한방안이비인후피부과 외래환자의 통계적 관찰

차재훈,김윤범,남혜정,Cha, Jae-Hoon,Kim, Yoon-Bum,Nam, Hae-Jeong 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.3

Objective : This study was to explore the change of new outpatients in ophthalmology, otolaryngology, dermatology. Methods : We did stastical analysis about 4638 new outpatients who had visited the department of ophthalmology, otolaryngology, dermatology in Kyunghee oriental medicine center from January 1, 2004 to December 31, 2006 and had ophthalmologic, otologic, rhinologic, laryngologic and dermatologic diseases. Results : The results were as follows. 1. Distribution of ophthalmology, otology, rhinology, laryngology and dermatology classification in new outpatients was 44.74% in dermatology the most, 26.50% in rhinology, 14.45% in otology, 8.78% in ophthalmology, 5.54% in laryngology. In all classifications except ophthalmology, outpatients increased, but the proportion of outpatients increased the most in dermatology. 2. The proportion of the new outpatients in ophthalmology was 20.15% in 51-60 years old the most. And 36.61% in dry eye the most, next 27.03% in visual disorder, 10.07% in strabismus. The proportion of the new outpatients in ophthalmology in strabismus decreased by 43.93 percent point but in dry eye increased by 32.17 percent point. 3. The proportion of the new outpatients in otology was 24.94% in 61+ years old the most. And 64.03% in tinnitus, hearing loss the most, next 17.46% in vertigo, dizziness. By 17.36 percent point, it in tinnitus, hearing loss decreased. But in vertigo, dizziness increased by 14.91 percent point. 4. The proportion of the new outpatients in rhinology was 40.93% in 0-10 years old the most. And it increased by 20.08 percent point. 69.30% in rhinitis the most but it decreased by 17.70 percent point. But 32.59% in sinusitis, that means it increased by 14.41 percent point. 5. The proportion of the new outpatients in laryngology was 68.09% in female, 23.35% in 51-60 years old the most. And it was 29.96% in laryngopharyngitis, 19.07% in stomatitis, 14.40% in the diseases of tongue. 6. The proportion of the new outpatients in dermatology was 37.21% in 21-30 years old the most.And it was 22.93% in atopic dermatitis the most, next 14.77% in urticaria. That means it increased by 8.19 percent point. But the proportion of the new outpatients in dermatology decreaed in acne, pruritus. Conclusions : We could know that there had been many changes of new outpatients in ophthalmology, otolaryngology, dermatology

20-30대 한국인의 경피수분 손실도 연구

차재훈,남혜정,김규석,신윤진,김윤범,Cha, Jae-Hoon,Nam, Hae-Jeong,Kim, Keoo-Seok,Shin, Yoon-Jin,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.2

Objective : Skin barrier protects skin against harmful environment. Its function includes antimicrobial barrier as well as physical barrier. But there are few studies about skin barrier function about men and women who don't have skin disease. The aim of this study is to investigate skin barrier function healthy men and women show. Method : There are many ways to measure skin barrier function, but lately transepidermal water loss is mainly used to know skin barrier function. Transepidermal water loss was measured over eight four the Korean twenties and thirties who don't have skin disease from March 14th, 2007 to March 16th 2007. We surveyed cubital fossa and cheek beside nose to measure transepidermal water loss and used vapometer. Result : After analyzed data, we concluded that cheek showed higher transepidermal water loss than cuital fossa. At cheek, the thirties had higher transepidermal water loss than the twenties. The male got higher transepidermal water loss than the female at cheek and in the average. And temperature and humidity effected on transepidermal water loss. Conclusion: In our study, it was observed that temperature and humidity effected on transepidermal water loss. In traditional korean medicine, the inbalance of cold(寒), heat(熱), dryness(燥), wetness(濕) makes many diseases and the inbalance of them induces dameum(痰飮) and the disorder of blood flow. Dameum(痰飮) and the disorder of blood flow make skin diseases made by abnormal skin barrier function in many ways. So we need to study dameum(痰飮) and the disorder of blood flow to take care of patients who have abnormal skin barrier function.

