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시뮬레이션을 이용한 석면 해체공사의 최적화 공정계획 모델
조형준 ( Cho Hyeong-jun ),노재윤 ( Noh Jae-yun ),이호현 ( Lee Ho-hyeon ),이수민 ( Lee Su-min ),한승우 ( Han Seung-woo ) 한국건축시공학회 2022 한국건축시공학회 학술발표대회 논문집 Vol.22 No.2
In Korea, asbestos removal has been actively carried out nationwide since 2015 when asbestos was completely banned as a first-class carcinogen. Since scattering dust generated in the process of removing asbestos causes fatal diseases such as asbestos lung disease and lung cancer, concerns are growing over the safety of construction workers and building users undergoing dismantling. For this reason, regulations on asbestos sites have been strengthened and prior studies on safety and risk assessment have been conducted, but research on actual site data collection and process planning is insufficient even though safety is reduced due to delay in site construction period. Therefore, it is necessary to analyze the work and delay factors of the asbestos dismantling process and develop an optimized process plan model for workers. This study is an initial step to develop an optimized process plan model that considers the safety and productivity of asbestos dismantling work, and aims to help establish an optimized process plan for asbestos dismantling process using website clone simulation.
폐암 치료 후 발생한 기관지 침범 Mycobacterium intracellulare 감염 1예
조형준 ( Hyeong Jun Cho ),이종민 ( Jongmin Lee ),이진국 ( Chin Kook Rhee ),김승준 ( Seung Joon Kim ),김석찬 ( Seok Chan Kim ),김영균 ( Young Kyoon Kim ),강지영 ( Ji Young Kang ) 대한내과학회 2022 대한내과학회지 Vol.97 No.6
The incidence of nontuberculous mycobacterial pulmonary disease is increasing, and Mycobacterium avium complex (MAC) is the most common causal species. Patients with underlying structural lung disease or an immunosuppressive condition are at increased risk for MAC infections. Endobronchial lesions caused by MAC infection are extremely rare, especially in immunocompetent hosts. Here, we describe a case of a 58-year-old woman with pulmonary infiltration and endobronchial involvement caused by MAC. The patient had shortness of breath and a productive cough. She had undergone surgery and chemoradiotherapy for lung cancer 10 years prior. Radiological findings revealed small centrilobular nodules with consolidation in the right lung and mild stenosis at the right main bronchus. Bronchoscopy revealed yellowish-white caseous necrosis in the right main bronchus. Mycobacterium intracellulare was identified in bronchial washing fluid. She was treated with antimicrobial medications. After 6 months of treatment, bronchial lesions, radiological findings, and symptoms had improved remarkably and she showed culture conversion. (Korean J Med 2022;97:375-380)
서원석,최지아,정형철,조형준,Seo, Won-Seok,Choi, Jee-A,Jeong, Hyeong-Chul,Cho, Hyung-Jun 한국통계학회 2010 응용통계연구 Vol.23 No.6
임상시험을 위한 표본 수 산정방법에 대해 지금까지 많은 방법이 개발되었고 현재 국내외 임상시험 기관에서 이 방법들을 토대로 표본 수를 산정하고 있다. 하지만 마이크로어레이칩 을 이용한 실험에 필요한 표본 수 산정에 대한 연구는 아직 미비하여 제대로 이용되지 않고 있다. 본 연구의 목적은 마이크로어레이 실험에 필요한 표본 수를 산정하는 데 있어 실제 마이크로어레이 자료의 재현성에 대한 정보를 이용하여 그 지침을 제공하는데 있다. 재현성 비교에서는 5가지 검정방법 즉, Fold change, Two-sample t-test, Wilcoxon rank-sum test, SAM, LPE 방법 별로 재현성을 측정하였다. 발현 값의 표준화 방법에 있어서는 MAS5, RMA 두 가지로 세분화 하였으며 반복수에 따라 상위 20개 또는 100개 유전자에 대한 일치성도 측정하였다. 또한, 표본수를 산정하는데 있어 기존에 제시한 방법에 현실적인 정보를 이용하여 좀 더 세분화하여 실험에 필요한 표본수를 산정해 보았다. A number of methods have been developed to determine sample sizes in clinical trial, and most clinical trial organizations determine sample sizes based on the methods. In contrast, determining sufficient sample sizes needed for experiments using microarray chips is unsatisfactory and not widely in use. In this paper, our objective is to provide a guideline in determining sample sizes, utilizing reproducibility of real microarray data. In the reproducibility comparison, five methods for discovering differential expression are used: Fold change, Two-sample t-test, Wilcoxon rank-sum test, SAM, and LPE. In order to standardize gene expression values, both MAS5 and RMA methods are considered. According to the number of repetitions, the upper 20 and 100 gene accordances are also compared. In determining sample sizes, more realistic information can be added to the existing method because of our proposed approach.
