중증 아토피피부염 환자 89명의 한의학적 치료 효과에 대한 후향적 연구

조아라,한수련,박건,서산,Cho, Ah-Ra,Han, Su-Ryun,Park, Gun,Seo, San 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.2

Objectives : The purpose of this study is to report the effectiveness of a Korean Medicine Treatment on 89 severe atopic dermatitis patients all through 12 months. Methods : The degree of atopic dermatitis was measured in Objective SCORAD Index (OSI) with photos of patients. Then, the OSI score was estimated according to gender, age and intensity. Results : 1. The ratio of male to female was 41.57 : 58.43. The 24.72% of patients were in 0~11 year-old group, 16.85% were in 12~18 year-old group and 58.43% were in the group above 19 years old. 2. The initial OSI score was 64.43 and the final was 37.03 after 12 months. After 3, 6, 9, 12 months, the OSI score was significantly lower than the initial visit. 3. There was no significant difference between male and female patients on age, OSI scores and OSI improvements. 4. The patients who treated acupuncture were significantly older then who not treated. The OSI improvement had no significant difference whether treated with acupuncture or not. 5. There was no significant difference among 3 different age groups on initial OSI scores. The OSI improvement of 0~11 year-old group was significantly higher than the other groups after 12 month treatment. 6. The OSI score of 97.75% was decreased after 12 month treatment compared to initial visit. 7. After 12 month treatment, the distribution of severe atopic dermatitis was decreased from 100% to 37.08%. 8. There was no significant difference betweent steroid group and non-steroid group on OSI scores at initial visit and after 12 month treatment. Conclusions : The OSI Score of severe atopic dermatitis patients was decreased on the significant rate with Korean medicine treatment for 12 months.

Gagamyeonryunggobon-dan(Ji?ji?nyanlinggub?n-d?n) induces hair regrowth effect from activating hair follicle

조아라,홍승욱,윤영준,Cho, Ah-Ra,Hong, Seung-Ug,Yoon, Young-Joon The Society of Korean Medicine Ophthalmology 2016 한방안이비인후피부과학회지 Vol.29 No.1

Objective : The purpose of this study is to report the hair regrowth effect of Gagamyeonryunggobon-dan on ICR mice from measuring the change of diverse factors.Methods : Gagamyeonryunggobon-dan was treated by oral administration with 2.5㎎/㎏/day amount for 3 weeks per mouse everyday. Hair regrowth was estimated by change of morphology, angiogenesis, hair follicle activation. The change of morphology was observed with external, internal change and sebaceous gland. Angiogenesis was estimated by image analysis, capillary distribution and angiogenic chemokine(MIP-2). Hair follicle activation was estimated by PCNA, IGF-2 and serotonin.Results : 1. Gagamyeonryunggobon-dan treated group had more and thicker hairs than the group not treated. Especially well developed sebaceous glands were seen in dermis of treated group. 2. Gagamyeonryunggobon-dan treated group had more capillaries near hair follicles of subcutaneous layer and more 2019% MIP-2 positive activity than the group not treated. 3. Gagamyeonryunggobon-dan treated group increased positive activity up to 596% in PCNA, 187% in IGF-2 and 547% in serotonin more than the group not treated.Conclusion : These results shows that Gagamyeonryunggobon-dan have the hair regrowth effect through verifying change of morphology, angiogenesis, chemokines. Consequently Gagamyeonryunggobon-dan is expected to apply to take care of extensive hair loss symptoms.

가감선방패독탕(加減仙防敗毒湯) 투약을 통한 탈모증 치험 1례 - 임파선염을 동반한 다발성 원형탈모증 치료를 중심으로

조아라,홍승욱,Cho, Ah-Ra,Hong, Seung-Ug 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.1

Objectives : This is a clinical report on a 27-year-old patient with Multi-patched Alopecia Areata(AA) assumed to be occurred by chronic lymphadenopathy, and treated by oriental medicine treatment. Methods : The patient was treated by herb medication and acupuncture. The improvement of the patient was judged by magnifying glass, camera and VAS scale. Results & Conclusions : The AA patches were shown the regrowth of hair. And the pain from lymphadenopathy was disappeared. Oriental medicine treatment including Gagamsunbangpaedok-tang $(Ji\bar{a}ji\check{a}nxi\bar{a}nf\acute{a}ngb\grave{a}id\acute{u}-t\bar{a}ng)$ was effective to regrow hair on AA patches and reduce the symptom of lymphadenopathy as well.

