내비게이션을 이용한 방법과 고식적 방법을 이용한 슬관절 전치환술 결과 비교

조현종(Hyun Jong Cho),선종근(Jong Keun Seon),임지현(Ji Hyeon Yim),오창선(Chang Seon Oh),송은규(Eun Kyoo Song) 대한정형외과학회 2012 대한정형외과학회지 Vol.47 No.5

목적: 내비게이션 시스템을 이용한 슬관절 전치환술과 고식적 방식을 이용한 전치환술 후 5년 이상 추시 가능하였던 환자들에서 슬관절 이완도, 방사선학적 결과 및 임상적 결과를 비교하고자 하였다. 대상 및 방법: 원발성 퇴행성 슬관절염 환자 92예(내비게이션 47예, 고식적 45예)에 대해 슬관절 전치환술을 시행하였다. 슬관절 이완도를 측정하기 위해,90˚ 굴곡 위에서 스트레스 방사선 검사를 시행한 후, 두 그룹 간에 방사선학적 및 임상적 결과를 비교하였다. 결과: 최종 추시상 90˚ 굴곡 상태에서 외반 이완도는 내비게이션 군에서 3.9˚와 고식적 군에서 4.0˚, 내반 이완도는 4.0˚와 4.3˚였다(p=0.19, 0.22). 또한, 이완도의 총합에서도 두 군 간 차이는 없었다(내비게이션 군 7.8˚, 고식적 군 8.1˚; p=0.35). 그러나, 이완도의 총합이 10˚ 이상의 불안정성을 보인 경우는 내비게이션 군에서 유의하게 적었다(내비게이션 군 1예, 고식적 군 6예, p=0.04). 결론: 내비게이션을 이용한 슬관절 전치환술은 고식적 방법에 의한 슬관절 전치환술에 비해 불안정성을 보이는 경우가 적었으며, 정확한 하지 정렬, 강직도의 향상을 제공할 수 있었다. Purpose: Authors compared the laxity, radiologic and clinical outcomes of total knee arthroplasty (TKA) performed using the navigation system and using the conventional technique at least 5-year follow-up. Materials and Methods: Total of 92 TKAs were included for this study. Forty seven TKAs were performed by the navigation group and 45 TKAs were performed by the conventional surgery. At the final follow up, to evaluate knee joint laxity, varus-valgus laxities were measured on the stress radiographs taken with varus or valgus loads at 90˚ of flexion. The radiologic measurements and the clinical evaluations were compared between two groups. Results: At the final follow-up, the mean of valgus laxities were 3.9˚ in the navigation group and 4.0˚ in the conventional group, and the corresponding mean of varus laxities were 4.0˚ and 4.3˚(p=0.19, p=0.22) at 90˚ flexion state. Although there was no significant difference in the total laxities (7.8˚ in the navigation group and 8.1˚ in the conventional group, p=0.35). However, more than 10˚ of total laxity was significantly reduced in the navigation group (1 knee in the navigation group and 6 knees in the conventional group, p=0.04). The outlier numbers at mechanical axis, the mean of coronal inclination of the femoral and tibial component and the mean of sagittal inclination of the femoral and tibial component in the two groups were significantly different. Stiffness of WOMAC score was significantly better in the navigation than in the conventional group (p<0.001). Conclusion: Varus-valgus laxity was significantly different in the two groups as were the outlier numbers. The navigation system could provide good, improved alignment accuracy of the lower extremity and better result in stiffness of knee compared with conventional technique.

근적외선 분광분석법을 이용한 벌꿀의 품질평가

조현종(Hyeon-Jong Cho),하영래(Yeong-Lae Ha) 한국식품과학회 2002 한국식품과학회지 Vol.34 No.3

내반 변형을 지닌 내측 반월상 연골판 후방 골 기시부 퇴행성 파열 환자에서 반월상 연골판 절제술 단독과 근위 경골 절골술 동반 수술의 결과 비교

문재영,선종근,송은규,김형순,임지현,조현종,Moon, Jae-Young,Seon, Jong-Keun,Song, Eun-Kyoo,Kim, Hyung-Soon,Yim, Ji-Hyeon,Cho, Hyun-Jong 대한정형외과스포츠의학회 2012 대한정형외과스포츠의학회지 Vol.11 No.1

