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김정욱,김형준,도재혁,조준형,문철,유경금,장세경,허철행 대한소화기학회 1998 대한소화기학회지 Vol.31 No.6
Baekground/Aims: Tumor suppressor genes are characterized by inactivation of both alleles, that is, especially loss of heterozygosity (LOH). The LOH at 18q21 chromosome region has been reported to be frequent in pancreatic and colon cancer. The chromosome region 18q21 has been shown to be frequently deleted in colorectal cancer. Such frequent allelic loss indicates the presence of a tumor suppressor gene in colorectal cancer. The DPC4 gene, which is located at the 18q21, has been identified as a putative tumor suppressor gene he from the studies of pancreatic cancer. The aim of the present study was to determine whether it is also altered in colorectal cancer. Methods: For 30 colorectal cancer tissues, we performed PCR-single strand conformation polymarphism (SSCP) with modified 'cold SSCP' and silver sequencing. Results: The DPC4 gene mutation of coIorectal cancer was found in 9 out of the 30 specimens (30%). Among the 9 specimens, mutations of exon 1, 8, and 10 were observed in 2 of 9 (22%), in 6 of 9 (66%) and in 1 of 9 (11%), respectively. Silver sequence showed substitution in 4 cases (44%), insertion in 4 cases (44%), silent mutation in 1 case (12%) and deletion was not observed. Presence of DPC4 mutation was correlated with tumor differentiation (well or moderate vs. poorly differentiation; p$lt;0.05). Conclusions: The DPC4 gene may be related to tumor development in a fraction of colorectal cancers.
대장 선종 - 선암에서 bcl - 2 종양 단백 발현에 대한 연구
김정욱,김형준,도재혁,조준형,장세경,문철,허철행 대한소화기학회 1998 대한소화기학회지 Vol.31 No.2
Background/Aims: The bcl-2 gene is an oncogene that inhibits programmed cell death or apoptosis. Overexpression of bcl-2 probably plays a role in colorectal carcinogenesis. The aim of our study was to assess the possible role of bcl-2 in colorectal tumorigenesis and to evaluate its clinical significance. Methods: We investigated bcl-2 expression in adenomas and carcinomas of the large bowel by immunohistochemistry. The cases included 20 adenomas and 24 colorectal carcinomas. Results: In normal mucosa bcl-2 immunoreactivity was detected only in the proliferative cells of the colonic crypts. Conversely, bcl-2 immunoreactivity was noted in 60% of adenomas and the potency of immunoreactivity was noted to be one positive in 10 cases of adenomas and two positive in 2 cases of adenomas. In colorectal carcinomas, bcl-2 expression was noted in 70.8% of carcinomas and was undetectable in 29.2% and focal staining (less than 50% immunostained neoplastic cells) in 54.2% of carcinomas. The remaining 16.6% of the carcinomas displayed diffuse (more than 50% immunostained neoplastic cells) bcl-2 immunoreactivity. In colorectal adenornas bcl-2 expression was not correlated with the pathologic type of adenomas, but correlated with adenoma size. In colorectal carcinomas, bcl-2 expression was not correlated with relevant clinicopathologic parameters, including disease stage and tumor differen.iation. Conclusions: Our data suggest that the bcl-2 oncoprotein may play a role in colorectal tumorigenesis and be correlated with tumor size. In the case of carcinomas, the expression of the bcl-2 oncoprotein did not show statistical significance compared with adenomas. But, the potency of bcl-2 expression was more stronger in carcinomas than in adenomas and showed statistical significance.
원발성 간세포암 환자에서 간동맥화학색전술 후 발생한 괴사성 간농양 및 담도괴사 1 예
김정욱,김상진,박중원,이종범,조준형,정규,김재규,장세경,박실무,유병철 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.4
Transcatheter arterial chemoembolization (TACE) is widely used in the treatment of hepatocellular carcinomas. We report a case of multiple liver abscess with bile duct necrosis following gallbladder infarction after TACE in a patient with hepatocellular carcinoma. A 62- year old man, wit h four cm sized hepatocellular carcinoma in right lobe, was treat ed by TACE for six times during 18 months. Two days after the last TACE, acute cholecystitis occurred and antibiotics were used until the recovery of cholecystitis. After two months, abdominal CT scan revealed a gas containing liver abscess and percutaneous transhepatic drainage was performed. Cholangiography via drainage cathet er showed findings of bile duct necrosis. Ant ibiotics sensit ive to the causative organism were administered intravenously. However, the abscess persisted despite of treatment for three mont hs. (Korean J Hepatol 1999;5:348-352)
김정욱,김미경,김상진,박중원,안주희,조준형,정규,김재규,장세경,박실무,유병철,한성혁 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.1
Hyperplastic polyps are a benign epithelial proliferation and a common type of colorectal and gastric polyps. Malignant change of hyperplatic polyps is rare. Patients with multiple lesions however, tend to have a high frequency of malignancy. Colorectal polyposis syndromes with gastric polyps include familial adenomatous polyposis, Gardners syndrome, Peutz-Jeghers syndrome, juvenile polyposis and others. But the case of colorectal hyperplastic polyposis with multiple gastric hyperplastic polyps has not been reported until now. A case was recently experienced involving a 32 year old women with both colorectal and gastric hyperplastic polyposis. Multiple hyperplastic polyps were found in the lower part of the body and the antrum of the stomach, rectosigmoid, transverse and ascending colon.