모세관 전기영동 분석법의 복합약물제제의 품질관리 분석에 응용을 위한 연구

허유정(Yoo Jeong Heo),이공주(Kong Joo Lee) 대한약학회 1997 약학회지 Vol.41 No.5

Capillary electrophoresis (CE) is perceived as an attractive tool for the analysis of pharmaceuticals and biological materials because of their high separation efficiency, easy separation and low running cost. New concept of micellar electrokinetic capillary chromatography (MECC) expanded the application of CE to the separation of neutral molecules. Validation of CE as an analytical technique for quality control of pharmaceuticals should be confirmed by quantitative analysis and the peak confirmation. In this study, the quantitative analyses of various types of neutral, acidic and basic components (acetaminophen, caffeine, ascorbic acid, riboflavin, thiamine, chlorpheniramine, phenylpropanolamine, dl-methylephedrine and dextromethorphan) in complex cold medicines have been accomplished using CE. Combined methods of MECC using SDS and capillary zone electrophoresis lowering the pH of running buffer were adopted to determine the ingredients in capsule type or liquid formula complex medicines without particular sample pretreatment. The results indicate that CE is a promising technique for quality control analysis of pharmaceuticals as a validation method.

혁신의 관점에서 본 서비스 디자인 가치 -실증 연구를 통한 의미도출-

허유정 ( Yu Jeong Heo ),유민호 ( Min Ho Yoo ) 커뮤니케이션디자인학회 2013 커뮤니케이션 디자인학연구 Vol.42 No.-

혁신은 기업의 경쟁력 강화를 위한 핵심전략이다. 최근 디자인혁신을 통해 시장을 공략함으로써 기업의 외부적 경쟁력을 강화하는 전략이 다양하게 이루어지고 있다. 디자인은 소비자를 대상으로 평준화된 기업 경쟁력을 차별화할 수 있는 혁신요소인 것이다. 서비스 디자인의 경우에서도 혁신이 중요한 가치요인으로 나타난다. 첫째, 서비스 디자인은 디자인 가치를 제품에서 유, 무형의 서비스로 확장함으로써 소비자에게 총체적 서비스를 제공하는 시스템과 프로세스를 디자인한다. 둘째, 서비스 디자인은 디자인과 경영, 공정 공학(process engineering)의 다양한 방법을 조합한 학제적 환경을 통해 뉴비즈니스 모델을 창출하여 새로운 사회 경제적 가치를 창출한다. 본 연구의 목적은 혁신의 관점에서 서비스 디자인 가치를 분석함으로써 서비스 디자인의 전략방향을 제시하는데 있다. 1) 슘페터(Schumpeter), 러브락(Lovelock)과 존슨(Johnson) 등의 이론에 근거한 혁신유형 및 요인분석을 통해 혁신과 디자인 가치의 상관관계를 제시할 수 있는 틀을 도출한다. 2) “IBK-KT 융합형 스마트 브랜치 디자인”을 실증연구 대상으로 혁신과 서비스 디자인 가치의 상관관계를 분석한다. 근거이론을 적용하여 개발에 참여한 서비스 디자인 전문 업체인 팀인터페이스, KT 및 IBK 기업은행의 의사결정자들을 대상으로 설문 및 심층면접을 시행하여 혁신요인과 서비스 디자인 가치의 상관관계를 분석함으로써 가치창출을 위한 전략방향을 제시한다. Innovation has come to a core strategy for enterprises. Design is an external innovation tool to differentiate enterprises` competitiveness. Innovation appears as an important factor in service design. First, service design is equipped with processes and methods to provide both tangible and intangible values to the customers. Second, service design combines design, management and process engineering; thus, forming interdisciplinary and innovative environments; leading to new business models and social values. The purpose of this research is to suggest relations between service design value and innovation, suggesting service design`s strategies. 1) Service design industry analysis model is formed, stemming from Shumpeter, Moritz and Lovelock. 2) These researches lead to a study of service design processes and methods affecting value and innovation. 3) "IBK-KT Convergence Smart Branch Design" is set to provide practical examples. Participating organizations such as IBK, KT and Teaminterface are interviewed in depth and survey is conducted on the basis of grounded theory to draw semantic resolutions, regarding service design value and innovation.