아토피피부염 환자 1035명의 장기간의 한의학적 치료효과에 대한 후향적 연구

조아라,한수련,박건,서산,Cho, Ah-Ra,Han, Su-Ryun,Park, Gun,Seo, San 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1

Objective : The purpose of this study is to report the effectiveness of a long-term Korean Medicine Treatment on 1035 atopic dermatitis patients Methods : Objective SCORAD Index(OSI) is used for measuring the degree of atopic dermatitis with photos of total 1035 atopic dermatitis patients who has visited oriental clinic from January 9, 2011 to October 31, 2013. Then, OSI was estimated according to gender, age, period of treatment and intensity. Results : 1. The ratio of male to female was 44.4 : 55.6. All patients were constituted with 26.5% of 0~11 year-old group, 15.7% of 12~18 year-old and 57.9% of 19 and more year-old. 2. The ratio of OSI improvement was significantly higher in women than in men after 3 month treatment, but there was no significant difference after 6, 9 and 12 months. 3. The OSI improvement of 0~11 year-old group was significantly higher than the other groups after 3 month treatment. But at the other periods of treatment, there was no significantly difference of the improvement among 3 different groups of age. 4. After 3, 6, 9 and 12 month treatment, the score of OSI was significantly lower than before treatment. After 12 month treatment, the score of OSI was lowest compared to the other periods of treatment. 5. The final OSI score of 87.7% patients was decreased compared to the initial. 6. All patients had been divided with 1.93% of the mild, 22.7% of the moderate and 75.4% of the severe by OSI intensity at initial visit. At final visit, the composition of patients was changed to 14.6% of the mild, 53.7% of the moderate and 31.7% of the severe. 7. The mild patients had got 42.56% of OSI improvement at the final. And the moderate had got 37.72% of OSI improvement at the final. 8. The severe patients had got 36.76% of OSI improvement at the final. And 89.2% of the severe had got decreased final OSI score compared to the initial. Conclusion : There was a definite decreasing of OSI score on the significant rate of Atopic dermatitis patients who had been treated by Korean medicine treatment at least for 3 months.

창원지역 초등학교 학생과 어머니의 김치에 대한 의식 및 섭취실태 조사

조아라 ( Ah Ra Cho ),강옥주 ( Ok Ju Kang ),정효숙 ( Hyo Sook Cheong ) 대한영양사협회 2011 대한영양사협회 학술지 Vol.17 No.3

This study aimed to examine consumers` interest, preference, and consumption frequency of Kimchi in elementary school students in the fifth grade and their mothers living in Changwon city. In a comparison of eating habits, students exhibited better eating habits than their mothers (P<0.01). Though the mothers` levels, were higher than those of the students in the category of ``eat foods with a bit of salt usually``, the students` levels were higher in the rest of the eating habit categories. The categories of ``like Kimchi``, ``spicy taste``, and ``appropriately spicy taste`` got high levels. Among several kinds of Kimchi, both students and mothers preferred ``cabbage Kimchi`` the most. Among various Kimchi foods, preferences for ``Kimchi pancake``, ``fried rice with Kimchi``, and ``tuna Kimchi soup``, were highest in that order. The preferences differed between students and mothers in each category; mothers` preferences were significantly higher than those of students. However, in the rest of categories, except ``boiled kimchi and fish`` and ``Kimchi and stir-fried spicy pork``, students` preferences were higher than mothers` ones. Compared to their preferences, students` consumption frequencies were significantly higher than mothers` ones (P<0.01). There were positive correlations among students` eating habits, awareness of Kimchi, consumption frequency, and preference. For mothers, there were positive correlations not only between eating habits and awareness, but also between awareness and preference.

