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천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),박현선(Hyun Sun Park),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Eye irritation of Sangmosu was evaluated in New Zealand White rabbits. In ocular irritation test, any injury on iris, conjunctival membrane, and cornea was not observed. No injuries of the ocular mucous membrane were also recorded. These results indicate that Sangmosu was not considered to be irritant in test organs of animals.
박현선(Hyun Sun Park),천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 대한약학회 1999 약학회지 Vol.43 No.3
Subacute toxicity study was performed in Sprague-Dawley rats after daily dermal administration of Sangmosu (0.2, 1.0 and 5.0g/kg) for one month. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and Sangimosu treatment groups. In histopathological examinations, there were some pneumonia in lung tissues at all groups of Sangmosu treatment including control, but it was not considered to be caused by Sangmosu. These results suggest that Sangmosu does not induce any significant subacute dermal toxicities in Sprague-Dawley rats.
랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구
김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,안병옥,홍성렬,이병무,Kim, Hyung-Sik,Kwack, Seung-Jun,Chun, Sun-Ah,Park, Hyun-Sun,Han, 한하수,Lim, So-Young,Ahn, Mi-Young,Kim, Won-Bae,Ahn, Byoung-Ok,Hong, Sung-Youl,Lee, Byung-Mu 한국독성학회 1998 Toxicological Research Vol.14 No.3
A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500IU/kg/day for a period of 3 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,5000IU/kg group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose- dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500IU/kg groups. The spleen weight was also increased in both sexes of 500 and 2,500IU/kg groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500IU/kg groups. From these results, it is concluded that the no-observed adverse effect level (NOAEL) of rHuEPO is 100 IU/kg in rats in the present study.
곽승준,김형식,천선아,임소영,박현선,한하수,홍채영,안미영,이병무,Kwack, Seung-Jun,Kim, Hyung-Sik,Chun, Sun-Ah,Lim, So-Young,Park, Hyun-Sun,Han, Ha-Su,Hong, Chae-Young,Ahn, Mi-Young,Lee, Byung-Mu 한국독성학회 1998 Toxicological Research Vol.14 No.3
The acute toxicity of DWP-311 was investigated in Sprague-Dawley rats. DWP-311 was subcutaneously administratered at dose levels of 595, 1,070, 1,930, 3,470, and 6,250mg/kg. In this study, we daily examined numbers of deaths, clinical signs, body weights, and pathological examinations for 7 days after administration of DWP-311. The results indicate that DWP-311 did not show any toxic effect in rats and the oral $LD_{50}$ value was over 6,250mg/kg in Sprague-Dawley rats.
비글개에서 인체 재조합 적혈구 조혈인자, rHu-EPO의 급성독성에 관한 연구
조명행,성하정,김형식,곽승준,천선아,임소영,김원배,김병문,안병옥,이병무,Cho, Myung-Hang,Seong, Ha-Jung,Kim, Hyung-Sik,Kwack, Seung-Jun,Chun, Sun-Ah,Lim, So-Young,Kim, Won-Bae,Kim, Byoung-Moon,Ahn, Byoung-Ok,Lee, Byung-Mu 한국독성학회 1996 Toxicological Research Vol.12 No.2
The acute toxicity of rHu-EPO, newly developed recombinant erythropoietin, was tested in beagle dogs. rHu-EPO, when administered intravenously at 25, 000 IU/kg, did not cause any death. Also, rHu-EPO did not induce any change of body weight, food intake and clinical signs compared to controls. There were no significant changes in hematological, urine analysis and pathological examination. These results showed that rHu-EPO did not induce any remarkable toxic response and the $LD_50$ was greater than 25, 000 IU/kg in beagle dogs.
