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최규완,장성호,Choi, Kyu-Wan,Chang, Sung-Ho 한국금형공학회 2016 한국금형공학회지 Vol.10 No.3
Recently, a hyaluronic acid micro needle patch for therapeutic and cosmetic purposes has been used by attaching directly to the skin with a pattern having a micro needle shape of 1/3 thickness of hair. These products are attracting attention as an innovative product that maximizes the effect by activating the active ingredient in the skin in the deep skin without blocking the horny layer because the micro needle shape exists on the patch surface so that it can penetrate effectively to the skin. Currently, DAB (droplet air blowing) or MEMS technology is used to make pattern shapes for patches. Because of this technology, manufacturing time is long and manufacturing cost is high, so we tried to develop the mold technology to machine the microneedle shape directly to the metal. In this study, we first fabricated a needle pattern with a quadrangular pyramid shape and finally produced a conical needle pattern.
DNA 검출 공정 전용 플라스틱 튜브형 시험관 개발에 관한 연구
최규완,라문우,강정희,장성호,Choi, Kyu-wan,La, Moon-woo,Gang, Jung-hee,Chang, Sung-ho 한국금형공학회 2017 한국금형공학회지 Vol.11 No.3
PCR(Polymerase chain reaction) is a technique to replicate and amplify a desired part of DNA. It is used in various aspects such as DNA fingerprint analysis and rare DNA amplification of an extinct animal. Especially in the medical diagnosis field, it provides various measurement methods at the molecular level such as genetic diagnosis, and is a basic tool for molecular diagnostics. The internal shape of the plastic vial tube for PCR analysis used in the DNA detection process, and the surface roughness and internal cleanliness can affect detection and discrimination results. The plastic vial tube demanded by the developer of the PCR analysis equipment should be changed to a structure that eliminates the residual washing solution in the washing process to ensure the internal cleanliness. Thus the internal structure and the internal surface design for improving the PCR amplification efficiency are key issues to develop the plastic vial tube for the DNA detection process.
흰쥐에서 미주신경 절단이 위점막 지표 및 G 세포수에 미치는 영향에 관한 형태계측학적 및 면역조직화학적 연구
최규완(Kyu Wan Choi),김우호(Woo Ho Kim),김용일(Yong Il Kim),김병천(Byeong Cheon Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1
In order to assess the trophic effect of the vagus on the morphologic parameters of the gastric mucosa and gastrin-producing cells, we performed bilateral or unilateral vagotomy on adult male Sprague-Dawley rats. Four weeks after operation, the gastric mucosal changes with respect to their height, area, and volume were analyzed using morphometric method. Total number and density of gastrin-producing (G) cells and argentaffin cells in frozen sections stained by peroxidase- antiperoxidase method and Fontana-Masson staining were compared respectively. In bilaterally vagotomized rats, the acid secretion was markedly reduced in both basal and stimulated states. However, unilateral vagotomy caused meager impact on acid secretion. In bilater- ally vagotomized rats, the mucosal height decreased while the mucosal area increased. However, in unilaterally vagotomized rats, both the mucosal height and mucosal area decreased, with subsequent decrease of mucosal volume in the vagotomized side. The G cells population increase occurred in both unilaterally or bilaterally vagotomized rats, but more prominent in the latter group. The total number of argentaffin cells varied considerably among animals in a control group and no statistically significant difference was elicited in vagotomized groups compared to control group. With the above findings we assume that the parietal cells are normally under the trophic effect of vagus and that the G cells might be able to proliferate in a condition of lowered gastric acidity, while the argeataffin cells being not affected by vagotomy or altered acid level.
최규완(Kyu Wan Choi),윤지환(Ji Hwan Yoon),박은정(Eun Jung Park) 한국호텔외식관광경영학회 2008 호텔경영학연구 Vol.17 No.3
The leverage risk of hotel is greater than other industry. The purpose of this study is to examine how the financial factors affect hotels` profitability by using panel model. The empirical results indicate that: (1) liquidity ratio is not changing but leverage ratio is going down in timely, (2) operational profitability of general hotel is greater than that of luxury hotel, and (3) debt ratio, total asset turnover ratio, and size of hotel affect their profitability. Implications for the managers and directors of tourist hotels were discussed.
자료포락분석(DEA)을 이용한 위탁급식전문업체의 산업체 급식소 효율성 평가
최규완(Kyu Wan Choi),박영민(Young Min Park),신서영(Seo Young Shin),곽동경(Tong Kyung Kwak) 대한지역사회영양학회 2007 대한지역사회영양학회지 Vol.12 No.2
This study was performed to suggest a new efficiency measurement indicator is necessary for evaluating management efficiency of food service operations in contract-managed foodservice companies, to distinguish efficient food service providers and inefficient ones by measuring comparative efficiency among food service operations, and to provide guidance for effective management through showing benchmarking targets for improving inefficient food service providers. The subjects of this study were the 93 B&I foodservice Operations of a domestic contract food service company. The analysis was conducted using CCR model in DEA model. A software, ``Frontier analyst``, was used for the analysis. Based on the results derived from comparison of efficiency evaluation classified by providers with use of DEA, it was possible to identify efficient food providers and inefficient providers, and subsequently provide benchmarking guidelines for improvement of the inefficient groups. In analyzing the differences between the results of DEA efficiency evaluation by detailed operation status of food service providers, there was significant difference of efficiency outcomes in terms of contract types, while there was no significant difference in terms of business condition. (Korean J Community Nutrition 12(2) : 178~188, 2007)