한국 중앙 일간지의 독자투고 특성 연구

조아라(Ah Ra Cho),이건호(Gunho Lee) 한국언론정보학회 2011 한국언론정보학보 Vol.55 No.3

본 연구는 한국의 주요 일간지가 오피니언 면을 만든 1990년대 후반부터 약 10년을 분석 기간으로 삼아, 조선일보ㆍ동아일보ㆍ한겨레 등 3개 중앙 일간지 독자투고의 내용, 투고자 특성, 피드백 기능 유무에 따른 독자투고의 특성을 분석했다. 그 결과, 우리나라 독자투고가 단순히 개인적인 불만이나 피해를 토로하는 공간에서 다양한 이슈에 대한 독자들의 의견이 표현되는 공간으로 변화하고 있음이 확인됐다. 비록 독자투고에서 거론되는 이슈가 아직 사회와 경제 등 전통적인 내용을 많이 다루기는 하지만 미디어ㆍ문화ㆍ스포츠 등의 영역으로까지 그 범위가 확대되고 있었다. 더불어 이 기간동안 투고자 중 전문가 및 사회단체 소속 독자들이 늘어나고, 특정 기사에 대한 반응을 명기함으로써 피드백 기능을 확실히 한 내용의 투고들이 증가하고 있었다. 이와 같은 변화는 여론 형성을 위한 공간으로써 독자투고의 질적 측면이 향상되고 있다는 해석을 가능하게 했다. 하지만 투고자의 거주 지역이 수도권에 크게 편중된 것으로 나타나, 독자투고란 운영방침 변화 등 다양한 지역 의견을 확보하기 위한 매체의 노력이 필요할 것으로 보인다. This study analyzed the contents of letters-to-the-editor and the characteristics of the letters’ writers, featured in three major newspapers, Chosun Ilbo, Dong-a Ilbo and Hankyoreh, in Korea from 1997 to 2009. Additionally, based on whether the letters contained the feedback function or not, it scrutinized the attributes of the letters-to-the-editor. The results indicated that the role of letters-to-the-editor has changed from a space for showing merely personal dissatisfactions or complaints into a space for expressing the reader’s opinions about various issues. The study also showed that the proportion of writers who have specialized jobs and are members of civic groups steadily increased. It seems to tell that the quality of the letters was improved accordingly, because they could give in-depth opinions about the matters in which the society were interested. The feedback function of the letters was also gradually more activated for those years, and it could be thought as another evidence supporting the quality improvement of the letters, which were supposed to form the healthful public opinion. However, the writers’ residential districts are heavily concentrated on the region surrounding Seoul, the capital of Korea. The study suggested that the newspapers should develop tools to overcome such defects.

설문조사를 통한 해양안전체험교육의 효율성 연구

조아라(Cho, Ah Ra),이정렬(Lee, Jung Lyul) 대한토목학회 2016 대한토목학회 학술대회 Vol.2016 No.10

정상임신 및 임신성 당뇨임신의 제대혈내 adiponectin 농도에 관한 연구

조아라 ( Ah Ra Cho ),김영주 ( Young Ju Kim ),전선희 ( Sun Hee Chun ),조수진 ( Su Jin Cho ),박은애 ( Eun Ae Park ),박미혜 ( Mi Hye Park ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.9

