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한성태,이상훈,Han, Seong-Tae,Lee, Sang-Hun 대한영상의학회 2003 대한영상의학회지 Vol.48 No.3
목적: 신체 각 부위의 동정맥 기형에 대한 경피적 색전술의 효과를 알아보고자 하였다. 대상과 방법:신장과 간, 폐, 흉벽, 자궁 및 척추방에 발생한 동정맥 기형 환자 7명을 대상으로 하였다. 7예 모두에서 혈관조영술과 경피적 색전술을 시행하였다. 색전물질로는 Coil, Gelfoam, Contour emboli와 무수알코올을 사용하였다. 색전술전 각부위 동정맥 기형의 혈관조영술 소견의 특징을 분석하였고 색전술후 임상경과를 추적관찰 하였다. 결과: 혈관조영술상 각부위의 동정맥 기형은 사행성으로 확장된 영양동맥 (n=7)과 유출정맥의 조기 출현 (n=6)을 보였다. 간의 동정맥 기형은 포도송이 모양의 이상혈관 (n=1)을 보였으며 자궁의 기형은 수 많은 영양혈관들이 벌집모양 (n=1)을 이루고 있었다. 흉벽과 폐의 복합형 기형은 영양동맥과 핵의 동맥류 (n=2)소견을 보였다. 단순형 동정맥 기형의 경우 1회의 색전술로 동정맥단락과 조기 정맥유출이 사라지고 임상증상이 개선되었다. 광범위한 다발성 영양동맥을 갖는 복합형 동정맥 기형들의 경우 1차 색전술 후 재발하였으나 색전술을 반복하여 증상이 호전되었다.색전술 후 발생한 발열 (n=3)과 통증 (n=3)은 보존적인 치료로써 호전되었고, 다른 합병증은 없었다. 결론: 경피적 색전술은 동정맥 기형 치료의 안전하고 효과적인 치료방법이며, 특히 수술적 절제가 불가능한 광범위한 다발성 기형환자에서는 반복적인 색전술만이 환자의 증상을 경감시킬 수 있는 유일한 치료방법으로 생각된다. Purpose: To determine the effectiveness of percutaneous transarterial embolization for the treatment of arteriovenous malformation (AVM). Materials and Methods: Seven patients with AVMs located in the kidney, liver, lung, chest wall, uterus and paraspinal region underwent angiography and percutaneous transarterial embolization. The embolic materials used were steel coil, gelfoam, contour emboli, and absolute alcohol; in some cases, more than one of these were employed. The analysed the angiographic findings and clinical status following embolization were assessed and analysed. Results: The AVMs had tortuous, dilated feeding arteries (n=7) and veins with early venous drainage (n=6). In the hepatic AVM, a grape-like dilated vessel arose from the hepatic artery and was connected to the portal vein. In the uterine AVM, numerous dilated feeding arteries formed a honeycomb. In the feeding arteries of the chest wall AVM and in the nidus of the pulmonary AVM, aneurysms were present. In simple AVMs, the patient's symptoms were relieved by first embolization. Complex AVMs, however, required repeated embolizations for symptomatic relief. Although extensive, complex AVMs of the chest wall and uterus recurred after initial embolization, repeated treatment successfully improved the clinical status of such patients. The complications developing after emboliation were fever (n=3) and pain (n=3), but these were relieved by conservative care. Conclusion: Percutaneous transarterial embolization is a safe and effective therapeutic method for the treatment of AVM. In a case of inoperable complex AVM, repeated embolization is the only method for symptomatic relief and the maintenance of life.
혈구응집억제반응과 효소면역측정법을 이용한 닭 뉴캣슬병 바이러스에 대한 혈중항체가 비교
한성태 ( Sung Tae Han ),이청산 ( Cheong San Lee ),곽학구 ( Hak Koo Kwak ),송종한 ( Jong Han Song ),이종인 ( Jong In Lee ) 한국가축위생학회 2003 韓國家畜衛生學會誌 Vol.26 No.3
This study was conducted to investigate the similarity between hemagglutination inhibition (HI) test and enzyme-linked immunosorbent assay(ELISA) titers and sample to positive ratio (S/P ratio) of Newcastle disease(ND) virus. To perform this study, the 372 sera of broiler chicks and 120 sera of layers and breed chicks were collected from slaughter house and farms, respectively. As a result of Hi test out of different chicks, the positive percentage of ND antibody titer of broiler, layer and breeder, when a standard positive HI titer were `2`, was 84.4%, 100% and 100%, respectively. The positive percentage of ND antibody titer by ELISA was shown 38.4%, 100% and 100% and S/P ratio were also shown 81.5%, 98.2% and 99.2%, respectively. The results of comparative survey with same sera by two experimental methods were as follows; In low HI titer, ELISA titer was not similar to HI titer, but S/P ratio was similar to it. In high HI titer, ELISA titer and S/P ratio were similar to HI titer. Therefore, HI titer was more similar to S/P ratio than ELISA titer.
