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Pyriproxyfen inhibits the suppressive effect of inflammatory signal on TR4 activity
최호중,박성수,김응석 한국곤충학회 2017 Entomological Research Vol.47 No.2
Obesity causes a chronic inflammatory state by increasing secretion of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα), which alters signaling pathways critical for metabolic homeostasis, leading to obesity‐related metabolic disorders. Here, we demonstrate that TNFα inhibits testicular orphan nuclear receptor 4 (TR4) transcriptional activity and this TNFα inhibition of TR4 activity is reduced by treatment of Pyriproxyfen (PYR), a juvenile hormone (JH) analog. In addition, nuclear factor‐kappa B (NF‐κB), a key transcription regulator of inflammation, also suppressed TR4 transactivation by physical interaction with TR4, reducing TR4 binding affinity for TR4 response elements located in its target gene promoters. Consistently, NF‐κB‐suppressed TR4 activity was partially restored by PYR treatment. Furthermore, TNFα inhibited mRNA levels of TR4 target genes such as, FATP1 and PC with reduction of lipid accumulation in 3 T3‐L1 adipocytes while PYR suppressed TNFα inhibition of TR4 target gene expression, resulting in recovery of lipid accumulation of adipocytes, suggesting that PYR enhances lipid homeostasis disturbed by inflammatory signaling and this PYR effect could be achieved in part by stimulating TR4 transcriptional activity. Together, our data show that PYR regulates inflammatory signaling in adipocytes and thus, small molecules based on insect hormones could be an alternative approach to control obesity‐related metabolic disorders.
O2O(Online to Offline)의 서비스 품질이 고객관계품질과 브랜드 이미지에 미치는 영향
최호중,김효진 (사)한국조리학회 2019 한국조리학회지 Vol.25 No.10
In this study, we examined the effect of O2O service quality on customer relationship quality and brand image for the dining out consumers and tried to verify through empirical analysis. The survey was conducted from May 01, 2019 to May 25, 2019, and 300 questionnaires were distributed, and 247 valid data were used for analysis, excluding questionnaires that did not meet the purpose of the study. The results of this study are as follows: First, the result of the hypothesis 1 verification, O2O service quality has a positive effect on the quality of customer relationship. Third, as a result of hypothesis 3, customer relationship quality has a positive effect on brand image. It is also meaningful to examine how customer relationship quality affects brand image and what direct influence it has on a company, or what evaluations are made according to consumer behavior.
최호중,강의성,다나카도시히사,고성제 한국통신학회 2000 韓國通信學會論文誌 Vol.25 No.1
영상 내에서 중요한 내용을 포함하고 있는 관심영역 (region of interest: ROI)을 나머지 영역보다 우선적으로 전송하는 점진적 관심영역 부호화 방법은 웹 검색이나 영상 데이터베이스 시스템에 유용하게 사용될 수 있다. 관심영역 부호화 방법은 전 영역을 동일한 중요도로 전송하는 일반적인 점진적 부호화(progressive coding) 방법과는 달리, 특정 영역을 우선적으로 부호화하여 전송하기 때문에 짧은 시간 내에 매우 적은 양의 수신된 비트스트림을 가지고 원영상의 내용을 파악할 수 있다는 장점이 있다. 본 논문에서는 비트율 제어와 점진적 전송 기술을 적용하기 용이한 임베디드 부호화 방법을 이용한 점진적 관심영역 부호화 방법과, 원영상에 대한 관심영역의 위치정보를 효율적으로 전송하는 방법을 제안한다. 제안한 방법은 웹 검색이나 영상 데이터베이스 시스템 등의 응용 분야에 효과적으로 적용할 수 있음을 실험 결과를 통하여 확인하였다. In image coding applications such as web browsing and image database searching, it is very useful to quickly view a small portion of the image with higher quality. Region of interest (ROI) coding technique provides the capability to reconstruct the ROI in advance of decompressing the rest of the image, with a smaller number of transmitted bits compared to the case where the entire image is treated with the same priority. In this paper, a progressive ROI coding method using the enbedded coder is presented, and an efficient transmission method for the ROI information. Experimental results show that the proposed progressive ROI coding technique can be effectively used for image coding applications such as web browsing and image database searching system.
Conjugated Linoleic Acid Negatively Regulates TR4 Activity in 3T3-L1 Adipocytes
최호중,김응석 한국축산식품학회 2011 한국축산식품학회지 Vol.31 No.3
Dietary conjugated linoleic acid (CLA) play key roles in lipid metabolism. Here, we investigated the effect of CLA on the transcriptional activity of TR4, an orphan nuclear receptor that plays an important role in lipid homeostasis. CLA increased TR4 gene mRNA level in 3T3-L1 adipocytes, but inhibited TR4 transcriptional activity in a dose-dependent manner. TR4induced perilipin expression in 3T3-L1 adipocytes by activating perilipin promoter activity. In a gel shift assay, TR4 bound direct to the putative TR4 response element in the perilipin promoter. Interestingly, CLA reduced the interaction between TR4 and consensus DR1, a well-known TR4 binding site. Additionally, CLA inhibited TR4-induced perilipin promoter activity in a dose-dependent manner. Together, our results suggest that CLA may play a role in lipid homeostasis in adipocytes by functionally regulating TR4.