목적: 내반 변형을 지닌 내측 반월 연골판 후방 골 기시부 퇴행성 파열 환자에 대해 관절경적 반월 연골판 절제술을 시행 중 개방형 경골 근위부 절골술을 시행하는 경우와 하지 않는 경우에서의 임상적 및 방사선학 결과를 비교 하고자 하였다. 대상 및 방법: $3^{\circ}$ 이상 내반 변형과 내측 반월 연골판 후방 골 기시부 퇴행성 파열을 지닌 환자에 대해 관절경적 반월 연골판 절제술을 시행받고, 최소 3년 이상 추시가 가능한 환자 42명을 대상으로 하였다. 그 중 30명에 대해서는 개방형 근위 경골 절골술을 함께 시행하였으며, 나머지 12명에 대해서는 반월 연골판 절제술만 시행하였었다. 평균 추시 시간은 52.5개월 (36.0~76.6)이었다. 최종 추시 상 두 군간에 수술 전 증상의 소실 유무, 수술에 대한 환자의 만족도, 및 HSS 점수에 대한 임상적 결과를 비교하였다. 또한 최종 추시 상 방사선학적 퇴행성 관절염의 진행 유무를 비교하였다. 결과: 증상의 호전은 근위 경골 절골술을 함께 시행한 군(83.3%, 25예)에서 의의있게 관절경적 반월 연골판 부분 절제술만을 시행한 군(66.7%, 8예)보다 호전을 보였다. 환자 만족도 역시 근위 경골 절골술을 함께 시행한 군(83.3%, 25예)에서 반월상부분 절제술만 시행한 군(58.3%, 7예)보다 의의있게 높게 나타났다. HSS 점수는 근위 경골 절골술을 같이 시행한 군은 술 전 56.9점에서 술 후 90.8점으로 향상되었으며, 반월 연골판 부분 절제술만을 시행한 군에서는 술 전 67.9점에서 술 후 89.0점으로 향상되었으나, 양군간의 통계학적 차이는 관찰할 수 없었다. WOMAC 점수 역시 양군간의 통계학적 차이는 관찰할 수 없었다. 최종 추시 상 방사선학적 퇴행성 관절염의 진행에 있어서 두 군간에 의의 있는 차이는 없었다. 결론: 내반 변형을 지닌 반월 연골판 후방 골 기시부 퇴행성 파열 환자의 치료에 있어 좋은 임상적 결과를 위해서는 근위 경골절골술이 반드시 필요할 것으로 생각된다. 그러나 퇴행성 관절염의 결과에 미치는 영향에 대해서는 장기적인 추시가 필요할 것으로 생각된다. Purpose: We compared the clinical and radiological results of meniscectomy with HTO or without HTO for degenerative medial meniscus posterior horn with varus deformity. Materials and Methods: Forty-two patients who had medial meniscus degenerative root tear with varus deformity more than 3 degrees were included for this study. Among them, 30 patients were performed meniscectomy combined with open wedge HTO and 12 patients were performed only meniscectomy without HTO. The mean follow-up period was 52.5 months. The clinical results were evaluated based on symptom improvement, patients' subjective satisfaction for surgery and HSS score. We also compared the osteoarthritic progression between the group on preoperative and at the final follow up radiographs. Results: Symptom improvement was achieved in 83.3% (25 cases) with HTO group and 66.7% (8 cases) without HTO group at final follow up with a significant difference. Patients' satisfaction was achieved in 83.3% (25 cases) with HTO group and 58.3% (7 cases) without HTO group which has a significant difference. The HSS score was improved in both group (90.8: with HTO group, 89.0: without HTO group) at the final follow up without significant difference. WOMAC score was improved in both groups at the final follow up without significant difference. There were no significant differences in the osteoarthritic progression between two groups. Conclusion: The good clinical result for treatment of patient who have medial meniscus degenerative root tear with varus deformity, proximal high tibial osteotomy is considered absolutely necessary. However, the progression of degenerative arthritis, its effect on long term follow up will be needed.

