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      • SCOPUSKCI등재

        배우자간의 C형 간염 항체 양성율

        이창구(Chang Goo lee),김종수(Jong Su Kim),최은석(Eun Suk Choi),전무련(Mu Ryeun Jeun),추성욱(Sung Uk Chu),허충(Chung Hur),이진관(Jin Kwan Lee) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2

        N/A Background/Aims: Parenteral exposure, such as transfusion, drug abuse, needle stick injury, tatooing, hemodialysis and transplantation, is well documented as the major route of transmission. But about half of hepatitis C virus(HCV) carriers have no previous history of parenteral infection. Therefore, other possible routes of the spread should be evaluated. The possibility of intrafomilial transmission of HCV was considered to be low as compared to that of hepatitis B virus(HBV), but recent publications from Japan and Europe elicit the interest in intrafamilial transrmission, especially in spousal transmission. The aim of this study is to investigate the possibility of spousal transmission of HCV. Methods: We analyzed clinical features, serum transaminase and anti-HCV in 56 spouses who got married to anti-HCV positive patients. The mean age in index cases was 44.7 years, 45.6 in male and 43.2 in female and that of spouses was 42.4 yenrs, 45.7 in male and 40.7 in female. The mean duration of marriage was 20,0 years, distributed from 1 to 50. Index cases included 8 asymptomatic carriers, 44 chronic hepatitis, 3 liver cirrhosis and 1 hepatoma. Four of those had previous history of blood transfusion. Results: Among 56 spouses, anti-HCV was detected in 9 cases representing 16.1%. Four of those were clinically asymptomatic carriers and remaining 5 had chronic hepatitis. The mean age in index cases of anti-HCV positive spouses was 56 years old and was older than that of anti-HCV negative spouses 42.6(P<0.01). The mean duration of marriage in index cases of anti-HCV positive spouses was 30,9 years and was longer than that of anti-HCV negative spouses 18.0(P<0.05). Conclusions: This study revealed higher prevalence of anti-HCV in spouses who got married to anti-HCV positive carriers compared to that of general population. As the duration of marriage was getting longer, the frequency of anti-HCV in spouses increased(P<0.01). These results suggest that the spouses of anti-HCV positive carriers could be a high risk group for HCV transmission. (Korean J Gastroenterol 1997; 29:207 - 213)

      • KCI등재후보

        급성 국소성 세균성신염의 임상적 고찰

        최은석(Eun Suk Choi),정수룡(Su Ryong Jung),전무련(Mu Ryeun Jeun),이창구(Chang Goo Lee),최형경(Hyeong Kyeong Choi),조욱현(Woo Hyun Cho),이진관(Jin Kwan Lee),김용림(Yong Lim Kim),조동규(Dong Kyu Cho) 대한내과학회 1996 대한내과학회지 Vol.50 No.5

        N/A Objectives: AFBN is a localized bacterial infection of the kidney presenting itself as an inflammatory mass without drainable pus. It is being increasingly recognized by current urographic imaging. It is important not to confuse AFBN with renal abscess or neoplasm as this might lead to inappropriate surgical therapy. This study was per- formed to find out clinical aspects of AFBN. Methods: From Jan. 1992 to Dec. 1993 in Dongkang hospital with a capacity of 600beds, 24cases thought to fulfill the sonographic criteria for AFBN were reviewed retrospectively. Results: 1) The overall male to female ratio was 4:20, and the age distribution ranged from 7 to 78years, and the mean age of overall patients was 35.7±15.9 years. 2) Underlying conditions could be identified in 13subjects(54.2%); pregnancy(N=5), diabetes mellitus (N=2), renal stone(N=2), previous urinary tract infection(N=2), etc. in order of frequency. 3) The duration of preadmission illness was 6.3±5.9 days(1-30). 4) Cardinal symptoms and signs were chills (100%), flank pain(83%), costovertebral angle tenderness(100%), fever(88%), pyuria(88%) and leukocytosis(79%). Urine culture revealed E. coli positive in 10out of 23patients tested: one patient had E. coli positive in blood culture. 5) In total 24 cases, There were two cases accompanying with intrarenal abscesses and one case progressing to intrarenal abscess. 6) All patients were admitted and treated with antibiotics. Fever and flank pain lasted 3.5±0.5 days and 4.1±2.2 days, respectively. No patient underwent surgical procedures. The duration of hospitalization was 8.9±4.4 days(2~20). Conclusion: AFBN is a focal variant of acute pyelonephritis with single area of suppuration. It is not an infrequent disease entity which has relatively good prognosis once diagnosed accurately in its early stage. With delayed treatment or inappropriate therapy, it probably progress to intrarenal abscess.

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