목적: 이번 연구의 목적은 정상임신군과 임신성 당뇨임신군의 비교를 통해 자궁내 환경의 차이가 제대혈내 adiponectin 농도에 어떠한 영향을 주는지 알아보고자 하는 것이다. 연구방법: 2004년 1월부터 2009년 6월까지 이화여자대학교 목동병원 산부인과에서 35주 이후에 분만한 정상 산모군 204명과 임신성 당뇨로 진단받은 산모 204명을 대상으로 하여 연구를 시행하였다. 임신성 당뇨로 진단받은 204명의 산모 중에서 118명은 식이조절만으로 혈당을 조절하였고, 나머지 86명은 임신 기간 동안 인슐린을 투여 받았다. 분만 시 제대정맥혈액을 채취하여 원심분리 후, 효소면역측정법 (enzyme-linked immunosorbent assay)을 사용하여 제대혈액내 adiponectin의 농도를 측정하였다. 결과: 제대혈내 adiponectin 농도는 정상임신군에 비해 임신성 당뇨로 진단받은 임신군에서 더 높은 수치를 나타내었다(P = 0.02). 정상임신군과 임신성 당뇨임신군 모두에서 제대혈내 adiponectin 농도는 남아에 비해 여아가 높은 수치를 보였다(P = 0.04, P = 0.03). 정상임신군에서 임신 주수와 제대혈내 adiponectin 농도는 유의한 양의 상관관계를 보였다(r = 0.2374, P = 0.0129). 출생 시 주수와 성별을 보정한 경우, 정상 임신군에서 출생 시 체중과 제대혈내 adiponectin 농도는 유의한 연관성이 없었다(P > 0.05). 임신성 당뇨를 진단받았던 임신군에서, 식이 조절만으로 혈당을 관리한 군과 인슐린 치료를 받은 군의 제대혈내 adiponectin 농도는 통계적으로 유의한 차이가 없었다(P > 0.05). 결론: 제대혈내 adiponectin 농도가 정상임신 및 임신성 당뇨임신군 사이에서 차이를 보이고, 성별 간 두형태성을 나타내는 것은 이들의 자궁내 환경이 다르기 때문이라고 생각된다. 임신성 당뇨임신군 및 여아에서 높은 제대혈내 adiponectin 농도를 보이는 것은, 이들의 증가된 지방 축적도를 반영한 결과라 할 수 있을 것이다. Objective: To investigate the effect of intrauterine environment on adiponectin level in cord blood through comparison of normal pregnancy group and gestational diabetes group. Methods: This cross sectional study included women with: normal pregnancy (n = 204); and patients with gestational diabetes mellitus (GDM) (n = 204). Among GDM patients, 118 were managed with diet alone and 86 were insulin requiring. Cord serum adiponectin concentration at birth was measured by enzyme-linked immunosorbent assay. Results: Cord serum adiponectin concentration was higher in GDM treatment pregnancies compared with normal pregnancies (P = 0.02). Cord serum adiponectin concentration was higher in female compared with male fetuses both normal and gestational diabetes pregnancies (P = 0.04, P = 0.03). In normal pregnancies, cord serum adiponectin concentration was positively correlated with gestational age (r = 0.2374, P < 0.02). In normal pregnancies, cord serum adiponectin concentration did not correlated with birth weight (r = -0.05, P > 0.05). Cord serum adiponectin concentration was not different between only diet treated women and insulin requiring women in GDM (P > 0.05). Conclusion: Sex dimorphism for adiponectin and the change of adiponectin in GDM off springs, first appear in utero. Higher adiponectin levels in females or GDM off springs reflect increased adiposity of the fetuses.

임상 ; 임신성 당뇨병 발생의 위험인자

조아라 ( A Ra Cho ),경규상 ( Kyu Sang Kyeung ),박민아 ( Min Ah Park ),이영미 ( Yung Mi Lee ),정은환 ( Eun Hwan Jeong ) 대한주산의학회 2007 Perinatology Vol.18 No.4

