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적갈색방사선학적 악성이나 조직학적으로 양성을 보인 신경절교종 - 증례보고 -
허원 ( Weon Heo ),김환수 ( Hwan Soo Kim ),정세헌 ( Se Heun Joung ),이동열 ( Dong Youl Rhee ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2
Gangliogliomas are rare tumors of the central nervous system, composed of neoplastic ganglion cells and neoplastic glial cells. They are characterized by slow growing, low incidence of malignancy, surgically curable, and usually occurred in children and young adults. We report a case of ganglioglioma occurred in 21 year-old male which radiological findings were compatible with the malignancy but histologically diagnosed as benign, with review of literatures.
Weon Heo(허원),Yonghae Son(손용해),Hyok-rae Cho(조혁래),Koanhoi Kim(김관회) 한국생명과학회 2022 생명과학회지 Vol.32 No.6
본 연구에서는 죽상경화 플락에서 발견되는 펩티도글리칸이 혈관염증에서 어떠한 역할을 하는지 알아보기 위하여 염증성 사이토카인의 한 종류인 인터루킨-1 알파의 발현에 대한 영향을 조사하였다. 실험방법으로는 혈관염증을 주도하는 단핵구/대식세포인 THP-1 세포주에 펩티도글리칸을 처리하고 인터루킨-1 알파의 발현을 RT-PCR, real-time PCR, ELISA 방법으로 분석하였다. 펩티도글리칸의 처리 시간과 농도에 비례하여 단핵구/대식세포에서 인터루킨-1 알파의 전사체와 단백질 분비가 증가함을 관찰하였다. 또한 펩티도글리칸의 작용기전을 규명하기 위하여 신호전달을 차단하는 억제제를 세포에 처리하고 인터루킨-1 알파의 발현을 조사하였다. TLR2/4의 억제제인 OxPAPC 그리고 세포 kinase의 작용을 억제하는 LY294002(PI3 kinase 억제), Akti IV (Akt 억제), rapamycin (mTOR 억제), U0126 (MEK 억제), SB202190 (p38 MAPK 억제), SP6001250 (JNK 억제), DPI (NOX 억제)를 처리하는 경우 인터루킨-1 알파 전사체의 발현 그리고 단백질의 분비가 감소되었다. 반면에 LPS의 작용을 억제하는 polymyxin B는 인터루킨-1 알파의 발현에 영향을 주지 않았다. 이상의 결과는, 펩티도글리칸이 TLR2, PI3K, Akt, mTOR, MAPKs를 통하여 단핵구/대식세포의 인터루킨-1 알파 발현을 증가시키고 혈관염증에 기여한다는 것을 나타낸다. The expression of interleukin-1α (IL-1α) is elevated in monocytic cells, such as monocytes and macrophages, within atherosclerotic arteries, yet the cellular molecules involved in cytokine upregulation remain unclear. Because peptidoglycan (PG), a major component of gram-positive bacterial cell walls, is detected within the inflammatory cell-rich regions of atheromatous plaques, it was investigated if PG contributes to IL-1α expression in monocytes/macrophages. Exposure of THP-1 monocytic cells to PG resulted in elevated levels of IL-1α gene transcripts and increased secretion of IL-1α protein. The transcription and secretion of IL-1α were abrogated by OxPAPC, an inhibitor of TLR2/4, but not by polymyxin B that inhibits lipopolysaccharide-induced TLR4 activation. To understand the molecular mechanisms of the inflammatory responses due to bacterial pathogen-associated molecular patterns (PAMPs) in diseased arteries, we attempted to determine the cellular factors involved in the PG-induced upregulation of IL-1α expression. Pharmacological inhibition of cell signaling pathways with LY294002 (a PI3K inhibitor), Akti IV (an inhibitor of Akt activation), rapamycin (an mTOR inhibitor), U0126 (a MEK inhibitor), SB202190 (a p38 MAPK inhibitor), SP6001250 (a JNK inhibitor), and DPI (a NOX inhibitor) also significantly attenuated the PG-mediated expression of IL-1α. These results suggest that PG induces the monocytic or macrophagic expression of IL-1α, thereby contributing to vascular inflammation, via multiple signaling molecules, including TLR2, PI3K/Akt/mTOR, and MAPKs.
방사선학적 악성이나 조직학적으로 양성을 보인 신경절교종 -증 례 보 고-
김환수 ( Hwan Soo Kim ),정세헌 ( Se Heun Joung ),허원 ( Weon Heo ),이동열 ( Dong Youl Rhee ) 대한뇌종양학회 대한신경종양학회 2014 Brain Tumor Research and Treatment Vol.2 No.1
Gangliogliomas are rare tumors of the central nervous system, composed of neoplastic ganglion cells and neoplastic glial cells. They are characterized by slow growing, low incidence of malignancy, surgically curable, and usually occurred in children and young adults. We report a case of ganglioglioma occurred in 21 year-old male which radiological findings were compatible with the malignancy but histologically diagnosed as benign, with review of literatures.
신부전이 동반된 신실질의 Malakoplakia 1 예
김경수,이현순,이순일,유태석,조화상,조영일,전혜정,유종길,임형래,허원만,유광하 대한내과학회 1996 대한내과학회지 Vol.51 No.6
Malakoplakia is a rare chronic granulomatous disease generally confined to the urinary bladder, but occasionally occuring in other tissue. Since the initial case of Michaelis-Gutmann in 1902, about 200 cases have been reproted. Among these cases, renal parenchymal malakoplakia accounts for only 16M. It is most common in middle-aged females with chronic urinary tract infection. The pathogenesis of malakoplakia is unclear, but defective killing and impaired digestion of phagocytosed bacteria as a result of a low GMP/AMP ratio is believed to contribute to its pathogenesis, Improperly digested bacteria becomes mineralized, leading to the formation of the pathognomonic Michaelis-Gutmann bodies. Renal parenchymal malakoplakia is very rare, and occurs bilateral in about 50% of the cases. Although conservative medical management with an intracellularly active antibiotics, ascorbic acid and a cholinergic agonist has been recommended for unilateral renal malakoplakia, nephrectomy has been advocated as the treatment of choice. Bilateral renal malakoplakia behaves as a progressive, destructive, and fatal disease, and little is known about the satisfactory treatment for it. We experienced a case of renal parenchymal malakoplakia with renal insufficiency in a 66-year-old man. He was admitted for surgery of anal prolapse. On preoperative evaluation, azotemia, pyuria, and an enlarged right kidney were incidentally detected. A percutaneous renal biopsy was performed and the specimen showed the characteristic Michaelis Gutmann bodies, After long-term therapy with antibiotics, renal function was recovered partially, pyuria disappeared and the enlarged kidney decreased in size. Herein, we report this case with a review of the literatures.