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Silymarin과 작약감초탕 병용투여의 C57BL/6 마우스 간조직 지질축적 및 염증 억제효과
최정원,조수정,신미래,박해진,Choi, Jeong Won,Cho, Su-Jung,Shin, Mi-rae,Park, Hae-Jin 대한본초학회 2022 大韓本草學會誌 Vol.37 No.5
Objective : The aim of the present study is to examine hepatic lipid-lowering and anti-inflammatory effects of silymarin combined with Jakyakgamcho-tang on non-alcoholic fatty liver disease in a high fat diet-induced obese mice model. Methods : C57BL/6 mice were divided into four dietary groups: (1) Normal, (2) Control (60% high-fat diet), (3) Control + silymarin 50 mg/kg/day (Silymarin), (4) Control + Silymarin 50 mg/kg/day + Jakyakgamcho-tang 100 mg/kg/day (SPG). After 12 weeks administration, mice were sacrificed and lipids and inflammation-related biomarkers were analyzed liver and plasma. Results : Silymarin and SPG treatments significantly lowered body and liver weights compared to the Control. Serumlipids (triglyceride (TG), total cholesterol) and pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin 1𝛽, and IL-6) concentrations were significantly lowered in the Silymarin and SPG groups than the Control group. Silymarin and SPG treatments suppressed hepatic TG level and hepatic lipid droplets compared to the Control. Theses two treatments significantly increased hepatic kinase B1 and AMP-activated protein kinase protein levels, and significantly decreased hepatic key lipogenic enzymes (acetyl-CoA carboxylase, fatty acid synthase and stearyl coenzyme A desaturase 1) protein levels than the Control. SPG also significantly increased hepatic fatty acid oxidation-related protein (peroxisome proliferator-activated receptor alpha and uncoupling protein 2) levels than the Control. Conclusions: Silymarin and SPG suppressed hepatic lipid accumulation by regulating hepatic protein expression, and lowered blood pro-inflammatory cytokines concentrations though the synergic effect of silymarin and Jakyakgamchotang was not clear.
재벌총수의 자신감이 소속 기업의 재무의사결정에 미치는 영향 연구
최정원(Jung-won Choi),오세경(Sekyung Oh) 한국경영학회 2017 한국경영학회 통합학술발표논문집 Vol.2017 No.08
혁신적인 경영자에게 자신감은 중요한 요소지만, 경영자의 자신감이 지나쳐 자기과신으로 이어질 경우 합리적인 기업 재무의사결정을 저해하는 요인으로 작용할 수 있다. 본 연구는 국내기업의 경우 재벌총수를 실질적인 기업의 의사결정을 수행하는 주체로 정의하고, 재벌총수의 자신감이 소속기업의 재무의사결정과 재무성과에 미치는 영향을 분석하였다. 이를 위하여 우선 재벌총수 및 기업에 대한 미디어 기사를 텍스트마이닝기법으로 분석하여 자신감을 계량화된 변수로 측정하였다. 이후 측정된 자신감 지표를 패널 모형에 설명변수로 활용하여 주요 재무지표와의 관계를 계량적으로 실증 분석하였다. 연구결과, 자신감이 높은 재벌총수는 부채 등의 자본을 추가적으로 조달하여 투자를 확대하는 적극적인 재무의사결정을 수행한다는 가설을 지지하였다. 또한 성장가치와 수익성 지표의 경우 시차를 두고 음(-)의 관계가 산출되었다. 이는 경영자의 지나친 자신감이 기업가치 및 재무성과에 악영향을 초래할 수 있음을 지지하는 결과이다. Confidence of CEO is an important factor, but over-confidence of CEO can result in adverse effects on corporate financial decision makings. The study aims to analyze the impact of CEO confidence on corporate financial decisions and financial performance in Korean Chaebols. First, we measure ‘CEO confidence’ by analyzing media articles about both CEOs and corporations of Korean Chaebols with a text mining technique. Second, we use the CEO confidence as an explanatory variable in panel regression model to analyze its effects on key financial variables. We find the results supporting the hypothesis that CEOs with higher confidence in Korean Chaebols make active financial decisions to expand investments. In addition, we find that debt ratio also rises when CEOs show a higher confidence if previous (t-1) debt level is included as an independent variable. On the other hand, we find that future value of growth opportunity (Tobin’s Q) and profitability (both are one year ahead) will deteriorate when CEOs show a higher confidence.
최정원 ( Jung Won Choi ),한호선 ( Ho Sun Han ),이미영 ( Mi Young Lee ),안준모 ( Jun Mo Ahn ) 한국생산성학회 2015 生産性論集 Vol.29 No.1
Traditional corporate bankruptcy prediction methodology basically relies on financial accounting data to objectively reflect the status of companies. However, since financial accounting data is difficult to immediately reflect changes in the status of companies, real-time financial data such as stock and bond prices are also used in order to make up for the shortcomings. In this study, we use news text information which is a typical real-time information to study the corporate bankruptcy prediction models. In the past, news text information was difficult to use in quantitative analysis but not any more due to the recent advances of information processing technology and text-mining techniques. For bankruptcy prediction using news information, we collect news text for six months before the bankruptcy events of companies actually occur and study the possibility of bankruptcy prediction based on the data by utilizing text-mining techniques. Results indicate that we can not get such a high level of predictability as that of existing corporate bankruptcy prediction models, but that there exists a high potential of this approach enough to increase the predictability of bankruptcy models. Further research on bankruptcy prediction model using news text information will be promising.