목적: 임신성 당뇨병의 발생과 관련이 있는 위험인자를 조사하고, 선별검사의 범위를 한정시킨 현행 의료급여고시의 타당성을 검토하기 위함이다. 방법: 1999년 6월부터 2006년 3월까지 임신 22주에서 39주 5일까지의 충북대학교병원 산부인과에서 선별검사를 시행한 임부 1,091명을 대상으로 하였다. 50 g 경구 당부하 검사를 시행하여 1시간 후 혈당이 140 mg/dL 이상인 임부에서 100 g 경구 당부하 검사를 하였고 미국 국립 당뇨병 연구회의 진단기준(1994)을 이용하여 2개 이상 양성인 경우 임신성 당뇨병으로 진단하였다. 임신성 당뇨병의 위험인자로는 임부의 연령, 비만, 임신 후 과도한 체중증가, 기형아나 거대아, 자궁 내 태아사망의 분만력, 주산기 사망, 당뇨병의 가족력, 고혈압과 임신중독증, 당뇨병의 기왕력을 조사하였다. 결과: 고령, 주산기 사망, 자궁 내 태아사망의 분만력, 당뇨병의 가족력, 임신중독증이나 임신성 당뇨병의 기왕력 등의 위험인자가 있는 임부는 임신성 당뇨병의 발생율과 거대아 출산의 확률이 의미있게 높았다. 또한 임신성 당뇨병 군에서 신체질량지수가 의미있게 증가되어 있었고 50 g 당부하 검사수치가 증가하였다. 그러나 위험인자가 없는 임부에서도 임신성 당뇨병이 발생하는 것을 보여주었다. 결론: 위험인자가 있는 임부는 임신성 당뇨병의 발생에 유의하여야 하지만, 예상치 않은 임신성 당뇨병을 조기에 발견하여 치료함으로써 임신결과를 향상시키기 위해서는 위험인자가 없더라도 모든 임부를 대상으로 선별검사를 하는 것이 훨씬 좋을 것으로 보인다. Objective: The purpose of this study was to identify the prevalence of risk factors related to Gestational Diabetes Mellitus (GDM). Methods: We retrospectively analyzed medical records of 1,091 pregnant women who had a 50 g oral glucose tolerance test (OGTT) at performed at the department of Obstetrics and Gynecology, Chungbuk National University Hospital from June, 1999 to March, 2006. The 1-hour plasma glucose level higher than 140 mg/dL was considered as a positive screening result. Patients with positive results underwent a 100 g OGTT as the diagnostic test for GDM, and more than 2 positive results were diagnosed as GDM, according to the American National Diabetes Data Group (NDDG) guideline. We investigated age, prevalence of obesity, weight gain, history of fetal anomaly, fetal death in uterus (FDIU), macrosomia, preeclampsia, GDM and familial history of diabetes mellitus, as the risk factors of GDM. Results: Elderly gravida, history of FDIU, perinatal death, preeclampsia, and GDM, familial history of diabetes mellitus were the risk factors of GDM and macrosomia to a statistically significant degree. We found out that BMI and 50 g OGTT results were increased in GDM group. However, there was a pregnant woman with no risk factors who had been diagnosed with GDM. Conclusion: Although the pregnant women with risk factors should be managed carefully to detect GDM, we also suggest all pregnant women to take screening test even if they have no risk factors, to improve pregnancy outcomes by detecting and treating unexpected GDM early in pregnancy.

영유아 아토피피부염 환자의 스테로이드 외용제 사용유무에 따른 한의학적 치료효과에 대한 후향적 연구

양윤홍,조아라,한수련,서산,박건,Yang, Yoon-Hong,Cho, Ah-Ra,Han, Su-Ryun,Seo, San,Park, Gun 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.4

Objectives: The purpose of this study is to examine whether there is a significant efficacy difference on infant and young child atopic dermatitis patients treated with Korean Medicine Treatment through 6 months between topical steroid used group and non-steroid group. Methods: The degree of atopic dermatitis was measured by the Objective SCORAD Index (OSI) with photographs of patients. Detailed analysis of the OSI score was compared based on the use of topical steroid. Results: 1. There was not a significant difference between the topical steroid group and the non-steroid group in regards of gender, age and initial OSI score. 2. The non-steroid group's OSI score decreased significantly from 50.17 to 29.20. 3. The topical steroid group's OSI score decreased significantly from 54.21 to 34.95. 76.19% of the patients in the topical steroid group discontinued steroid use within the 6-month period. The average time of discontinuation since the beginning of treatment was 3.36 months. 4. The OSI Improvement rate comparison of topical steroid group with non-steroid group did not show a significant difference over a 3-month and 6-month period. 5. Distribution of severe cases decreased in Both topical steroid and non-steroid group after 6 month treatment. Conclusions: The OSI score of infant and young child atopic dermatitis patients in both topical steroid and non-steroid group was decreased significantly with Korean medicine treatment through 6 months. There was no significant difference between topical steroid group and non-steroid group in OSI improvements over a 3-month period and 6-month period.