CT위장검사시 체위변화에 따른 영상의 비교

장진규(Jin Kyoo Jang),김정훈(Jeong Hoon Kim),조현종(Hyeon Jong Cho),하동윤(Dong Yoon Ha),이용문(Yong Moon Lee) 대한CT영상기술학회 2007 대한CT영상기술학회지 Vol.9 No.1

Purpose We classified three groups with position change from effection of bubble by using effervescent granules in CT gastrography. We compared the CT gastrography images with 3D reconstruction of the stomach and evaluated an effect to stomach tube image clinically. Materials and Methods In 90 adults (M:F=67:23, mean age; 59years) were performed. Before scanning, 8 g of effervescent granules with a small amount of vvater is administered orally to distend the stomach. CT gastrography is three groups: group I is only spine. roup II is Adjusted supine. groub III is prone, supine and LPO position. Ionic contrast material injection(150ml) was administered at a rate of 3ml/sec by a power injector for better reproducibility in follow-up examinations. We were taken a axial images(0.7mm) using the Siemens Somatom sensation 16(Erlangen, Germany) MIXT and then transmited the data GE workstation(AW4.1_06). We performed of 3 types randering method (Transparent Image, shaded surface display, virtual Endoscopy) using the Image quality grading method:(many, small, nil) Results The Results obtained as followed: group I Quantity of bubble (many=13, small=9, nil=8) group II Quantity of bubble (many=3, small=4, nil=23) group III Quantity of bubble (many=1, small=7, nil=22) Conclusion CT gastrography showed bubble using effervescent granules. group I got the image where the bubble is many, the group II, III got the image quality which is excellent. From the results of these studies, We were taken the best Image quality of all types post processing method in group III. group III for CT gastrography guaranteed the excellent 3D CT gastrographic images.

조영제와 생리식염수 주입 순서에 의한 Syringe내에서의 CT Number값 변화

김도훈(Do Hun Kim),김기홍(Ki Hong Kim),정재연(Jae Yeon Chung),조현종(Hyeon Jong Cho) 대한CT영상기술학회 2007 대한CT영상기술학회지 Vol.9 No.1

Purpose A lot of hospitals use Contrast Medium mixed with Normal Saline when they operate CT study. This brings about cut down in expenditures as well as reduction of artifact in Subclavian vein. This thesis try to mearsure CT Number in the syringe when they were used mixed clinically, and to come up with right method of using those Contrast Medium, and Normal Saline. Materials and Methods We used the same materials and equipment as an actual CT Study. We used UltraVist300 as Contrast Medium, NaCl 0.9% for Normal Saline, and the ratio of Contrast Medium and Normal Saline is 1:1, 1:2, and 2:1 respectively. At the experiment, we measured CT Number in 200ml-syringe and measured the changed of CT Number for ten minutes, which is similar amount of time as the actual experiment. We used SIEMENS Somatom Sensation 16, and measured with Sequence Mode lOmm. ROI was 1cm/sq at the measurement. To distinguish Normal Saline from Contrast Medium, we put 1ml of blue ink into Normal Saline. Results At the Chest examination, it is beuer to pour Contrast Medium first and then Normal Saline later. When we put Normal Saline first and Contrast Medium later, it is diluted by just pouring them together. At all the experiments, when turned upside down, it shows the sTable distribution. At all the experiments, the CT Number show the highest at the lowest level. Conclusion We have checked CT Number in the syringe when we had experiment using Contrast Medium adding Normal Saline. Through this experiment, we could find out the mixed degree of Contrast Medium and Normal Saline that had been able to be checked only by naked eyes. Based on the results above, it is expected to apply it in an appropriate density. At the future research, based on the result above, I would like to find out the ideal CT Scan Start Time when the Artifact comes th the least at Image by finding out the time Contrast Medium is poured into Subclavian vein with flow rate, total volume of Contrast Medium and Normal Saline and the pouring pressure.

노이즈 변화에 따른 전산화단층촬영장치의 팬텀성능 평가

김정훈(Jeong Hoon Kim),김선기(Sun Ki Kim),조현종(Hyeon Jong Cho),하동윤(Dong Yoon Ha) 대한CT영상기술학회 2007 대한CT영상기술학회지 Vol.9 No.1

