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대한간학회지 제8차 춘계학술대회 초록집 : 포스터 발표 ; Lamivudine 치료 후 만성 B형 간염환자의 혈청내 Nitric Oxide(NO) 대사체 농도의 감소
조용균 ( Jo Yong Gyun ),김병익 ( Kim Byeong Ig ),황상태 ( Hwang Sang Tae ),김정욱 ( Kim Jeong Ug ),이준행 ( Lee Jun Haeng ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),전우규 ( Jeon U Gyu ),모지원 ( Mo Ji Won ),박창신 ( Pa 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
만성 B형 간질환에서 Adefovir Dipivoxil의 적용과 효능
조용균 ( Jo Yong Gyun ),김병익 ( Kim Byeong Ig ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.5
In therapy of chronic hepatitis B, there are new and exciting developments in antivirals such as nucleotide analogues. Adefovir dipivoxil is an oral prodrug of adefovir, a nucleotide analogue of adenosine monophosphate. This agent has a potent in vitro and in vivo effect against herpes virus, retroviruses, and hepadnaviruses. In the hepatitis B virus (HBV) setting, adefovir dipivoxil inhibits both the wild type and lamivudine-resistant HBV strains. The safety profile of adefovir dipivoxil 10 mg is excellent, but higher doses can produce renal tubular damage, particularly when the drug is used for prolonged therapy. Adefovir dipivoxil is an important new addition to the current first-line treatments for HBeAg positive and negative chronic hepatitis B, as well as being rescue therapy for lamivudine-resistant HBV strains. It is also licensed for use in adults with decompensated liver disease, as well as compensated liver disease where there is evidence of active viral replication, persistently elevated serum alanine aminotransferase levels and active liver inflammation and fibrosis. However, a longer follow-up is needed to establish the long term safety and efficacy of adefovir dipivoxil in patients with chronic HBV infection.(Korean J Gastroenterol 2003;42:357-362)
임신성 고혈압과 정상 산모 태아에서의 제대혈 leptin 측정에 대한 연구
김명환 ( Kim Myeong Hwan ),조용균 ( Jo Yong Gyun ),고지경 ( Go Ji Gyeong ),강웅선 ( Kang Ung Seon ),박기현 ( Park Gi Hyeon ),이철민 ( Lee Cheol Min ),최훈 ( Choe Hun ),김복린 ( Kim Bog Lin ),이홍균 ( Lee Hong Gyun ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.12
목적 : 16 KDa 단백인 leptin은 Ob gene에 의해 지방세포 (adipocyte) 등에서 생성되어 식욕과 체중을 조절하는 새로운 호르몬으로 생각되고 있다. 임신시는 말초 혈액에서 농도가 증가되어 있으며, 반응성이 감소되어 있고, 지방 조직 이외의 태반 등에서도 leptin 생성이 가능한 특징을 가지고 있다. 임신성 고혈압 산모에서 정상산모보다 태반의 leptin 생성이 증가하여 혈중에 유의하게 높아지는 것으로 알려져 있다. 이에 저자들은 제 Objective : Leptin, the protein encoded by the Ob gene in the adipose cell, is produced by the placenta during pregnancy and materanal serum leptin is increased in preeclampsia. The objective of this study was to compare umbilical cord plasma leptin level
분만시 저체중아의 제대혈에서 측정한 미성숙 망상적혈구 분율의 평가
강웅선 ( Kang Ung Seon ),조용균 ( Jo Yong Gyun ),고지경 ( Go Ji Gyeong ),김명환 ( Kim Myeong Hwan ),박기현 ( Park Gi Hyeon ),이철민 ( Lee Cheol Min ),한태희 ( Han Tae Hui ),최훈 ( Choe Hun ),김복린 ( Kim Bog Lin ),이홍균 ( Lee Ho 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.1
목적 : 출생시 저 체중 신생아의 자궁내 만성 질식상태 (perinatal asphyxia)의 예측인자 역할을 하는, 자동화 계측기로 산출한 미성숙 망상 적혈구 분율의 의의를 평가하고자 하였다. 연구 방법 : 2000년 5월 8일부터 2002년 4월 2일까지 인제대학교 의과대학 상계백병원 산부인과에서 질식 자연 분만된 신생아중 출생시 정상체중을 보인 47명과 저 체중아 (출생체중<10 percentile) 40명을 대상으로 출생직후 제대혈 5 cc를 채 Objective : To evaluate the immature reticulocyte fraction (IRF) by automated calculator that have played a role of predicting marker for hematopoiesis induced by perinatal asphyxia. Methods : Hospital charts of 40 neonates with diagnosis of small for ges
대간간학회지 제6차 춘계학술대회 초록집 : 포스터 전시 ; 만성 비대상성 간경변증, 만성간염, 간세포성 간암환자에서 혈청 Thrombopoietin과 비장종대와의 관계
구은실 ( Gu Eun Sil ),김병익 ( Kim Byeong Ig ),조용균 ( Jo Yong Gyun ),김창섭 ( Kim Chang Seob ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),전우규 ( Jeon U Gyu ),정을순 ( Jeong Eul Sun ) 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
이훈구(Lee Hoon-Goo),최권희(Choi Kwon-Hee),조용균(Jo Yong-Gyun),이영호(Lee Young-Ho),황현철(Hwang Hyeon-Chyeol) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.4
