jung, Soo-Mi,Kim, Sung-Jin,Kim, Bang-Ul,Jun, Sang-Yun,Hong, Seok,Kim, Haeng-Jin 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
This study was designed to analyze the effectiveness of the diagnosis and treatments of hemorrhagic infarction patients in oriental medicine. In this study the clinical symptoms of two hemorrhagic infarction patients improved after diagnosis and treatment of oriental medicine. Though improvement was seen after diagnosis and treatment of both hemorrhagic infarction patients, the early stage of hemorrhagic infarction required western fluid therapy treatments. Study of more cases will be needed in order to varify efficacy for these oriental treatments to be generally applied.