지루성 피부염의 최신 지견

차재훈,남혜정,김희정,박외숙,김규석,김윤범,Cha, Jae-Hoon,Nam, Hae-Jeong,Kim, Hee-Jeong,Park, Owe-Suk,Kim, Keoo-Seok,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.3

Seborrheic dermatitis is characterized by the appearance of red, flacking, greasy lesions in regions rich in sebaceous glands. There are various opinions about the relation between seborrheic dermatitis and dandruff. Considering all available data, we consider seborrheic dermatitis and dandruff to be differing severity manifestations of similar origin. The known etiologies of seborrheic dermatitis are the abnormality of lipid and hormnes, Malassezia species, immune response. We recently focus on the relation between seborrheic dermatitis and HIV positive and AIDS patients, seborrheic dermatitis and neurological disease. The treatments of seborrheic dermatitis include topical treatments, oral treatments. There are non-specific agents, antifungal medication, corticosteroids in the topical treatments. Narrow band UVB and oral medications are known as the prophylaxis of seborrheic dermatitis but we need further study. In traditional korean medicine, the literature studies and case reports have been published. But we don't know what herbal medicine has antifungal effect against Malassezia species. So we should discriminate herbal medicines which have antifungal effect against Malassezia specieses. Then we could treat seborreic dermatitis by traditional korean medicine effectively.

피부장벽회복에 영향을 미치는 인자에 관한 연구

차재훈,김윤범,Cha, Jae-Hoon,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.2

Objective : Skin barrier protects skin against harmful environment. Its function includes antimicrobial barrier as well as physical barrier. But there are few studies about the factors which improve skin barrier recovery after injury. The aim of this study is to investigate the factors which improve skin barrier recovery. Method : Nine hairless mice was anesthetized by inhalation and we tape stripped them. We used thermometer to know temperature one day ago, before anesthesia, before tape stripping, and after tape stripping. Vapometer was used to know transepidermal water loss before tape stripping, after tape stripping. And we used doppler flowmeter to measure blood flow before tape stripping, after tape stripping. Result : After analyzed data, we concluded that temperature was lower after anesthesia than before anesthesia and after tape stripping than before tape stripping. We could know that transepidermal water loss was lower after tape stripping than before tape stripping and more blood flowed after tape stripping. Conclusion : In our study, it was observed that temperature, transepidermal water loss, blood flow changed after tape stripping. But we thought lowered temperature was pathologic situation, more blood flow was to recover after injury. In traditional korean medicine, cold(寒) and imbalance of blood flow(血行) don't only make many skin diseases, but cold(寒) also obstructs blood flow. So we need to study how to warm cold(寒) and improve blood flow.

Box-Behnken법을 이용한 Geobacter lovleyi 의 TCE 탈염소화 공정 최적화 연구

차재훈(Cha, Jaehun),안상우(An, Sangwoo),천석영(Chun, sukyoung),박재우(Park, Jaewoo),장순웅(Chang, Soonwoong) 한국지반환경공학회 2012 한국지반환경공학회논문집 Vol.13 No.11

본 연구는 TBOS를 기질로 적용한 Geobacter lovleyi의 TCE 탈염소화 공정에 관하여 조사하였다. Geobacter lovleiy를 이용한 TCE 탈염소화 반응은 TCE 초기농도와 Geobacter lovleyi 주입량, 초기 TBOS 농도의 독립변수를 수학적으로 표시하였고, 반응표면법(RSM)을 활용하여 모델화하였다. 이 실험들은 Box-Behnken Design(BBD)을 통해 계획된 15개의 실험을 통해 이루어졌다. RSM을 통하여 TCE 제거효율과 독립변수들의 모델식이 도출되었다 : Y1 = -11.50(initial concentration of TCE) + 4.25(단백질 양, 주입된 Geobacter lovleyi의 양) - 4.75(initial concentration of TBOS) - 6.58X1<SUP>2</SUP> - 8.583X3<SUP>2</SUP> + 93.67, Y2=-10.92X1 + 5.06X2 - 4.89X3- 4.93X3<SUP>2</SUP> - 2.19X1X<SUP>2</SUP> + 2.54X1X3 - 2.19X2X3 + 16.71. 도출된 반응모델은 수정결정계수는 각 0.975, 0.934로 1에 가깝게 나타났으며, 모델의 기여율이 높은 것으로 나타났다. 또한, 통계적 분석결과 TCE 탈염소화 효율에 미치는 영향은 TCE 초기농도 > TBOS 초기농도 > 단백질 양의 순으로 나타났으며, 상호항의 영향은 나타나지 않았다. This study investigated the use of Geobacter lovleyi with TBOS(Tetrabutoxysilane) for TCE(Trichloroethylene) dechlorination. The TCE dechlorination by Geobacter lovleiy was mathematically described as the independent variables such as initial concentration of TCE, protein mass of Geobacter lovleyi and initial concentration of TOBS, and these were modeled by the use of response surface methodology(RSM). These experiments were carried out as a Box-Behnken Design(BBD) consisting of 15 experiments. The application of RSM yielded the following equation, which is empirical relationship for the dechlorination efficiency(Y1, %) of TCE and first order kinetic constant of TCE(Y2, d<SUP>-1</SUP>) by independent variables in coded unit : Y1 = -11.50X1(initial concentration of TCE) + 4.25X2(protein mass as Geobacter lovleyi injected mass) - 4.75X3(initial concentration of TBOS) - 6.58X1<SUP>2 -</SUP> 8.58X2<SUP>2</SUP> + 93.67, Y2=-10.92X1 + 5.06X2- 4.89X3 - 4.93X3<SUP>2</SUP> - 2.19X1X2 + 2.54X1X3 - 2.19X2X3 + 16.71. In this case, the value of the adjusted determination coefficient(adjusted R<SUP>2</SUP> = 0.975 and 0.934) were closed to 1, showing a high significance of the model. Statistical results showed the order of TCE dechlorination at experimental factors to be initial TCE concentration 〉 initial TBOS concentration 〉 protein mass, but the interaction effects were non-significant.