Purpose The image quality relies on how it can clearly and correctly present the fine structure of human body into the image and the factors influencing on the quality of CT image are accuracy of CT number, noise, spatial resolution and contrast resolution, artifact, dosimetry and accuracy of device. Among these factors, this paper finds out the change of CT number, spatial resolution, contrast resolution, linearity of CT number, etc. followed by the noise change which is the standard deviation of CT number. Materials and Methods As for CT device, Light speed CT/I/pro of GE medical company was used for the CT device of this experiment. CT phantom used in this experiment is the Nuclear Associates CT for CT performance evaluation designed by the American Association of Physicists in Medicine (AAPM) and manufactured by Victoreen, and it is used for CT performance evaluation in Korea. For the method of experiment, the size of noise in CT Phantom was changed into 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18 and 20 and its change was compared and recorded by measuring CT number, high contrast spatial resolution, low contrast spatial solution, linearity of CT number, etc. for 4 times. The size of noise was changed with slice thickness, reformative algorithm, kVp, dosimetry, etc. Results 1. CT numb.er CT number in the change of noise changed from 0 to 0.9HU with the noise change from 1 to 10 and changed about -3HU with the noise change from 12 to 20. 2. High contrast resolution The high contrast resolution in the change of noise changed from 0.75 to 1mm with the noise change from 1 to 8 and decreased to 1.25mm with the noise change from 9 to 20. 3. Low contrast resolution The low contrast resolution in the change of noise changed from 3.2 to 6.4mm with the noise change from 1 to 4 and changed from 19. 5 to 25. 4mm with the noise change from 7 to 10. However, the low contrast resolution changed a lot above the scale of measuring Phantom with the noise change up to 12-20. 4. Linearity of CT number The linearity of CT number in the change of noise uniformly showed the change of CT number such as water, acrylic, nylon, polystyrene, polyethylene and lexan which are used for the linearity within the permitted limit with the noise change from 1 to 10, however, CT number rapidly fell down with the noise change from 12 to 20. Conclusion In the CT performance evaluation from the noise change, the result shows that CT. number, high contrast resolution and linearity of CT number maintained their performance recommended by Korean Institute for Accreditation of Medical Image within the permitted limit of noise but low contrast resolution ran off the permitted limit of noise in the noise with over 7. In the experiment, the result does not satisfy the current condition which has the accepTable standard easier than the company’s regulation. Therefore, it is necessary to suggest the performance evaluation list and criteria satisfying the condition used in the real examination for the patients.

Headspace법에 의한 솔향의 분석

이미정(Mi-Jeong Lee),정은주(Eun-Joo Jung),이신조(Shin-Jo Lee),조지은(Ji-Eun Cho),이양봉(Yang-Bong Lee),조현종(Hyeon-Jong Cho),윤정로(Jungro Yoon) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.1

Pinus densiflora(2엽송) 1년생을 채취하여 가지, 잎, 새순 부분으로 구분하고, 시료병에 넣어 밀봉한 뒤, solide phase microextraction(SPME)과 dynamic headspace analysis(DHA)를 이용하여 휘발성 성분을 분리, 동정하였다. SPME와 DHA의 결과를 terpenes의 구성 성분에 따라 monoterpenes과 sesquiterpenes, oxygenated terpenes으로 나누어 조성비를 살펴보면, monoterpenes의 조성은 잎의 경우 각각 66.7%와 14.3%, 새순은 90.6%와 0.7%, 가지에서는 90.6%와 1.2%로 나타났다. Sesquiterpenes의 함량은 SPME의 결과에서만, 잎이 25.8%, 가지 4.4%, 새순 1.5%로 나타났다. 산소를 함유하고 있는 terpenes의 함량은 새순 부위가 4.7%, 79.0%로 나타났으며, 가지 부위는 3.7%와 70.4%, 잎에서 1.0%와 50.7%를 각각 차지하였다. SPME의 결과는 이전의 용매추출을 통한 결과와 다소 비슷한 양상을 보였으며, DHA의 결과는 100℃ 이상의 고비점 화합물들이 나타나지 않은 반면, 50℃이하의 저비점 화합물이 15개 더 분리되었다. Volatile compounds from three parts of needles, sprouts and twigs in Pinus densiflora were extracted by solid phase microextraction (SPME) and dynamic headspace analysis (DHA), separated by gas chromatography, and identified by using mass selective detector and Kovat's retention index. The amounts of monoterpenes isolated by SPME and DHA were 66.7% and 14.3% in needles, 90.6% and 0.7% in sprouts, and 90.6% and 1.2% in twings, respectively. The amounts of sesquiterpenes detected only by SPME were 25.8% in needles, 4.4% in twings and 1.5% in sprouts. And the amounts of oxygenated terpenes isolated by SPME and DHA were 4.7% and 79.0% in sprouts, 3.7% and 70.4% in twigs, and 1.0% and 50.7% in needles, respectively. The kinds of volatile compounds isolated by SPME were similar to those by solvent extraction, but the number of compounds identified to have a boiling point below 50℃ by DHA was larger than that of SPME.

