섬유조합에 따른 UHPFRCC의 균열 거동 및 전자파 차폐 특성 평가

이호진(Lee, Ho Jin),최진석(Choi, Jin Suck),윤영수(Yoon, Young Soo) 한국콘크리트학회 2023 한국콘크리트학회 학술대회 논문집 Vol.35 No.2

솔비톨 및 Salicylic Acid 처리가 토마토 과실의 품질 및 기능성 물질 함량에 미치는 영향

김정태(Jung-Tae Kim),김윤하(Yoon-Ha Kim),최진석(Jin-Suck Choi),이인중(In-Jung Lee) 한국원예학회 2014 원예과학기술지 Vol.32 No.6

본 연구는 솔비톨과 살리실산의 토마토 과시의 품질과 기능성 물질에 미치는 효과를 알아보기 위해 수행되었다. 0.5mM과 1.0mM의 솔비톨과 살리실산 단독 및 혼합처리는 무처리보다 토마토 과실의 적색도, 당 함량, 경도 및 무게와 리코펜, 안토시아닌류 및 비타민류와 같은 기능성 물질의 함량을 증가시켰다. 토마토 식물체에 살리실산 단독 및 솔비톨과 살리실산 혼합처리는 시아니딘 함량을 약 52-61% 정도, 그리고 델피니딘 함량이 20-24%, 39-41% 가량 증가되었다. 뿐만 아니라 비타민 B₁과 C의 함량도 증가시켰다. 특히 비타민 C는 솔비톨 단독처리에서 무처리보다 약 1.2배, 살리실산 단독처리에서는 2배 가량 증가되었다. 솔비톨과 살리실산 혼합처리에서는 무처리보다 약 4배 가량 비타민C 함량이 증가되었다. In this study, we aimed to understand the effect of sorbitol and salicylic acid (SA) on quality and functional food contents of tomato. Sole or combined application of sorbitol and SA in different concentrations (0.5 mM and 1.0 mM) greatly improved the characteristics of tomato, such as red color tone, soluble solid content, hardness and weight as well as increasing the functional food contents such as of lycopene, anthocyanins and vitamins in comparison with the control. The cyanidin content increased approximately 52-61% and delphinidin contents also increased 20-24% and 39-41% in tomato plants treated with SA alone and sorbitol with SA, respectively. Furthermore, the sole or combined application of sorbitol and SA also increased the vitamin B1 and C contents. In particular, vitamin C content was increased 1.2-fold by treatment with sorbitol alone and was increased 2-fold by SA treatment compared to the control. In the sorbitol with SA treatments, vitamin C content was approximately 4-fold increased relative to control plants.

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

만성폐쇄성 폐질환 환자의 복약지도

최경숙,박경호,이병구,조남춘,신완균,심영수,최진석 한국병원약사회 1995 병원약사회지 Vol.12 No.3

Medication teaching and patient counseling was pharmacist's important task to improve cost-benefit efficiency, safty of medication, which contribute to the better medical service. COPD(Chronic Obstructive Pulmonary Disease) has markedly increased incidence as a result of more industrialization, air pollutions and it is representative one of which management demand close medication teaching. Since March, 1993 to May, 1994 we have conducted and counseled the COPD patient for medication teaching. At this time, we would evaluate current status of them and present. Total 135 COPD patient was counseled for medication teaching was recruited in this study. Pharmacist have conducted the COPD patients for medication teaching including TDM services at pulmonology clinics in Seoul National University Hospital. The patient were more than 50 years old, of which male were predominant. They were prescribed bronchodilator such as theophylline, beta-agonist, quatery ammonium anticholinergic agents, especially inhaler form, mucolytics and antibiotics. 101 patients (74.8%) had been conducted to get more compliant. As the frequency of patient education and counseling increased, patients' awareness of their medication, drives and compliance to that were improved. Pharmacist have roles of not only prescription but also patient education and counseling. Patient get benefit from this important responsibility of ours. Further befined and effective methodology is needed in the future.

Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium

Yong, Chul Soon,Choi, Jin Suck,Quan, Qi-Zhe,Rhee, Jong-Dal,Kim, Chong-Kook,Lim, Soo-Jeong,Kim, Kyung-Mi,Oh, Phil-Soo,Choi, Han-Gon 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

Liquid suppository systems composed of poloxamers and bioadhesive polymers were easy to administer to the anus and mucoadhesive to the rectal tissues without leakage after the dose. However, a liquid suppository system containing diclofenac sodium could not be developed using bioadhesive polymers, since the drug was precipitated in this preparation. To develop a lipuid suppository system using sodium chloride insteas of bioadhesive polymers, the physicochemical properties such as gelation temperature, gel strength and bioadhesive force of various formulations composed of diclofenac sodium, poloxamers and sodium chloride were investigated. The mixtures of P 407(15%) and P 188 (15-20%) existed as a liquid at room temperature, but gelled at physiological temperature. Diclofenac sodium significantly increased the gelation temperature and weakend the gel strength and bioadhesive force, while sodium chloride did the opposite. Furthermore, the poloxamer gels with less than 1.0% of sodium chloride, in which the drug was not precipitated, were inserted into the rectum of rabbits without difficulty and leakage, and retained in the rectum of rats for at least 6 h. Our results suggested that a thermosensitive liquid suppository system with sodium chloride and poloxamers was a more physically stable and convenient rectal dosage form for diclofenac sodium.

트리메부틴 말레이트 서방정제의 약물동태학적 평가

박경호,이민화,최진석 한국병원약사회 1995 病院藥師會誌 Vol.12 No.4

In vitro dissolution test and pharmacokinetic study in human volunteers were conducted to evaluate the pharmacokinetic characteristics of 300㎎ trimebutine maleate(TMB-M) sustained-release tablet(TMB-M-SR300). As a reference product, 100㎎ trimebutine maleate immediately-release tablet(TMB-M-IR100) was used. Dissolution tests of two products were run in distilled water at 37±0.5℃and agitation of 100±5 rpm by the Paddle method described in KP VI, TMB-M-IR100 was dissolved very rapidly, and it took only 1hr to be dissolved over 97%, whereas 18hr for TMB-M-SR300 or three tablets of TMB-M-IR100 with randomized two period cross-over study. Significant differences between TMB-M-IR100 and TMB-M-SR300 were found in mean times to reach peak concentration, mean resident times and mean terminal phase half-lives, while not in AUC/Dose (Student's-test). In ANOVA for AUC/Dose to compare the bioavailabilities of two TMB-M products, there was no significant difference. From the comparison of the simulated steady-state plasma concentration-time curves following multiple medications of TMB-M_IR100 (2 tablets t.i.d) and TMB-M-SR300(1 tablet b.i.d) based on the above results obtained from single doses of two TMB-M products, it was noted that the medication of TMB-M-SR300 is more useful in clinical application rather than TMB-B-IR100.