혁신의 관점에서 본 서비스 디자인 프로세스와 방법론 -실증 연구를 통한 의미도출-

허유정 ( Yu Jeong Heo ),유민호 ( Min Ho Yoo ) 커뮤니케이션디자인학회 2013 커뮤니케이션 디자인학연구 Vol.43 No.-

본 연구의 목적은 실제 서비스 디자인 개발 사례에 적용된 프로세스와 방법론을 혁신의 관점에서 분석함으로써 가치창출을 위한 전략적 접근방향을 제시하는 것이다. 실증대상 분석에 있어 설명적 연구법을 적용하는데, 참여인력을 대상으로 심층인터뷰 및 설문을 진행하고, 이를 사례연구기법을 통해 분석한다. 서비스 디자인의 가치분석에 러브락(Lovelock)과 존슨(Johnson)의 혁신성 평가지표를 적용하고, 서비스 디자인 가치에 프로세스와 방법론이 미치는 영향을 논하는 과정을 통해 다음과 같은 결론이 도출되었다. 1) 단순 서비스개선을 추구하는 점진적 혁신 전략에 비해 신규서비스 및 비즈니스 모델을 개발하는 급진적 혁신 전략이 가치창출을 증대시킨다. 2) 방법론은 수요자와 공급자 2개 측면으로 나뉠 수 있는데, 수요자 중심의 경우 점진적 혁신성향을 보이는 반면, 공급자 중심의 경우 급진적 혁신성향을 보인다. 따라서 신규서비스 및 비즈니스 모델 디자인에 경우, 공급자 중심의 디자인 개발이 이루어진다. 3)디자인 혁신 성향이 낮을 경우, 서비스 디자인 및 브랜드디자인 결과에 대한 만족도가 시각, 제품, 인테리어, 인터랙티브 디자인과 같은 유형의 결과물을 주로 도출하는 디자인 유형에 비해 낮게 나타난다. The purpose of this research is to suggest strategies for design values by analyzing processes and methods of a service design case. An explanatory study was applied; thus, participating manpower was interviewed and surveyed. The results were analyzed by case study methods. Lovelock and Johnson`s Innovation methods were used in analyzing influential factors of service design processes and methods to design values. Following outcomes were realized. 1) Radical innovative strategies tend to enlarge the opportunities of creating values as apposed to gradual innovative strategies. 2) Methods can be either consumer driven showing gradual innovative strategies or supplier driven resulting in radical innovative strategies. 3) When innovative tendency is low, it affects service and brand design satisfactory index more than the equivalence of visual, product, interior or interactive design.

당 침지액 농도에 따른 건조 둥근 마의 품질 특성 및 항산화 효과

조혜민 ( Hye Min Jo ),김희영 ( Hee Young Kim ),허유정 ( Yoo Jeong Heo ),송다혜 ( Da Hye Song ),김경지 ( Gyeong-ji Kim ),김인수 ( In-su Kim ),윤진아 ( Jin-a Yoon ),정강현 ( Kang-hyun Chung ),안정희 ( Jeong Hee An ) 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.6

This study was investigated the quality characteristics and antioxidant of dried Dioscorea bulbifera with various pre-soaking concentrations of oligosaccharide. Dioscorea bulbifera are prepared by additions of 0, 4, 6, 8 and 10% oligosaccharide solution, and dried at 50℃. The effects of pre-soaking percent of Dioscorea bulbifera slices were evaluated by the moisture, soluble solid, pH, titratable acidity, color, browning degree, texture, antioxidant activities and sensory test. According to the percent of pre-soaking oligosaccharide solution was increased, the moisture was increased but soluble solids and titratable acidity were decreased. With respect to the result of colors, Dioscorea bulbifera slices that underwent the 10% pre-soaked process (85.86%) were lighter than control (73.88%). However, the redness and yellowness scores were the lowest than control. The springiness and cohesiveness of texture showed no significant differences among all groups. Gumminess and chewiness of texture results were increased according to per-soaking concentration increase. Also the polyphenol, flavonoid and DPPH (α, α-diphenyl-β-picrylhydrazyl) and ABTS [2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] radical scavenging activities were significantly increased with increasing immersion concentration. The Dioscorea bulbifera slices supplemented with 6% pre-soaking oligosaccharide solution treatment showed the highest total sensory score. The results of our study indicated that when pre-soaking oligosaccharide solution is used to immerse the Dioscorea bulbifera slice, it has browning inhibition and antioxidant effect.

모세관 전기영동 분석법의 복합약물제제의 품질관리 분석에 응용을 위한 연구

허유정,이공주 梨花女子大學校 藥學硏究所 1998 藥學硏究論文集 Vol.- No.7

Capillary electrophoresis (CE) is perceived as an attractive tool for the analysis of pharmaceuticals and biological materials because of their high separation efficiency. easy separation and low running cost. New concept of micellar electrokinetic capillary chromatography (MECC) expanded the application of CE to the separation of neutral molecules. Validation of CE as an analytical technique for quality control of pharmaceuticals should be confirmed by quantitative analysis and the peak confirmation. In this study, the quantitative analyses of various types of neutral. acidic and basic components (acetaminophen. caffeine. ascorbic acid. riboflavin. thiamine. chlorpheniramine. phenylpropanolamine. dl-methylephedrine and dextromethorphan) in complex cold medicines have been accomplished using CE. Combined methods of MECC using SDS and capillary zone electrophoresis lowering the pH of running buffer were adopted to determine the ingredients in capsule type or liquid formula complex medicines without particular sample pretreatment. The results indicate that CE is a promising technique for quality control analysis of pharmaceuticals as a validation method.