Astaxanthin 처리 산란계로부터 생산된 난황이 Mouse Liver Microsome의 산화에 미치는 영향

김홍출(Hong Chul Kim),박숙자(Sook Jahr Park),김정곤(Jung Kon Kim),박철우(Cherl Woo Park),조용운(Yong Un Cho),조현종(Hyeon Jong Cho),하영래(Yeong Lae Ha) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.1

AEY의 acetone추출물이 mouse liver microsome의 산화에 미치는 영향을 조사하였다. Mouse liver microsome에 함유된 단백질 함량은 AEY 처리구가 CEY 처리구에 비해 상대적으로 7~48%정도가 증가하였다. 지방산 분석 결과, CEY 처리에 비해 AEY 처리구에서 stearic acid를 포함하는 포화지방산의 함량비가 상대적으로 높았으며, oleic acid, linoleic acid 등을 함유하는 불포화지방산의 함량비가 현저히 감소하였다. AEY 처리구는 Fe2+가 관여하는 Asc/Fe^(+2), NADPH/Fe^(+2)를 산화유도물질로 사용한 경우에 TC와 비슷하거나 보다 강력한 항산화 효과를 보였다. ABIN이나 CuOOH가 산화유도물질로 작용할 시에는 AEY처리에 의해 유의성있는 항산화 효과가 나타나지 않았다. Effect of the egg yolks from laying hens intubated, p.o., astaxanthin (designated AEY) on the oxidation of mouse liver microsome was investigated using female ICR mouse (6~7 weeks of age). Mice were adapted in a temperature- and humidity-controlled house for one week and randomly divided into 7 treatment groups (10 mice/cage/treatment). Mice were intubated p.o., AEY (50, 100 and 150 mg) or control egg yolk (CEY, 150 mg) every week for 3 weeks. BHT (5 mg) and α-tocopherol (50 mg) were fed to mice as positive control. At week 4, the liver microsome was prepared from sacrificed mice. Protein content of mouse liver microsome with AEY treatment was relatively higher than that with CEY treatment. AEY treatment remarkably lowered the content of unsaturated fatty acids including oleic acid and linoleic acid, but raised that of the saturated fatty acids including stearic acid. AEY group showed relatively higher antioxidative activity than CEY, when used Asc/Fe^(+2) or NADPH/Fe^(+2) as oxidant. Antioxidative activity of AEY was more effective than α-tocopherol, but less effective than BHT.

Astaxanthin처리 산란계로부터 생산된 난황이 Mouse의 마크로파지 활성과 응집소가 및 용혈소가에 미치는 영향

김홍출(Hong-Chul Kim),박숙자(Sook-Jahr Park),김정곤(Jeong-Kon Kim),김영림(Young-Rim Kim),박원석(Won-Seck Park),조용운(Yong-Un Cho),조현종(Hyeon-Jong Cho),김정환(Jeong-Hwan Kim),하영래(Yeong-Lae Ha) 한국식품영양과학회 2001 한국식품영양과학회지 Vol.30 No.6