최정원 ( Jung Won Choi ),조광현 ( Kwang Hyun Cho ),박경찬 ( Kyoung Chan Park ),윤상웅 ( Sang Woong Youn ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.9
A 23-year-old man presented with two asymptomatic, yellowish papules surrounded with several whitish papules localized on the right cheek. Gross findings of the whitish lesions corresponded with milia. Histopathologic examinations of yellowish lesions revealed folded cyst walls consisting of several layers of epithelial cells, which were consistent with the diagnosis of steatocystoma. This case could be further proof steatocystoma and milia originate from the same pilosebaceous unit. It is important to differentiate steatocystoma from milia for less scarring after surgical treatment. (Korean J Dermatol 2008;46(9):1232~1235)
장애인 임금근로자의 자기효능감, 행복, 직무만족도 사이의 매개효과와 장애로 인한 업무 지장의 조절된 매개효과
최정원(Choi, Jeong won),오현정(Oh, Hyun jung),홍세희(Hong, Se hee) 한국직업재활학회 2020 職業再活硏究 Vol.30 No.2
The purposes of this study were to examine the mediating effect of job satisfaction and the moderated mediating effect of work interference due to disabilities on the relationship between self-efficacy and happiness among workers with disabilities. For the study, the data of 1,622 workers with disabilities who participated in the 3rd survey of 2nd wave in the Panel Survey of Employment for the Disabled (PSED) was analyzed using Mediation analysis and Moderated-Mediation analysis with SPSS Process Macro. The results can be summarized as follows. First, job satisfaction mediated the relationship between self-efficacy and happiness. Second, the indirect effect of self-efficacy through job satisfaction on happiness was moderated by work interference due to disabilities. This study is meaningful in that it provided theoretical foundation regarding the intervention and policy of workers with disabilities. 본 연구는 장애인 임금근로자의 자기효능감이 행복에 미치는 영향에서 직무만족도의 매개효과를 검증하고, 자기효능감, 직무만족도, 행복의 관계에서 장애로 인한 업무 지장의 조절된 매개효과를 검증하는 것을 목적으로 한다. 이를 위해 장애인고용패널조사 2차 웨이브의 3차 조사 자료를 활용하였으며, SPSS Process Macro로 매개효과와 조절된 매개효과를 검증하였다. 연구결과를 정리하면 다음과 같다. 첫째, 장애인 임금근로자의 자기효능감이 행복에 유의한 영향을 미치고 이 관계를 직무만족도가 매개하는 것으로 나타났다. 둘째, 자기효능감이 직무만족도를 통해 행복에 미치는 간접효과는 장애로 인한 업무 지장에 의해 조절되는 것으로 나타났다. 본 연구는 장애인 임금근로자의 자기효능감과 행복의 관계 사이에서 직무만족도의 역할을 확인함으로써 장애인 고용을 복지의 측면에서 분석했다는 점에서 의미가 있고, 장애인 고용의 질을 높이기 위해 장애인이 일하는 과정에서 장애로 인해 겪을 수 있는 환경적, 업무 내용적 어려움을 중심으로 접근할 필요성을 제시함으로써 정책 개입을 위한 이론적 토대를 마련했다는 점에서 의의가 있다.
광범위한 뇌연수막 파종으로 나타난 역형성 성상세포종의 특이 발현 Temozolomide를 기초로 치료한 두 증례 보고
최정원 ( Jung Won Choi ),김인아 ( In A Kim ),최기영 ( Ghee Young Choe ),김재용 ( Chae Yong Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2008 대한뇌종양학회지 Vol.7 No.2
We describe two unusual cases of diffuse leptomeningeal seeding as the initial manifestation of a subtle brain mass lesion. At first, they were misdiagnosed as tuberculous encephalitis because there was no obvious mass lesion in magnetic resonance(MR) images of the brain and the cerebrospinal fluid profile was highly suggestive of an infective process. The MR images showed only ill-defined lesions in the basal ganglia. Anaplastic astrocytomas were finally diagnosed following stereotactic brain biopsies. Whole-spine MR images from these two patients revealed diffuse leptomeningeal enhancing lesions that affected the whole spine. We planned aggressive multimodal treatment including concurrent chemoradiation therapy using temozolomide. One patient died from disease progression eight months after the initial diagnosis. The second patient was treated more aggressively. She survived for more than thirteen months after diagnosis. Biopsy and aggressive treatment must be considered in cases of ill-defined lesions with clinical manifestation indicating unusual encephalitis.
산업진흥교육 : 공적 사회복지 전달체계에 나타난 조직운영 상의 실태분석을 통한 극복요인 연구
최정원 ( Jung Won Choi ),김보기 ( Bo Ki Kim ) 산업진흥원 2016 산업진흥연구 Vol.1 No.1
본 연구는 사회복지의 발전추세에 따라 향후 공적 사회복지 전달체계가 더욱 중요함을 인식하고 여기에 나타난 조직운영 상의 실태분석을 통해 극복요인을 파악하고자 하였다. 극복요인으로는, 첫째, 전달체계의 속성에 대한 극복이다. 둘째, 업무의 비효율성에 대한 극복이다. 셋째, 전달체계 및 인력상의 부조화에 대한 극복이다. 넷째, 사회복지통합관리망의 관리부실에 대한 극복이다. 결론적으로 본 연구를 통해 위와 같은 극복요인이 해결될 때 비로소공적 사회복지 전달체계가 원활히 이루어질 수 있음을 알 수 있다. This study recognized public social welfare delivery system will be more important in the future according to the developing trend of social welfare that and intended to find overcome factors by analyzing actual status of operating organization. The study results showed that characteristics of delivery system, ineffectiveness of task, delivery system and inconcinnity of personnel are the overcome factors of social welfare. Consequently, this study revealed that public social welfare delivery system will go on smoothly at last when the problems of the overcome factors get solved.