독도?울릉도 및 동해안 암반조간대 무척추동물상의 분포 연구를 위한 예비연구

차재훈 ( Jae Hoon Cha ),김미경 ( Mi Kyoung Kim ) 한국환경생물학회 2013 환경생물 : 환경생물학회지 Vol.31 No.3

본 논문은 2012년도 교육과학기술부 지정, 정책중점연구소 지원사업으로 수행되었습니다. 또한 본 연구는 대구지방환경청에서 주관하는 2009년도 독도생태계모니터링의 일환으로 수행되었으며, 독도와 동해안조사에 많은 도움을 주신 대구지방환경청 자연환경과장님과 생태관리팀, 김두찬, 김성대, 박강욱 생태조사연구원의 지원과 협조로 이루어졌음을 밝히며, 심심한 감사를 드립니다. To study the characteristics of rocky intertidal invertebrate fauna on the coastal areas of the East Sea, seven regions including Dokdo, Ulleungdo, Gyeongju, Pohang, Yeongdeok, Uljin, and Gangwondo, the common species ratio (%) and similarity index using Bray-Curtis similarity matrix were calculated. The contributed species for dissimilarity between Dokdo and the other East Sea`s coastal areas were selected by using SIMPER. The common species ratio and the cluster analysis showed that Ulleungdo presented the highest similarity. However, Yeongdeok showed the highest similarity in the eastern costal areas, and Gangwondo showed the lowest one. However the cluster analysis revealed the discrimination of the rocky intertidal invertebrate community on Dokdo with others region caused by the particularity of rocky shores exposed to strong wave action and by the particular distribution of rocky intertidal invertebrate fauna in Dokdo.

중개(Mediation)전략에 미치는 문화적 요소분석: 6자회담에 대한 정책적 시사(2)

차재훈 ( Jae Hoon Cha ) 한국협상학회 2004 협상연구 Vol.10 No.2

대통령 국정 어젠다와 정책화 과정 평가

차재훈(Cha Jaehoon) 한국정치정보학회 2012 정치정보연구 Vol.15 No.1

This study aims at two major focus points of concern. First of all, it analyzes presidential agenda of four regimes from Kim Young-sam, Kim Dae-jung, Roh Moo-hyun to Lee, Myung Bak, and their policy-making processes in order to realize the agenda. It involves how to select presidential agenda, whether order of priority is considered to select agenda, and which elements and reasons are considered in selecting agenda. The second focus of study lies in exploring into the relation between policy decision process and legalization of agenda. These days, we go through some changes which all kinds of political issues and media reports propose a wide variety of challenging tasks in setting agenda. Studies on setting presidential agenda has evaluated that the president has had greater influences upon agenda of national assembly and the press. When the president gives organized concern to the pending issues and set policy priorities on them, the chances become higher that the presidential agenda would be realized with success. 본 연구는 두 가지 초점을 가지고 연구를 하고자 한다. 우선, 민주화 이후 김영삼-김대중-노무현-이명박 네 개 정권의 국정 어젠다와 이를 실현하기 위한 정책화 과정을 분석하고자 했다. 국정 어젠다를 어떻게 선택하는지 어젠다 선택의 우선 순위를 가지고 있는지 정책 어젠다를 선택하는 요소와 이유 등에 대해 살펴보고자 했다. 두 번째 연구 초점은 어젠다의 정책결정과정과 입법화 관계를 살펴보는데 있다. 어젠다 설정에서 언론보도와 각종 정치적 이슈는 과거 모델에 대해 다양한 도전적 과제를 제시하는 시대적 변화를 겪고 있다. 대통령의 어젠다 설정에 관한 연구를 볼 때 대통령은 언론과 의회의 어젠다에 더 큰 영향력을 행사하고 있다고 평가하고 있다. 현안에 대한 체계적인 관심이 기울여지고 대통령이 그 현안에 대해 정책 우선 순위를 두게 되면, 대통령의 국정 어젠다 형성과정에서 성공할 가능성이 커지게 된다.