꽃사슴의 Clostridium perfringens A형에 의한 장독혈증 발생보고
이청산 ( Cheong San Lee ),한성태 ( Sung Tae Han ),곽학구 ( Hak Koo Kwak ),박경재 ( Kyung Jae Park ),현공율 ( Gong Yul Hyun ),조우영 ( Woo Young Cho ),이종인 ( Jong In Lee ),배유찬 ( You Chan Bae ),진영화 ( Yong Hwa Jean ) 한국가축위생학회 2002 韓國家畜衛生學會誌 Vol.25 No.2
The case reports for clostridium perfringens type A enterotoxemia in Formosan deer have rarely been reported. This paper describes a natural case of type A enterotoxemia in farmed Formosan deer in Cheongwon-gun. A dead, male 10-month-old Formosan deer was submitted to Chungbuk Livestock and Veterinary Research Institute, March 24, 2001 and examined. That deer was fed with assorted grain feed, oak leaves, acorn and bean curd. Grossly there was no visible external change. Despite of the carcass being examined within 12 hours of death, there was a quite degree of postmortem decomposition. There was severe hemorrhage in the serosa of abomasum and small intestine. Much blood tinged and watery contents were contained in those organs. Also there were severe swelling of spleen, some red foci in hepatic parenchyma. Microscopically there were severe congestion and hemorrhage in mucosa, submucosa, muscular layer, and serosa of abomasum and small intestine. Also spleen and pancreas showed severe congestion and hemorrhage. There were multifocal hemorrhage with hepatic necrosis in periportal area and focal mononuclear cell deposition in sinusoid. In bacterial culture for small intestine, Cl peifringens was isolated. By toxin typing for the strain, that had α-toxin belonged to type A. In electronmicroscopy for feces, no virus particle was detected. Considering clinical signs, gross lesions, microscopic lesions, bacterial culture, and toxin typing of the isolate, this case was diagnosed as enterotoxemia by Cl perfringens type A.
오수아(Soo A Oh),강승이(Seung Yi Kang),한성태(Sung Tae Han),안덕근(Dog Gn An),신차균(Cha-Gyun Shin) 대한약학회 2006 약학회지 Vol.50 No.2
Human foamy virus (HFV) integrase mediates integration of viral c-DNA into cellular DNA. In this process, HFV preintegration complex (PIC) in which integrase is a key component moves to nuclei of the infected cells and leads to integration of viral DNA to the cellular genome, which is essential in viral life cycle. In general nuclear localization signals (NLS) have been suggested to be involved in localizing retroviral PIC to muclei, but the mechanisms for nuclear localization of the HFV PIC remains unclear. To functionally identufy the NLS of HFV integrase, various subdomains of the protein were expressed as GFP fusions and fusions and their subcellular locations were analyzed with comfocal laser scanning microscopy. Wild type HFV integrase was karyophilic by targeting the fusion protein to nuclei of the COS-1 and 294T cells. Our results showed that strong NLS of HFV integrase was mapped to the C-terminal regions. In addition the karyophimic properties of N-ter- minal and central regions are not individually strong enough to direct localization of the fusion proteins to nuclei, but their cooperative activity for nuclear inport was comfirmed.
변현섭 ( Hyeon Seop Byun ),이현주 ( Hyun Ju Lee ),이상명 ( Sang Myung Lee ),한성태 ( Seong Tae Han ),곽학구 ( Hak Ku Quak ),최해연 ( Hae Yeon Choi ),조윤상 ( Yun Sang Cho ),안병우 ( Byeong Woo Ahn ) 한국가축위생학회 2007 韓國家畜衛生學會誌 Vol.30 No.3
There were eight Korean indigenous cattles affected with bovine tuberculosis(BTB) detected by inspectors at slaughterhouses located in Chungbuk province from May 2006 through July 2007. Postmortem finding of BTB cases was characterized by the presence of several caseous or calcified nodules encapsulated by connective tissue from the pleural/peritoneal surface, livers, lungs and regional lymph nodes. On microscopic examinations, the characteristic lesion of BTB was the formation granulomatous nodules, which contains central calcified necrotic zone surrounded by epithelioid cells, macrophages and a few Langhans` type giant cells. In addition, mononuclear cells and fibroblasts were also infiltrated. At the periphery, encapsulation was formed that protect the neighboring healthy tissues.