세기관지염 환아에서 혈청 Tryptase 및 요 N - methylhistamine 치의 역할
이준성(Joon Sung Lee),천선아(Sun Ah Chun),조성훈(Sung Hoon Cho) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1994 소아알레르기 및 호흡기학회지 Vol.4 No.2
N/A Bronchiolitis and bronchopneumonia are common lower airway diseases usually caused by respiratory viral infection in infancy. Especially, bronchiolitis may be the initial manifestation of asthma in many infants. These two disorders have mutual clinical manifestation and pathophysiology. To evaluate the involvement of histamine and mast cell in clinical feature and pathophysiology of bronchiolitis during infancy, we measured serum tryptase as mast cell activation marker and urinary N-methylhistamine levels in 20 patients with broncholitis, bronchopneumonia respectively and 20 normal infants. The results were as follows: 1. There were no significant difference in sreum tryptase levels among bronchiolitis, bronchopneumonia and normal infants. 2. Urinary N-methylhistamine levels in infants with bronchiolitis were significantly raised than those in normal infants (<0.001) and than those in bronchopneumonia infants (<0.01). 3. Serum IgE levels in infants with bronchiolitis were significantly raised than those in infants with bronchopneumonia and normal infants (<0.01), but those in infants with bronchopneumonia were not significantly raised than those in normal infants. 4. In bronchiolits, there was significant negative correlation between urinary N-methylhistamine levels and Pa02 (r= -0.52, p=0.021), but there was no significant correlation in bronchopneumonia(r= -0.40, p=0.081). 5. In bronchiolitis, there was siginifant correlation between urinary N-methylhistamine levels and serum IgE levels (r= 0.55, p=0.012). These results suggest that histamine contributes to the pathogenesis of bronchiolitis in infancy. But it did not come from mast cells and the cellular source of histamine could not be established in bronchiolitis. Elevation serum IgE levels influences on the increment of histamine release, which partially causes hypoxia in bronchiolitis,
곽승준(Seung Jun Kwack),김형식(Hyung Sik Kim),이소영(So Young Lee),천선아(Sun Ah Chun),홍채영(Che Young Hong),한하수(Ha Su Han),최병천(Byung Chun Choi),이병무(Byung Mu Lee) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
The subacute toxicity was investigated in Sprague-Dawley rats orally treated with KDRD-010 at the doses of 0.056, 0.28, and 1.4 g/㎏ for one month. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and treatment groups. In hematological and biochemical serum parameters, all mean values appear to be within the normal range. In pathological examinations, hemorrhages of lung was observed in one male rat at low dose group and one female rat at high dose group of KDRD-010, but it was not considered to be caused by KDRD-010. These results suggest that KDRD-010 dose not induce any significant subacute oral toxicities in Sprague-Dawley rats.
김형식(Hyung Sik Kim),곽승준(Seung Jun Kwack),천선아(Sun Ah Chun),한하수(Ha Su Han),박현선(Hyun Sun Park),안미영(Mi Young Ahn),배기환(Ki Hwan Bae),이병무(Byung Mu Lee) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.3
The subacute oral toxicity study of DWP-311 was carried out in Sprague-Dawley rats of both sexes. We daily examined clinical signs, body weights, hematological and biochemical parameters, and histopathological examinations for 30 days after administration of DWP-311 with different dose levels (0, 0.04, 0.2, and 1.0 g/kg). There were no clinical signs and pathological changes compared with control group except slight decreases in spontaneous motor activities and locomotions at high dose group of DWP-311. Body weights were not significantly changed in animals treated with DWP-311. In histopathological examinations, there were 2 cases of pneumonia in control group for one male and one female, but it was not directly related to DWP-311. These results indicate that subacute oral toxicities of DWP-311 were low and the no-observed adverse effect level (NOAEL) was considered to be 1.0 g/kg in rats.
랫드에서 인체 재조합 적혈구 조혈인자 , rHu-EPO 의 급성정맥독성시험
곽승준(Seung Jun Kwack),김형식(Hyung Sik Kim),임소영(So Young Lim),천선아(Sun Ah Chun),홍채영(Chae Young Hong),박현선(Hyun Sun Park),김원배(Won Bae Kim),김병문(Byoung Moon Kim),안병옥(Byoung Ok Ahn),이병무(Byung Mu Lee) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
Acute intravenous toxicities of rHu-EPO (recombinant human erythropoietin) were investigated in Sprague-Dawley rats. Seven days after administration of rHu-EPO, we examined the clinical signs, mortalities, body weight and etc. No clinical signs and mortalities of toxicity were observed in animals. Also, a significant change of body weights was not observed. These results suggest that LD_(50) value was >25,000 unit/kg in Sprague-Dawley rats and the acute intravenous toxicities of rHu-EPO were not significant.
김대영(Dae Young Kim),최설민(Sul Min Choi),천선아(Sun Ah Chun),박현선(Hyun Sun Park),우동준(Mi Kyung Lee),이미경(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Acute subcutaneous toxicity of Sangmosu was investigated in Sprague-Dawley rats. Seven days after administration of Sangmosu (0.078~20 ml/kg), we examined the clinical signs, mortalities, body weight changes, etc. No clinical signs and mortalities were observed in animals. Any significant change of body weights was not observed. These results suggest that LD50 value of Sangmosu was above 20 ml/kg in Sprague-Dawley rats.