김경훈 ( Kyung Hoon Kim ),이진수 ( Jin Soo Lee ),조형준 ( Hyeong Jun Cho ),최승봉 ( Seung Bong Choi ),정대영 ( Dae Young Cheung ),김진일 ( Jin Il Kim ),이인규 ( In Kyu Lee ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.4
Actinomycosis is a chronic suppurative granulomatous infectious disease caused by actinomyces species that is characterized by formation of characteristic clumps called as sulfur granules. Abdominal actinomycosis is a rare disease and is often difficult to diagnose before operation. Abdominal actinomycosis infiltrating into the abdominal wall and adhering to the colon is even rarer. Most abdominal actinomycosis develops after operation, trauma or inflammatory bowel disease, and is also considered as an opportunistic infection in immunocompromised patient with underlying malignancy, diabetes mellitus, human immunodefidiency virus infection, etc. Actinomycosis is diagnosed based on histologic demonstration of sulfur granules in surgically resected specimen or pus, and treatment consists of long-term penicillin based antibiotics therapy with or without surgical resection. Herein, we report an unusual case of abdominal wall actinomycosis which developed in a patient after acupuncture and presented as abdominal wall mass that was first mistaken for abdominal wall invasion of diverticulum perforation. (Korean J Gastroenterol 2015;65:236-240)
증례 : 신장 ; 우연히 발견된 무증상 기종성 신우신염 1예
이현정 ( Hyeon Jung Lee ),신새봄 ( Sae Bom Shin ),고세은 ( Se Eun Go ),서주현 ( Ju Hyun Seo ),한덕재 ( Deok Jae Han ),조형준 ( Hyeong Jun Cho ),김영옥 ( Young Ok Kim ) 대한내과학회 2015 대한내과학회지 Vol.89 No.5
기종성 신우신염은 주로 당뇨병 환자에서 발생하는 심한 괴사성 감염으로 발생빈도는 낮지만 임상경과가 매우 빠르고 예후가 나쁠 수 있기에 즉각적인 처치가 필요한 것으로 알려져 있다. 대개 급성 신우신염과 유사한 증상을 보이나 요로감염을 시사하는 증상 없이 우연히 영상검사 중에 진단된 증례가 국외에서 1예[7] 보고된 바 있다. 저자들은 진단 시점부터 치료 시작 전까지 무증상이었으나 연속적으로 시행한 영상검사상 악화 소견을 보여 항생제 치료를 시작하였고 영상검사상에서 호전을 확인한 증례를 경험하였기에 유사한 증례의 고찰과 함께 보고하는 바이다. Emphysematous pyelonephritis (EPN) is a severe gas-forming infection of the renal parenchyma and surrounding tissues. Patients with EPN commonly present with high fever, chills, and flank pain. These symptoms mimic a simple urinary tract infection, such that diagnosis is often delayed. Because of its life-threatening fulminant course, the early detection of EPN and its prompt treatment with intravenous antibiotics with or without percutaneous drainage are critical. Here we describe a case of a 63-year-old Korean female with diabetes mellitus who had no specific symptoms or signs of EPN. A chest computed tomography (CT) scan to assess a right pleural effusion incidentally detected an abnormal gas shadow in the renal parenchyma. An abdominal CT scan performed 5 days later showed increased gas within the kidney parenchyma, but the patient still had no symptoms of EPN. She was treated with intravenous antibiotics alone. A follow-up abdominal CT scan revealed the complete disappearance of the features of EPN. (Korean J Med 2015,89:567-570)