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Dyrk1A Positively Stimulates ASK1-JNK Signaling Pathway during Apoptotic Cell Death
최형경,정광철 한국뇌신경과학회 2011 Experimental Neurobiology Vol.20 No.1
Dual-specificity tyrosine (Y)-phosphorylation-regulated protein kinase 1A (Dyrk1A) is the mammalian homologue of Drosophila melanogaster minibrain and its human gene is mapped to the Down syndrome critical region of chromosome 21. Dyrk1A phosphorylates several transcription factors, including NFAT and CREB and a number of cytosolic proteins such as APP, tau, and Ձ-synuclein. Although Dyrk1A is involved in the control of cell growth and postembryonic neurogenesis, its potential role during cell death and signaling pathway is not clearly understood. In the present study, we show that Dyrk1A is activated under the condition of apoptotic cell death. In addition, Dyrk1A is coupled to JNK1 activation, and directly interacts with apoptosis signal- regulating kinase 1 (ASK1). Moreover, Dyrk1A positively regulates ASK1-mediated JNK1-signaling, and appears to directly phosphorylate ASK1. These data indicate that Dyrk1A regulates cell death through facilitating ASK1-mediated signaling events.
Yersinia Enterocolitica에 의한 Emphysematous Pyelonephritis 1예
김종수,이진관,이창구,정지인,김용림,최형경 대한감염학회 1994 감염 Vol.26 No.3
Emphysematous pyelonephritis is uncommon, life-threatening suppurative infection of the renal parenchyma and perirenal tissues characterized by the production of gas. we experienced a case of emphysematous pyelonephritis with massive perirenal gas collection caused by Yersinia enterocolitica in a 59 years old man with diabetes mellitus. The patient was successfully managed with nephrectomy, antibiotics, and control of diabetes. We reported this case with a review of literatures.
김종수,최은석,허충,최형경,정수룡,이진관 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.3
Insulinoma is rare functioning islet cell tumor of pancreas and its main feature is frequent attacks of hypoglycemia. Because of frequent seizure, the disease is occasionally mistook as epilepy. We experienced a case of insulinoma with dilantin toxicity in a 45 year old patient who had been treated with dilantin for 7 years. Selective splenic arteriogram showed 0.8cm mass in the tail of pancreas which was proven insulin secreting tumor on histiopathological examination. After operation no more seizure attack was detected and her blood sugar level was well maintained within normal range. This case might provide an insight that the possibility of insulinoma should be considered in patient with episodic neurobehavioral dysfunction such as epilepsy(J Kor Soc Endocrinol 9: 265-271, 1994).
종합검진상 발견된 C형 간염 항체 양성자의 추적과 HCV RNA 검출율
이진관(Jin Kwan Lee),김정철(Jung Chul Kim),정정희(Jung Hee Jung),이창구(Chang Goo lee),최형경(Hyeong Kyoeng Choi),손석호(Suk Ho Sohn),조욱현(Wook Hyun Cho),허충(Chung Hur) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Follow up study and HCV RNA test by PCR was performed on the 26 asymptomatic subjects with anti-HCV found in routine health check. Among the 26 sugjects, 16 have persistently normal ALT level and 10 abnormal ALT level. In 6 subjects, anti-HCV turned to be negative on follow up test and among those, 5 have normal ALT level and one abnormal ALT level. 15 subjects with normal ALT level have HCV RNA and those subjects were assumed to be asymptomatic hepatitis C carrier. HCV RNA was positive in 8 out of 10 subjects with abnormal ALT level. In conclusion, 23 out of 26 asymptomatic subjects with anti-HCV have HCV-RNA and among them 15 with normal ALT level were assumed to be asymptomatic hepatitis C carrier.
최은석(Eun Suk Choi),정수룡(Su Ryong Jung),전무련(Mu Ryeun Jeun),이창구(Chang Goo Lee),최형경(Hyeong Kyeong Choi),조욱현(Woo Hyun Cho),이진관(Jin Kwan Lee),김용림(Yong Lim Kim),조동규(Dong Kyu Cho) 대한내과학회 1996 대한내과학회지 Vol.50 No.5
N/A Objectives: AFBN is a localized bacterial infection of the kidney presenting itself as an inflammatory mass without drainable pus. It is being increasingly recognized by current urographic imaging. It is important not to confuse AFBN with renal abscess or neoplasm as this might lead to inappropriate surgical therapy. This study was per- formed to find out clinical aspects of AFBN. Methods: From Jan. 1992 to Dec. 1993 in Dongkang hospital with a capacity of 600beds, 24cases thought to fulfill the sonographic criteria for AFBN were reviewed retrospectively. Results: 1) The overall male to female ratio was 4:20, and the age distribution ranged from 7 to 78years, and the mean age of overall patients was 35.7±15.9 years. 2) Underlying conditions could be identified in 13subjects(54.2%); pregnancy(N=5), diabetes mellitus (N=2), renal stone(N=2), previous urinary tract infection(N=2), etc. in order of frequency. 3) The duration of preadmission illness was 6.3±5.9 days(1-30). 4) Cardinal symptoms and signs were chills (100%), flank pain(83%), costovertebral angle tenderness(100%), fever(88%), pyuria(88%) and leukocytosis(79%). Urine culture revealed E. coli positive in 10out of 23patients tested: one patient had E. coli positive in blood culture. 5) In total 24 cases, There were two cases accompanying with intrarenal abscesses and one case progressing to intrarenal abscess. 6) All patients were admitted and treated with antibiotics. Fever and flank pain lasted 3.5±0.5 days and 4.1±2.2 days, respectively. No patient underwent surgical procedures. The duration of hospitalization was 8.9±4.4 days(2~20). Conclusion: AFBN is a focal variant of acute pyelonephritis with single area of suppuration. It is not an infrequent disease entity which has relatively good prognosis once diagnosed accurately in its early stage. With delayed treatment or inappropriate therapy, it probably progress to intrarenal abscess.