It is a proven fact with the opening of the Seoul metro line number 1 in 1974 traffic congestion on the roads has decreased and the efficiency of people transportation in general has greatly been enhanced in the downtown and surrounding areas of Seoul. Even today construction of new subway lines are under way and many more are being planned due to the easy access to stations, short waiting and average traval times, compared with personal vehicles, contributing to the efficiency of the public transportation systems that are linking the downtown areas and also the intercity systems in moving passengers during rush hour and times of special event. Since the labour costs of the train operator in any large city based subway system accounts for a major part of the operating costs per kilometer and to ensure cost efficient operations, especially during non-peak hours, it is necessary to implement an unmanned(auto-driven) subway system. In order to implement such a system it is imperative that the on-board and wayside signalling control systems be fully automated as well. Only through proper examination of safety procedures not only by the AUGT(Automated Urban Guided Transport)system but also by all the international standards organizations involved can safely and stability be ensured.
김정욱 ( Kim Jeong Ug ),전우규 ( Jeon U Gyu ),윤중원 ( Yun Jung Won ),박동일 ( Park Dong Il ),조용균 ( Jo Yong Gyun ),성인경 ( Seong In Gyeong ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),김병익 ( Kim Byeong Ig ),김은정 ( 대한소화기학회 2004 대한소화기학회지 Vol.43 No.2
Background/Aims: Increased intestinal permeability has been possible contributing factors to the pathogenesis of alcoholic liver disease. Moreover, it can contribute to the development of bacterial infection and intestinal endotoxemia in patients with liver cirrhosis. This study aimed to examine the difference of intestinal barrier dysfunction between alcoholic and viral liver disease patients through the comparison of the intestinal permeabilities of patients with clinical characteristics. Methods: Intestinal permeabilities were measured in 18 healthy controls, 41 patients with alcoholic liver disease (17 cases of alcoholic liver disease without cirrhosis and 24 cases of alcoholic liver cirrhosis) and 46 patients with viral liver disease (14 cases of chronic viral hepatitis and 32 cases of viral liver cirrhosis) by measuring 24 hour urine excretion of 51Cr-EDTA. Results: The intestinal permeability was significantly increased in the patients with alcoholic liver disease without cirrhosis (5.62±80%), alcoholic liver cirrhosis (5.29±48%) and viral liver cirrhosis (3.15±39%) compared with that in control subjects (1.99±53%). On the contrary, it was not increased in the patients with chronic viral hepatitis (2.05±57%) versus controls. The significant correlation was not found between intestinal permeability and clinical and laboratory findings. Conclusions: The intestinal permeability was elevated in patients with alcoholic liver disease compared to those with viral liver cirrhosis. The pathophysiology of liver injury secondary to intestinal epithelial damage may be different between alcoholic and viral liver diseases. (Korean J Gastroenterol 2004; 43:104-111)
상부 소화관 내시경 검사시 midazolam의 적절한 투여용량 및 투여용량에 영향을 미치는 인자와 검사 후 flumazenil의 투여시기
서정열 ( Seo Jeong Yeol ),윤중원 ( Yun Jung Won ),김정욱 ( Kim Jeong Ug ),박동일 ( Park Dong Il ),조용균 ( Jo Yong Gyun ),성인경 ( Seong In Gyeong ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),전우규 ( Jeon U Gyu ),김병익 대한내과학회 2003 대한내과학회지 Vol.65 No.4
목적: 최근 midazolam을 이용한 상부 소화관 수면 내시경법이 널리 시행되고 있으나 피검자에 따라 midazolam 투여에 따른 진정효과 및 수면 내시경을 시행 받은 후 만족도가 다르다. 이에 저자들은 midazolam의 적절한 투여용량 및 투여용량에 영향을 미치는 인자를 알아보고, 검사 후 그 길항제인 flumazenil의 적절한 투여시기에 대해 연구하였다. 방법: 상부 소화관 수면 내시경을 시행한 126명의 피검자를 대상으로 투여된 midazo Background: Intravenous administration of midazolam is widely used as a premedication for esophagogastroduonenoscopy. However, there are individual differences in midazolam doses for premedication and controversies for starting point of esophagogastroduon