마크로파지의 활성을 조사하기 위해 carbon clearance time을 조사한 결과 AEY 처리구가 control이나 CEY 처리구에 비해 짧았다. 특히 AEY 500 μg 처리에서 carbon clearance 시간이 5분으로 control에서 9.42분, CEY(250 μg 처리)에서 9.01분보다 유의성있는 감소를 보였다. AEY 처리에 의해 응집소가와 용혈소가가 다소 증가되었다. SRBC 처리 1일째와 3일째에 250 μg 처리구를 비교해 보면, control, CEY, AEY의 응집소가는 각각 5.50, 5.63, 6.00 및 5.25, 5.38, 5.50로 용혈소가는 각각 4.75, 5.38, 5.50 및 4.25, 5.63, 5.63으로 AEY 처리구가 control, CEY 처리구에 비해 면역 활성이 있었지만 유의성은 없었다. Effect of the egg yolks from laying hens intubated, p.o., astaxanthin (designated AEY) on mouse humoral immunity was investigated using male ICR mouse (6~7 weeks of age). Mice were adapted in a temperature- and humidity-controlled house for one week and randomly divided into 5 treatment groups (9 mice/cage/treatment). Mice were intubated p.o., AEY (100, 250 and 500 μg) or control egg yolks (CEY, 250 μg), dissolved in 0.1 mL DMSO, for consecutive 4 days. At day 5, carbon suspension (pilot drawing ink 3 mL+3% gelatine 3 mL) was injected 3 μL per 1 g body weight through tail vein. Carbon clearance time was measured at 5 and 35 minutes post the injection of carbon suspension. Another two experiments were conducted to determine the hemagglutinin-titer (HGT) and hemolysin-titer (HLT) with male ICR mouse (8 mice/cage/treatment). Mice treated with AEY were induced immune activity with SRBC. HGT and HLT were measured from the blood at day 1 and 3 after treatment of SRBC. AEY treatment reduced the carbon clearance time. Especially the carbon clearance time by 500 μg AEY treatment was 5.00 minutes, which was very short time compared with 9.42 minutes by control and 9.01 minutes by CEY. AEY group showed slightly higher values of HGT and HLT than CEY group and control. At day 1, HGT in control, 250 μg CEY and 250 μg AEY groups was 5.50, 5.63, and 6.00, respectively. Similarly, HLT in control, 250 μg CEY and 250 μg AEY groups was 4.75, 5.38, and 5.50, respectively, at day 1. These results suggest that AEY exhibited immunity-enhancing effect.

Astaxanthin 처리 산란계로부터 생산된 난황의 Mouse에 대한 Catabolic Response Overcome 효과

김홍출(Hong-Chul Kim),박숙자(Sook-Jahr Park),박철우(Cherl-Woo Park),김영림(Young-Rim Kim),김정환(Jeong-Hwan Kim),최의성(Eui Sung Choi),조현종(Hyeon-Jong Cho),조용운(Yong Un Cho),하영래(Yeong Lae Ha) 한국식품영양과학회 2001 한국식품영양과학회지 Vol.30 No.6

Astaxanthin을 산란계에 경구 투여하여 얻은 AEY에는 총 2.88 mg%의 carotenoid가 함유되어 있었다. Carotenoid 성분을 HPLC로 분석한 결과, CEY에는 존재하지 않는 α-cryptoxanthin, canthaxanthin, cynthiaxanthin, triol 등이 AEY에서 확인되었다. CEY에서는 존재하지 않기 때문에 이들은 astaxanthin의 대사생성물로 예상할 수 있다. AEY는 LPS로 유발한 mouse의 catabolic response overcome의 효과 시험에서 control구에 비해 유의성있는 체중 감소 억제 효과를 보였다. 또한 AEY는 LPS 처리에 의한 면역기관에 미치는 영향에서는 췌장과 간의 체중에 대한 상대적 비율을 증가시켰다. 따라서 AEY 처리가 면역작용을 하는 세포의 활성에 관여하는 것으로 생각되고 이것은 AEY 처리구에서 관찰되는 α-cryptoxanthin, canthaxanthin, cynthiaxanthin, triol 등에 의한 것으로 추측된다. Effect of the egg yolks from laying hens intubated, p.o., astaxanthin (designated AEY) on the catabolic response overcome of mice was examined. Female ICR mice (6~7 weeks of age) were adapted in a temperature- and humidity-controlled house for one week and randomly divided into 5 groups (6 mice/cage/treatment). Mice were intubated p.o., AEY (5, 10 and 15 mg), control egg yolk (CEY, 10 mg), or fish oil (5 mg) dissolved in 0.2mL phosphate buffered saline (PBS) every two days for 14 days. At day 15, the 0.1 mL of lipopolysaccharide solution (LPS, 30 μg/0.1 mL 10 mM HEPES) was injected through tail vein, and then, the body weight of mouse and the amount of feed intake were measured over a period of 72 hours. Control group mice were received only PBS and LPS. AEY treatment suppressed the loss of mice body weight in a dose-response manner. Twenty four hours post LPS injection, the reduced body weight per mouse of AEY 5, AEY 10, and AEY 15 mg treatment groups was 3.70, 3.54, and 3.25 g, respectively. Body weight suppression effect of AEY treatment was greater than that of CEY, but less than fish oil. AEY treatment did not alter thymus weight, but increased the weight of spleen or liver. These results indicate that AEY suppressed the loss of body weight by LPS via any function of the spleen and/or liver.