임신 중 만성스트레스가 생후 4주 幼鼠의 피부장벽에 미치는 영향

차재훈(Jae-Hoon Cha),김윤범(Yoon-Bum Kim) 대한한의학회 2009 대한한의학회지 Vol.30 No.1

Slow Release Substrate를 이용한 Geobacter lovleyi의 TCE 탈염소화 연구

차재훈(Cha, Jae Hun),안상우(An, Sang Woo),박재우(Park, Jae Woo),장순웅(Chang, Soon Woong) 한국지반환경공학회 2012 한국지반환경공학회논문집 Vol.13 No.9

본 연구에서는 Slow Release Substrate(SRS)로 사용되는 TBOS의 분해특성과 TBOS 분해생성물인 acetate와 butyrate를 적용한 탈염소화 효율을 파악하고자 하였다. 회분식 실험은 GC/FID를 이용하여 TCE 및 cis-dichloroethene(cis-DCE), 1-butanol, TBOS를 분석하였으며, acetate와 butylate는 HPLC를 이용하여 분석하였다. 혐기성 가수분해 반응을 통해 1M의 TBOS는 4M의 1-butanol로 전환 및 축적되었으며, 가수분해율은 0.186μM/day로 나타났다. 또한, 1-butanol은 퇴적토 내 토착균주에 의해 acetate와 butyrate로 분해되었다. 이 결과 TBOS는 자연에서의 탈염소화 공정에서 SRS로 사용하기에 적합한 것으로 판단된다. Acetate와 butyrate를 전자공여체로 적용한 TCE 탈염소화 반응은 초기 TCE 농도가 낮아짐에 따라 탈염소화 효율은 높아지는 것으로 나타났다. 또한, acetate를 적용한 탈염소화 반응의 1차 반응 상수가 butyrate를 적용한 경우보다 높게 나타났다. 이는 탈염소화 반응에서 Geobacter lovleyi의 기질친화도 및 생분해성, 그리고 다양한 기질에 대한 적응도의 영향으로 판단된다. 그러나 Geobacter lovleyi의 TCE 탈염소화 반응에 따른 cis-DCE의 축적이 발생할 경우 Geobacter lovleyi의 탈염소화 능력이 감소하는 것으로 나타났다. 결론적으로 SRS는 Geobacter lovleyi를 이용한 TCE 탈염소화 공정 향상에 도움이 될 것이며, 이에 따라 발생되는 cis-DCE는 영가철 같은 환원성 금속이나 공존 가능한 탈염소화 미생물을 이용한 처리가 함께 필요할 것으로 판단된다. This study investigated characteristics of decomposition of tetrabutoxysilane (TBOS) as a slow release substrate (SRS) and on effect of TBOS decompostion compounds (acetate and butylate) for anaerobic dechlorination of trichloroethylene (TCE). In the batch experiment, TCE, cis-dichloroethene (cis-DCE), 1-butanol and TBOS were analysed by GC/FID and acetate and butylate were measured by HPLC. 1M of TBOS transferred and accumulated 4M of 1-butanol by abiotically hydrolysis reaction. The hydrolysis rate was in a range of 0.186 μM/day. On other hand, 1-butanol fermented to butyrate and acetate with indigenous culture from natural sediments. This results showed that TBOS could be used a slow release substrate in the natural sites. The dechlorinated potential of TCE with acetate and butyrate was increased with a decreasing initial TCE concentrations. In addition, first order coefficients of dechlorination with acetate as electron donor was higher then that with butyrate. It is because that dechlorination of Geobacter lovleyi was affected by substrate affinity, biodegradability and microbial acclimation on various substrates. However, dechlorinated potential of Geobacter lovleyi was decreased with accumulation cis-DCE in the anaerobic decholoronation process. The overall results indicated that SRS with Geobacter lovleyi might be a promising material for enhancing dechlorination of TCE on natural site and cis-DCE should be treated by ZVI as reductive material or by coexisting other dechlorinated bacteria.